Abstract：
BACKGROUND:Cutaneous melanoma is the most aggressive type of skin cancer, with high implications on the morbidity and mortality of patients. Matrix metalloproteinases (MMP) 2 and 9 have been involved in melanoma progression because they degrade important components of the basement membrane. We studied the relationship between the levels of active and inactive MMP 2, MMP 9, and clinicopathological parameters. MATERIALS AND METHODS:Expression of both active and latent forms of MMP 2 and MMP 9 was evaluated by zymography in 21 melanoma tissue samples and 19 benign melanocytic nevi samples. RESULTS:In the melanoma group, inactive MMP 2 was detected in 100% of samples and active MMP 2 in 95%. Inactive MMP 9 was detected in 85% of samples and active MMP 9 in 38%. In the nevi group, 78.9% of samples expressed inactive MMP 2, 5.26% active MMP 2, 21% inactive MMP 9, and 0% active MMP 9. Both forms of MMP 2 and MMP 9 were found to be correlated with skin tumor malignancy. Expression of active and latent MMP 9 was higher in tumors >2 mm thick (P = 0.03, P = 0.014). A correlation was also found between positive lymph node metastasis, inactive MMP 9, and active MMP 9 expression (r = 0.59 P < 0.01, r = 0.668, P < 0.01). The amount of active and latent form of MMP 2 did not have an impact on lymph node metastasis. CONCLUSIONS:Our study demonstrates that active and latent MMP 2 and MMP 9 correlate with melanoma, and both forms of MMP 9 correlate with positive lymph node metastasis.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Candrea E,Senila S,Tatomir C,Cosgarea Rdoi
10.1111/j.1365-4632.2012.05772.xsubject
Has Abstractpub_date
2014-05-01 00:00:00pages
575-80issue
5eissn
0011-9059issn
1365-4632journal_volume
53pub_type
杂志文章abstract：:The role of cell-mediated immunity (CMI) in wart infection was demonstrated. The correlation with humoral immunity was also suggested. Patients with cell-mediated immune deficiency were found to be more susceptible to wart infection than those with humoral immune deficiency. ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1982.tb00510.x
更新日期：1982-03-01 00:00:00
abstract：BACKGROUND AND DESIGN:The clinical, histologic, and direct (DIF) and indirect (IIF) immunofluorescence findings are used in a critical, although arbitrary, manner in the routine diagnostic process of bullous pemphigoid (BP). Our purpose was to estimate their relative value. In the present retrospective study, a follow-...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.1998.00271.x
更新日期：1998-03-01 00:00:00
abstract：:Twenty-nine patients who had decubitus ulcers and a variety of underlying diseases had good responses to the use of the Clinitron Bed, an air-fluidized system. More research is needed to determine its place in dermatologic care. ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1980.tb00379.x
更新日期：1980-11-01 00:00:00
abstract：BACKGROUND:Tinea capitis is a dermatophyte infection of the scalp, eyebrows, and eyelashes caused by species of Microsporum and Trichophyton. The purpose of this study was to discover the incidence and causal agents of tinea capitis in Saudi Arabia. METHODS:Hair roots, skin scrapings, and pus swabs were collected from...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1993.tb00961.x
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (r...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12304
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Lichen planus pigmentosus (LPP) is an acquired disorder of hyperpigmentation affecting certain racial and ethnic groups. OBJECTIVE:To retrospectively analyze the demographic and clinical characteristics of LPP. METHODS:Clinical and demographic records of all LPP patients attending our pigmentary clinic fro...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14540
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Acne is a common skin disorder that affects both adolescents and adults. However, few epidemiological studies on this condition have been conducted in Asia. OBJECTIVES:The purpose of this study was to analyze the incidence of acne and to identify its demographic and clinical features and aggravating factors...
journal_title：International journal of dermatology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-4632.2010.04726.x
更新日期：2011-06-01 00:00:00
abstract：:Pneumocystis jiroveci pneumonia is an opportunistic infection associated with substantial rates of mortality in immunosuppressed patients. Prophylaxis recommendations are mostly targeted toward patients with non-dermatologic diagnoses. This study was conducted to determine when dermatology patients treated with immuno...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/ijd.13231
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Cutaneous leishmaniasis is a common disease in Iran, especially in the north-east, central and southern parts of the country. Many treatments have been suggested for this disease but none is completely effective and without side-effects such as pain, arthralgia and renal or cardiac complications. Lasers have...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-4632.2004.02349.x
更新日期：2004-10-01 00:00:00
abstract：:Ten patients with chronic purpuric and pigmented angiodermatitis in the extremities and two patients with acute and disseminated eczematoid-like purpura angiodermatitis were studied with current hemostasis parameters: (1) platelet aggregation, (2) platelet circulating aggregates, (3) clotting factor measurements and h...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb04244.x
更新日期：1992-11-01 00:00:00
abstract：:There is some debate regarding the risk of developing malignancy and progression of malignancy in patients with psoriasis treated with biologics. The lack of extensive, long-term, and large studies, including patients with psoriasis, to assess these aforementioned risks makes it difficult to ascertain the safety profi...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/ijd.13129
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Psoriasis is a chronic debilitating disease affecting approximately one million Canadians. The objective of this study is to estimate the economic burden in $CDN (2008) of moderate to severe plaque psoriasis among Canadian adults. METHODS:Using a cross-sectional design, direct resource use, costs, lost prod...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05359.x
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving the skin bearing apocrine glands. There are numerous comorbidities and associated diseases among patients with HS. The association of HS and thyroid abnormalities is equivocal. We aimed to explore whether HS is associated with thyroid ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.15319
更新日期：2020-11-25 00:00:00
