Abstract:
BACKGROUND:Psoriasis is a chronic debilitating disease affecting approximately one million Canadians. The objective of this study is to estimate the economic burden in $CDN (2008) of moderate to severe plaque psoriasis among Canadian adults. METHODS:Using a cross-sectional design, direct resource use, costs, lost productivity, and quality of life were obtained for 90 subjects diagnosed with psoriasis in three dermatology clinics in British Columbia, Ontario, and Québec. An Excel-based economic model was developed to project the annual cost of psoriasis, from the societal perspective. RESULTS:The estimated mean annual cost of psoriasis was $7999/subject (95% CI: $3563-$12,434) with direct costs accounting for 57%. Mean lost productivity costs, which accounted for 43% of the mean annual costs of psoriasis, were $3442/subject (95% CI: $1293-$5590). CONCLUSION:Projecting the mean costs per patient to the afflicted population yields an estimated total annual cost of $1.7 billion (95% CI: $0.8-$2.6 billion) attributable to moderate to severe psoriasis in Canada. Understanding the interplay between direct costs, lost productivity, and quality of life is critical for accurately identifying and evaluating effective treatments for this disease.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Levy AR,Davie AM,Brazier NC,Jivraj F,Albrecht LE,Gratton D,Lynde CWdoi
10.1111/j.1365-4632.2011.05359.xsubject
Has Abstractpub_date
2012-12-01 00:00:00pages
1432-40issue
12eissn
0011-9059issn
1365-4632journal_volume
51pub_type
杂志文章abstract::There are rapidly increasing opportunities for dermatologists to see patients suffering from retrovirus infections. The HTLV-I was the first class of human oncogenic retrovirus that was found in cultured cells of a patient with skin manifestations similar or identical to those of CTCL (MF). It was soon recognized as t...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4362.1991.tb03483.x
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:The aim was to examine cadexomer iodine paste in a comparative clinical trial. METHODS:A 12-week, randomized, open, controlled, multicenter, multinational trial in patients with exudating, venous leg ulcers of cadexomer iodine paste (Iodosorb/Iodoflex), hydrocolloid dressing (Duoderm E, Granuflex E), or par...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1046/j.1365-4362.1998.00415.x
更新日期:1998-05-01 00:00:00
abstract::To date, various treatment modalities have failed to produce consistent improvement in patients having Behçet's disease. Recent reports in the literature, however, have shown promising results with the use of colchicine. Our patient, an 18-year-old white woman, satisfied the 1977 Istanbul Conference criteria for Behçe...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1982.tb01202.x
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:The incidence of basal cell carcinoma (BCC) in younger individuals has increased in recent decades. However, the characteristics of BCCs in this population, especially in Ibero-Latin American countries, have not been completely defined. OBJECTIVE:To describe the demographic, clinical, and histopathological ...
journal_title:International journal of dermatology
pub_type: 杂志文章,多中心研究
doi:10.1111/ijd.14195
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Reduced cell-mediated immunity associated with pregnancy may cause a flaring or exacerbation of some skin conditions. Little is known about the magnitude of and risk factors for skin diseases among human immunodeficiency virus (HIV)-infected antiretroviral therapy-naïve pregnant women. METHODS:Cross-section...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12455
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Lichen planus pigmentosus inversus (LPPI) is a rare variant of LP. Only 31 cases have been reported in the literature. METHODS:Here we report a series of 10 patients with LPPI from North Africa. RESULTS:Ten cases of LPPI, clinically suspected and histologically confirmed, were seen over 3 years (2013-2015)...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13295
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Pruritus is a common subjective symptom of psoriasis whose levels may be affected by a range of variables. The objective of this study was to evaluate the frequency of pruritus and its associations with clinical and psychological characteristics of psoriasis patients. MATERIALS AND METHODS:One-hundred and s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12074
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To characterize epidemiologic and clinical features of red primary amelanotic melanomas, an atypical presentation of melanoma that is underemphasized in patient and physician education. PATIENTS AND METHODS:Review of a prospectively collected melanoma database identified 46 patients with red amelanotic melan...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05066.x
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes. OBJECTIVES:The aims of this study were: (i) to present quantitative information on the linoleic acid fractio...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12831
更新日期:2016-03-01 00:00:00
abstract::Twenty-eight psoriatic patients received PUVA treatment (psoralen and long ultraviolet irradiations. Two preparations were used; 8-methoxypsoralen and a mixture of 5-methoxypsoralen and 8-methoxypsoralen. Both gave considerable improvement, but in 6 cases the lesions reappeared after 2 to 8 weeks, in spite of maintena...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1976.tb01829.x
更新日期:1976-11-01 00:00:00
abstract::Certain cutaneous conditions have been reported to be associated with diabetes mellitus, insulin resistance, and metabolic syndrome. In this novel review paper, the evidence linking various cutaneous phenomena (e.g. skin tags, acanthosis nigricans, ear lobe creases, and xanthelasma) and metabolic syndrome and cardiova...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.12463
更新日期:2014-09-01 00:00:00
abstract::Primary cutaneous follicle center lymphoma (PCFCL) is a neoplasm with differentiation of centrocytes and centroblasts presenting in the skin. At the time of initial manifestation, extracutaneous involvement is absent. PCFCL is considered as an indolent variant of primary cutaneous B-cell lymphomas since dissemination ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03953.x
更新日期:2008-11-01 00:00:00
abstract::In 107 cases of facial contact dermatitis, routine Finn chamber epicutaneous tests with TROLAB European Standard Allergens (ESAs) were performed. Sixty-one (57%) had positive reaction. The most frequent contact allergens were paraphenylenediamine dihydrochloride (16%), followed by fragrance mix (15%), and nickel sulfa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1991.tb04867.x
