Abstract：
BACKGROUND:Prurigo pigmentosa (PP), a rare inflammatory disease of the skin, is mostly reported in the ethnic Japanese population. Its pathogenesis remains unclear. The chronic and recurrent nature of PP implies a possible role of viral infection in the pathogenesis. The anti-inflammatory mechanism of doxycycline, which is well documented as a good treatment for PP, is related to the suppression of interleukin expression. METHODS:We identified and retrospectively analyzed 16 biopsy-proven and criteria-matched patients over a seven year period at a single medical center. DNA extracted from formalin-fixed, paraffin-embedded specimens was analyzed for herpes simplex virus-1 (HSV-1), HSV-2, and human herpes virus-6 (HHV-6) DNA by polymerase chain reaction. Immunohistochemistry was performed to determine the interleukin-6 (IL-6) and interleukin-8 (IL-8) expression in PP skin lesions. RESULTS:Clinicopathological findings in the ethnic Chinese population are similar to those reported in Japanese studies. All patients had a good response to doxycycline treatment, with a mean duration of use of 2.4 weeks. However, recurrence was noted in six patients. HSV-1, HSV-2, and HHV-6 DNA in PP skin lesions were negative. Immunohistochemistry showed IL-6 (P = 0.035) to be more strongly expressed in PP skin lesions. There was no statistical significance of elevated IL-8 expression in PP (P = 0.123). CONCLUSIONS:Prurigo pigmentosa is not uncommon in the ethnic Chinese population. There was no evidence of herpes virus DNA in PP skin lesions. Increased expression of IL-6 in PP skin lesions may explain the effects of doxycycline in terms of its anti-inflammatory properties.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Lu PH,Hui RC,Yang LC,Yang CH,Chung WHdoi
10.1111/j.1365-4632.2010.04625.xsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
36-43issue
1eissn
0011-9059issn
1365-4632journal_volume
50pub_type
杂志文章abstract：OBJECTIVE:The purpose of the study was to examine the eggs of pubic lice with consideration of their clinical relevance. STUDY DESIGN:Pubic lice eggs were examined by scanning electron microscopy (SEM). RESULTS:The egg is totally encased by a proteinaceous sheath, except for the operculum, by which oxygen exchange oc...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2000.00901.x
更新日期：2000-03-01 00:00:00
abstract：BACKGROUND:Pyoderma gangrenosum (PG)-like lesions can be associated with Wegener's granulomatosis (WG); in rare instances, they could be the presenting sign of WG. The purpose of this study was to elucidate the relationship between these two disorders. METHODS:The clinical and histologic data from a case of WG with pr...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4362.1994.tb02858.x
更新日期：1994-07-01 00:00:00
abstract：:Trimethylpsoralen, psoralen and 8-methoxypsoralen were adminstered in 10 mg dosage orally to 37, 29 and 23 patients with vitiligo. Complete improvement was noted in 8.9% and partial improvement was recorded in 59.5%. The overall results produced by trimethylpsoralen and psoralen were superior to those of 8-methoxyps...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章
doi：10.1111/ijd.1975.14.3.205
更新日期：1975-04-01 00:00:00
abstract：:A survey of 115 pemphigus patients who have been followed for 4-24 years was carried out in an attempt to analyze the possible factors influencing the course and prognosis of the disease. At the time of the study, 45 patients were in complete remission, 45 still had lesions, and 25 had died. In 12 cases, the death occ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1988.tb02409.x
更新日期：1988-10-01 00:00:00
abstract：BACKGROUND:Associations between vitamin D deficiency and a broad variety of independent diseases, including several bone diseases, various types of cancer, autoimmune diseases, hypertension, and cardiovascular disease, have been suggested. It is therefore important to detect and treat vitamin D deficiency in high-risk ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.13119
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Hidradenitis suppurativa (HS) is a chronic, inflammatory, and recurring disease mainly observed in adults. Obesity is considered an important independent factor in HS development and is associated with a higher prevalence of HS in children. We aimed to characterize the clinical presentation of HS in overweig...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14639
更新日期：2019-09-09 00:00:00
abstract：:Fifty-seven patients with primary localized cutaneous amyloidosis (PLCA) were clinically and histopathologically reviewed. Two-thirds of patients had macular amyloidosis (MA). Intermediate cases having macular lesions with micropapules and/or lichens were identified. A spectrum for the disease is proposed, in which th...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb03245.x
更新日期：1992-02-01 00:00:00
