Update on the use of dapsone in dermatology.

Abstract:

:Dapsone (4,4'-diaminodiphenylsulfone) is the only remaining sulfone used in anthropoid therapeutics and is commercially available as an oral formulation, an inhaled preparation, and a 5% or 7.5% cream. Dapsone has antimicrobial effects stemming from its sulfonamide-like ability to inhibit the synthesis of dihydrofolic acid. It also has anti-inflammatory properties such as inhibiting the production of reactive oxygen species, reducing the effect of eosinophil peroxidase on mast cells and down-regulating neutrophil-mediated inflammatory responses. This allows for its use in the treatment of a wide variety of inflammatory and infectious skin conditions. Currently in dermatology, the US Food and Drug Administration (FDA)-approved indications for dapsone are leprosy, dermatitis herpetiformis, and acne vulgaris. However, it proved itself as an adjunctive therapeutic agent to many other skin disorders. In this review, we discuss existing evidence on the mechanisms of action of dapsone, its FDA-approved indications, off-label uses, and side effects.

journal_name

Int J Dermatol

authors

Ghaoui N,Hanna E,Abbas O,Kibbi AG,Kurban M

doi

10.1111/ijd.14761

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

787-795

issue

7

eissn

0011-9059

issn

1365-4632

journal_volume

59

pub_type

杂志文章,评审
  • WhatsApp platforms in tropical public health resource-poor settings.

    abstract::In order to deliver equal healthcare access to resource-poor settings, sustainable, cost-effective systems of communication should be used. As mobile phone use increases, remote care can be delivered via teledermatology using Apps. This commentary covers how WhatsApp could be used by dermatologists seeking to deliver ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14237

    authors: Hogan SC,van Hees C,Asiedu KB,Fuller LC

    更新日期:2019-02-01 00:00:00

  • A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women.

    abstract:OBJECTIVE:To assess the efficacy and safety of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women. Topical 5% cysteamine is an antioxidant and tyrosinase inhibitor that has been shown to be effective in the treatment of melasma. However, to date, no study has compared the performan...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.15146

    authors: Lima PB,Dias JAF,Cassiano D,Esposito ACC,Bagatin E,Miot LDB,Miot HA

    更新日期:2020-12-01 00:00:00

  • Sézary cell count in exfoliative dermatitis.

    abstract::Sézary cells were present in a number of less than 1000/mm3 in 52 of 78 cases of various benign diffuse dermatoses and mycosis fungoides. The count was higher than 1000/mm3 in two cases of Sézary syndrome in which the histopathology was that of mycosis fungoides and in six cases of exfoliative erythroderma of undeterm...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1988.tb03219.x

    authors: Duangurai K,Piamphongsant T,Himmungnan T

    更新日期:1988-05-01 00:00:00

  • Comorbidity of psychiatric disorders in children and adolescents with alopecia areata in a child and adolescent psychiatry clinical sample.

    abstract:BACKGROUND:This study reports the comorbidity of lifetime psychiatric disorders in children and adolescents with alopecia areata (AA) in a child and adolescent psychiatry clinical sample. METHODS:Fourteen patients with AA were interviewed using the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03743.x

    authors: Ghanizadeh A

    更新日期:2008-11-01 00:00:00

  • Cutaneous larva migrans (creeping eruption) in an urban slum in Brazil.

    abstract:BACKGROUND:Cutaneous larva migrans (CLM) is caused by the penetration of larvae of animal hookworms into the skin. Knowledge about this ectoparasitosis is mainly based on the examination of travelers or other expatriates. Population-based studies in an endemic area have never been performed. METHODS:A representative p...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02152.x

    authors: Heukelbach J,Wilcke T,Feldmeier H

    更新日期:2004-07-01 00:00:00

  • Epidemiological studies on head lice infestation in Israel. I. Parasitological examination of children.

    abstract::Of 3,079 children in a medium-sized community near Jerusalem, 11.2% were found to be infested with living lice and eggs and another 23.4% had only nits. Boys and girls were equally infested. The incidence of infestation was highest among children 4-11 years of age. About 78% of the infested children had from one to te...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1990.tb04845.x

    authors: Mumcuoglu KY,Miller J,Gofin R,Adler B,Ben-Ishai F,Almog R,Kafka D,Klaus S

