Abstract:
BACKGROUND:Vitiligo is an autoimmune depigmentation disorder. Polymorphisms in the vitamin D receptor (VDR) have been found to be associated with vitiligo. OBJECTIVES:To evaluate the potential association between VDR gene polymorphisms (ApaI, TaqI, and FokI) and vitiligo susceptibility, and to detect if there is correlation between serum 25-hydroxyvitamin D [25(OH)D] levels and vitiligo and between VDR gene polymorphisms and 25(OH)D levels in vitiligo. MATERIALS AND METHODS:Seventy-five patients with vitiligo and 75 age and sex-matched controls were subjected to detailed history taking and dermatological examination to determine the extent and clinical type of vitiligo. A blood sample (5 ml) was retrieved to investigate VDR gene polymorphisms and serum 25(OH)D level. RESULTS:Our results showed that the serum level of vitamin D is statistically significantly lower in patients than controls. The frequency of the ApaI variant a allele, the variant genotype (aa), and the variant genotype (tt) were significantly higher among the vitiligo cases than among controls. Our study also showed that the serum 25(OH)D levels were not significantly different among the different ApaI, TaqI, and FokI genotypes. CONCLUSION:The present study showed that serum level of 25(OH)D is statistically significantly lower in patients than controls, so screening for vitamin D deficiency seems of value in patients with vitiligo for the possibility of vitamin D supplementation. We also report that VDR gene polymorphisms may be a risk for the development of vitiligo in an Egyptian population.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Sobeih S,Mashaly HM,Gawdat H,Amr K,Hamid MF,Shaalan Edoi
10.1111/ijd.13363subject
Has Abstractpub_date
2016-12-01 00:00:00pages
1329-1335issue
12eissn
0011-9059issn
1365-4632journal_volume
55pub_type
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journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1986.tb04547.x
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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pub_type: 杂志文章,多中心研究
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更新日期:2019-11-01 00:00:00
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02249.x
更新日期:2004-12-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04126.x
更新日期:2009-09-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
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更新日期:2004-12-01 00:00:00