Lack of association between angiotensin I-converting enzyme insertion/deletion polymorphism and psoriasis or psoriatic arthritis in Spain.

Abstract:

:Data on the potential influence of the angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) genotype on psoriasis are contradictory. Our aim was to investigate the relationship between the ACE gene I/D polymorphism and psoriasis/psoriatic arthritis. To investigate this, a genetic association study was conducted among 268 unrelated patients with psoriasis and 272 controls. The distribution of DD, ID, and II genotypes did not significantly differ between psoriatic patients and controls (DD: 39.6% vs. 34.2%; ID: 46.3% vs. 53.3%; II: 14.1% vs. 12.5%). In conclusion, the ACE polymorphism is not likely to be associated with either psoriasis or psoriatic arthritis in this study.

journal_name

Int J Dermatol

authors

Coto-Segura P,Alvarez V,Soto-Sánchez J,Morales B,Coto E,Santos-Juanes J

doi

10.1111/j.1365-4632.2009.04245.x

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1320-3

issue

12

eissn

0011-9059

issn

1365-4632

pii

IJD4245

journal_volume

48

pub_type

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