Iron, copper, and zinc concentrations in normal skin and in various nonmalignant and malignant lesions.

Abstract:

:The concentrations of zinc (Zn), copper (Cu), and iron (Fe) in the skin have been noninvasively determined in vivo by diagnostic x-ray spectrometry. The skin of healthy controls was divided into two major groups based upon the distribution of the concentrations of these elements. In the face and upper neck, the following wet weight concentrations were recorded: Fe, 14.2 +/- 3.3 ppm; Cu, 1.3 +/- 0.3 ppm; and Zn, 6.7 +/- 1.1 ppm. In the chest, abdomen, arm, axilla, and lower neck, the concentrations of these elements were as follows: Fe, 10.2 +/- 2.5 ppm; Cu, 0.8 +/- 0.3 ppm; and Zn, 4.5 +/- 1.7 ppm. In most lesions of solar dermatitis, solar keratosis, basal and squamous cell carcinomas, variable elevations of Zn and Fe (up to significant levels) were recorded in most of the contralateral, apparently uninvolved skin. In the majority of pigmented nevi and malignant melanomas, the levels of Fe and Zn were elevated. In some of these, the Cu concentration also was increased.

journal_name

Int J Dermatol

authors

Gorodetsky R,Sheskin J,Weinreb A

doi

10.1111/j.1365-4362.1986.tb03449.x

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

440-5

issue

7

eissn

0011-9059

issn

1365-4632

journal_volume

25

pub_type

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