abstract：BACKGROUND:β-Cyclodextrin (βCD) xerogel containing silk fibroin (SF) was prepared, and the efficacy of the xerogel for a pressure sore developed on the back of an ICR mouse was investigated. MATERIALS AND METHODS:Tosyl βCD was conjugated to polyethyleneimine (PEI), and the βCD residues were cross-linked in an aqueous ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05389.x
更新日期：2012-08-01 00:00:00
abstract：:One hundred thirteen patients with fixed drug eruption (FDE) were studied for any drug-specific clinical pattern. The causative drugs were identified and confirmed by provocation tests. A trimethoprim-sulfamethoxazole combination caused maximum incidence (36.3%), followed by tetracycline (15.9%), pyrazolones (14.2%), ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1991.tb04354.x
更新日期：1991-12-01 00:00:00
abstract：BACKGROUND:Several case reports and case series have recently explored the association between hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD). OBJECTIVE:We performed a systematic review and meta-analysis of case-control studies to determine (i) the pooled prevalence of IBD in HS cohorts, and (ii) ...
journal_title：International journal of dermatology
pub_type： 杂志文章,meta分析
doi：10.1111/ijd.14697
更新日期：2020-02-01 00:00:00
abstract：:In a randomized, double-blind, parallel comparative study of 80 patients, impetigo and ecthyma were treated effectively by sulconazole nitrate 1% cream and miconazole nitrate 2% cream applied to lesions twice daily for 14 days. When treatment began, bacterial cultures from all pyodermal lesions yielded Group A beta-he...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1111/j.1365-4362.1988.tb01273.x
更新日期：1988-12-01 00:00:00
abstract：:Ten patients with chronic purpuric and pigmented angiodermatitis in the extremities and two patients with acute and disseminated eczematoid-like purpura angiodermatitis were studied with current hemostasis parameters: (1) platelet aggregation, (2) platelet circulating aggregates, (3) clotting factor measurements and h...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb04244.x
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND:The treatment of melanoma in situ (MIS), particularly the lentigo maligna (LM) subtype, has been a controversial subject in the literature for over a decade. Surgical excision with 5 mm margins is the standard of care in the USA, while several variations of Mohs surgery are frequently used to treat clinicall...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4632.2010.04423.x
更新日期：2010-05-01 00:00:00
abstract：:With the advent of various new methods of treating psoriasis, it is necessary to remind physicians to consider an agent that is easy to administer, locally effective, relatively inexpensive, not time-consuming and without systemic toxic effects. Nineteen patients were treated with topical nitrogen mustard between 1972...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1979.tb05017.x
更新日期：1979-11-01 00:00:00
abstract：BACKGROUND:Though acral lentiginous melanoma (ALM) is a major type of malignant melanoma, no immunohistochemical study on this type of melanoma has been reported. OBJECTIVE:The purpose of this study is to analysis the immunohistochemical findings of ALM using routinely used immune markers. METHODS:An immunohistochemi...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2003.01583.x
更新日期：2003-02-01 00:00:00
abstract：:Favus has become a rarly found chronic fungal infection mainly caused by Trichophyton schoenleini and occasionally by Trichophyton violaceum or Microsporum gypseum. It can still be found in areas where the population suffers from poor hygiene and malnutrition. Cases are seen in the Mediterranean basin, the Middle East...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1980.tb00259.x
更新日期：1980-03-01 00:00:00
abstract：:A 73-year-old Celtic man presented with a linear pigmented 20-mm lesion on the left infraorbital cheek (Fig. 1). Clinical impression was pigmented basal cell epithelioma. Removal was accomplished by linear excision under local anesthesia. The wound was closed with a running 5-0 nylon subcuticular suture, which was rem...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1985.tb05396.x
更新日期：1985-03-01 00:00:00
abstract：BACKGROUND:With the increasing incidence of human immunodeficiency virus (HIV) infection and immunosuppressive therapy, the incidence of syphilis has been increasing. Given the fact that the above conditions may mask or obscure the usual clinical signs and symptoms of syphilis, a means of enhanced detection is essentia...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2000.00029.x
更新日期：2000-08-01 00:00:00
abstract：BACKGROUND:Health-related quality of life instruments are typically developed and validated for use in developed countries by patients who can read and write. Little is known about the feasibility of using adaptations of validated instruments in situations where literacy rates are low. OBJECTIVE:We aimed to translate,...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.04894.x
