Current therapies for actinic keratosis.

Abstract:

:Actinic keratosis (AK) is a very common skin disease caused by chronic sun damage, which in 75% of cases arises on chronically sun-exposed areas, such as face, scalp, neck, hands, and forearms. AKs must be considered an early squamous cell carcinoma (SCC) for their probable progression into invasive SCC. For this reason, all AK should be treated, and clinical follow-up is recommended. The aims of treatment are: (i) to clinically eradicate evident and subclinical lesions, (ii) to prevent their evolution into SCC, and (iii) to reduce the number of relapses. Among available treatments, it is possible to distinguish lesion-directed therapies and field-directed therapies. Lesion-directed treatments include: (i) cryotherapy; (ii) laser therapy; (iii) surgery; and (iv) curettage. Whereas, field-directed treatments are: (i) 5-fluorouracil (5-FU); (ii) diclofenac 3% gel; (iii) chemical peeling; (iv) imiquimod; and (v) photodynamic therapy (PDT). Prevention plays an important role in the treatment of AKs, and it is based on the continuous use of sunscreen and protective clothing. This review shows different types of available treatments and describes the characteristics and benefits of each medication, underlining the best choice.

journal_name

Int J Dermatol

authors

Dianzani C,Conforti C,Giuffrida R,Corneli P,di Meo N,Farinazzo E,Moret A,Magaton Rizzi G,Zalaudek I

doi

10.1111/ijd.14767

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

677-684

issue

6

eissn

0011-9059

issn

1365-4632

journal_volume

59

pub_type

杂志文章,评审
  • Cutaneous larva migrans (creeping eruption) in an urban slum in Brazil.

    abstract:BACKGROUND:Cutaneous larva migrans (CLM) is caused by the penetration of larvae of animal hookworms into the skin. Knowledge about this ectoparasitosis is mainly based on the examination of travelers or other expatriates. Population-based studies in an endemic area have never been performed. METHODS:A representative p...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02152.x

    authors: Heukelbach J,Wilcke T,Feldmeier H

    更新日期:2004-07-01 00:00:00

  • Tinea capitis in Lahore, Pakistan.

    abstract:BACKGROUND:The causative fungi of tinea capitis vary with geography and time. This study was planned to identify the etiologic agents and determine clinicoetiologic correlations of tinea capitis in Lahore, Pakistan. METHODS:From clinically suspected cases of tinea capitis, skin scrapings and hair samples were taken an...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1994.tb01037.x

    authors: Hussain I,Aman S,Haroon TS,Jahangir M,Nagi AH

    更新日期:1994-04-01 00:00:00

  • Considerable variation among Iranian dermatologists in the dosing and monitoring of methotrexate for treating psoriasis.

    abstract:BACKGROUND:Methotrexate (MTX) is a risky medication requiring careful attention to dosing and monitoring. Dosing and monitoring practices are not well characterized. AIMS:The aim of this study was to assess variation in the dosing and monitoring of methotrexate among Iranian dermatologists. METHODS:A questionnaire wa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12201

    authors: Zargari O,Hejazi S,Shahidi-Dadras M,Younespour S,Robati R,Firooz A,Toosi P,Feldman SR

    更新日期:2014-03-01 00:00:00

  • Chronic generalized pruritus without primary skin lesions: a longitudinal prospective observational study.

    abstract::Pruritus is among the most common complaints in the field of dermatology. It is also a disturbing symptom of many systemic disorders. Chronic pruritus (CP) refers to the cases of the symptom which last longer than 6 weeks. We conducted a prospective analysis of patients with generalized pruritus without primary skin l...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14125

    authors: Alizadeh N,Mirpour SH,Golmohamadi R,Darjani A,Eftekhari H,Rafiei R,Gharaei Nejad K,Azimi SZ

    更新日期:2019-03-01 00:00:00

  • Anthralin therapy for alopecia areata.

    abstract::Topical anthralin application producing a brisk irritant contact dermatitis has been reported to have therapeutic benefit in alopecia areata. A pilot clinical study was undertaken to determine whether topical anthralin application in doses low enough to produce only minimal contact dermatitis would produce a similar t...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-4362.1985.tb05863.x

    authors: Nelson DA,Spielvogel RL

    更新日期:1985-11-01 00:00:00

  • Diagnostic evaluation of the lupus band test in discoid and systemic lupus erythematosus.

