Clinical and histological evaluation of 1% nadifloxacin cream in the treatment of acne vulgaris in Korean patients.


OBJECTIVES:Nadifloxacin is a fluoroquinolone with broad-spectrum antibacterial activity. Although it is used as an acne treatment in some European countries, it has not been used to treat Korean acne patients. We aimed to evaluate the clinical efficacy and safety of 1% nadifloxacin cream and the histological changes it incurs when used to treat mild to moderate facial acne in Korean patients. METHODS:An eight-week, randomized, prospective, split-face, double-blind, vehicle-controlled trial was performed. All participants were treated with 1% nadifloxacin cream on one-half of the face and vehicle cream on the other, twice per day for eight weeks. RESULTS:At final visits, inflammatory acne lesions were reduced by 70% on nadifloxacin-treated skin and increased by 13.5% on vehicle-treated skin; non-inflammatory acne lesions showed reductions of 48.1 and 10.1%, respectively. A significant difference was observed between the two treatments at four weeks. Histopathological examinations of the acne lesions showed decreased inflammation and interleukin-8 expression but no change in transforming growth factor-β expression in nadifloxacin-treated skin compared with vehicle-treated skin after eight weeks of treatment. CONCLUSIONS:Nadifloxacin 1% cream is an effective, safe, and well-tolerated topical treatment for Korean patients with mild to moderate acne vulgaris. Histopathological changes after nadifloxacin treatment were well correlated with clinical outcomes. Therefore, nadifloxacin can be used as an effective and safe treatment option in the management of mild to moderate acne in Asian subjects.


Int J Dermatol


Jung JY,Kwon HH,Yeom KB,Yoon MY,Suh DH




Has Abstract


2011-03-01 00:00:00












  • The CARE approach to reducing diagnostic errors.

    abstract:BACKGROUND:Diagnostic errors appear to be the most common, costly, and dangerous of all medical mistakes. There has been a notable increase on the focus of error prevention as part of a growing patient safety movement. However, diagnostic errors have received less attention than other types of error. Our goal is to pre...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Rush JL,Helms SE,Mostow EN

    更新日期:2017-06-01 00:00:00

  • Characteristics of superficial mycoses in Malta.

    abstract:BACKGROUND:A study was conducted to determine the chief agents of superficial mycoses in Malta. Data were collected over a 5-year period from mycologic investigations carried out on all dermatologic specimens sent to the Mycology Laboratory at St. Luke's Hospital in Malta. METHODS:In the period between January 1995 an...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Vella Zahra L,Gatt P,Boffa MJ,Borg E,Mifsud E,Scerri L,Vella Briffa D,Pace JL

    更新日期:2003-04-01 00:00:00

  • Dermatologists' level of compliance with the prescription guidelines of isotretinoin for females of childbearing potential.

    abstract:BACKGROUND:Potent teratogenicity limits the use of isotretinoin among females of childbearing potential (FCBP). OBJECTIVE:To explore the current practice of dermatologists for pregnancy prevention when prescribing isotretinoin for FCBP. MATERIALS AND METHODS:A self-administered questionnaire was distributed to 160 de...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: AlGhamdi KM,Khurram H,Asiri YA,Mandil A

    更新日期:2011-09-01 00:00:00

  • Efficacy of lipectomy and liposuction in the treatment of multiple symmetric lipomatosis.

    abstract:BACKGROUND:Multiple symmetric lipomatosis (MSL) is a rare disease characterized by enlarging, symmetric, nonencapsulated, fat deposits mainly on the neck and upper trunk. Liposuction and lipectomy, although palliative, are the treatments of choice, especially indicated when vital structures are compromised. OBJECTIVE:...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Martínez-Escribano JA,Gonzalez R,Quecedo E,Febrer I

    更新日期:1999-07-01 00:00:00

  • The effects of cadexomer iodine paste in the treatment of venous leg ulcers compared with hydrocolloid dressing and paraffin gauze dressing. Cadexomer Iodine Study Group.

    abstract:BACKGROUND:The aim was to examine cadexomer iodine paste in a comparative clinical trial. METHODS:A 12-week, randomized, open, controlled, multicenter, multinational trial in patients with exudating, venous leg ulcers of cadexomer iodine paste (Iodosorb/Iodoflex), hydrocolloid dressing (Duoderm E, Granuflex E), or par...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Hansson C

