Active and inactive forms of matrix metalloproteinases 2 and 9 in cutaneous melanoma.


BACKGROUND:Cutaneous melanoma is the most aggressive type of skin cancer, with high implications on the morbidity and mortality of patients. Matrix metalloproteinases (MMP) 2 and 9 have been involved in melanoma progression because they degrade important components of the basement membrane. We studied the relationship between the levels of active and inactive MMP 2, MMP 9, and clinicopathological parameters. MATERIALS AND METHODS:Expression of both active and latent forms of MMP 2 and MMP 9 was evaluated by zymography in 21 melanoma tissue samples and 19 benign melanocytic nevi samples. RESULTS:In the melanoma group, inactive MMP 2 was detected in 100% of samples and active MMP 2 in 95%. Inactive MMP 9 was detected in 85% of samples and active MMP 9 in 38%. In the nevi group, 78.9% of samples expressed inactive MMP 2, 5.26% active MMP 2, 21% inactive MMP 9, and 0% active MMP 9. Both forms of MMP 2 and MMP 9 were found to be correlated with skin tumor malignancy. Expression of active and latent MMP 9 was higher in tumors >2 mm thick (P = 0.03, P = 0.014). A correlation was also found between positive lymph node metastasis, inactive MMP 9, and active MMP 9 expression (r = 0.59 P < 0.01, r = 0.668, P < 0.01). The amount of active and latent form of MMP 2 did not have an impact on lymph node metastasis. CONCLUSIONS:Our study demonstrates that active and latent MMP 2 and MMP 9 correlate with melanoma, and both forms of MMP 9 correlate with positive lymph node metastasis.


Int J Dermatol


Candrea E,Senila S,Tatomir C,Cosgarea R




Has Abstract


2014-05-01 00:00:00












  • Multiple agminated pigmented Spitz nevi (mimicking acral lentiginous malignant melanoma and dysplastic nevus) in an African-American girl.

    abstract:BACKGROUND:Reed's nevi are distinguished from Sptiz tumors by their significant melanogenesis and growth pattern. They may be confused with melanoma on clinical and histologic grounds. CASE REPORT:An unusual case in which multiple agminated Reed's nevi mimicked acral lentiginous malignant melanoma in an African-Americ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Abramovits W,Gonzalez-Serva A

    更新日期:1993-04-01 00:00:00

  • Considerable variation among Iranian dermatologists in the dosing and monitoring of methotrexate for treating psoriasis.

    abstract:BACKGROUND:Methotrexate (MTX) is a risky medication requiring careful attention to dosing and monitoring. Dosing and monitoring practices are not well characterized. AIMS:The aim of this study was to assess variation in the dosing and monitoring of methotrexate among Iranian dermatologists. METHODS:A questionnaire wa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Zargari O,Hejazi S,Shahidi-Dadras M,Younespour S,Robati R,Firooz A,Toosi P,Feldman SR

    更新日期:2014-03-01 00:00:00

  • Paracetamol induced Stevens-Johnson syndrome--toxic epidermal necrolysis overlap syndrome.

    abstract:BACKGROUND:Though any drug can be a potential cause of such hypersensitivity reactions, paracetamol, an over-the-counter drug used extensively as an analgesic and antipyretic agent, is considered to be relatively safe, with hepatotoxicity as a major adverse effect only in large doses. MATERIALS AND METHODS:We report a...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Biswal S,Sahoo SS

    更新日期:2014-08-01 00:00:00

  • Teaching & Learning Tips 11: Teaching a procedure.

    abstract::Challenge: Balancing patient-centered clinical care with learner-centered teaching in a clinical setting becomes particularly challenging when it comes to teaching procedures to trainees (e.g. biopsies, excisions, etc.). How can procedures be taught in a way that reinforces repetition and mastery without compromising ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Ojevwe C,Rana J,Burgin S

    更新日期:2018-09-01 00:00:00

  • Treatment of axillary hyperhidrosis with botulinum-A toxin.

    abstract:BACKGROUND:Severe axillary hyperhidrosis is a source of great embarrassment and considerable emotional stress to individuals afflicted with this condition. Existing topical and surgical therapies are either ineffective or associated with unacceptable morbidity. We attempt to determine the effect of botulinum-A toxin (D...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Salmanpoor R,Rahmanian MJ