    abstract:BACKGROUND:The usefulness of the lupus band test (LBT) in the diagnosis of cutaneous lupus erythematosus remains controversial. The study was done to determine the sensitivity, specificity, and predictive value of the LBT in discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE). METHODS:During the s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1995.tb01560.x

    authors: George R,Kurian S,Jacob M,Thomas K

    更新日期:1995-03-01 00:00:00

  • Ivermectin treatment of three cases of demodecidosis during human immunodeficiency virus infection.

    abstract::Demodecidosis is an ectoparasitosis that is infrequently observed in subjects with human immunodeficiency virus (HIV) infection. It has a rosacea-like presentation. We present three cases in patients with acquired immunodeficiency syndrome (AIDS). Two of these patients had a profuse eruption, and all three cases were ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2006.02924.x

    authors: Clyti E,Nacher M,Sainte-Marie D,Pradinaud R,Couppie P

    更新日期:2006-09-01 00:00:00

  • Facial linear focal elastosis: a case report.

    abstract:BACKGROUND:Linear focal elastosis is an uncommon disorder that clinically shows band-like stria and a histological focal increase in elastic fibers. The disorder preferentially affects men after the age of 60 years and occurs on the lower back. The pathogenesis of linear focal elastosis is still somewhat of an enigma. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.2003.01733.x

    authors: Inaloz HS,Kirtak N,Karakok M,Ozgoztasi O

    更新日期:2003-07-01 00:00:00

  • Facial contact dermatitis. Pathogenetic factors in China.

    abstract::In 107 cases of facial contact dermatitis, routine Finn chamber epicutaneous tests with TROLAB European Standard Allergens (ESAs) were performed. Sixty-one (57%) had positive reaction. The most frequent contact allergens were paraphenylenediamine dihydrochloride (16%), followed by fragrance mix (15%), and nickel sulfa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1991.tb04867.x

    authors: Zhao B,Fan WX

    更新日期:1991-07-01 00:00:00

  • IgG from atopic dermatitis patients induces IL-17 and IL-10 production in infant intrathymic TCD4 and TCD8 cells.

    abstract:INTRODUCTION:Our group recently demonstrated that IgG modulates αβT cell cytokine production during the maturation process in the human thymus. The effects of this modulation are IgG repertoire dependent and can exert a systemic and long-term impact. OBJECTIVE:To investigate whether IgG from atopic dermatitis (AD) pat...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13907

    authors: Sgnotto FDR,de Oliveira MG,Lira AAL,Inoue AHS,Titz TO,Orfali RL,Bento-de-Souza L,Sato MN,Aoki V,Duarte AJS,Victor JR

    更新日期:2018-04-01 00:00:00

  • Primary localized cutaneous amyloidosis.

    abstract::Fifty-seven patients with primary localized cutaneous amyloidosis (PLCA) were clinically and histopathologically reviewed. Two-thirds of patients had macular amyloidosis (MA). Intermediate cases having macular lesions with micropapules and/or lichens were identified. A spectrum for the disease is proposed, in which th...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1992.tb03245.x

    authors: Kibbi AG,Rubeiz NG,Zaynoun ST,Kurban AK

    更新日期:1992-02-01 00:00:00

  • Dermatologists' level of compliance with the prescription guidelines of isotretinoin for females of childbearing potential.

    abstract:BACKGROUND:Potent teratogenicity limits the use of isotretinoin among females of childbearing potential (FCBP). OBJECTIVE:To explore the current practice of dermatologists for pregnancy prevention when prescribing isotretinoin for FCBP. MATERIALS AND METHODS:A self-administered questionnaire was distributed to 160 de...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2011.04875.x

    authors: AlGhamdi KM,Khurram H,Asiri YA,Mandil A

    更新日期:2011-09-01 00:00:00

  • Puncta pruritica.

    abstract::Puncta pruritica is a chronic condition of unknown cause that is characterized by the occurrence of one or more intensely itchy pinpoint spots in clinically normal skin. Four cases are reported here. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1991.tb02619.x

    authors: Crissey JT

    更新日期:1991-10-01 00:00:00

  • Allergic reactions to insulin.

