Dihydroxyacetone: a safe camouflaging option in vitiligo.

Abstract:

BACKGROUND:Most treatment protocols for vitiligo usually do not result in complete repigmentation. Therefore, cosmetically acceptable camouflage, low cost and easy to handle alternatives are warranted. OBJECTIVE:To evaluate the efficacy of low-cost self-tanner available in the Thai market in normal subjects with skin types III, IV, and V, and the efficacy for camouflage of 6% dihydroxyacetone (DHA) cream in the treatment of vitiligo on exposed areas of Asian skin. METHODS:The study was divided into two parts. Part 1 is a prospective study of 15 healthy volunteers using three different DHA creams which were available in the Thai market with concentrations of 3.5%, 4.2%, and 5%. Part 2 was a retrospective study of 20 patients suffering from vitiligo affecting the face and/or hands and feet who were treated with 6% DHA. The data were collected through direct examination, telephone interview, face-to-face interview, and photographs. RESULTS:In healthy volunteers, we found that color matching was achieved by using a higher concentration of DHA in darker-skin subjects. Most of the vitiligo patients (88.9%) reported moderate to marked satisfaction with the cosmetic results of 6% DHA cream. CONCLUSION:Dihydroxyacetone offers a safe and effective therapeutic option for recalcitrant vitiligo. Dark-skin subjects need a higher concentration of DHA cream than lighter-skin subjects.

journal_name

Int J Dermatol

authors

Rajatanavin N,Suwanachote S,Kulkollakarn S

doi

10.1111/j.1365-4632.2008.03356.x

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

402-6

issue

4

eissn

0011-9059

issn

1365-4632

pii

IJD3356

journal_volume

47

pub_type

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