    更新日期:1998-05-01 00:00:00

  • A histopathologic study of mechanic's hands associated with dermatomyositis: a report of five cases.

    abstract:BACKGROUND:Mechanic's hand is a defined specific skin eruption associated with dermatomyositis; there are few reports concerning its histopathology. As mechanic's hand clinically resembles hand eczema, it is important to distinguish between these two conditions. AIM:To determine the characteristic clinical and histopa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Mii S,Kobayashi R,Nakano T,Harada H,Okada M,Matsui Y,Fujii T,Eto H

    更新日期:2009-11-01 00:00:00

  • Evaluation of CO laser efficacy in the treatment of cutaneous leishmaniasis.

    abstract:BACKGROUND:Cutaneous leishmaniasis is a common disease in Iran, especially in the north-east, central and southern parts of the country. Many treatments have been suggested for this disease but none is completely effective and without side-effects such as pain, arthralgia and renal or cardiac complications. Lasers have...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Asilian A,Sharif A,Faghihi G,Enshaeieh Sh,Shariati F,Siadat AH

    更新日期:2004-10-01 00:00:00

  • IgA dermatosis in an adult Chinese population. A 10-year study of linear IgA and dermatitis herpetiformis in Singapore.

    abstract::During a 10-year period (1976-1985), eight Chinese patients from a population of 2.5 million fulfilled the criteria for dermatitis herpetiformis and linear IgA bullous dermatosis (LABD). These rare diseases among Asians presented during the third decade of life with homogenous linear IgA deposits along the dermoepider...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ratnam KV

    更新日期:1988-01-01 00:00:00

  • Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study.

    abstract:BACKGROUND:Chronic idiopathic urticaria (CIU) is defined by the almost daily presence of urticaria for at least 6 weeks without an identifiable cause. Symptoms include short-lived wheals, itching, and erythema. CIU impedes significantly a patient's quality of life (QoL). Levocetirizine is an antihistamine from the late...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kapp A,Pichler WJ

    更新日期:2006-04-01 00:00:00

  • Spectrum of skin diseases presented at LAUTECH Teaching Hospital, Osogbo, southwest Nigeria.

    abstract:BACKGROUND:Patterns of skin disease in developing nations are changing as frequencies of non-communicable diseases continue to increase. Appraisal of the current status of the disease profile is of utmost importance for health planning and resource allocation. METHODS:A prospective analysis of 895 cases of outpatient ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Akinboro AO,Mejiuni AD,Akinlade MO,Audu BM,Ayodele OE

    更新日期:2015-04-01 00:00:00

  • Hair loss: is there a relationship with hair care practices in Nigeria?

    abstract::BACKGROUND Hair loss occurs in all ethnic populations, but the etiology varies considerably from group to group. In black women, many forms of alopecia are associated with hair care practices. However, the causes of alopecias in African women have not been extensively investigated. OBJECTIVE This descriptive, cross-se...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Nnoruka EN

    更新日期:2005-10-01 00:00:00

  • Mycetoma.

    abstract::We have reviewed the outstanding facts about mycetoma, including the history, first reports in India, the different causal agents according to their geographic distribution, mycologic characteristics, pathology, microbiology, behavior, evolution, immunology, experimental inoculations, associated bacterial complication...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Magana M

    更新日期:1984-05-01 00:00:00

  • Lipodermatosclerosis: a clinicopathologic correlation.

    abstract:BACKGROUND:Lipodermatosclerosis (LDS) is a chronic fibrosing panniculitis associated with venous insufficiency. Although LDS is often a clinical diagnosis, it can be confused with other panniculitides. Microscopic examination is therefore essential to support the diagnosis in this condition. Histopathologic changes, ho...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Choonhakarn C,Chaowattanapanit S,Julanon N

    更新日期:2016-03-01 00:00:00

  • Psychodermatological disorders: recognition and treatment.

    abstract::Many dermatological disorders have a psychosomatic or behavioral aspect. Skin and brain continually interact through psychoneuroimmunoendocrine mechanisms and through behaviors that can strongly affect the initiation or flaring of skin disorders. It is important to consider these mind-body interactions when planning t...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Shenefelt PD