    abstract::Allergic reactions to insulin, although very common, are usually mild and self-limited. Many persistent effects can be corrected by simple means available to the discerning physician. In a few patients, however, they are severe and cause extreme morbidity or even mortality. These patients need to be recognized promptl...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1980.tb00277.x

    authors: Jegasothy BV

    更新日期:1980-04-01 00:00:00

  • Ectopic geographic tongue and AIDS.

    abstract::A 23-year-old man with AIDS developed a lesion with the clinical characteristics of an ectopic geographic tongue in the lower lip, near the right commissure. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4362.1990.tb04080.x

    authors: Grinspan D,Fernández Blanco G,Agüero S,Bianchi O,Stringa S

    更新日期:1990-03-01 00:00:00

  • Development of anthralin short-contact therapy in psoriasis: survey of published clinical trials.

    abstract::In a survey of clinical trials concerning the efficacy of short-contact therapy with anthralin in psoriasis vulgaris, focusing principally on methodologic issues, twenty-four papers published between January 1982 and December 1989, in English, French, and Italian, were selected. Nine of 24 papers reported on more than...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1365-4362.1992.tb03254.x

    authors: Naldi L,Carrel CF,Parazzini F,D'Oro LC,Cainelli T

    更新日期:1992-02-01 00:00:00

  • Cutaneous adverse events in patients receiving anticancer therapy in a tertiary hospital setting: the old and the new.

    abstract:BACKGROUND:Targeted therapies and immunotherapies are increasingly prescribed, but classic chemotherapy agents are still highly used in cancer treatment. Both therapies, the old and the new, are associated with cutaneous adverse events (CAEs) that can cause treatment interruptions or reduce the quality of life of patie...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.15081

    authors: Suh HJ,Flórez Á,Sacristán V,Rodríguez Martinez Á,Fernández F,Vilanova-Trillo L,Constenla M,Pereiro M

    更新日期:2021-02-01 00:00:00

  • Elevated plasma homocysteine levels in patients on isotretinoin therapy for cystic acne.

    abstract:BACKGROUND:The use of Isotretinoin (Iso) for cystic acne (CA) therapy includes marked side-effects such as dyslipidemia, increased liver enzymes, and reduction of biotinidase activity. Moreover, Homocysteine (Hcy), an amino acid, is metabolized in the liver requiring folate, vitamin B6, vitamin B12, and the activity of...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-4362.2001.00146.x

    authors: Schulpis KH,Karikas GA,Georgala S,Michas T,Tsakiris S

    更新日期:2001-01-01 00:00:00

  • Prurigo pigmentosa: a clinicopathological study and analysis of associated factors.

    abstract:BACKGROUND:Prurigo pigmentosa (PP), a rare inflammatory disease of the skin, is mostly reported in the ethnic Japanese population. Its pathogenesis remains unclear. The chronic and recurrent nature of PP implies a possible role of viral infection in the pathogenesis. The anti-inflammatory mechanism of doxycycline, whic...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2010.04625.x

    authors: Lu PH,Hui RC,Yang LC,Yang CH,Chung WH

    更新日期:2011-01-01 00:00:00

  • An open-label, single-arm trial of the safety and efficacy of a novel preparation of glutathione as a skin-lightening agent in Filipino women.

    abstract:BACKGROUND:Glutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less succ...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/ijd.12999

    authors: Handog EB,Datuin MS,Singzon IA

    更新日期:2016-02-01 00:00:00

  • Skin cancer prevention campaign aimed at beachgoers on the Costa del Sol (southern Spain).

    abstract:BACKGROUND:Sunbathing on the beach is one of the main risks for skin cancer. OBJECTIVE:In the summer of 2010, a skin cancer prevention campaign aimed at beachgoers was undertaken on the western Costa del Sol (southern Spain). METHODS:The campaign took place on beaches during July and August. A multicomponent interven...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12389

    authors: de Troya-Martín M,Delgado-Sánchez N,Blázquez-Sánchez N,Ortega-Tudela G,Toribio-Montero JC,Jabalera-Mesa ML,Ríos-Almellones I,Rivas-Ruiz F

    更新日期:2014-11-01 00:00:00

  • Live bee acupuncture (Bong-Chim) dermatitis: dermatitis due to live bee acupuncture therapy in Korea.

