Comparative study of β-catenin and CD44 immunoexpression in oral lichen planus and squamous cell carcinoma.

Abstract:

BACKGROUND:Dysfunction of adhesion molecules is believed to play an early and important role in developing cancer. Accordingly, this study aims to compare beta-catenin (β-catenin) and CD44 expression in oral lichen planus (OLP) as a condition with malignant potential and oral squamous cell carcinoma (OSCC). METHODS:β-Catenin and CD44 expression were evaluated in 15 patients with epithelial hyperplasia (group A), 20 OLP (group B), and 20 OSCC (group C) by immunohistochemistry. RESULTS:Quantitative and semi-quantitative evaluations revealed β-catenin, and CD44 membranous expression had significant differences among the three groups. Expression of these markers in the OSCC group decreased significantly compared to that of the OLP. Also, nuclear/cytoplasmic expression of β-catenin was significantly different among the three groups, considering that nuclear expression was not observed in any of the epithelial hyperplasia and OLP samples. CONCLUSIONS:According to the findings of this study, β-catenin and CD44 can differentiate between behavior of OLP and OSCC, while the precancerous nature of OLP and malignant transformation potential of it are not suggested.

journal_name

Int J Dermatol

authors

Zargaran M,Baghaei F,Moghimbeigi A

doi

10.1111/ijd.14007

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

794-798

issue

7

eissn

0011-9059

issn

1365-4632

journal_volume

57

pub_type

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