Healing effect of Pilocarpine gel 4% on skin lesions of pemphigus vulgaris.

Abstract:

BACKGROUND:The high rate of morbidity and mortality resulting from long-term use of corticosteroids in pemphigus vulgaris (PV) warrants discovery of a new treatment strategy. Based on a new theory on the pathophysiology of PV, cholinomimetics can block the process of blister formation. AIMS:This study was conducted to evaluate the clinical effectiveness of Pilocarpine gel in the treatment of skin lesions of PV. METHODS:In a double-blind, placebo-controlled study, three PV patients with a total of 64 skin lesions were treated by either Pilocarpine or placebo gel. After 15 days of treatment an epithelialization index of the two groups was compared. RESULTS:The mean of the epithelialization index in skin lesions that received Pilocarpine was significantly higher than that of the placebo group (40.3 +/- 1.7 vs. 24.4 +/- 3.3, P < 0.001). CONCLUSIONS:Pilocarpine gel effectively treats PV.

journal_name

Int J Dermatol

authors

Iraji F,Yoosefi A

doi

10.1111/j.1365-4632.2006.02766.x

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

743-6

issue

6

eissn

0011-9059

issn

1365-4632

pii

IJD2766

journal_volume

45

pub_type

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