Abstract：
OBJECTIVE:This study analyzes the major clinical characteristics of patients with active leprosy in relation to the in vitro immune response to the T-lymphocyte activator anti-CD3. METHODS:Thirty-eight patients with an established diagnosis of leprosy were classified according to the Ridley and Jopling table. Peripheral blood mononuclear cells from both lepromatous leprosy (LL) and tuberculoid leprosy (TL) patients and healthy controls were used to evaluate lymphocyte proliferation; immunoenzymatic assays were used to evaluate cytokine production (IL-1, IL-2, IL-4, IL-6, IL-10, IFN-gamma). RESULTS:Peripheral blood mononuclear cells from both LL and TL patients displayed blastogenic responses to anti-CD3. The cytokines IL-1 beta, IL-6, IL-10, and IFN-gamma were detected in culture supernatants. Endogenous production of IL-1 beta was significantly higher in cell cultures from patients with the lepromatous form of the disease compared to those with tuberculoid leprosy. Production of IL-6 in response to anti-CD3 was observed in a significantly higher proportion of LL than TL patients (P = 0.0025). Gamma-interferon production did not differ between TL and LL, but a direct correlation was observed between time of multidrug treatment and IFN production in vitro (P = 0.016). Interleukin-10 was detected in culture supernatants of lymphocytes activated by anti-CD3 from both patient groups, but not from healthy controls. CONCLUSIONS:The findings of this study suggest that patients with the two distinct forms of leprosy are capable of responding to a polyclonal T-lymphocyte stimulus such as anti-CD3 and provide evidence suggestive of alterations in the immune responses mediated by cytokines that may contribute to the spectrum of disease and response to treatment.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Ochoa MT,Valderrama L,Ochoa A,Zea A,Escobar CE,Moreno LH,Falabella Rdoi
10.1111/j.1365-4362.1996.tb02974.xsubject
Has Abstractpub_date
1996-11-01 00:00:00pages
786-90issue
11eissn
0011-9059issn
1365-4632journal_volume
35pub_type
杂志文章abstract：BACKGROUND:Genetic factors seem to play a significant role in the susceptibility to systemic lupus erythematosus (SLE). Some researchers have described amino acid polymorphisms within the interleukin-4 receptor (IL-4R) [isoleucine50valine (Ile50Val), arginine576glutamine (Arg576Gln), etc.], the IL-10R (G241A and G520A)...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2007.03258.x
更新日期：2007-11-01 00:00:00
abstract：:A 58-year-old woman with progressive systemic sclerosis developed a butterfly erythematous eruption, hemorrhagic maculae, crusting, and erosions on the face 15 days following administration of D-penicillamine. This appeared to be a lupus erythematosus-like eruption due to an adverse drug reaction to D-penicillamine be...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1990.tb03471.x
更新日期：1990-10-01 00:00:00
abstract：:Ten patients with benign familial chronic pemphigus (BFCP) (Hailey-Hailey disease) were evaluated; semiologic and localization differences were described, and special attention was given to solitary or atypical forms. In all the cases, the diagnosis was confirmed by histopathology; some histopathologic differences and...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1988.tb00929.x
更新日期：1988-09-01 00:00:00
abstract：BACKGROUND:Over a 3-year period (March 1999 to March 2002), 944 patients with scalp lesions attended a dermatology reference center in the city of Fortaleza, Ceará, Brazil. Clinical specimens were examined at the Specialized Medical Mycology Center, Federal University of Ceará, Fortaleza-CE, Brazil, to detect patients ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02150.x
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Dermatofibroma (DF) is a common benign skin lesion in a majority of cases located on the legs or upper limbs. The etiology of DF is still unclear. OBJECTIVES:Reflectance confocal microscopy features of DF were described. METHODS:Forty patients with DF diagnosis confirmed by dermoscopy were examined using r...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14972
更新日期：2020-08-01 00:00:00
abstract：BACKGROUND:Matrine is a traditional Chinese medicine with significant inhibitory activity against malignant tumors. Its effects on the invasiveness and metastasis of malignant tumors have rarely been reported. AIM:To investigate whether matrine can inhibit the metastasis-related activities of the human malignant melan...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2008.03627.x
更新日期：2008-05-01 00:00:00
abstract：:Although tamoxifen (TAM) is routinely used in advanced melanoma, it is still uncertain whether evidence exists to support this practice. This review assesses the benefits and harms of systemic therapy with TAM vs. without TAM on response and mortality in patients with advanced melanoma. MEDLINE, The Cochrane Database ...
