Evaluating serum prolactin and serum dehydroepiandrosterone sulfate levels in patients with pemphigus.

Abstract:

BACKGROUND:Altered levels of sex hormones have been observed in many autoimmune disorders, but there is no considerable data about pemphigus. The aim of this study is to compare serum total and free prolactin and dehydroepiandrosterone sulfate (DHEAS) levels between patients with pemphigus and healthy controls and to determine the correlation of these hormones with disease severity. METHODS:This study included 52 newly diagnosed cases of pemphigus and 57 healthy controls. Serum prolactin (total and free) and DHEAS were measured in all subjects. Data analyses were performed using JMP, Version 7. RESULTS:Pemphigus patients had significantly higher levels of total and free serum prolactin (both P = 0.01) and lower levels of DHEAS (P = 0.005) than healthy controls. A significant association was found between severity of pemphigus and total prolactin levels (r = 0.40, P = 0.003). CONCLUSIONS:The patients with pemphigus had higher total and free prolactin and lower DHEAS concentrations, and patients with more severe disease had higher levels of serum total prolactin. These new data may suggest a potential role for sex hormones in the pathogenesis of pemphigus disease and provide new insights for the better management of this chronic and life-threatening disease.

journal_name

Int J Dermatol

authors

Yousefi M,Mozafari N,Hosseini MS,Gholamin S,Razavi SM,Namazi MR,Younespour S

doi

10.1111/ijd.13199

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

e332-7

issue

6

eissn

0011-9059

issn

1365-4632

journal_volume

55

pub_type

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