Abstract:
BACKGROUND:Tumor necrosis factor alpha (TNFα) gene -238G/A polymorphism (rs361525) is associated with psoriasis in several populations worldwide. To the best of our knowledge, there is no information about this polymorphism in Indian psoriatic patients. This study was undertaken to fill the gap in knowledge. METHODS:This case-control study involved 72 patients with psoriasis vulgaris (PsV) and 72 age and gender matched healthy individuals. TNFα -238G/A polymorphism was genotyped by PCR-RFLP method. RESULTS:TNFα -238A allele was 5 times commoner in PsV patients than in the control group (P = 4.1 × 10-7 ; odds ratio [OR] = 6.5 [0.95 CI: 2.9-14.6]). Distribution of the genotypes in the two groups showed statistically significant difference in dominant genetic model (P = 2.3 × 10-7 ) and not in recessive genetic model (P = 2.5 × 10-1 ). Odds ratio for the occurrence of -238A genotype in PsV patients was 8.8 (0.95 CI: 3.5-20.2). The association showed no major difference when PsV patients were subgrouped into type I and type II categories and tested separately. Subgroup analysis on the basis of disease severity showed higher association with the moderate-severe subgroup (P = 2.4 × 10-9 , OR 15.4 [0.95 CI: 5.8-41.0]) than with mild subgroup (P = 1.3 × 10-2 , OR 3.8 [0.95 CI: 1.3-10.9]). CONCLUSIONS:Our results indicate that TNFα gene -238G/A polymorphism increases the risk of developing psoriasis vulgaris among Indians. Also, the data show that severity and not the type affects the strength of association in this population.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Rajesh D,Gurumurthy R,Kutty AV,Balakrishna Sdoi
10.1111/ijd.13482subject
Has Abstractpub_date
2017-03-01 00:00:00pages
307-311issue
3eissn
0011-9059issn
1365-4632journal_volume
56pub_type
杂志文章abstract::Idiopathic palmar and plantar hyperhidrosis is a relatively common disorder of eccrine sweat gland function. Treatment with glutaraldehyde of formaldehyde, although successful, may cause undesirable side effects. Methenamine is a polycyclic organic compound which release ammonia and formaldehyde at acid pH. Five per c...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1976.tb00240.x
更新日期:1976-07-01 00:00:00
abstract::In a consecutive series of 1,067 patients entered into the data base of the Melanoma Cooperative Group at New York University School of Medicine between 1972 and 1980, 120 men were of draft age (18-31 years) during World War II (1941-1945). Questionnaires were sent to these 120 individuals; 89 responded. Simultaneousl...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1984.tb01228.x
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Multiple symmetric lipomatosis (MSL) is a rare disease characterized by enlarging, symmetric, nonencapsulated, fat deposits mainly on the neck and upper trunk. Liposuction and lipectomy, although palliative, are the treatments of choice, especially indicated when vital structures are compromised. OBJECTIVE:...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1999.00743.x
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Millions of people are infested by head lice every year. However, louse transfer between hosts is not well-understood. Our goals were to determine: (1) which stages were most likely to disperse and why, (2) the likelihood of fomites transmission, and (3) if host blood gender affects louse development. METHO...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2005.02418.x
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Genetic factors seem to play a significant role in the susceptibility to systemic lupus erythematosus (SLE). Some researchers have described amino acid polymorphisms within the interleukin-4 receptor (IL-4R) [isoleucine50valine (Ile50Val), arginine576glutamine (Arg576Gln), etc.], the IL-10R (G241A and G520A)...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03258.x
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Several case reports and case series have recently explored the association between hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD). OBJECTIVE:We performed a systematic review and meta-analysis of case-control studies to determine (i) the pooled prevalence of IBD in HS cohorts, and (ii) ...
journal_title:International journal of dermatology
pub_type: 杂志文章,meta分析
doi:10.1111/ijd.14697
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Crystal storing histiocytosis (CSH) imitating rhabdomyoma is a very rare disease entity involving different tissues. The skin is involved in extremely rare cases. OBJECTIVES:To describe the clinical and histopathological characteristics in a patient with unusually extensive skin involvement. OBSERVATIONS:A...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02919.x
更新日期:2006-12-01 00:00:00
abstract::Psoriasis is a chronic inflammatory skin disorder which can impair general routine activities and has been closely related to poor quality of life. Pruritus and scratching are frequently observed, occurring mainly during sleep and precipitating nighttime arousals. Indeed, sleep quality has been shown to be negatively ...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.13026
更新日期:2015-12-01 00:00:00
abstract::There are 70.8 million persons displaced worldwide due to war, persecution, and violence. Eighty percent of displaced persons reside in low- and middle-income countries with limited healthcare resources. Cutaneous diseases are commonly reported among displaced persons owing to numerous interrelated factors such as ina...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.15063
更新日期:2020-07-19 00:00:00
abstract::In order to deliver equal healthcare access to resource-poor settings, sustainable, cost-effective systems of communication should be used. As mobile phone use increases, remote care can be delivered via teledermatology using Apps. This commentary covers how WhatsApp could be used by dermatologists seeking to deliver ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14237
更新日期:2019-02-01 00:00:00
abstract::Biopsy specimens of cutaneous discoid lesions of 71 patients with cutaneous lupus erythematosus (CLE) were studied. The material was examined by direct immunofluorescence (DIF) to establish positivity and morphologic patterns of immunoglobulins and complement deposits in the basement membrane zone (BMZ). A correlation...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03567.x
更新日期:1992-04-01 00:00:00
abstract::Growth differentiation factor-15 (GDF-15), a member of the transforming growth factor-β superfamily of cytokines, plays an important role in cell growth, signal transduction, and apoptosis regulation. The aim of this study was to evaluate serum GDF-15 levels and their relationships with disease-related variables in pa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13309
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:The aim of this study was to test the linguistic validation of the Turkish version of the Dermatology Life Quality Index (DLQI) for Turkish speaking dermatology patients. METHODS:The DLQI is a 10-item dermatology specific index developed originally in English. The methodology of this study consists of four ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02881.x