journal_title：International journal of dermatology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1365-4632.2010.04529.x
更新日期：2010-10-01 00:00:00
abstract：:A 32-year-old Thai woman developed acquired hypertrichosis lanuginosa with generalized lanugo hair, deeply furrowed tongue, and keratosis pilaris. She had metastatic adenocarcinoma of the liver. A review of world literature reveals 24 cases of which 22 were associated with proven malignancies. Acquired hypertrichosis ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1982.tb02043.x
更新日期：1982-12-01 00:00:00
abstract：:Squamous cell carcinoma (scc) of the skin was studied in two similar populations, one living in the temperate zone of Australia, the other living in the tropics. In the tropics, the patients were significantly younger, the man to woman ratio approached unity, and women had significantly more sccs on the legs. In the t...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb02697.x
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:Dermatologic diseases vary widely as a result of geographic location and may be influenced by environmental factors. Aim To determine the epidemiology of dermatological diseases in the Peruvian Amazonia. METHODS:Transversal and multicentric study, which were carried out during February of 2006, 2007, and 20...
journal_title：International journal of dermatology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-4632.2010.04473.x
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Even with the widespread clinical use of cannabinoid receptor (CBR) stimulating compounds, such as palmitoylethanolamine, the role of CBR agonists on inflammatory skin diseases is not yet fully understood. This study was performed to investigate the effects of CBR agonists on skin inflammation, using acute a...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12841
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Ultrasonography (US) has recently proved to be useful in diagnostic dermatology. It is convenient to use, completely safe, and provides valuable information. OBJECTIVE:This study was performed to compare the diagnostic accuracy of US with that of clinical diagnosis in patients with benign subcutaneous lesio...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12989
更新日期：2015-11-01 00:00:00
abstract：:A 31-year-old man, an intravenous drug user and in an advanced stage of acquired immune deficiency syndrome (AIDS), was admitted in our Department for the treatment of skin lesions that had been diagnosed as molluscum contagiosum (MC). The clinical examination revealed the presence of multiple nodular lesions, some of...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1996.tb01616.x
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Though acral lentiginous melanoma (ALM) is a major type of malignant melanoma, no immunohistochemical study on this type of melanoma has been reported. OBJECTIVE:The purpose of this study is to analysis the immunohistochemical findings of ALM using routinely used immune markers. METHODS:An immunohistochemi...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2003.01583.x
更新日期：2003-02-01 00:00:00
abstract：:A 36-year-old Asian man with von Hippel-Lindau syndrome was referred to the dermatology clinic in January 2005 with stiff fingers and ankles of 3 months' duration. He had undergone bilateral nephrectomy for renal squamous cell carcinoma in 2002 and had started hemodialysis. Multiple cerebellar hemangiomata were resect...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2008.03655.x
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Tattoos have reached broadening mainstream acceptance. Medical professional societies have noted that tattoos may co-occur with high risk behaviors. METHODS:Using a variety of statistical models applied to a sample of 2,008 adults residing in the United States via Amazon's Mechanical Turk, we estimate the a...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14372
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:β-Cyclodextrin (βCD) xerogel containing silk fibroin (SF) was prepared, and the efficacy of the xerogel for a pressure sore developed on the back of an ICR mouse was investigated. MATERIALS AND METHODS:Tosyl βCD was conjugated to polyethyleneimine (PEI), and the βCD residues were cross-linked in an aqueous ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05389.x
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:Reduced cell-mediated immunity associated with pregnancy may cause a flaring or exacerbation of some skin conditions. Little is known about the magnitude of and risk factors for skin diseases among human immunodeficiency virus (HIV)-infected antiretroviral therapy-naïve pregnant women. METHODS:Cross-section...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12455
