Abstract:
:One hundred thirteen patients with fixed drug eruption (FDE) were studied for any drug-specific clinical pattern. The causative drugs were identified and confirmed by provocation tests. A trimethoprim-sulfamethoxazole combination caused maximum incidence (36.3%), followed by tetracycline (15.9%), pyrazolones (14.2%), sulfadiazine (12.4%), dipyrine (9.3%), acetaminophen (7.9%), aspirin (1.7%), thiacetazone (0.88%), and levamizole (0.88%). Sulfas, including trimethoprim-sulfamethoxazole, induced lesions on the lips (91%) and trunk and limbs (89%), with only minimal involvement of mucosae. Tetracycline caused lesions only on the glans penis, sparing other sites. Pyrazolones affected mainly the lips and mucosae, with a few lesions of the trunk and limbs. Dipyrine, aspirin, and acetaminophen caused lesions of the trunk and limbs, sparing the lips, genitalia, and mucosae. Levamizole caused associated constitutional disturbances with extensive skin lesions, as did thiacetazone. The current study indicates that the clinical pattern and distribution of lesions in FDE are influenced by the drug in question, and the study of the pattern may provide useful information in selecting the most likely causative drug, especially when the details of the drugs are unknown.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Thankappan TP,Zachariah Jdoi
10.1111/j.1365-4362.1991.tb04354.xsubject
Has Abstractpub_date
1991-12-01 00:00:00pages
867-70issue
12eissn
0011-9059issn
1365-4632journal_volume
30pub_type
杂志文章abstract:BACKGROUND:Mycetoma is a chronic suppurative and/or granulomatous inflammatory lesion of skin, subcutaneous tissue, fascia, and tendons caused by the traumatic inoculation of either fungal (eumycotic) or bacterial (actinomycotic) organisms present in the soil. The disease is characterized by triad of tumefaction, disch...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2010.04610.x
更新日期:2010-11-01 00:00:00
abstract::The auricle is a flexible structure because it is formed by elastic cartilage. In the rare occurrence of ectopic auricular ossification, however, the cartilage is replaced by lamellar bone and becomes petrified. Such unphysiological replacement has been reported in association with local trauma, inflammation, systemic...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03512.x
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Glutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less succ...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/ijd.12999
更新日期:2016-02-01 00:00:00
abstract::Cutaneous fibrinolytic activity was found to be increased in a patient with aquagenic pruritus both before and after contact with water. This could explain the lack of wheal formation in this affection, which is characterized by increased histamine release. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1984.tb05665.x
更新日期:1984-01-01 00:00:00
abstract::The patient, aged 50 years, with no relevant clinical history, complained of a symptomless, soft tumor of the right buttock that had been present for many years. On examination, it was found to be pediculate, oval, somewhat erythematous, firm on palpation, and with a central keratin plug. The greatest diameter of the ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb04659.x
更新日期:1995-10-01 00:00:00
abstract:BACKGROUND:There are few published guidelines that describe the forethought and logistical considerations needed to create a dermatology-specific medical mission. OBJECTIVE:To report the experience of planning and executing a successful medical mission to an underserved community in Puerto Rico. METHODS:We identified...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05750.x
更新日期:2013-03-01 00:00:00
abstract::In 107 cases of facial contact dermatitis, routine Finn chamber epicutaneous tests with TROLAB European Standard Allergens (ESAs) were performed. Sixty-one (57%) had positive reaction. The most frequent contact allergens were paraphenylenediamine dihydrochloride (16%), followed by fragrance mix (15%), and nickel sulfa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1991.tb04867.x
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Millions of people are infested by head lice every year. However, louse transfer between hosts is not well-understood. Our goals were to determine: (1) which stages were most likely to disperse and why, (2) the likelihood of fomites transmission, and (3) if host blood gender affects louse development. METHO...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2005.02418.x
更新日期:2005-10-01 00:00:00
abstract::Hydroxyurea is a hydroxylated derivate of urea commonly used in the treatment of various hematologic disorders. Cutaneous side-effects such as alopecia, diffuse hyperpigmentation, scaling, poikiloderma, atrophy of the skin and subcutaneous tissues or nail changes can develop after long-term treatment with hydroxyurea....