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Until now mortality trends of melanoma and nonmelanoma skin cancer (NMSC) in Germany have been studied only in West Germany. We were interested in comparing mortality trends of melanoma and NMSC in West and East Germany before and after the post-communist transition. By analyses of health care...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.03892.x
更新日期:2009-04-01 00:00:00
abstract::A male fetus which was the product of full-term pregnancy and normal delivery with no family history is presented. The skin was hard and thick, waxy, yellowish in color, and was crossed by horizontal and or perpendicular red fissures. The eyelids were semiclosed, hard, and stiff resulting in ectropion and the conjunct...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1982.tb03144.x
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:Basal cell carcinoma (BCC) is one of the most frequent malignancies in the general population. Its best treatment option is the complete excision of the lesion. Mohs' micrographic surgery has demonstrated to be the surgical method with the highest cure rates, however, it is not available in many countries or...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02091.x
更新日期:2004-02-01 00:00:00
abstract::The present work compared the clinical efficacy of topically applied 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) in 16 cases with psoriasis vulgaris, 5 with ichthyosis vulgaris and 8 with X-linked ichthyosis. Sixty-nine percent of the psoriatic cases responded to 1 alpha,25-(OH)2D3 therapy, whereas no ichthyot...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1991.tb05885.x
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Self-reported complaints in people having tattoos, including swelling, itch, and photosensitivity, are frequent. Tattooists are usually heavily tattooed with multiple extended colored tattoos and constitute a specific population of interest. OBJECTIVES:To assess the prevalence of cutaneous complications on ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13030
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:'"Inflammatory vitiligo" cases with clear lichenoid infiltrates have been reported. However, the inflammatory nature of common vitiligo has not gained wide acceptance because of its benign appearance and scanty cellular infiltrates. We have observed in our patients a few lesions with mild erythema, scaling a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03672.x
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Epidemiological data have established an association between cardiovascular disease and psoriasis. Only one general population study has so far compared prevalences of cardiovascular risk factors among subjects with psoriasis and control subjects. We aimed to determine the prevalence of cardiovascular risk f...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05408.x
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Demodex mites are almost ubiquitous on older adult skin but are infrequent in young children. In immunocompromised patients, demodicosis may be more frequent and severe, and systemic therapy may be needed to achieve clinical resolution. CASE REPORT:A six-year-old boy having maintenance chemotherapy for acut...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01916.x
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Rosacea is a common, chronic dermatosis that requires long-term therapy. Oral isotretinoin and topical and/or oral antibiotics are effective, but their usage may be limited due to side-effects. OBJECTIVE:The goal of the study was to compare the efficacy of topical adapalene gel (0.1%) and topical metronidaz...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-4632.2004.02130.x
更新日期:2005-03-01 00:00:00
abstract::Fifty-seven patients with primary localized cutaneous amyloidosis (PLCA) were clinically and histopathologically reviewed. Two-thirds of patients had macular amyloidosis (MA). Intermediate cases having macular lesions with micropapules and/or lichens were identified. A spectrum for the disease is proposed, in which th...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03245.x
更新日期:1992-02-01 00:00:00
abstract::The syndrome of tinea pedis caused by human-adapted Trichophyton mentagrophytes (interdigitale) can be recognized by two signs not characteristically seen in tinea pedis caused by T. rubrum and Epidermophyton floccosum:1 bullous > 2 mm vesicles in the thin skin of the plantar arch and along the sides of the feet and h...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-4362.2003.01783.x
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Over a 3-year period (March 1999 to March 2002), 944 patients with scalp lesions attended a dermatology reference center in the city of Fortaleza, Ceará, Brazil. Clinical specimens were examined at the Specialized Medical Mycology Center, Federal University of Ceará, Fortaleza-CE, Brazil, to detect patients ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02150.x
更新日期:2004-08-01 00:00:00
abstract::A 70-year-old patient with a history of hypertension and hypercholesterolemia was referred for evaluation of necrotic toes. The patient had a history of several cerebrovascular accidents during the previous month. Initially, she developed sudden-onset left upper extremity weakness which, over the ensuing 4 days, progr...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2000.00935.x
更新日期:2000-04-01 00:00:00
abstract::A 39-year-old female patient with systemic lupus erythematosus was treated with terbinafine for onychomycosis. After only 7 days of treatment with 250 mg terbinafine, a widespread severe erythematous eruption developed. The results of clinical, histological and immunofluorescent examinations confirmed the diagnosis of...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02472.x
更新日期:2006-03-01 00:00:00
abstract::Live bee acupuncture (Bong-Chim) dermatitis is an iatrogenic disease induced by so-called live bee acupuncture therapy, which applies the honeybee (Apis cerana) stinger directly into the lesion to treat various diseases in Korea. We present two cases of live bee acupuncture dermatitis and review previously published a...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.12161
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Psoriasis is a chronic debilitating disease affecting approximately one million Canadians. The objective of this study is to estimate the economic burden in $CDN (2008) of moderate to severe plaque psoriasis among Canadian adults. METHODS:Using a cross-sectional design, direct resource use, costs, lost prod...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05359.x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The Israel Defense Forces (IDF) medical records offer a unique and valid 28-year view of the striking differences in cutaneous leishmaniasis (CL) seasonality patterns and incidence rates between the military and civilian sectors in Israel. AIM:To determine the annual epidemiology and seasonality trends of C...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.03979.x
更新日期:2009-06-01 00:00:00