Absence of Merkel cells in lesional skin of vitiligo [corrected].

Abstract:

BACKGROUND:In vitiligo, other than loss of melanocytes and melanin pigment in the lesional skin, keratinocytes are also involved. Human fetal Merkel cells are now generally considered to be derived from the epidermis. To date, no observations on Merkel cells in lesional skin of active vitiligo have been reported. METHODS:Merkel cells were identified by indirect immunofluorescence microscopy using the monoclonal antibody TROMA 1. RESULTS:No TROMA 1-positive cells were observed in the vitiliginous skin lesions in any of the specimens examined, whereas normal numbers of these cells were seen in the adjacent pigmented skin. CONCLUSIONS:This finding suggests that the processes that lead to damage of keratinocytes in vitiligo also involve other keratin-expressing cells such as the Merkel cells.

journal_name

Int J Dermatol

authors

Bose SK

doi

10.1111/j.1365-4362.1994.tb02859.x

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

481-3

issue

7

eissn

0011-9059

issn

1365-4632

journal_volume

33

pub_type

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