Abstract:
:Dapsone (4,4'-diaminodiphenylsulfone) is the only remaining sulfone used in anthropoid therapeutics and is commercially available as an oral formulation, an inhaled preparation, and a 5% or 7.5% cream. Dapsone has antimicrobial effects stemming from its sulfonamide-like ability to inhibit the synthesis of dihydrofolic acid. It also has anti-inflammatory properties such as inhibiting the production of reactive oxygen species, reducing the effect of eosinophil peroxidase on mast cells and down-regulating neutrophil-mediated inflammatory responses. This allows for its use in the treatment of a wide variety of inflammatory and infectious skin conditions. Currently in dermatology, the US Food and Drug Administration (FDA)-approved indications for dapsone are leprosy, dermatitis herpetiformis, and acne vulgaris. However, it proved itself as an adjunctive therapeutic agent to many other skin disorders. In this review, we discuss existing evidence on the mechanisms of action of dapsone, its FDA-approved indications, off-label uses, and side effects.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Ghaoui N,Hanna E,Abbas O,Kibbi AG,Kurban Mdoi
10.1111/ijd.14761subject
Has Abstractpub_date
2020-07-01 00:00:00pages
787-795issue
7eissn
0011-9059issn
1365-4632journal_volume
59pub_type
杂志文章,评审abstract::In order to deliver equal healthcare access to resource-poor settings, sustainable, cost-effective systems of communication should be used. As mobile phone use increases, remote care can be delivered via teledermatology using Apps. This commentary covers how WhatsApp could be used by dermatologists seeking to deliver ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14237
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women. Topical 5% cysteamine is an antioxidant and tyrosinase inhibitor that has been shown to be effective in the treatment of melasma. However, to date, no study has compared the performan...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15146
更新日期:2020-12-01 00:00:00
abstract::Sézary cells were present in a number of less than 1000/mm3 in 52 of 78 cases of various benign diffuse dermatoses and mycosis fungoides. The count was higher than 1000/mm3 in two cases of Sézary syndrome in which the histopathology was that of mycosis fungoides and in six cases of exfoliative erythroderma of undeterm...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb03219.x
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:This study reports the comorbidity of lifetime psychiatric disorders in children and adolescents with alopecia areata (AA) in a child and adolescent psychiatry clinical sample. METHODS:Fourteen patients with AA were interviewed using the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03743.x
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Cutaneous larva migrans (CLM) is caused by the penetration of larvae of animal hookworms into the skin. Knowledge about this ectoparasitosis is mainly based on the examination of travelers or other expatriates. Population-based studies in an endemic area have never been performed. METHODS:A representative p...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02152.x
更新日期:2004-07-01 00:00:00
abstract::Of 3,079 children in a medium-sized community near Jerusalem, 11.2% were found to be infested with living lice and eggs and another 23.4% had only nits. Boys and girls were equally infested. The incidence of infestation was highest among children 4-11 years of age. About 78% of the infested children had from one to te...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1990.tb04845.x
更新日期:1990-09-01 00:00:00
abstract::Trimethylpsoralen, psoralen and 8-methoxypsoralen were adminstered in 10 mg dosage orally to 37, 29 and 23 patients with vitiligo. Complete improvement was noted in 8.9% and partial improvement was recorded in 59.5%. The overall results produced by trimethylpsoralen and psoralen were superior to those of 8-methoxyps...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/ijd.1975.14.3.205
更新日期:1975-04-01 00:00:00
abstract::A 30-year-old woman presented with an orange-yellow discoloration of the skin, most noticeable on the palms and soles and nasolabial folds; sclera appeared normal. The patient had observed the abnormal pigmentation of her skin 3 months earlier and noticed that it had become more evident after a sauna she had taken 2 d...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03521.x
更新日期:1992-01-01 00:00:00
abstract::Erosive pustular dermatosis of the scalp is a rare condition which primarily affects older women after local trauma and has historically been treated with topical steroids. As it is a rare entity and resembles other dermatologic conditions, it may easily be misdiagnosed. Identifying the causes and evaluating the effic...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14955
更新日期:2021-01-01 00:00:00
abstract::A 14-year-old boy was referred to the Dermatology Clinic of the Medical University of Mashhad, Iran, with numerous cutaneous telangiectasias on the face, ears, lips, and back of the hands, with lesions in the temporal region being the first to appear (Figs 1-3). His mother stated that the lesions had been present for ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02775.x
更新日期:2006-07-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is a rare destructive, ulcerative, and inflammatory cutaneous disease. PG can be associated with inflammatory bowel disease (IBD), arthritis, autoinflammatory syndromes, and hematological malignancies. Multiple reports in the literature have found an association between PG and solid organ tum...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14637
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Erythroderma is a generalized erythema of the skin accompanied by a variable degree of scaling. However, most of the published series originate from Western countries. There is only one report from Africa, conducted in Dakar in 1979. The aim of our study was to provide information about this condition in our...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02100.x
更新日期:2005-09-01 00:00:00
abstract::A clinical trial using tretinoin lotion 0.05%, benzoyl peroxide 5% and 10% as topical application was performed on 250 ambulatory patients suffering from various degrees of acne vulgaris. The results indicate that tretinoin applied in the morning and benzoyl peroxide applied at night is the most efficacious regimen to...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1979.tb01956.x
更新日期:1979-07-01 00:00:00
abstract::The skin manifestations of dermatomyositis infrequently occur without the myositis. A 24-year-old woman presented with concordance of the skin and muscle components of dermatomyositis, followed by a remission of the myositis with a persistence of significant rash for 17 years, finally presenting with a flare of both s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1985.tb05834.x
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Melanocytic nevi are well-known, important precursors of melanoma among children and adults. The adolescence period is an important period for nevi formation and evolution. This study provides data of a longitudinal study of nevi in a Hispanic adolescent population. MATERIALS AND METHODS:A cross-sectional s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.5784.x
更新日期:2014-03-01 00:00:00
abstract::In a survey of clinical trials concerning the efficacy of short-contact therapy with anthralin in psoriasis vulgaris, focusing principally on methodologic issues, twenty-four papers published between January 1982 and December 1989, in English, French, and Italian, were selected. Nine of 24 papers reported on more than...
