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Paracetamol induced Stevens-Johnson syndrome--toxic epidermal necrolysis overlap syndrome.

Abstract：

BACKGROUND:Though any drug can be a potential cause of such hypersensitivity reactions, paracetamol, an over-the-counter drug used extensively as an analgesic and antipyretic agent, is considered to be relatively safe, with hepatotoxicity as a major adverse effect only in large doses. MATERIALS AND METHODS:We report an instance of a severe case of SJS-TEN overlap syndrome in a 12-year-old girl, induced by three over-the-counter doses of 500 mg of paracetamol taken at 8-hour intervals for fever. RESULTS AND DISCUSSION:Stevens-Johnson Syndrome and its severe variant toxic epidermal necrolysis (TEN) are idiosyncratic, delayed hypersensitivity inflammatory adverse drug reactions that are associated with increased morbidity and mortality. However, treatment with antibiotics and intravenous corticosteroids along with supportive therapy improved the course of the disorder. CONCLUSION:This case report addresses the fact that severe hypersensitivity reactions can occur with paracetamol, which can be potentially dangerous and life threatening. It is hence important for the clinicians to be alert to such severe hypersensitivity reactions even with drugs which are considered to be potentially safe such as paracetamol.

journal_name

Int J Dermatol

journal_title

International journal of dermatology

authors

Biswal S,Sahoo SS

doi

10.1111/ijd.12355

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

1042-4

issue

8

eissn

0011-9059

issn

1365-4632

journal_volume

53

pub_type

杂志文章

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