    更新日期:2002-07-01 00:00:00

  • Dermatologists' level of compliance with the prescription guidelines of isotretinoin for females of childbearing potential.

    abstract:BACKGROUND:Potent teratogenicity limits the use of isotretinoin among females of childbearing potential (FCBP). OBJECTIVE:To explore the current practice of dermatologists for pregnancy prevention when prescribing isotretinoin for FCBP. MATERIALS AND METHODS:A self-administered questionnaire was distributed to 160 de...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: AlGhamdi KM,Khurram H,Asiri YA,Mandil A

    更新日期:2011-09-01 00:00:00

  • The investigation of autonomic functions in patients with psoriasis.

    abstract:BACKGROUND:Psoriasis is a common Th1-mediated skin disease whose etiology remains obscure. Loss of sweating caused by retention hyperkeratosis is seen in psoriasis plaques, which is likely to have resulted from autonomic dysfunction. OBJECTIVE:In the present study, we aimed to evaluate autonomic nervous system (ANS) f...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Halıgür BD,Cicek D,Bulut S,Berilgen MS

    更新日期:2012-05-01 00:00:00

  • Mongolian spots with involvement of the temporal area.

    abstract::A Chinese baby girl was born after an uncomplicated pregnancy and a normal spontaneous vaginal delivery to a gravida 2, para 1, 32-year-old mother at 37 weeks' gestation. Neither parent had a history of alcohol or drug ingestion. There was no history of consanguinity. The Apgar scores were 7 at 1 min and 9 at 5 min. H...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Leung AK,Kao CP,Lee TK

    更新日期:2001-04-01 00:00:00

  • Increased cutaneous fibrinolytic activity in a case of aquagenic pruritus.

    abstract::Cutaneous fibrinolytic activity was found to be increased in a patient with aquagenic pruritus both before and after contact with water. This could explain the lack of wheal formation in this affection, which is characterized by increased histamine release. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Lotti T,Cappugi P,Lattari P,Panconesi E

    更新日期:1984-01-01 00:00:00

  • Evaluation of the correlation between serum levels of vitamin D and vitamin D receptor gene polymorphisms in an Egyptian population.

    abstract:BACKGROUND:Vitiligo is an autoimmune depigmentation disorder. Polymorphisms in the vitamin D receptor (VDR) have been found to be associated with vitiligo. OBJECTIVES:To evaluate the potential association between VDR gene polymorphisms (ApaI, TaqI, and FokI) and vitiligo susceptibility, and to detect if there is corre...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sobeih S,Mashaly HM,Gawdat H,Amr K,Hamid MF,Shaalan E

    更新日期:2016-12-01 00:00:00

  • Transitioning patients from efalizumab to alternative psoriasis therapies: findings from an open-label, multicenter, Phase IIIb study.

    abstract:BACKGROUND:Rebound in psoriasis is, by definition, a rapid worsening of disease following the discontinuation of therapy for psoriasis; it occurs following the abrupt discontinuation of many therapies. To prevent rebound on discontinuation of efalizumab, this study evaluated the effectiveness of transitioning patients ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,多中心研究


    authors: Menter A,Hamilton TK,Toth DP,Leung HM,Wetherill G,Hennessey B,Garovoy M,Kwon P,Pariser DM,Efalizumab Study Group.

    更新日期:2007-06-01 00:00:00

  • The effects of cadexomer iodine paste in the treatment of venous leg ulcers compared with hydrocolloid dressing and paraffin gauze dressing. Cadexomer Iodine Study Group.

    abstract:BACKGROUND:The aim was to examine cadexomer iodine paste in a comparative clinical trial. METHODS:A 12-week, randomized, open, controlled, multicenter, multinational trial in patients with exudating, venous leg ulcers of cadexomer iodine paste (Iodosorb/Iodoflex), hydrocolloid dressing (Duoderm E, Granuflex E), or par...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Hansson C

    更新日期:1998-05-01 00:00:00

  • A rare case of leishmaniasis recidiva cutis evolving for 31 years caused by Leishmania tropica.

    abstract::A 64-year-old woman presented with erythematous, infiltrative plaques with a central atrophic area on both zygomatic regions. Several yellow-reddish papules were seen at the periphery of the plaques and showed an "apple-jelly" color on diascopy (Fig. 1). No visceral involvement was detected. The past medical history r...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Stefanidou MP,Antoniou M,Koutsopoulos AV,Neofytou YT,Krasagakis K,Krüger-Krasagakis S,Tselentis Y,Tosca AD