    更新日期:2011-11-01 00:00:00

  • Effects of vitamin C vs. multivitamin on melanogenesis: comparative study in vitro and in vivo.

    abstract:BACKGROUND:Vitamin C has been used for the treatment of hyperpigmented diseases. However, there is no study available on hypopigmenting effect of multivitamin. OBJECTIVES:To investigate the inhibitory effects of multivitamin and vitamin C on melanogenesis. METHODS:We assessed the effect of multivitamin and vitamin C ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,随机对照试验


    authors: Choi YK,Rho YK,Yoo KH,Lim YY,Li K,Kim BJ,Seo SJ,Kim MN,Hong CK,Kim DS

    更新日期:2010-02-01 00:00:00

  • A retrospective review of cutaneous lymphoma in Botswana.

    abstract:BACKGROUND:Primary cutaneous lymphoma (PCL) represents a heterogeneous collection of non-Hodgkin lymphomas originating in the skin. Our study describes the clinical and histological findings of cutaneous lymphoma within Botswana to expand the paucity of data on this rare disease in sub-Saharan Africa. METHODS:We condu...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Rodriguez O,Sowash M,Mosojane KI,Ralefala T,Grover S,Haun P,Kovarik C,Williams VL

    更新日期:2020-03-01 00:00:00

  • Paraneoplastic pyoderma gangrenosum in solid organ malignancy: a literature review.

    abstract::Pyoderma gangrenosum (PG) is a rare destructive, ulcerative, and inflammatory cutaneous disease. PG can be associated with inflammatory bowel disease (IBD), arthritis, autoinflammatory syndromes, and hematological malignancies. Multiple reports in the literature have found an association between PG and solid organ tum...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Shah M,Sachdeva M,Gefri A,Jfri A

    更新日期:2020-02-01 00:00:00

  • Skin disease in rural Tanzania.

    abstract:BACKGROUND:Skin disease is a common problem, accounting for significant morbidity in developing countries. Knowledge about the prevalence of different skin conditions allows appropriate planning for provision for these health needs. There are currently few data about the needs in rural areas; therefore, this study was ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Henderson CA

    更新日期:1996-09-01 00:00:00

  • Current therapies for actinic keratosis.

    abstract::Actinic keratosis (AK) is a very common skin disease caused by chronic sun damage, which in 75% of cases arises on chronically sun-exposed areas, such as face, scalp, neck, hands, and forearms. AKs must be considered an early squamous cell carcinoma (SCC) for their probable progression into invasive SCC. For this reas...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Dianzani C,Conforti C,Giuffrida R,Corneli P,di Meo N,Farinazzo E,Moret A,Magaton Rizzi G,Zalaudek I

    更新日期:2020-06-01 00:00:00

  • A multicenter epidemiological study of acne vulgaris in Korea.

    abstract:BACKGROUND:Acne is a common skin disorder that affects both adolescents and adults. However, few epidemiological studies on this condition have been conducted in Asia. OBJECTIVES:The purpose of this study was to analyze the incidence of acne and to identify its demographic and clinical features and aggravating factors...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,多中心研究


    authors: Suh DH,Kim BY,Min SU,Lee DH,Yoon MY,Kim NI,Kye YC,Lee ES,Ro YS,Kim KJ

    更新日期:2011-06-01 00:00:00

  • Cicatricial pemphigoid vegetans.

    abstract::A 58-year-old woman with ulcerative colitis of 5 years' duration was first seen in March 2002 with a 5-month history of widespread erosions on the palate and gingiva, subtle scarring of the conjunctiva, and xerostomia accompanying a flare of ulcerative colitis. No skin lesions were observed. Direct immunofluorescence ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Woźniak K,Górkiewicz A,Olszewska M,Schwartz RA,Kowalewski C

    更新日期:2007-03-01 00:00:00

  • Value of routine diagnostic criteria of bullous pemphigoid.

