Coexisting subacute and systemic lupus erythematosus after terbinafine administration: successful treatment with mycophenolate mofetil.

Abstract:

:A 39-year-old female patient with systemic lupus erythematosus was treated with terbinafine for onychomycosis. After only 7 days of treatment with 250 mg terbinafine, a widespread severe erythematous eruption developed. The results of clinical, histological and immunofluorescent examinations confirmed the diagnosis of coexisting subacute and systemic lupus erythematosus. The patient was treated with drug withdrawal and administration of cyclosporine and methylprednisolone. One year later, mycophenolate mofetil was successfully used. Exacerbation or induction of lupus erythematosus is an extremely rare cutaneous side-effect of terbinafine. Patients with lupus erythematosus should be advised about the risk of some drugs that might exacerbate their disease.

journal_name

Int J Dermatol

authors

Cetkovská P,Pizinger K

doi

10.1111/j.1365-4632.2004.02472.x

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

320-2

issue

3

eissn

0011-9059

issn

1365-4632

pii

IJD2472

journal_volume

45

pub_type

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