Abstract：
BACKGROUND:Plantar hyperhidrosis is a common illness with significant impact on quality of life. Oxybutynin presents good short-term results, but longer follow-up results are lacking. We evaluated oxybutynin effectiveness in patients who were not surgically treated and who had at least six months of follow-up. METHODS:From September 2007 to September 2013, 85 consecutive patients were enrolled in our institutional protocol for the "pharmacological-first" treatment of primary plantar hyperhidrosis with oxybutynin. Eight patients were lost to follow-up, 15 patients have not yet been under treatment for six months, and data were available for 39 patients (all female) treated for at least six months. Data at the start of the protocol, six weeks after beginning treatment, and at their final visit were analyzed. RESULTS:Twenty-three of the 77 patients (29.87%) did not improve after pharmacological therapy. From the 39 patients with more than six months of follow-up (median 16.9 months, range 9-71), 79.5% reported moderate/great improvement in excessive plantar sweating after six weeks of treatment, and this rate increased to 84.7% in the last follow-up visit; 82.85% showed improvement in other sites presenting hyperhidrosis. Dry mouth was the most common side effect; 51.6% of patients reported it to be moderate/severe at the last visit. CONCLUSION:In patients with good initial response to oxybutynin, more than 82% presented moderate or great improvement in plantar and other sites' excessive sweating; dry mouth was the most common side effect but was tolerable and did not lead any patient to interrupt treatment.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Wolosker N,Teivelis MP,Krutman M,de Paula RP,Kauffman P,de Campos JR,Puech-Leão Pdoi
10.1111/ijd.12729subject
Has Abstractpub_date
2015-01-01 00:00:00pages
605-11issue
5eissn
0011-9059issn
1365-4632journal_volume
54pub_type
杂志文章abstract：:Clinical, histologic, and immunofluorescence studies were performed in 15 patients with pemphigus herpetiformis. The initial diagnosis was dermatitis herpetiformis, IgA linear bullous dermatosis or bullous pemphigoid. The histology varied depending on the character of skin lesions, and showed eosinophilic spongiosis o...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1987.tb02308.x
更新日期：1987-11-01 00:00:00
abstract：:A male patient with underlying lepromatous leprosy mimicked Sweet's syndrome clinically. He was believed to be in an atypical reactional state recognized as a variant form of erythema nodosum leprosum. In addition to the antileprosy treatment, steroid hormone was required to control the systemic symptoms. ...
journal_title：International journal of dermatology
pub_type： 杂志文章
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abstract：BACKGROUND:Pruritus is a common subjective symptom of psoriasis whose levels may be affected by a range of variables. The objective of this study was to evaluate the frequency of pruritus and its associations with clinical and psychological characteristics of psoriasis patients. MATERIALS AND METHODS:One-hundred and s...
journal_title：International journal of dermatology
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doi：10.1111/ijd.12074
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journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1988.tb02423.x
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abstract：:Classical acupuncture focuses primarily on treating the person, and secondarily treating the illness. The "symptoms" are regarded as "branch" expressions of a "root" (constitutional) imbalance. Different root imbalances can produce the same symptoms. Five patients with eczema, for example, may reveal five distinct roo...
journal_title：International journal of dermatology
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journal_title：International journal of dermatology
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journal_title：International journal of dermatology
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journal_title：International journal of dermatology
pub_type： 杂志文章
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journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2008.03356.x
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journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb03564.x
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journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1982.tb02043.x
更新日期：1982-12-01 00:00:00
abstract：:With the advent of various new methods of treating psoriasis, it is necessary to remind physicians to consider an agent that is easy to administer, locally effective, relatively inexpensive, not time-consuming and without systemic toxic effects. Nineteen patients were treated with topical nitrogen mustard between 1972...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1979.tb05017.x
更新日期：1979-11-01 00:00:00
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journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2006.02775.x
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journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-4362.2003.01565.x
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journal_title：International journal of dermatology
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journal_title：International journal of dermatology
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journal_title：International journal of dermatology
pub_type： 杂志文章,评审
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journal_title：International journal of dermatology
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abstract：:Actinic keratosis (AK) is a very common skin disease caused by chronic sun damage, which in 75% of cases arises on chronically sun-exposed areas, such as face, scalp, neck, hands, and forearms. AKs must be considered an early squamous cell carcinoma (SCC) for their probable progression into invasive SCC. For this reas...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
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journal_title：International journal of dermatology
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abstract：BACKGROUND:The diagnosis of Japan spotted fever (JSF) is very difficult in some cases. The initial diagnosis of JSF is very important to treat. METHODS:We report nine cases of Japan spotted fever (JSF) with variable clinical features diagnosed at our hospital in 2008. RESULTS:Concerning clinical symptom, the most fre...
journal_title：International journal of dermatology
pub_type： 杂志文章
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abstract：BACKGROUND:Allergic contact dermatitis (ACD) is a manifestation of a cell-mediated immune response, but its mechanism remains unknown. Recently, we investigated whether ACD involves various neuropeptides. Substance P (SP) is a neuropeptide that is known to act as a neurokinin receptor when the immune response is initia...
journal_title：International journal of dermatology
pub_type： 杂志文章
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journal_title：International journal of dermatology
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journal_title：International journal of dermatology
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journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1980.tb00277.x
更新日期：1980-04-01 00:00:00
abstract：BACKGROUND:There is little research available that describes the natural progression of split-thickness skin graft (STSG) donor site wounds after re-epithelialization. The purpose of this study was to evaluate the longitudinal clinical progress of transepidermal water loss (TEWL), color, and sensory elements in STSG do...
journal_title：International journal of dermatology
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更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Onychomycosis, a fungal infection of the nail, is caused by dermatophytes, yeasts, and nondermatophyte molds. The causative pathogen and incidence of onychomycosis depend on age, gender, geographic and climatic conditions, living habits, and immune status of the host. AIM:To determine the incidence and etio...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.04126.x
更新日期：2009-09-01 00:00:00