journal_title:International journal of dermatology
pub_type: 杂志文章,meta分析
doi:10.1111/j.1365-4362.1992.tb03254.x
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Papulopustular lesions (PPL), the commonest presentation of skin lesions in Behcet's disease (BD) are cutaneous, sterile folliculitis or acne-like lesions on erythematous base. Our purpose was to determine the true frequency and anatomic location of the PPL and compare this with controls. We also sought to d...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1998.00401.x
更新日期:1998-11-01 00:00:00
abstract::The care of breast cancer patients is important to dermatologists. Breast cancer's initial presentation, clinical progression, and its associated treatments can result in a variety of cutaneous complications. Dermatologists may be the first to identify a breast cancer diagnosis, as a subset of patients first present w...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.15303
更新日期:2020-11-23 00:00:00
abstract:BACKGROUND:Glutathione (GSH) is a naturally occurring thiol that has been reported to cause skin lightening in a manner for which several mechanisms have been proposed. Highest plasma concentrations are achieved with IV administration but are accompanied by greater levels of risk. Oral administration has been less succ...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/ijd.12999
更新日期:2016-02-01 00:00:00
abstract:IMPORTANCE:Scleromyxedema is a chronic disease with high morbidity and mortality and no definitive therapeutic guidelines. OBJECTIVE:To review all available data on the efficacy and the safety of the available treatments of scleromyxedema and suggest a possible therapeutic approach. EVIDENCE REVIEW:We performed a sys...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14888
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Papulonecrotic tuberculid is a rarely reported cutaneous reaction to the mycobacterium bacillus. It is most often encountered in association with tuberculosis. The clinical and histologic picture of the entity is a distinctive one, but the etiology of the disease process is uncertain. Therapy directed agains...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1994.tb01537.x
更新日期:1994-02-01 00:00:00
abstract:BACKGROUND:Dermatologic diseases vary widely as a result of geographic location and may be influenced by environmental factors. Aim To determine the epidemiology of dermatological diseases in the Peruvian Amazonia. METHODS:Transversal and multicentric study, which were carried out during February of 2006, 2007, and 20...
journal_title:International journal of dermatology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-4632.2010.04473.x
更新日期:2010-07-01 00:00:00
abstract::Twenty-nine patients who had decubitus ulcers and a variety of underlying diseases had good responses to the use of the Clinitron Bed, an air-fluidized system. More research is needed to determine its place in dermatologic care. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1980.tb00379.x
更新日期:1980-11-01 00:00:00
abstract::Vegetable oils have been used for a wide variety of purposes since time immemorial; however, their principle use remains as skin moisturizers, especially in neonates and children. Because of their considerable efficacy and a low side effect profile and bearable cost, these oils are hugely popular as moisturizers among...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.13623
更新日期:2017-11-01 00:00:00
abstract::Grover disease (GD) is a benign eruption that causes a papulovesicular rash on the trunk and proximal extremities. It often resolves spontaneously but can follow a more chronic and fluctuating course that may last several years. Although the etiology remains unknown, several associated triggers have been identified in...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14700
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Treatment of wrinkles has become an increasing problem for dermatologists. Hyaluronic acid is a component of the family of glycosaminoglycans (GAGS, substances known for their property of retaining water), that significantly decreases with aging and in wrinkles. A new technique that uses a specific pulsed el...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1994.tb02933.x
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Chronic plaque psoriasis has a profound impact on a patient's daily life. To understand the effects of psoriasis treatments, it is essential to assess the patient's experience of symptoms and how they impact their daily life. The goal of this study was to develop and establish the content validity of a new p...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05798.x
更新日期:2014-06-01 00:00:00
abstract::The classical treatment of severe forms of dermatomyositis includes high doses of steroids and/or cytotoxic agents. Acute forms are frequently life threatening. Because cyclosporine is a fast-acting immunosuppressive drug, it appears to be a good candidate for the treatment of refractory forms of acute dermatomyositis...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb02707.x
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND:Basal cell carcinoma (BCC) is the most common cutaneous malignancy in the white population and occurs infrequently in dark-pigmented individuals. Albinism is an established risk factor for skin cancer in black Africans. METHODS:We evaluated the clinical histories and treatment outcomes of patients with a hi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03272.x
更新日期:2007-07-01 00:00:00
abstract::A 20-year-old woman with a 2-year history of histologically confirmed palmoplantar keratoderma due to psoriasis, resistant to several topical agents, was admitted to the Department of Dermatology, Uludag University, Bursa, Turkey. Therapy with oral acitretin (0.5 mg/kg/day, 35 mg/day) was initiated. A month after star...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.03059.x
更新日期:2007-05-01 00:00:00