Bazex-Dupré-Christol syndrome: review of clinical and molecular aspects.

Abstract:

:Bazex-Dupré-Christol syndrome is a rare genodermatosis that manifests with the classical triad of basal cell carcinoma, follicular atrophoderma, and hypotrichosis; yet it may be accompanied by milia, ichthyosis, neurological symptoms, and visceral malignancies. Symptom onset is nonsimultaneous, and hence the diagnosis is often made late and the opportunity of counseling and following up is missed. This article aims toward providing a comprehensive review of the clinical perspective of Bazex-Dupré-Christol syndrome, highlighting the major clinical variants to facilitate reaching a prompt diagnosis. In addition, the molecular aspects are discussed. Though the gene responsible for this syndrome is yet nonspecified, it is confirmed to be localized to the long arm of chromosome X.

journal_name

Int J Dermatol

authors

AlSabbagh MM,Baqi MA

doi

10.1111/ijd.14065

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

1102-1106

issue

9

eissn

0011-9059

issn

1365-4632

journal_volume

57

pub_type

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