    更新日期:2008-06-01 00:00:00

  • Jaipur block in postherpetic neuralgia.

    abstract:BACKGROUND:Postherpetic neuralgia, a common sequele to herpes zoster infection, is a chronic debilitating problem. The available therapeutic modalities are usually ineffective. METHODS:A total of 3960 patients (1326 women and 2634 men; age group, 21-84 years), with postherpetic neuralgia as the presenting complaint an...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Bhargava R,Bhargava S,Haldia KN,Bhargava P

    更新日期:1998-06-01 00:00:00

  • Psychodermatological disorders: recognition and treatment.

    abstract::Many dermatological disorders have a psychosomatic or behavioral aspect. Skin and brain continually interact through psychoneuroimmunoendocrine mechanisms and through behaviors that can strongly affect the initiation or flaring of skin disorders. It is important to consider these mind-body interactions when planning t...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Shenefelt PD

    更新日期:2011-11-01 00:00:00

  • Epidemiology and prognosis of plantar melanoma in 62 Japanese patients over a 28-year period.

    abstract:BACKGROUND:The plantar surface is one of the commonest sites of malignant melanoma in the Japanese; however, the biological behavior is not sufficiently clarified, because of the paucity of long-term studies. We attempted an epidemiologic survey of the cases of plantar melanoma treated in our institute to study the sur...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kato T,Suetake T,Tabata N,Takahashi K,Tagami H

    更新日期:1999-07-01 00:00:00

  • Prevalence of different skin conditions in an outpatients' setting in north-western Nigeria.

    abstract:BACKGROUND:Information on skin diseases in north-western Nigeria is scanty. We therefore conducted a prospective survey of 2611 new patients seen between August 1999 and July 2001 at the consultant medical/dermatology clinics of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. METHODS:The personal bio-d...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Onayemi O,Isezuo SA,Njoku CH

    更新日期:2005-01-01 00:00:00

  • Efficacy of lipectomy and liposuction in the treatment of multiple symmetric lipomatosis.

    abstract:BACKGROUND:Multiple symmetric lipomatosis (MSL) is a rare disease characterized by enlarging, symmetric, nonencapsulated, fat deposits mainly on the neck and upper trunk. Liposuction and lipectomy, although palliative, are the treatments of choice, especially indicated when vital structures are compromised. OBJECTIVE:...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Martínez-Escribano JA,Gonzalez R,Quecedo E,Febrer I

    更新日期:1999-07-01 00:00:00

  • Epidermal changes associated with symptomatic resolution of dandruff: biomarkers of scalp health.

    abstract:BACKGROUND:Dandruff is a common scalp condition characterized by flakes, pruritus and sometimes mild erythema. These symptoms reflect underlying histopathologic and biochemical events that must be reversed if treatment is to be effective. OBJECTIVES:This study aimed to better characterize the state of the epidermis in...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,随机对照试验


    authors: Kerr K,Darcy T,Henry J,Mizoguchi H,Schwartz JR,Morrall S,Filloon T,Wimalasena R,Fadayel G,Mills KJ

    更新日期:2011-01-01 00:00:00

  • A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.

    abstract:BACKGROUND:Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (r...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Nekoroski T,Paladini RD,Sauder DN,Frost GI,Keller GA

    更新日期:2014-06-01 00:00:00

  • Morphology, growth rate, and thickness of the nail plate during the pregnancy.

    abstract::Pregnancy causes some physiological skin changes, such as hyperpigmentation and striae gravidarum. Thickening of scalp hair and a prolonged anagen phase are also known to occur during pregnancy. However, a limited number of studies have been conducted on the effect of pregnancy on the nails. We aimed to investigate th...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Altan Ferhatoğlu Z,Göktay F,Yaşar Ş,Aytekin S

    更新日期:2018-10-01 00:00:00

  • Oral lichen planus and HCV infection: a clinical evaluation of 263 cases.

    abstract:BACKGROUND:Hepatitis C virus (HCV) infection induces variable dermatologic manifestations. Our purpose was to determine whether there is an association between HCV infection and oral lichen planus (OLP). METHODS:Antibodies to HCV were determined in patients with OLP (263 patients; 156 women and 107 men, with a mean ag...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Mignogna MD,Lo Muzio L,Favia G,Mignogna RE,Carbone R,Bucci E

