Abstract:
BACKGROUND:Lichen planus is a mucocutaneous papulosquamous itchy disease with unknown etiology. A number of factors such as immune mechanisms, viral agents, and drugs have been implicated in pathogenesis of lichen planus. In recent years, several studies have indicated the role of viral agents in this disease, including human herpesvirus-7 (HHV-7). Studies have given contradictory results, which is why we decided to study the possible association between lichen planus with HHV-7. METHODS:In this case-control study, which was conducted on 60 cutaneous classic lichen planus samples as well as 60 healthy control skin samples after matching the two groups in terms of gender and age, tissue samples of patients and controls were studied by real time polymerase chain reaction to detect for HHV-7. RESULTS:According to this study, HHV-7 DNA was found in 18 samples of the case group (30.0%) and in six (10.0%) of the control group (P = 0.006). CONCLUSION:The results of this study support the likely role of HHV-7 in pathogenesis of lichen planus. As an exogenous antigen, this virus may be involved in cellular immune-mediated destruction of keratinocytes.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Nahidi Y,Tayyebi Meibodi N,Ghazvini K,Esmaily H,Esmaeelzadeh Mdoi
10.1111/ijd.13416subject
Has Abstractpub_date
2017-01-01 00:00:00pages
49-53issue
1eissn
0011-9059issn
1365-4632journal_volume
56pub_type
杂志文章abstract::Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine...
journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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pub_type: 杂志文章,多中心研究
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