更新日期：2011-10-01 00:00:00
abstract：:The patient, aged 50 years, with no relevant clinical history, complained of a symptomless, soft tumor of the right buttock that had been present for many years. On examination, it was found to be pediculate, oval, somewhat erythematous, firm on palpation, and with a central keratin plug. The greatest diameter of the ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1995.tb04659.x
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND:In vitiligo, other than loss of melanocytes and melanin pigment in the lesional skin, keratinocytes are also involved. Human fetal Merkel cells are now generally considered to be derived from the epidermis. To date, no observations on Merkel cells in lesional skin of active vitiligo have been reported. METH...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1994.tb02859.x
更新日期：1994-07-01 00:00:00
abstract：:Challenge: Clinical and research responsibilities often leave little or no time to plan thoughtful teaching encounters with trainees. This "Teaching & Learning Tips" series is designed to be an accessible guide for dermatologists who want to improve their teaching skills. It is comprised of 12 articles about how to en...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/ijd.13751
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Information on skin diseases in north-western Nigeria is scanty. We therefore conducted a prospective survey of 2611 new patients seen between August 1999 and July 2001 at the consultant medical/dermatology clinics of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. METHODS:The personal bio-d...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02298.x
更新日期：2005-01-01 00:00:00
abstract：:Currently available treatment options for melasma include prevention of UV radiation, topical lightening agents, chemical peels, and light-based and laser therapies. However, none have shown effective and sustained results, with incomplete clearance and frequent recurrences. There has been increasing interest recently...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/ijd.13578
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:Vitiligo is a common idiopathic skin disorder. The etiology is unknown, although various hypotheses have been advanced. These include the neuronal hypothesis, where neuronal factors are thought to play a role in the pathogenesis of this disease. METHODS:Skin biopsies were taken from marginal and central par...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1995.tb04417.x
更新日期：1995-12-01 00:00:00
abstract：:Pityriasis lichenoides et varioliformis acuta (PLEVA), or Mucha-Habermann disease (MHD), is a cutaneous disorder evident with crops of erythematous macules and papules, usually on the trunk and flexural areas of the extremities. Its etiology remains unknown. PLEVA is speculated to be an inflammatory reaction triggered...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4632.2008.03915.x
更新日期：2010-03-01 00:00:00
abstract：:With more than 3 years' follow-up, dramatic clinical transfiguration of granuloma annulare was observed in a 59-year-old man with perforating granuloma annulare. The eruption was at first localized, then became generalized, developed perforations, and subsided in parallel with the improvement of associated diabetes me...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1985.tb05855.x
更新日期：1985-11-01 00:00:00
abstract：BACKGROUND:The plantar surface is one of the commonest sites of malignant melanoma in the Japanese; however, the biological behavior is not sufficiently clarified, because of the paucity of long-term studies. We attempted an epidemiologic survey of the cases of plantar melanoma treated in our institute to study the sur...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.1999.00736.x
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:A 42-year-old male patient suffering from the rare Comèl-Netherton syndrome is reported, and the symptoms are discussed together with the results of light and electron microscopic examinations. CASE REPORT:Our case presented peeling skin syndrome type B with spontaneous, lifelong skin shedding with underlyi...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2002.01418.x
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Chronic plaque psoriasis has a profound impact on a patient's daily life. To understand the effects of psoriasis treatments, it is essential to assess the patient's experience of symptoms and how they impact their daily life. The goal of this study was to develop and establish the content validity of a new p...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2012.05798.x
更新日期：2014-06-01 00:00:00