    更新日期:1998-08-01 00:00:00

  • Ichthyosis congenital fetalis (Harlequin fetus).

    abstract::A male fetus which was the product of full-term pregnancy and normal delivery with no family history is presented. The skin was hard and thick, waxy, yellowish in color, and was crossed by horizontal and or perpendicular red fissures. The eyelids were semiclosed, hard, and stiff resulting in ectropion and the conjunct...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kouskoukis C,Minas A,Tousimis D

    更新日期:1982-07-01 00:00:00

  • Tumor necrosis factor alpha gene promoter -238G/A polymorphism increases the risk of psoriasis vulgaris in Indian patients.

    abstract:BACKGROUND:Tumor necrosis factor alpha (TNFα) gene -238G/A polymorphism (rs361525) is associated with psoriasis in several populations worldwide. To the best of our knowledge, there is no information about this polymorphism in Indian psoriatic patients. This study was undertaken to fill the gap in knowledge. METHODS:T...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Rajesh D,Gurumurthy R,Kutty AV,Balakrishna S

    更新日期:2017-03-01 00:00:00

  • Psoriasis in elderly patients in the Côte d'Ivoire: socio-demographic, clinical, and therapeutic aspects, and follow-up.

    abstract:BACKGROUND:Psoriasis is a chronic, inflammatory, and recurrent dermatological disease. In the Côte d'Ivoire, it is about 0.75% of dermatology cases. Psoriasis care is challenging in elderly patients. We aimed to show its specificities related to the sociodemographic, clinical, and therapeutic aspects, and follow-up in ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kassi K,Djeha D,Gbery IP,Kouame K,Sangaré A

    更新日期:2016-02-01 00:00:00

  • Adaptation of a Runyankore version of Skindex-16 for oral administration in Mbarara, Uganda.

    abstract:BACKGROUND:Health-related quality of life instruments are typically developed and validated for use in developed countries by patients who can read and write. Little is known about the feasibility of using adaptations of validated instruments in situations where literacy rates are low. OBJECTIVE:We aimed to translate,...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Chua SL,Maurer T,Chren MM

    更新日期:2011-10-01 00:00:00

  • Cutaneous angiosarcoma in a site of healed herpes zoster.

    abstract::A 57-year-old woman presented with an erythematous plaque of the left postauricular area that was diagnosed as metastatic carcinoma on clinical and histologic bases. It was revealed that herpes zoster had been diagnosed in the same dermatomal distribution 10 years previously. The lesion recurred 2 years after irradiat...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Hudson CP,Hanno R,Callen JP

    更新日期:1984-07-01 00:00:00

  • Risks for noncutaneous second primary malignancy in cutaneous malignant melanoma survivors: an analysis of data from the Surveillance, Epidemiology, and End Results (SEER) program.

    abstract:BACKGROUND:It is known that malignant melanoma (MM) survivors are at increased risk of future primary MM. However, the risk for noncutaneous second primary malignancies (SPMs) is not as well-understood. METHODS:An observational study utilizing data from the Surveillance, Epidemiology, and End Results (SEER) database w...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Vakharia PP,Kelm RC,Orrell KA,Patel KR,Singam V,Ali Y,Rastogi S,Yousif R,Rangel SM,West DP,Nardone B

    更新日期:2020-04-01 00:00:00

  • Amelanotic melanomas presenting as red skin lesions: a diagnostic challenge with potentially lethal consequences.

    abstract:OBJECTIVE:To characterize epidemiologic and clinical features of red primary amelanotic melanomas, an atypical presentation of melanoma that is underemphasized in patient and physician education. PATIENTS AND METHODS:Review of a prospectively collected melanoma database identified 46 patients with red amelanotic melan...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: McClain SE,Mayo KB,Shada AL,Smolkin ME,Patterson JW,Slingluff CL Jr

    更新日期:2012-04-01 00:00:00

  • Efficacy of topical calcineurin inhibitors in vitiligo.

    abstract::Topical tacrolimus and pimecrolimus are indicated for the treatment of atopic dermatitis, but they have been studied in many off-label uses. We reviewed the English language literature to define their roles in treatment of vitiligo. Double-blind studies show that tacrolimus 0.1% ointment combined with excimer laser is...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Wong R,Lin AN

    更新日期:2013-04-01 00:00:00