Abstract:
BACKGROUND:Glutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less successful in elevating plasma GSH levels. OBJECTIVES:The use of a lozenge containing GSH was investigated in order to evaluate the buccal mucosa as a route for GSH administration. Substances that are absorbed through the buccal route go directly into the systemic circulation, effectively bypassing the gastrointestinal tract. METHODS:Thirty Filipino females with Fitzpatrick skin types IV or V received a glutathione-containing lozenge daily for eight weeks. RESULTS:Findings showed a significant decrease in melanin indices from baseline to endpoint that became evident in as little as two weeks. There were no serious adverse events, and laboratory examination findings remained normal. CONCLUSIONS:The authors conclude that the lozenge containing glutathione was safe and effective in lightening the skin of Filipino women.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Handog EB,Datuin MS,Singzon IAdoi
10.1111/ijd.12999subject
Has Abstractpub_date
2016-02-01 00:00:00pages
153-7issue
2eissn
0011-9059issn
1365-4632journal_volume
55pub_type
临床试验,杂志文章abstract::Previous reports have shown that alterations in cutaneous and plasmatic fibrinolytic activity are found in cutaneous necrotizing vasculitis (CNV). In a combined investigation with direct immunofluorescence and autohistographic evaluation of tissue fibrinolytic activity in the lesional skin of 20 subjects affected by S...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1983.tb03323.x
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:Psoriasis is a common Th1-mediated skin disease whose etiology remains obscure. Loss of sweating caused by retention hyperkeratosis is seen in psoriasis plaques, which is likely to have resulted from autonomic dysfunction. OBJECTIVE:In the present study, we aimed to evaluate autonomic nervous system (ANS) f...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05111.x
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Climatologic factors may affect atopic dermatitis (AD), and there have been few explorations into this topic. Because of its size, the United States (US) has a broad range of climates. The objective of this study is to assess the relationship between ambulatory office visits physicians for AD with temperatur...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14289
更新日期:2019-04-01 00:00:00
abstract::The effects of prednisone, oral acyclovir, and radiotherapy were compared with placebo in the prevention of post-herpetic neuralgia. No treatment used was able to prevent, with statistical significance, post-herpetic neuralgia, although prednisone and acyclovir showed some pain reduction in the acute phase. Radiothera...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-4362.1991.tb04642.x
更新日期:1991-04-01 00:00:00
abstract::Light and electron microscopic studies in a case of nasal glioma revealed a tumor composed nearly entirely of astrocytes. No ganglion cells or neurons were present and the mass was not surrounded by a capsule reminiscent for meningeal tissue. The vasculature resembled dermal patterns rather than typical central nervou...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1982.tb02076.x
更新日期:1982-05-01 00:00:00
abstract::A mild dermatitis probably due to Cheyletiella yasguri was observed in 2 persons whose pet dog was infested with this parasite. Cheyletiella mites differ morphologically from sarcoptic mites, which cause canine and human scabies. Treatment of man and dog with 1% gamma benzene hexachloride is usually successful in clea...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1977.tb01882.x
更新日期:1977-10-01 00:00:00
abstract:BACKGROUND:Rebound in psoriasis is, by definition, a rapid worsening of disease following the discontinuation of therapy for psoriasis; it occurs following the abrupt discontinuation of many therapies. To prevent rebound on discontinuation of efalizumab, this study evaluated the effectiveness of transitioning patients ...
journal_title:International journal of dermatology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-4632.2007.03158.x
更新日期:2007-06-01 00:00:00
abstract::Behçet's Disease (BD) is a systemic disorder with an unknown etiopathogenesis. The need for clinical criteria in the establishment of diagnosis is of great importance. We present the case of a 27-year-old man with BD, who had a surgical operation during the active period of his disease and experienced subsequent compl...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb02722.x
更新日期:1992-08-01 00:00:00
abstract::The concentrations of zinc (Zn), copper (Cu), and iron (Fe) in the skin have been noninvasively determined in vivo by diagnostic x-ray spectrometry. The skin of healthy controls was divided into two major groups based upon the distribution of the concentrations of these elements. In the face and upper neck, the follow...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1986.tb03449.x
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes. OBJECTIVES:The aims of this study were: (i) to present quantitative information on the linoleic acid fractio...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12831
更新日期:2016-03-01 00:00:00
abstract::Three heroin addicts had Candida folliculitis of the scalp, beard, and pubis associated with fever, chills, headache, and fatigue. In each case, pseudohyphae were found within a hair and yeasts around it and Candida was recovered from urine. These facts support a systemic dissemination. Since serious ocular and osteoa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1986.tb04547.x
更新日期:1986-03-01 00:00:00
abstract:BACKGROUND:Genodermatoses represent genetic anomalies of skin tissues including hair follicles, sebaceous glands, eccrine glands, nails, and teeth. Ten consanguineous families segregating various genodermatosis phenotypes were investigated in the present study. METHODS:Homozygosity mapping, exome, and Sanger sequencin...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13778
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Though melasma is a common skin condition in India, epidemiological studies are few and geographically confined. The present study was designed to gain insights into factors involved in causation and aggravation of melasma, demographic distribution, clinical presentations, and treatment patterns. METHODS:A ...