    更新日期:1990-09-01 00:00:00

  • A comparative clinical evaluation of trimethylpsoralen, psoralen and 8-methoxypsoralen in treating vitiligo.

    abstract::Trimethylpsoralen, psoralen and 8-methoxypsoralen were adminstered in 10 mg dosage orally to 37, 29 and 23 patients with vitiligo. Complete improvement was noted in 8.9% and partial improvement was recorded in 59.5%. The overall results produced by trimethylpsoralen and psoralen were superior to those of 8-methoxyps...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/ijd.1975.14.3.205

    authors: Sehgal VN

    更新日期:1975-04-01 00:00:00

  • Carotenoderma: a possible pit-fall in the immunopathologic diagnosis of pemphigus vulgaris.

    abstract::A 30-year-old woman presented with an orange-yellow discoloration of the skin, most noticeable on the palms and soles and nasolabial folds; sclera appeared normal. The patient had observed the abnormal pigmentation of her skin 3 months earlier and noticed that it had become more evident after a sauna she had taken 2 d...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1992.tb03521.x

    authors: Palleschi GM,Knoepfel BR,Lotti T

    更新日期:1992-01-01 00:00:00

  • Erosive pustular dermatosis of the scalp: causes and treatments.

    abstract::Erosive pustular dermatosis of the scalp is a rare condition which primarily affects older women after local trauma and has historically been treated with topical steroids. As it is a rare entity and resembles other dermatologic conditions, it may easily be misdiagnosed. Identifying the causes and evaluating the effic...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.14955

    authors: Karanfilian KM,Wassef C

    更新日期:2021-01-01 00:00:00

  • Hereditary benign telangiectasia: first case in Iran.

    abstract::A 14-year-old boy was referred to the Dermatology Clinic of the Medical University of Mashhad, Iran, with numerous cutaneous telangiectasias on the face, ears, lips, and back of the hands, with lesions in the temporal region being the first to appear (Figs 1-3). His mother stated that the lesions had been present for ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2006.02775.x

    authors: Javidi Z,Maleki M,Mashayekhi V,Nahidi Y,Omidvar Borna A

    更新日期:2006-07-01 00:00:00

  • Paraneoplastic pyoderma gangrenosum in solid organ malignancy: a literature review.

    abstract::Pyoderma gangrenosum (PG) is a rare destructive, ulcerative, and inflammatory cutaneous disease. PG can be associated with inflammatory bowel disease (IBD), arthritis, autoinflammatory syndromes, and hematological malignancies. Multiple reports in the literature have found an association between PG and solid organ tum...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.14637

    authors: Shah M,Sachdeva M,Gefri A,Jfri A

    更新日期:2020-02-01 00:00:00

  • Erythroderma in adults: a report of 80 cases.

    abstract:BACKGROUND:Erythroderma is a generalized erythema of the skin accompanied by a variable degree of scaling. However, most of the published series originate from Western countries. There is only one report from Africa, conducted in Dakar in 1979. The aim of our study was to provide information about this condition in our...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02100.x

    authors: Rym BM,Mourad M,Bechir Z,Dalenda E,Faika C,Iadh AM,Amel BO

    更新日期:2005-09-01 00:00:00

  • The combined use of topical benzoyl peroxide and tretinoin in the treatment of acne vulgaris.

    abstract::A clinical trial using tretinoin lotion 0.05%, benzoyl peroxide 5% and 10% as topical application was performed on 250 ambulatory patients suffering from various degrees of acne vulgaris. The results indicate that tretinoin applied in the morning and benzoyl peroxide applied at night is the most efficacious regimen to...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-4362.1979.tb01956.x

    authors: Handojo I

    更新日期:1979-07-01 00:00:00

  • Discordance of skin and muscle involvement in dermatomyositis.