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND AND DESIGN:Scorpion stings are a serious problem in Khuzestan, a southwestern province of Iran. In around 5 years, 36,463 patients with scorpion stings have been seen. Most of the patients had no cutaneous findings, but a small group of patients developed various local and generalized skin manifestations. Pa...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.1998.00386.x
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:The relationship between infantile seborrheic dermatitis (ISD) and infantile atopic dermatitis (IAD) is controversial. METHODS:Ninety-six children aged 2-12 months diagnosed with atopic dermatitis and a comparable control group of healthy children were evaluated. Demographic data, personal history of ISD an...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2002.01497.x
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:In recent years, the rare association of Sweet's syndrome with nontuberculous mycobacterial lymphadenitis has been reported. OBJECTIVE:To report the clinical, demographic, and bacteriologic data and association with Sweet's syndrome of 18 patients with scrofuloderma and scrofuloderma-like condition caused b...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2002.01362.x
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Epidemiological data have established an association between cardiovascular disease and psoriasis. Only one general population study has so far compared prevalences of cardiovascular risk factors among subjects with psoriasis and control subjects. We aimed to determine the prevalence of cardiovascular risk f...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05408.x
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND:Although the causes of striae distensae (SD) remain to be elucidated, the condition is known to relate to changes in the structures that provide the skin with its tensile strength and elasticity. OBJECTIVE:This study was conducted to evaluate whether premature birth is a risk factor for SD. METHODS:A total...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.04899.x
更新日期：2011-10-01 00:00:00
abstract：:Based on a study of 400 patients (272 patients with herpes zoster and 128 with postzoster neuralgia), the subcutaneous injection of triamcinolone in saline is concluded to be a safe and effective measure for reducing pain. The acute eruption and symptoms of herpes zoster cleared in an average of less than four days. P...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1981.tb05299.x
更新日期：1981-01-01 00:00:00
abstract：OBJECTIVES:Oral lichen planus (OLP) is a chronic inflammatory disease of unknown cause. Malignant transformation in OLP lesions may be favored by changes in the expression of proteins that regulate cell proliferation and apoptosis. This study aimed to investigate these issues by immunohistochemical staining for Bcl-2 a...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12279
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The improvement of acne in summertime or the aggravation of acne in winter is a traditional dermatologic opinion. Ultraviolet rays are thought to be beneficial in the treatment of acne. In the existing literature there is no proof of this. The purpose of this study was to find out whether or no...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1996.tb03274.x
更新日期：1996-02-01 00:00:00
abstract：BACKGROUND:Epidemiological studies of molluscum contagiosum (MC) in children are limited. PATIENTS AND METHOD:Between 1997 and 1999, 110 children with MC (60 boys, 50 girls, mean age: 4.8 years) were studied. Treatment consisted of removal of all MC lesions in a single session by sterilized tweezers. RESULTS:In child...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02074.x
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Erythroderma is a generalized erythema of the skin accompanied by a variable degree of scaling. However, most of the published series originate from Western countries. There is only one report from Africa, conducted in Dakar in 1979. The aim of our study was to provide information about this condition in our...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02100.x
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Psoriasis is a chronic debilitating disease affecting approximately one million Canadians. The objective of this study is to estimate the economic burden in $CDN (2008) of moderate to severe plaque psoriasis among Canadian adults. METHODS:Using a cross-sectional design, direct resource use, costs, lost prod...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05359.x
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To characterize epidemiologic and clinical features of red primary amelanotic melanomas, an atypical presentation of melanoma that is underemphasized in patient and physician education. PATIENTS AND METHODS:Review of a prospectively collected melanoma database identified 46 patients with red amelanotic melan...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05066.x
更新日期：2012-04-01 00:00:00