    abstract::Live bee acupuncture (Bong-Chim) dermatitis is an iatrogenic disease induced by so-called live bee acupuncture therapy, which applies the honeybee (Apis cerana) stinger directly into the lesion to treat various diseases in Korea. We present two cases of live bee acupuncture dermatitis and review previously published a...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.12161

    authors: Park JS,Lee MJ,Chung KH,Ko DK,Chung H

    更新日期:2013-12-01 00:00:00

  • Clinical characteristics of patients with facial psoriasis in Malaysia.

    abstract:BACKGROUND:Psoriasis involving the face is visible and can cause considerable emotional distress to patients. Its presence may also confer a poorer prognosis for the patient. This study sought to evaluate the characteristics of facial psoriasis in Malaysia. METHODS:A cross-sectional study conducted using data from the...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13307

    authors: Syed Nong Chek SR,Robinson S,Mohd Affandi A,Baharum N

    更新日期:2016-10-01 00:00:00

  • Comorbidity of psychiatric disorders in children and adolescents with alopecia areata in a child and adolescent psychiatry clinical sample.

    abstract:BACKGROUND:This study reports the comorbidity of lifetime psychiatric disorders in children and adolescents with alopecia areata (AA) in a child and adolescent psychiatry clinical sample. METHODS:Fourteen patients with AA were interviewed using the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03743.x

    authors: Ghanizadeh A

    更新日期:2008-11-01 00:00:00

  • Tricho-rhino-phalangeal syndrome.

    abstract::The major characteristics of tricho-rhino-phalangeal syndrome (TRPS) include shortened and deviated digits, a typical facies with a pear-shaped nose, a long philtrum and slow-growing, fine, sparse hair. Cone-shaped digital epiphyses are seen on x-ray. A few patients with TRPS are mentally retarded. Associated endocrin...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1979.tb01972.x

    authors: Hansen DD,Shewmake SW

    更新日期:1979-09-01 00:00:00

  • Evaluation of serum zinc level in patients with newly diagnosed and resistant alopecia areata.

    abstract:BACKGROUND:Alopecia areata (AA) is a non-scarring, autoimmune, inflammatory hair loss disease. Zinc is a trace element involved in important functional activities of hair follicles. PURPOSE:To evaluate serum zinc levels in patients with newly diagnosed and resistant lesions of AA in comparison to age- and sex-matched ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12769

    authors: Abdel Fattah NS,Atef MM,Al-Qaradaghi SM

    更新日期:2016-01-01 00:00:00

  • Sézary cell count in exfoliative dermatitis.

    abstract::Sézary cells were present in a number of less than 1000/mm3 in 52 of 78 cases of various benign diffuse dermatoses and mycosis fungoides. The count was higher than 1000/mm3 in two cases of Sézary syndrome in which the histopathology was that of mycosis fungoides and in six cases of exfoliative erythroderma of undeterm...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1988.tb03219.x

    authors: Duangurai K,Piamphongsant T,Himmungnan T

    更新日期:1988-05-01 00:00:00

  • Psoriasis and pregnancy: hormone and immune system interaction.

    abstract:BACKGROUND:Various hormonal states are known to be associated with the waxing and waning of psoriasis. Patients with psoriasis commonly experience changes in their cutaneous disease during pregnancy or post partum. OBJECTIVE:We evaluated 100 women with psoriasis by questionnaire and interview. The women had been seen ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1996.tb01632.x

    authors: Boyd AS,Morris LF,Phillips CM,Menter MA

    更新日期:1996-03-01 00:00:00

  • Senile erythroderma with serum hyper IgE.

    abstract::Eight patients with senile erythroderma with serum hyper IgE were studied. Characteristic laboratory findings were persistently elevated IgE levels, high peripheral-blood eosinophils, and high lactic dehydrogenase (LDH). Immunologic analysis using immunoglobulin antibodies showed frozen sections of inguinal lymph node...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1989.tb04815.x

    authors: Asai T,Horiuchi Y

    更新日期:1989-05-01 00:00:00

  • A retrospective review of cutaneous lymphoma in Botswana.

    abstract:BACKGROUND:Primary cutaneous lymphoma (PCL) represents a heterogeneous collection of non-Hodgkin lymphomas originating in the skin. Our study describes the clinical and histological findings of cutaneous lymphoma within Botswana to expand the paucity of data on this rare disease in sub-Saharan Africa. METHODS:We condu...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14690

    authors: Rodriguez O,Sowash M,Mosojane KI,Ralefala T,Grover S,Haun P,Kovarik C,Williams VL

    更新日期:2020-03-01 00:00:00