    abstract::The skin manifestations of dermatomyositis infrequently occur without the myositis. A 24-year-old woman presented with concordance of the skin and muscle components of dermatomyositis, followed by a remission of the myositis with a persistence of significant rash for 17 years, finally presenting with a flare of both s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1985.tb05834.x

    authors: Gertner E,Urowitz MB

    更新日期:1985-10-01 00:00:00

  • Clinical and dermoscopic patterns of melanocytic nevi in Hispanic adolescents: a descriptive study.

    abstract:BACKGROUND:Melanocytic nevi are well-known, important precursors of melanoma among children and adults. The adolescence period is an important period for nevi formation and evolution. This study provides data of a longitudinal study of nevi in a Hispanic adolescent population. MATERIALS AND METHODS:A cross-sectional s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2012.5784.x

    authors: Sosa-Seda IM,Valentín-Nogueras S,Figueroa LD,Sánchez JL,Mercado R

    更新日期:2014-03-01 00:00:00

  • Development of anthralin short-contact therapy in psoriasis: survey of published clinical trials.

    abstract::In a survey of clinical trials concerning the efficacy of short-contact therapy with anthralin in psoriasis vulgaris, focusing principally on methodologic issues, twenty-four papers published between January 1982 and December 1989, in English, French, and Italian, were selected. Nine of 24 papers reported on more than...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,meta分析

    doi:10.1111/j.1365-4362.1992.tb03254.x

    authors: Naldi L,Carrel CF,Parazzini F,D'Oro LC,Cainelli T

    更新日期:1992-02-01 00:00:00

  • A randomized, controlled and blinded study of papulopustular lesions in Turkish Behçet's patients.

    abstract:BACKGROUND:Papulopustular lesions (PPL), the commonest presentation of skin lesions in Behcet's disease (BD) are cutaneous, sterile folliculitis or acne-like lesions on erythematous base. Our purpose was to determine the true frequency and anatomic location of the PPL and compare this with controls. We also sought to d...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.1998.00401.x

    authors: Alpsoy E,Aktekin M,Er H,Durusoy C,Yilmaz E

    更新日期:1998-11-01 00:00:00

  • Dermatologic sequelae of breast cancer: From disease, surgery, and radiation.

    abstract::The care of breast cancer patients is important to dermatologists. Breast cancer's initial presentation, clinical progression, and its associated treatments can result in a variety of cutaneous complications. Dermatologists may be the first to identify a breast cancer diagnosis, as a subset of patients first present w...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.15303

    authors: Milam EC,Rangel LK,Pomeranz MK

    更新日期:2020-11-23 00:00:00

  • An open-label, single-arm trial of the safety and efficacy of a novel preparation of glutathione as a skin-lightening agent in Filipino women.

    abstract:BACKGROUND:Glutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less succ...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/ijd.12999

    authors: Handog EB,Datuin MS,Singzon IA

    更新日期:2016-02-01 00:00:00

  • Scleromyxedema treatment: a systematic review and update.

    abstract:IMPORTANCE:Scleromyxedema is a chronic disease with high morbidity and mortality and no definitive therapeutic guidelines. OBJECTIVE:To review all available data on the efficacy and the safety of the available treatments of scleromyxedema and suggest a possible therapeutic approach. EVIDENCE REVIEW:We performed a sys...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.14888

    authors: Haber R,Bachour J,El Gemayel M

    更新日期:2020-10-01 00:00:00

  • Papulonecrotic tuberculid secondary to disseminated Mycobacterium avium complex.

    abstract:BACKGROUND:Papulonecrotic tuberculid is a rarely reported cutaneous reaction to the mycobacterium bacillus. It is most often encountered in association with tuberculosis. The clinical and histologic picture of the entity is a distinctive one, but the etiology of the disease process is uncertain. Therapy directed agains...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1994.tb01537.x

    authors: Williams JT,Pulitzer DR,DeVillez RL

    更新日期:1994-02-01 00:00:00

  • Skin diseases in the Peruvian Amazonia.

    abstract:BACKGROUND:Dermatologic diseases vary widely as a result of geographic location and may be influenced by environmental factors. Aim To determine the epidemiology of dermatological diseases in the Peruvian Amazonia. METHODS:Transversal and multicentric study, which were carried out during February of 2006, 2007, and 20...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-4632.2010.04473.x

    authors: Gutierrez EL,Galarza C,Ramos W,Tello M,Jiménez G,Ronceros G,Chía H,Hurtado J,Ortega-Loayza AG