    abstract:BACKGROUND AND DESIGN:The clinical, histologic, and direct (DIF) and indirect (IIF) immunofluorescence findings are used in a critical, although arbitrary, manner in the routine diagnostic process of bullous pemphigoid (BP). Our purpose was to estimate their relative value. In the present retrospective study, a follow-...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Chaidemenos GC,Maltezos E,Chrysomallis F,Kouskoukis K,Kapetis E,Mourellou O,Gotsis N

    更新日期:1998-03-01 00:00:00

  • Molluscum contagiosum in Greek children: a case series.

    abstract:BACKGROUND:Epidemiological studies of molluscum contagiosum (MC) in children are limited. PATIENTS AND METHOD:Between 1997 and 1999, 110 children with MC (60 boys, 50 girls, mean age: 4.8 years) were studied. Treatment consisted of removal of all MC lesions in a single session by sterilized tweezers. RESULTS:In child...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kakourou T,Zachariades A,Anastasiou T,Architectonidou E,Georgala S,Theodoridou M

    更新日期:2005-03-01 00:00:00

  • Omalizumab for atopic dermatitis: case series and a systematic review of the literature.

    abstract::Omalizumab is a recombinant humanized monoclonal antibody targeting the high-affinity Fc receptor of IgE, registered for the treatment of chronic spontaneous urticaria and severe allergic asthma. We present a case series of nine patients with atopic dermatitis (AD) treated off-label with omalizumab and a systematic re...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Holm JG,Agner T,Sand C,Thomsen SF

    更新日期:2017-01-01 00:00:00

  • Treatment of psoriasis with topical nitrogen mustard.

    abstract::With the advent of various new methods of treating psoriasis, it is necessary to remind physicians to consider an agent that is easy to administer, locally effective, relatively inexpensive, not time-consuming and without systemic toxic effects. Nineteen patients were treated with topical nitrogen mustard between 1972...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Handler RM,Medansky RS

    更新日期:1979-11-01 00:00:00

  • Anthralin therapy for alopecia areata.

    abstract::Topical anthralin application producing a brisk irritant contact dermatitis has been reported to have therapeutic benefit in alopecia areata. A pilot clinical study was undertaken to determine whether topical anthralin application in doses low enough to produce only minimal contact dermatitis would produce a similar t...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Nelson DA,Spielvogel RL

    更新日期:1985-11-01 00:00:00

  • Linear basal cell epithelioma.

    abstract::A 73-year-old Celtic man presented with a linear pigmented 20-mm lesion on the left infraorbital cheek (Fig. 1). Clinical impression was pigmented basal cell epithelioma. Removal was accomplished by linear excision under local anesthesia. The wound was closed with a running 5-0 nylon subcuticular suture, which was rem...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Lewis JE

    更新日期:1985-03-01 00:00:00

  • Tinea capitis in Lahore, Pakistan.

    abstract:BACKGROUND:The causative fungi of tinea capitis vary with geography and time. This study was planned to identify the etiologic agents and determine clinicoetiologic correlations of tinea capitis in Lahore, Pakistan. METHODS:From clinically suspected cases of tinea capitis, skin scrapings and hair samples were taken an...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Hussain I,Aman S,Haroon TS,Jahangir M,Nagi AH

    更新日期:1994-04-01 00:00:00

  • Association of Propionibacterium acnes with the efficacy of minocycline therapy for cutaneous sarcoidosis.

    abstract:BACKGROUND:Although tetracycline has been used to treat cutaneous sarcoidosis, the mechanism of action for this treatment remains unclear. This study evaluated the efficacy of minocycline treatment on cutaneous sarcoidosis and the relationship between its efficacy and the presence of Propionibacterium acnes in skin sar...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Inoue Y,Teraki Y

    更新日期:2020-06-01 00:00:00

  • Psoriasis in elderly patients in the Côte d'Ivoire: socio-demographic, clinical, and therapeutic aspects, and follow-up.

    abstract:BACKGROUND:Psoriasis is a chronic, inflammatory, and recurrent dermatological disease. In the Côte d'Ivoire, it is about 0.75% of dermatology cases. Psoriasis care is challenging in elderly patients. We aimed to show its specificities related to the sociodemographic, clinical, and therapeutic aspects, and follow-up in ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kassi K,Djeha D,Gbery IP,Kouame K,Sangaré A

    更新日期:2016-02-01 00:00:00