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02450.x
更新日期:2006-02-01 00:00:00
abstract::Affecting approximately 9.4% of the population worldwide, acne vulgaris is a common chronic inflammatory skin disease. Medical students are exposed to higher levels of stress and have a higher prevalence of acne. However, the risk factors and the impact of acne on medical students' mental health remains poorly underst...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.15280
更新日期:2020-10-31 00:00:00
abstract::Oral mucous membrane involvement occurs uncommonly in mycosis fungoides and reports of it are scarce. We present two patients with severe involvement of the oral mucous membranes. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1991.tb04353.x
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:Needle biopsy is a rapid, reliable, and reproducible procedure for histological confirmation of metastatic melanoma localization. Nonetheless, this procedure presents a theoretical risk of a mechanical weakening of the lymph node capsule with perinodal tumor seeding. The objective of the study was to evaluat...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13936
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Deep dermal and full-thickness burns are not only difficult to treat, but they are also associated with significant morbidity and mortality. Recent reports have proposed the use of mesenchymal stromal cells (MSCs) for inducing tissue repair in burn injuries. OBJECTIVE:We aim to evaluate the effect of alloge...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14949
更新日期:2020-08-01 00:00:00
abstract::A Chinese baby girl was born after an uncomplicated pregnancy and a normal spontaneous vaginal delivery to a gravida 2, para 1, 32-year-old mother at 37 weeks' gestation. Neither parent had a history of alcohol or drug ingestion. There was no history of consanguinity. The Apgar scores were 7 at 1 min and 9 at 5 min. H...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2001.01212-4.x
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Diagnostic errors appear to be the most common, costly, and dangerous of all medical mistakes. There has been a notable increase on the focus of error prevention as part of a growing patient safety movement. However, diagnostic errors have received less attention than other types of error. Our goal is to pre...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13532
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Primary cutaneous CD4+ small-medium pleomorphic T cell lymphoma (SMPTCL) is a low-grade cutaneous T cell lymphoma. Its clinical and histopathologic features are comparable with those of CD8+ lymphoid proliferations (LPs) of the ear and acral sites. OBJECTIVES:We performed a retrospective analysis of patient...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13340
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Antitumor necrosis factor (anti-TNF) agents are a well-established treatment for various medical conditions, including psoriasis and psoriatic arthritis. However, anti-TNF agents may themselves induce psoriasis in some patients. METHODS:The authors report two cases of patients with severe and refractory inf...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05601.x
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Primary Antiphospholipid Antibody Syndrome (PAAS) is characterized by detection of antiphospholipid antibodies associated with venous or arterial thrombosis and/or miscarriages by patients with no other associated disease such as systemic lupus erythematosus (SLE). Primary Antiphospholipid Antibody Syndrome ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.01939.x
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Alopecia areata (AA) is a non-scarring, autoimmune, inflammatory hair loss disease. Zinc is a trace element involved in important functional activities of hair follicles. PURPOSE:To evaluate serum zinc levels in patients with newly diagnosed and resistant lesions of AA in comparison to age- and sex-matched ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12769
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Over a 3-year period (March 1999 to March 2002), 944 patients with scalp lesions attended a dermatology reference center in the city of Fortaleza, Ceará, Brazil. Clinical specimens were examined at the Specialized Medical Mycology Center, Federal University of Ceará, Fortaleza-CE, Brazil, to detect patients ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02150.x
更新日期:2004-08-01 00:00:00
abstract::Dapsone (4,4'-diaminodiphenylsulfone) is the only remaining sulfone used in anthropoid therapeutics and is commercially available as an oral formulation, an inhaled preparation, and a 5% or 7.5% cream. Dapsone has antimicrobial effects stemming from its sulfonamide-like ability to inhibit the synthesis of dihydrofolic...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14761
更新日期:2020-07-01 00:00:00
abstract::Birt-Hogg-Dubé Syndrome is an autosomal dominant condition characterized by a triad of fibrofolliculomas, trichodiscomas, and acrochordons. Since the first description in 1977, many conditions have been described in association with its clinical triad. Recent epidemiological studies have shown a significant associatio...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02095.x
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Various hormonal states are known to be associated with the waxing and waning of psoriasis. Patients with psoriasis commonly experience changes in their cutaneous disease during pregnancy or post partum. OBJECTIVE:We evaluated 100 women with psoriasis by questionnaire and interview. The women had been seen ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1996.tb01632.x
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVE:The purpose of the study was to examine the eggs of pubic lice with consideration of their clinical relevance. STUDY DESIGN:Pubic lice eggs were examined by scanning electron microscopy (SEM). RESULTS:The egg is totally encased by a proteinaceous sheath, except for the operculum, by which oxygen exchange oc...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2000.00901.x
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving the skin bearing apocrine glands. There are numerous comorbidities and associated diseases among patients with HS. The association of HS and thyroid abnormalities is equivocal. We aimed to explore whether HS is associated with thyroid ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15319
更新日期:2020-11-25 00:00:00
abstract:BACKGROUND:In recent years, the rare association of Sweet's syndrome with nontuberculous mycobacterial lymphadenitis has been reported. OBJECTIVE:To report the clinical, demographic, and bacteriologic data and association with Sweet's syndrome of 18 patients with scrofuloderma and scrofuloderma-like condition caused b...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2002.01362.x
更新日期:2002-01-01 00:00:00
abstract::A 40-year-old black man who was HIV positive developed generalized hypertrophic lichen planus in areas previously affected by a photosensitivity eruption. After unsuccessful attempts to induce remission of his lichen planus with conventional therapies, etretinate produced a dramatic response. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb02423.x
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Genodermatoses represent genetic anomalies of skin tissues including hair follicles, sebaceous glands, eccrine glands, nails, and teeth. Ten consanguineous families segregating various genodermatosis phenotypes were investigated in the present study. METHODS:Homozygosity mapping, exome, and Sanger sequencin...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13778
更新日期:2017-12-01 00:00:00
abstract::Ten patients with chronic purpuric and pigmented angiodermatitis in the extremities and two patients with acute and disseminated eczematoid-like purpura angiodermatitis were studied with current hemostasis parameters: (1) platelet aggregation, (2) platelet circulating aggregates, (3) clotting factor measurements and h...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb04244.x
更新日期:1992-11-01 00:00:00
abstract::A 30-year-old woman presented with an orange-yellow discoloration of the skin, most noticeable on the palms and soles and nasolabial folds; sclera appeared normal. The patient had observed the abnormal pigmentation of her skin 3 months earlier and noticed that it had become more evident after a sauna she had taken 2 d...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03521.x
更新日期:1992-01-01 00:00:00