Abstract:
BACKGROUND:The objective of this study was to determine the presence of anti-Dsg1 and Dsg3 antibodies in healthy subjects of the high Peruvian Amazon (Tuemal, Rodriguez de Mendoza province, department of Amazonas) to establish the theoretical presence of environmental factors or triggers in the area. MATERIALS AND METHODS:Cross-sectional study. The study population included persons of any age or gender, clinically healthy, who were evaluated by a dermatologist to confirm the absence of blistering diseases. Blood samples were analyzed by indirect immunofluorescence (IIF), immunoprecipitation (IP), anti-Dsg1 IgM antibody (Ab) enzyme-linked immunosorbent assay (ELISA), as well as anti-Dsg1 and anti-Dsg3 IgG Ab ELISA. RESULTS:Participants included 21 healthy subjects comprised of 61.9% males and 38.1% females; 47.6% had a positive anti-Dsg1 Ab ELISA for total IgG (or any subclasses). IIF detected antibodies against intercellular spaces in one subject. Anti-Dsg1 Ab IP was mildly positive in 33.3% of the subjects. Anti-Dsg1 IgG subclasses found positive were: IgG1 (19.0%), IgG2 (33.3%), and IgG3 (28.6%); none of the samples were positive for anti-Dsg1 Ab IgM ELISA, and 23.8% of the subjects were positive for anti-Dsg3 Ab ELISA. The age distribution was similar for subjects positive for anti-Dsg1 and anti-Dsg3 Ab ELISA, with higher frequencies found among the 20-29 and 40-49 year-old age groups. CONCLUSION:A fraction of healthy subjects of the high Peruvian Amazon developed anti-Dsg1 and anti-Dsg3 antibodies, demonstrating the possible presence of environmental factors for endemic pemphigus (EP) at a higher altitude than previously described.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Ramos W,Díaz J,Gutierrez EL,Lazarte JS,Bohnett MC,Ronceros G,Ortega-Loayza AGdoi
10.1111/ijd.13824subject
Has Abstractpub_date
2018-03-01 00:00:00pages
344-348issue
3eissn
0011-9059issn
1365-4632journal_volume
57pub_type
杂志文章abstract:BACKGROUND:In vitiligo, other than loss of melanocytes and melanin pigment in the lesional skin, keratinocytes are also involved. Human fetal Merkel cells are now generally considered to be derived from the epidermis. To date, no observations on Merkel cells in lesional skin of active vitiligo have been reported. METH...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1994.tb02859.x
更新日期:1994-07-01 00:00:00
abstract:BACKGROUND:Dysfunction of adhesion molecules is believed to play an early and important role in developing cancer. Accordingly, this study aims to compare beta-catenin (β-catenin) and CD44 expression in oral lichen planus (OLP) as a condition with malignant potential and oral squamous cell carcinoma (OSCC). METHODS:β-...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14007
更新日期:2018-07-01 00:00:00
abstract::Cutaneous fibrinolytic activity was found to be increased in a patient with aquagenic pruritus both before and after contact with water. This could explain the lack of wheal formation in this affection, which is characterized by increased histamine release. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1984.tb05665.x
更新日期:1984-01-01 00:00:00
abstract::Fifty-seven patients with primary localized cutaneous amyloidosis (PLCA) were clinically and histopathologically reviewed. Two-thirds of patients had macular amyloidosis (MA). Intermediate cases having macular lesions with micropapules and/or lichens were identified. A spectrum for the disease is proposed, in which th...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03245.x
更新日期:1992-02-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1046/j.1365-4362.2002.01448.x
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:There is a worrying lack of epidemiological data on the geographical distribution and burden of subcutaneous mycoses in Peru, hindering the implementation of surveillance and control programs. OBJECTIVES:This study aimed to estimate the disease burden of subcutaneous mycoses in Peru and identify which funga...
journal_title:International journal of dermatology
pub_type: 杂志文章,meta分析,评审
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abstract:BACKGROUND:'"Inflammatory vitiligo" cases with clear lichenoid infiltrates have been reported. However, the inflammatory nature of common vitiligo has not gained wide acceptance because of its benign appearance and scanty cellular infiltrates. We have observed in our patients a few lesions with mild erythema, scaling a...
journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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doi:10.1111/j.1365-4362.1993.tb02790.x
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1976.tb01829.x
更新日期:1976-11-01 00:00:00
abstract:BACKGROUND:Vitiligo is a common disorder whose exact cause is unknown, but genetic factors are thought to be involved. We analyzed 120 Korean proband families to clarify which genetic factors are involved in the pathogenesis of vitiligo in Korean patients. METHODS:The genetics of vitiligo were analyzed in 120 Korean p...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1998.00549.x
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Vitiligo is an autoimmune depigmentation disorder. Polymorphisms in the vitamin D receptor (VDR) have been found to be associated with vitiligo. OBJECTIVES:To evaluate the potential association between VDR gene polymorphisms (ApaI, TaqI, and FokI) and vitiligo susceptibility, and to detect if there is corre...
journal_title:International journal of dermatology
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Venous ulcer is the most serious consequence of chronic venous insufficiency and is responsible for almost 70% of chronic leg ulcers. The main purpose of this research was to describe social, demographic and clinical characteristics of patients with venous ulcers and to identify some professional repercussio...
journal_title:International journal of dermatology
pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Cutaneous lymphomas are a heterogeneous group of tumors with various clinical manifestations, histological features, and prognoses. METHODS:Among 425 cases of cutaneous lymphoma, we describe eight cases of peripheral T-cell lymphoma, unspecified, presenting with generalized benign-looking dermatitis. RESUL...
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更新日期:2017-06-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
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abstract:BACKGROUND:The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation. AIMS:This study was conducted to...
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