journal_title:International journal of dermatology
pub_type: 杂志文章,多中心研究
doi:10.1111/ijd.14541
更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:Various hormonal states are known to be associated with the waxing and waning of psoriasis. Patients with psoriasis commonly experience changes in their cutaneous disease during pregnancy or post partum. OBJECTIVE:We evaluated 100 women with psoriasis by questionnaire and interview. The women had been seen ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1996.tb01632.x
更新日期:1996-03-01 00:00:00
abstract::Skin cancers are the most common malignancies and, historically, ionizing radiation has played an important role in their treatment. However, less experienced dermatologists generally consider radiation last in the line of therapeutic options. The authors sought to evaluate the effectiveness and safety of office-based...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.03108.x
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Harlequin ichthyosis (HI) is a severe genetic disorder caused by the mutation in the ABCA12 gene. Infants born with this condition have markedly thickened, hard stratum corneum skin all over the body. METHODS:A female child born with a thick white plate of skin with deep cracks all over the body was investi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13923
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Tranexamic acid (TA) is a traditional plasmin inhibitor, and its role in the renovation of damaged skin has become the topic of a lot of research. The aim of this study is to determine whether TA could repair the skin barrier by means of tight intercellular junctions. METHODS:Two kinds of damaged skin model...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12099
更新日期:2014-08-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13253
更新日期:2016-08-01 00:00:00
abstract::A 14-year-old boy was referred to the Dermatology Clinic of the Medical University of Mashhad, Iran, with numerous cutaneous telangiectasias on the face, ears, lips, and back of the hands, with lesions in the temporal region being the first to appear (Figs 1-3). His mother stated that the lesions had been present for ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02775.x
更新日期:2006-07-01 00:00:00
abstract::The care of breast cancer patients is important to dermatologists. Breast cancer's initial presentation, clinical progression, and its associated treatments can result in a variety of cutaneous complications. Dermatologists may be the first to identify a breast cancer diagnosis, as a subset of patients first present w...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.15303
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Mycetoma is a chronic suppurative and/or granulomatous inflammatory lesion of skin, subcutaneous tissue, fascia, and tendons caused by the traumatic inoculation of either fungal (eumycotic) or bacterial (actinomycotic) organisms present in the soil. The disease is characterized by triad of tumefaction, disch...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2010.04610.x
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Even with the widespread clinical use of cannabinoid receptor (CBR) stimulating compounds, such as palmitoylethanolamine, the role of CBR agonists on inflammatory skin diseases is not yet fully understood. This study was performed to investigate the effects of CBR agonists on skin inflammation, using acute a...
journal_title:International journal of dermatology
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Herpes simplex virus (HSV) infections are usually chronically recurrent in the normal population and represent a significant cause of morbidity in immunocompromised patients. Acyclovir (ACV) is widely used for the treatment and prophylaxis of HSV infections. The emergence of ACV-resistant strains has been fr...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03449.x
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:Mycosis fungoides (MF) is an indolent, most common type of cutaneous T-cell lymphoma (CTCL) with an average estimated incidence of 0.5 cases per 100,000 persons per year in the western world. Although various clinical and epidemiological features are well delineated in the western population, the data is sca...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2010.04567.x
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Body piercing is a known and popular method of body ornamentation. Modern body piercing includes wearing jewelry in such body areas as the helix (ear), eyebrows, nose, lips, tongue, chin, nipples, navel, and genitals. The current piercing definition does not comprise piercing of the earlobe; however, this bo...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12115
更新日期:2014-08-01 00:00:00
abstract::The topical application of mechlorethamine is associated with a high incidence of irritant contact dermatitis. An attempt was made to avoid this complication by the use of a topical tolerogenic schedule. Seven of ten patients developed contact dermatitis to the medication after they had completed the schedule, The use...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.1979.18.5.390
更新日期:1979-06-01 00:00:00
abstract::Healthy adult (New Zealand, Dutch Belt, and Wild) rabbits were infected with rabbit papilloma virus (Shope variety). The resultant papillomas were treated with salicylic acid in a new transdermal drug delivery system utilizing a karaya gum glycol matrix. Biopsy samples of treated papillomas were taken at 1, 2, and 3 w...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb02414.x
更新日期:1988-10-01 00:00:00
abstract::There is some debate regarding the risk of developing malignancy and progression of malignancy in patients with psoriasis treated with biologics. The lack of extensive, long-term, and large studies, including patients with psoriasis, to assess these aforementioned risks makes it difficult to ascertain the safety profi...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.13129
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Warts are a common chronic skin disorder that can be cosmetically disfiguring and, depending on the location, cause inhibition of function. The presence of dozens of topical and systemic treatments for warts is a testament to the lack of a rapid, simple, uniformly effective, inexpensive, nonscarring, and pai...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1046/j.1365-4362.2001.01242.x
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Hypomelanosis of Ito (HI), a neurocutaneous disorder characterized by hypopigmented skin lesions along Blaschko's line with multiple accompanying diseases, may occasionally present with sexual precocity. METHODS:We reviewed cases of HI with sexual precocity reported in the literature and focused on collecti...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2010.04639.x
更新日期:2011-02-01 00:00:00