Abstract：
BACKGROUND:Actinic prurigo (AP) is a photodermatosis with a restricted ethnic distribution, mainly affecting Mestizo women (mixed Indian and European). The lesions are polymorphic and include macules, papules, crusts, hyperpigmentation and lichenification. Thalidomide, an effective immunomodulatory drug, was first used successfully to treat AP in 1973. In this work we describe the effect that thalidomide had on TNF-alpha sera levels and on IL-4- and IFN gamma (IFNgamma)-producing lymphocytes of actinic prurigo (AP) patients. METHODS:Actinic prurigo patients were analyzed before and after thalidomide treatment. The percentage of IL-4+ or IFNgamma+ CD3+ lymphocytes was analyzed in eight of them by flow cytometry. TNFalpha in sera was measured by ELISA in 11 patients. RESULTS:A direct correlation was observed between resolution of AP lesions and an increase in IFNgamma+ CD3+ peripheral blood mononuclear cells (P < or = 0.001) and a decrease in TNFalpha serum levels (no statistical difference). No IL-4+ CD3+ cells were detected. CONCLUSIONS:Our findings confirm that AP is a disease that has an immunological component and that thalidomide clinical efficacy is exerted not only through inhibition of TNFalpha synthesis, but also through modulation of INFgamma-producing CD3+ cells. These cells could be used as clinical markers for recovery.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Estrada-G I,Garibay-Escobar A,Núñez-Vázquez A,Hojyo-Tomoka T,Vega-Memije E,Cortés-Franco R,Pérez-Uribe A,Flores-Romo L,Santos-Argumedo L,Estrada-Parra S,Domínguez-Soto Ldoi
10.1111/j.1365-4632.2004.02274.xsubject
Has Abstractpub_date
2004-12-01 00:00:00pages
893-7issue
12eissn
0011-9059issn
1365-4632pii
IJD2274journal_volume
43pub_type
杂志文章abstract：OBJECTIVE:To assess the safety and efficacy of a 0.005% mixture of solasodine glycosides (Zycure) in the treatment of basal cell carcinoma. Design Double-blind, randomized, and vehicle-controlled, parallel group study. SETTING:Ten centers in the United Kingdom. Participants Male, n = 50; female, n = 44; age range, 32-...
journal_title：International journal of dermatology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1365-4632.2007.03363.x
更新日期：2008-01-01 00:00:00
abstract：:A 23-year-old man with AIDS developed a lesion with the clinical characteristics of an ectopic geographic tongue in the lower lip, near the right commissure. ...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4362.1990.tb04080.x
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:In July 2008, the German statutory health insurance introduced a nationwide skin cancer screening program. Before the introduction, eligible physicians had to qualify to perform the screening test and counsel their patients on skin cancer screening. To educate physicians, a curriculum and training materials ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.13688
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Epidemiological studies of molluscum contagiosum (MC) in children are limited. PATIENTS AND METHOD:Between 1997 and 1999, 110 children with MC (60 boys, 50 girls, mean age: 4.8 years) were studied. Treatment consisted of removal of all MC lesions in a single session by sterilized tweezers. RESULTS:In child...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02074.x
更新日期：2005-03-01 00:00:00
abstract：:The calcipotriene/betamethasone dipropionate two-compound scalp formulation has been shown to be safe and effective in the treatment of scalp psoriasis over 8 weeks, but the patients studied were mainly White and non-Hispanic. The aim of this study was to evaluate the efficacy and safety of the two-compound scalp form...
journal_title：International journal of dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-4632.2010.04598.x
更新日期：2010-11-01 00:00:00
abstract：:The correlation between combined chemotherapy, including 6-mercaptopurine, and development of excessive number of melanocytic nevi in childhood has been previously reported and studied. As of yet, no such relation has been reported in adults. We recently observed a 27-year-old female patient who developed numerous ben...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2005.02086.x
更新日期：2005-04-01 00:00:00
abstract：BACKGROUND:Ducatalon is a bipyridylium herbicide containing a mixture of diquat and paraquat, and is used in agriculture. Adverse reactions due to contact of this compound with the skin have rarely been described. CASE REPORTS:Two men were seen for severe pain due to extensive chemical burns in the perineal and scrota...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1995.tb04371.x
更新日期：1995-01-01 00:00:00
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journal_title：International journal of dermatology
pub_type： 杂志文章,评审
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journal_title：International journal of dermatology
pub_type： 杂志文章
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abstract：:Actinic granuloma is a rare skin disorder that develops in an area of actinic elastosis. The pathogenesis of the disease is obscure but the most accepted hypothesis implicates the solar radiation as the triggering factor. Typically the disease presents in middle-aged individuals with significant past sun-exposure and ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2005.02043.x
更新日期：2005-02-01 00:00:00
abstract：:A 58-year-old woman with progressive systemic sclerosis developed a butterfly erythematous eruption, hemorrhagic maculae, crusting, and erosions on the face 15 days following administration of D-penicillamine. This appeared to be a lupus erythematosus-like eruption due to an adverse drug reaction to D-penicillamine be...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1990.tb03471.x
更新日期：1990-10-01 00:00:00
abstract：OBJECTIVES:Nadifloxacin is a fluoroquinolone with broad-spectrum antibacterial activity. Although it is used as an acne treatment in some European countries, it has not been used to treat Korean acne patients. We aimed to evaluate the clinical efficacy and safety of 1% nadifloxacin cream and the histological changes it...
