Abstract:
:Biopsy specimens of cutaneous discoid lesions of 71 patients with cutaneous lupus erythematosus (CLE) were studied. The material was examined by direct immunofluorescence (DIF) to establish positivity and morphologic patterns of immunoglobulins and complement deposits in the basement membrane zone (BMZ). A correlation between DIF results and thickening of the epidermis basement membrane (BM) stained by periodic acid-Schiff (PAS), obtained from 31 matched biopsy specimens, also is presented. Direct immunofluorescence had positive results in 66.20% of the 71 examinations and 70.97% of the matched examinations, whereas PAS showed BM thickening in 100% of the specimens. This observation stresses the importance of such histopathologic findings in the diagnosis of discoid lesions in CLE. There was no correlation between DIF patterns and PAS-stained BMZ thickening. These findings merit additional study. In conclusion, an accordance between PAS-stained BM thickening and immunoglobulin deposits has occurred in 70.97% of cases. This phenomenon does not depend on the presence of immunocomplexes, for it occurs even in cases in which immunocomplex deposits were not detected.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Sugai SA,Gerbase AB,Cernea SS,Sotto MN,Oliveira ZN,Vilela MA,Rivitti EA,Miyauchi LM,Sampaio SAdoi
10.1111/j.1365-4362.1992.tb03567.xsubject
Has Abstractpub_date
1992-04-01 00:00:00pages
260-4issue
4eissn
0011-9059issn
1365-4632journal_volume
31pub_type
杂志文章abstract:BACKGROUND:The Psoriasis Area and Severity Index (PASI) is used to quantify the extent of the disease, and to evaluate its improvement with treatment. It is considered to be a slow, rough, nonsensitive, and complex tool, with high interobserver variability and low reproducibility. OBJECTIVES AND METHODS:To develop a s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2000.00017.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To report three cases of mycosis fungoides with milia formation in the regressing lesions. PATIENTS AND SETTING:Dermatology clinic of a university hospital (referral center). Three patients with mycosis fungoides with body surface involvement of 10% in one case (stage IIb) and exceeding 30% in two cases (sta...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.01944.x
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Skin disease is a common problem, accounting for significant morbidity in developing countries. Knowledge about the prevalence of different skin conditions allows appropriate planning for provision for these health needs. There are currently few data about the needs in rural areas; therefore, this study was ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1996.tb03688.x
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Warts are a common chronic skin disorder that can be cosmetically disfiguring and, depending on the location, cause inhibition of function. The presence of dozens of topical and systemic treatments for warts is a testament to the lack of a rapid, simple, uniformly effective, inexpensive, nonscarring, and pai...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1046/j.1365-4362.2001.01242.x
更新日期:2001-06-01 00:00:00
abstract::Live bee acupuncture (Bong-Chim) dermatitis is an iatrogenic disease induced by so-called live bee acupuncture therapy, which applies the honeybee (Apis cerana) stinger directly into the lesion to treat various diseases in Korea. We present two cases of live bee acupuncture dermatitis and review previously published a...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.12161
更新日期:2013-12-01 00:00:00
abstract::A 54-year-old woman presented with a 5-month history of tender nodules in both nasolabial folds that had developed 4 months after the injection of hyaluronic acid (HA) (Restylane) for wrinkles. The patient was treated with 1.5 mg/day betamethasone for 6 days and her lesions disappeared within 1 week. About 8 days afte...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2005.01930.x
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:The association between hepatitis C virus (HCV) infection and lichen planus (LP) is a subject of controversy. Prevalence studies of HCV infection in LP patients in various countries reveal diverse results. The Slovenian population is rather homogenous with specific geographic and epidemiological characterist...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03832.x
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Tinea versicolor (TV) is commonly described on the trunk without giving attention to involvement of the scalp. We examined cases with dandruff with and without TV on the body to see how frequent Malassezia furfur (M. furfur) is present in dandruff scales. METHODS:A total of 80 patients were examined mycolog...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb02946.x
更新日期:1995-08-01 00:00:00
abstract::A 59-year-old man presented with a 10-cm x 8-cm tumoral plaque with a superficial nodule in the interscapular region of the back (Fig. 1). The lesion had been growing for 25 years. As a cystic lesion was suspected, the superficial nodule was biopsied. The histopathologic diagnosis was low-grade sarcoma with sclerosis....
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02340.x
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12650
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) is a non-surgical method for treating non-melanoma skin cancer and precancerous lesions which involves the activation of a photosensitizer by visible light to produce activated oxygen species within target cells, resulting in the destruction of the latter. The present study evaluat...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2010.04700.x
更新日期:2011-03-01 00:00:00
abstract::The correlation between combined chemotherapy, including 6-mercaptopurine, and development of excessive number of melanocytic nevi in childhood has been previously reported and studied. As of yet, no such relation has been reported in adults. We recently observed a 27-year-old female patient who developed numerous ben...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2005.02086.x
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:Khite (also known as fatlah in Egypt) is a manual technique of temporary vellus hair removal that is widely performed in the Middle East. METHODS:The technique of khite is reviewed as illustrated. RESULTS:Khite is an effective method of removing unwanted vellus hairs. CONCLUSIONS:Dermatologists in all par...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1997.00189.x
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is a common inflammatory skin disease resulting from the interplay between environmental, immunological and genetic factors. In our study, we investigated the role of three single nucleotide polymorphisms (SNPs) at 5'-UTR of DEFB1 gene, encoding for the human beta defensin-1, on the su...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04343.x
更新日期:2010-06-01 00:00:00
abstract:UNLABELLED:Methotrexate (MTX) treatment for psoriasis is most often administered weekly, because the drug has been considered more hepatotoxic when taken daily. However, some patients may tolerate smaller, more frequent doses better. OBJECTIVE:To study the efficacy and toxicity of daily vs. weekly MTX. PATIENTS AND M...
journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-4632.2011.04967.x
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Prompt management of acute graft-versus-host disease (GVHD) may prevent its morbidity and mortality. Maculopapular (MP) eruption is a presenting sign of acute GVHD, but differentiation from other causes of MP rash is challenging. METHODS:A retrospective study was conducted among patients developing MP erupt...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15186
更新日期:2021-01-01 00:00:00
abstract::Ten healthy volunteers were studied to find out whether tachyphylaxis occurs on repeated application of topical steroids. The Singh and Singh modification of the Reddy and Singh (1976) technique was used. Fluocinolone acetonide cream (0.1%) under occlusion was applied daily for 14 days on the flexor aspect of the fore...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1986.tb02258.x
更新日期:1986-06-01 00:00:00
abstract::Challenge: Clinical and research responsibilities often leave little or no time to plan thoughtful teaching encounters with trainees. This "Teaching & Learning Tips" series is designed to be an accessible guide for dermatologists who want to improve their teaching skills. It is comprised of 12 articles about how to en...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.13751
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:Although atopic dermatitis is a chronic skin disease that can have a major impact on a patient's life, the burden of illness associated with this condition has not been well characterized. OBJECTIVE:To determine the health-related quality of life (HRQL) of patients with atopic dermatitis by disease severity...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2002.01436.x
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:The treatment of melanoma in situ (MIS), particularly the lentigo maligna (LM) subtype, has been a controversial subject in the literature for over a decade. Surgical excision with 5 mm margins is the standard of care in the USA, while several variations of Mohs surgery are frequently used to treat clinicall...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2010.04423.x
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Postadolescent acne is defined as acne that is seen even after the age of 25 years, regardless of the age at onset. The causes of postadolescent acne have not been completely clarified up to now. Androgens are considered to be the major factor involved in pathogenesis. OBJECTIVE:We aimed to investigate the ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12547
更新日期:2015-12-01 00:00:00
abstract::A 58-year-old woman with ulcerative colitis of 5 years' duration was first seen in March 2002 with a 5-month history of widespread erosions on the palate and gingiva, subtle scarring of the conjunctiva, and xerostomia accompanying a flare of ulcerative colitis. No skin lesions were observed. Direct immunofluorescence ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02961.x
更新日期:2007-03-01 00:00:00
abstract::Health authorities in the USA, Canada and Australia recommend a "no nit" policy, i.e. the immediate dismissal of all children who have head lice, eggs and/or nits on their hair from school, camp or child-care settings. These children would be readmitted to the institution only when all head lice, eggs and nits have be...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2006.02827.x
更新日期:2006-08-01 00:00:00
abstract::The porphyrias are diverse in pathophysiology, clinical presentation, severity, and prognosis, presenting a diagnostic and therapeutic challenge. Although not easily curable, the dermatological manifestations of these diseases, photosensitivity and associated cutaneous pathology, can be effectively prevented and manag...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.12016
更新日期:2014-01-01 00:00:00
abstract::Skin lesions are frequent in human T-cell lymphotropic virus type 1 (HTLV-1) infection and may constitute an alert for the diagnosis of this condition. The most severe skin diseases related to this virus are adult T-cell leukemia/lymphoma (ATLL), an aggressive form of leukemia/lymphoma that fails to respond to chemoth...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2010.04568.x
更新日期:2010-10-01 00:00:00
abstract::A 20-year-old woman with a 2-year history of histologically confirmed palmoplantar keratoderma due to psoriasis, resistant to several topical agents, was admitted to the Department of Dermatology, Uludag University, Bursa, Turkey. Therapy with oral acitretin (0.5 mg/kg/day, 35 mg/day) was initiated. A month after star...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.03059.x
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Linear focal elastosis is an uncommon disorder that clinically shows band-like stria and a histological focal increase in elastic fibers. The disorder preferentially affects men after the age of 60 years and occurs on the lower back. The pathogenesis of linear focal elastosis is still somewhat of an enigma. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01733.x
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Vitiligo is a common idiopathic skin disorder. The etiology is unknown, although various hypotheses have been advanced. These include the neuronal hypothesis, where neuronal factors are thought to play a role in the pathogenesis of this disease. METHODS:Skin biopsies were taken from marginal and central par...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb04417.x
更新日期:1995-12-01 00:00:00
abstract::Netherton syndrome is a rare disorder inherited in an autosomal recessive pattern consisting of ichthyosiform dermatosis, hair shaft abnormalities (trichorrhexis invaginata), and an atopic diathesis. Patients with Netherton syndrome have been found to have a mutation on chromosome 5q32 in a gene named SPINK5 (serine p...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2005.02637.x
更新日期:2006-06-01 00:00:00
abstract::The authors describe ten cases of cutis marmorata telangiectatica congenita (CMTC). All of these cases were sporadic. The incidence of associated anomalies was relatively low, and three patients had skin manifestations (cutaneous atrophy and nevus telangiectaticus). In two patients, the right leg was shorter and thinn...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03564.x
更新日期:1992-04-01 00:00:00