abstract：BACKGROUND:Hidradenitis suppurativa (HS) is a chronic, inflammatory, and recurring disease mainly observed in adults. Obesity is considered an important independent factor in HS development and is associated with a higher prevalence of HS in children. We aimed to characterize the clinical presentation of HS in overweig...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14639
更新日期：2019-09-09 00:00:00
abstract：BACKGROUND:An allogeneic human skin graft is a temporary biologic dressing used in extensive burns that can be a providential treatment for affected patients. Skin quality depends directly on its microbial decontamination after processing in a tissue bank. Our objective was to describe the skin donor profiles in relati...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14254
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:In July 2008, the German statutory health insurance introduced a nationwide skin cancer screening program. Before the introduction, eligible physicians had to qualify to perform the screening test and counsel their patients on skin cancer screening. To educate physicians, a curriculum and training materials ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.13688
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:To characterize epidemiologic and clinical features of red primary amelanotic melanomas, an atypical presentation of melanoma that is underemphasized in patient and physician education. PATIENTS AND METHODS:Review of a prospectively collected melanoma database identified 46 patients with red amelanotic melan...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05066.x
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Pemphigus is a group of vesiculobullous disorders in which the blisters usually heal with hyper or hypopigmentation. The appearance of acanthomata at sites of previous blisters has been noted in some cases. METHODS:All cases of pemphigus admitted to the Madras Medical College hospitals during a 2-year perio...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.1997.00092.x
更新日期：1997-03-01 00:00:00
abstract：UNLABELLED:BACKGROUND> An unchecked proliferation of fibrous tissue after an injury to the skin is the basic mechanism for keloid formation. Recent studies have shown the inhibitory effect of interferons on dermal fibroblast growth and/or collagen production. Various therapeutic modalities have been used for the treatm...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-4362.1996.tb01671.x
更新日期：1996-07-01 00:00:00
abstract：:Atypical presentations of cutaneous tuberculosis are not so uncommon and are frequently overlooked in clinical practice, leading to late diagnosis and increased morbidity. We report three cases of lupus vulgaris with atypical presentations. The cases mimicked other chronic skin lesions like actinomycosis, mycetoma, an...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.03863.x
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:Cases of hydroa vacciniforme-like eruptions caused by latent Epstein-Barr virus (EBV) infection have been reported in Asia and Mexico, some of which progressed to lymphoproliferative disorders. The precise clinical features of the disease are not, however, clear. METHODS:We performed an artificial provocati...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2003.01307_2.x
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:The use of Isotretinoin (Iso) for cystic acne (CA) therapy includes marked side-effects such as dyslipidemia, increased liver enzymes, and reduction of biotinidase activity. Moreover, Homocysteine (Hcy), an amino acid, is metabolized in the liver requiring folate, vitamin B6, vitamin B12, and the activity of...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-4362.2001.00146.x
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Considerable studies showed that tumor suppressor phosphatase and tensin homolog (PTEN) deleted on chromosome 10 is a major tumor suppressor, which inhibits cell proliferation through inactivation of the PI3 kinase (PI3K)/Akt signal pathway. In many human tumors, there is loss of function or mutations in PTE...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12061
更新日期：2014-07-01 00:00:00
abstract：:Leiomyosarcoma (LMS) of the skin is rare, and no management guideline currently exists. Although LMS is historically classified as either dermal (cutaneous) or subcutaneous, definition for its classfication is inconsistent in the literature. Studies on the managenent of LMS are scarce, and there is no consensus on the...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/ijd.14705
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Post-kala-azar dermal leishmaniasis (PKDL) manifests as a skin eruption after healing of visceral leishmaniasis (VL), either spontaneously or as a result of treatment. This study was undertaken to describe the demographic, clinical, and histopathologic features of PKDL in Nepal. METHODS:Demographic, clinica...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2001.01198.x
更新日期：2001-03-01 00:00:00
abstract：:A 5-year study of 668 patients with genital lesions revealed that teenagers and those in the age group of 20 to 40 are most vunerable. The poor, the uneducated and unmarried persons are at high risk. Chancroid and syphilis are the majority of cases. Inguinal bubo, herpes pregenitalis, condylomata acuminata, erosive ba...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
abstract：:Sézary cells were present in a number of less than 1000/mm3 in 52 of 78 cases of various benign diffuse dermatoses and mycosis fungoides. The count was higher than 1000/mm3 in two cases of Sézary syndrome in which the histopathology was that of mycosis fungoides and in six cases of exfoliative erythroderma of undeterm...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1988.tb03219.x
更新日期：1988-05-01 00:00:00
abstract：:The major characteristics of tricho-rhino-phalangeal syndrome (TRPS) include shortened and deviated digits, a typical facies with a pear-shaped nose, a long philtrum and slow-growing, fine, sparse hair. Cone-shaped digital epiphyses are seen on x-ray. A few patients with TRPS are mentally retarded. Associated endocrin...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1979.tb01972.x
更新日期：1979-09-01 00:00:00
abstract：:A 70-year-old patient with a history of hypertension and hypercholesterolemia was referred for evaluation of necrotic toes. The patient had a history of several cerebrovascular accidents during the previous month. Initially, she developed sudden-onset left upper extremity weakness which, over the ensuing 4 days, progr...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2000.00935.x
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:COVID-19 cutaneous manifestations have been recently described and classified in five different clinical patterns, including acral erythema-edema (pseudo-chilblain), maculopapular exanthemas, vesicular eruptions, urticarial lesions, and livedo or necrosis. OBJECTIVES:The objective of this study was to exami...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.15180
更新日期：2020-09-24 00:00:00