journal_title：International journal of dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-4632.2010.04701.x
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Mechanic's hand is a defined specific skin eruption associated with dermatomyositis; there are few reports concerning its histopathology. As mechanic's hand clinically resembles hand eczema, it is important to distinguish between these two conditions. AIM:To determine the characteristic clinical and histopa...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.04164.x
更新日期：2009-11-01 00:00:00
abstract：BACKGROUND:Ultrasonography (US) has recently proved to be useful in diagnostic dermatology. It is convenient to use, completely safe, and provides valuable information. OBJECTIVE:This study was performed to compare the diagnostic accuracy of US with that of clinical diagnosis in patients with benign subcutaneous lesio...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12989
更新日期：2015-11-01 00:00:00
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journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.1998.00437.x
更新日期：1998-07-01 00:00:00
abstract：:A survey of people with skin cancer in tropical Australia detected a change in site of the prevalent cancer. In the post-war generation more basal cell carcinomas are occurring on the back and fewer on the head and neck. A reversal of the sex ratio was also detected, with more women being afflicted. ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb02667.x
更新日期：1992-06-01 00:00:00
abstract：:Favus has become a rarly found chronic fungal infection mainly caused by Trichophyton schoenleini and occasionally by Trichophyton violaceum or Microsporum gypseum. It can still be found in areas where the population suffers from poor hygiene and malnutrition. Cases are seen in the Mediterranean basin, the Middle East...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1980.tb00259.x
更新日期：1980-03-01 00:00:00
abstract：:Comparative studies were performed on clinical and laboratory features of four patients with different types of T-cell lymphoma of the skin; adult T-cell leukemia/lymphoma (ATLL), Sézary syndrome, mycosis fungoides, and Ki-1-positive lymphoma. All neoplastic cells studied showed a helper-inducer T-cell phenotype. A Ki...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1989.tb01329.x
更新日期：1989-03-01 00:00:00
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更新日期：2014-07-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1046/j.1365-4362.1998.00415.x
更新日期：1998-05-01 00:00:00
abstract：:Pityriasis lichenoides et varioliformis acuta (PLEVA), or Mucha-Habermann disease (MHD), is a cutaneous disorder evident with crops of erythematous macules and papules, usually on the trunk and flexural areas of the extremities. Its etiology remains unknown. PLEVA is speculated to be an inflammatory reaction triggered...
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pub_type： 杂志文章,评审
doi：10.1111/j.1365-4632.2008.03915.x
更新日期：2010-03-01 00:00:00
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journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.03937.x
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abstract：BACKGROUND:Warts are a common chronic skin disorder that can be cosmetically disfiguring and, depending on the location, cause inhibition of function. The presence of dozens of topical and systemic treatments for warts is a testament to the lack of a rapid, simple, uniformly effective, inexpensive, nonscarring, and pai...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-4362.2001.01242.x
更新日期：2001-06-01 00:00:00
abstract：:The use of teledermatology as an adjunct to conventional clinical dermatology on the Faroe Islands is described. The service is based on a nurse-led dermatological clinic, and teledermatology is combined with specialist visits for more complex diagnosis or procedures. ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2008.03718.x
更新日期：2008-09-01 00:00:00
abstract：:Oral mucous membrane involvement occurs uncommonly in mycosis fungoides and reports of it are scarce. We present two patients with severe involvement of the oral mucous membranes. ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1991.tb04353.x
更新日期：1991-12-01 00:00:00
abstract：:There are rapidly increasing opportunities for dermatologists to see patients suffering from retrovirus infections. The HTLV-I was the first class of human oncogenic retrovirus that was found in cultured cells of a patient with skin manifestations similar or identical to those of CTCL (MF). It was soon recognized as t...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4362.1991.tb03483.x
更新日期：1991-09-01 00:00:00
abstract：:Like all organ systems, the skin undergoes significant changes during pregnancy. The majority of physiologic skin conditions related to gestation resolve after childbirth. However, they may cause significant concern or cosmetic distress or be mistaken for one of the specific dermatoses of pregnancy. Dermatoses unique ...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4632.2010.04869.x
更新日期：2011-07-01 00:00:00
abstract：BACKGROUND:Millions of people are infested by head lice every year. However, louse transfer between hosts is not well-understood. Our goals were to determine: (1) which stages were most likely to disperse and why, (2) the likelihood of fomites transmission, and (3) if host blood gender affects louse development. METHO...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2005.02418.x
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:The Israel Defense Forces (IDF) medical records offer a unique and valid 28-year view of the striking differences in cutaneous leishmaniasis (CL) seasonality patterns and incidence rates between the military and civilian sectors in Israel. AIM:To determine the annual epidemiology and seasonality trends of C...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.03979.x
更新日期：2009-06-01 00:00:00