    更新日期:2010-07-01 00:00:00

  • Clinitron therapy and the decubitus ulcer: preliminary dermatologic studies.

    abstract::Twenty-nine patients who had decubitus ulcers and a variety of underlying diseases had good responses to the use of the Clinitron Bed, an air-fluidized system. More research is needed to determine its place in dermatologic care. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1980.tb00379.x

    authors: Parish LC,Witkowski JA

    更新日期:1980-11-01 00:00:00

  • Use of vegetable oils in dermatology: an overview.

    abstract::Vegetable oils have been used for a wide variety of purposes since time immemorial; however, their principle use remains as skin moisturizers, especially in neonates and children. Because of their considerable efficacy and a low side effect profile and bearable cost, these oils are hugely popular as moisturizers among...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.13623

    authors: Sarkar R,Podder I,Gokhale N,Jagadeesan S,Garg VK

    更新日期:2017-11-01 00:00:00

  • Grover disease: review of subtypes with a focus on management options.

    abstract::Grover disease (GD) is a benign eruption that causes a papulovesicular rash on the trunk and proximal extremities. It often resolves spontaneously but can follow a more chronic and fluctuating course that may last several years. Although the etiology remains unknown, several associated triggers have been identified in...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.14700

    authors: Aldana PC,Khachemoune A

    更新日期:2020-05-01 00:00:00

  • Ultrastructural study of hyaluronic acid before and after the use of a pulsed electromagnetic field, electrorydesis, in the treatment of wrinkles.

    abstract:BACKGROUND:Treatment of wrinkles has become an increasing problem for dermatologists. Hyaluronic acid is a component of the family of glycosaminoglycans (GAGS, substances known for their property of retaining water), that significantly decreases with aging and in wrinkles. A new technique that uses a specific pulsed el...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1994.tb02933.x

    authors: Ghersetich I,Teofoli P,Benci M,Lotti T

    更新日期:1994-09-01 00:00:00

  • The Psoriasis Symptom Diary: development and content validity of a novel patient-reported outcome instrument.

    abstract:BACKGROUND:Chronic plaque psoriasis has a profound impact on a patient's daily life. To understand the effects of psoriasis treatments, it is essential to assess the patient's experience of symptoms and how they impact their daily life. The goal of this study was to develop and establish the content validity of a new p...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2012.05798.x

    authors: Lebwohl M,Swensen AR,Nyirady J,Kim E,Gwaltney CJ,Strober BE

    更新日期:2014-06-01 00:00:00

  • Severe acute form of adult dermatomyositis treated with cyclosporine.

    abstract::The classical treatment of severe forms of dermatomyositis includes high doses of steroids and/or cytotoxic agents. Acute forms are frequently life threatening. Because cyclosporine is a fast-acting immunosuppressive drug, it appears to be a good candidate for the treatment of refractory forms of acute dermatomyositis...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1992.tb02707.x

    authors: Correia O,Polónia J,Nunes JP,Resende C,Delgado L

    更新日期:1992-07-01 00:00:00

  • Basal cell carcinoma in five albino Africans from the south-eastern equatorial rain forest of Nigeria.

    abstract:BACKGROUND:Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the white population and occurs infrequently in dark-pigmented individuals. Albinism is an established risk factor for skin cancer in black Africans. METHODS:We evaluated the clinical histories and treatment outcomes of patients with a hi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2007.03272.x

    authors: Asuquo ME,Agweye P,Ugare G,Ebughe G

    更新日期:2007-07-01 00:00:00

  • Acitretin-induced subungual hemorrhage.

    abstract::A 20-year-old woman with a 2-year history of histologically confirmed palmoplantar keratoderma due to psoriasis, resistant to several topical agents, was admitted to the Department of Dermatology, Uludag University, Bursa, Turkey. Therapy with oral acitretin (0.5 mg/kg/day, 35 mg/day) was initiated. A month after star...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2006.03059.x

    authors: Aydogan K,Karadogan SK,Tunali S

    更新日期:2007-05-01 00:00:00