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor alpha (TNFα) gene -238G/A polymorphism (rs361525) is associated with psoriasis in several populations worldwide. To the best of our knowledge, there is no information about this polymorphism in Indian psoriatic patients. This study was undertaken to fill the gap in knowledge. METHODS:T...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13482
更新日期:2017-03-01 00:00:00
abstract::Scars are problematic for thousands of patients. Scarring is a natural part of the healing process after an injury. However, the appearance of a scar and its treatment depend on multiple factors and on the experience of the therapist and the options available. Despite a plethora of rapidly evolving treatment options a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13253
更新日期:2016-08-01 00:00:00
abstract::A 20-year-old woman with a 2-year history of histologically confirmed palmoplantar keratoderma due to psoriasis, resistant to several topical agents, was admitted to the Department of Dermatology, Uludag University, Bursa, Turkey. Therapy with oral acitretin (0.5 mg/kg/day, 35 mg/day) was initiated. A month after star...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.03059.x
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Mesenchymal neoplasms (sarcomas) of skin are rare. Patients with sarcomas were analyzed over the last decade. METHODS:Over a 10-year period, we conducted a retrospective analysis of patients diagnosed and treated in an urban academic teaching hospital in Saxony, Germany. Clinical and pathologic files were u...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05484.x
更新日期:2013-10-01 00:00:00
abstract::Three heroin addicts had Candida folliculitis of the scalp, beard, and pubis associated with fever, chills, headache, and fatigue. In each case, pseudohyphae were found within a hair and yeasts around it and Candida was recovered from urine. These facts support a systemic dissemination. Since serious ocular and osteoa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1986.tb04547.x
更新日期:1986-03-01 00:00:00
abstract::Two patients with premycotic poikiloderma developed one squamous cell carcinoma each. A review of the literature reveals 28 reported cases of this association, but in 26 of these the patient had been exposed to carcinogens. Our patients had no history of exposure to carcinogenic agents. In both our cases, the squamous...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1986.tb03424.x
更新日期:1986-07-01 00:00:00
abstract::In this article, we review the salient features of tinea versicolor and describe the epidemiology, clinical presentation, and histopathology of this mycosis in dark-skinned individuals. Tinea versicolor is caused by an overgrowth of the Malassezia genus. It manifests clinically as asymptomatic hypopigmented macules, h...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.12345
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women. Topical 5% cysteamine is an antioxidant and tyrosinase inhibitor that has been shown to be effective in the treatment of melasma. However, to date, no study has compared the performan...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15146
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Lipodermatosclerosis (LDS) is a chronic fibrosing panniculitis associated with venous insufficiency. Although LDS is often a clinical diagnosis, it can be confused with other panniculitides. Microscopic examination is therefore essential to support the diagnosis in this condition. Histopathologic changes, ho...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12856
更新日期:2016-03-01 00:00:00
abstract::A 70-year-old patient with a history of hypertension and hypercholesterolemia was referred for evaluation of necrotic toes. The patient had a history of several cerebrovascular accidents during the previous month. Initially, she developed sudden-onset left upper extremity weakness which, over the ensuing 4 days, progr...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2000.00935.x
更新日期:2000-04-01 00:00:00
abstract::Biopsy specimens of cutaneous discoid lesions of 71 patients with cutaneous lupus erythematosus (CLE) were studied. The material was examined by direct immunofluorescence (DIF) to establish positivity and morphologic patterns of immunoglobulins and complement deposits in the basement membrane zone (BMZ). A correlation...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03567.x
更新日期:1992-04-01 00:00:00
abstract::Behçet's Disease (BD) is a systemic disorder with an unknown etiopathogenesis. The need for clinical criteria in the establishment of diagnosis is of great importance. We present the case of a 27-year-old man with BD, who had a surgical operation during the active period of his disease and experienced subsequent compl...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb02722.x
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) is a non-surgical method for treating non-melanoma skin cancer and precancerous lesions which involves the activation of a photosensitizer by visible light to produce activated oxygen species within target cells, resulting in the destruction of the latter. The present study evaluat...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2010.04700.x
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:Antitumor necrosis factor (anti-TNF) agents are a well-established treatment for various medical conditions, including psoriasis and psoriatic arthritis. However, anti-TNF agents may themselves induce psoriasis in some patients. METHODS:The authors report two cases of patients with severe and refractory inf...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05601.x
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Dermatofibrosarcoma protuberans (DFSP) is a rare tumor that grows with tentacle-like projections. In particular, on the scalp this could explain the frequent incomplete resections and the high rate of multiple local recurrences. Adequate pre- and postoperative imaging methods to visualize these prolongations...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13050
更新日期:2016-02-01 00:00:00
abstract::A 40-year-old black man who was HIV positive developed generalized hypertrophic lichen planus in areas previously affected by a photosensitivity eruption. After unsuccessful attempts to induce remission of his lichen planus with conventional therapies, etretinate produced a dramatic response. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb02423.x
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Ducatalon is a bipyridylium herbicide containing a mixture of diquat and paraquat, and is used in agriculture. Adverse reactions due to contact of this compound with the skin have rarely been described. CASE REPORTS:Two men were seen for severe pain due to extensive chemical burns in the perineal and scrota...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb04371.x
更新日期:1995-01-01 00:00:00