Abstract:
BACKGROUND:The patient with xeroderma pigmentosum provides an appropriate human model for the evaluation of tumor development and progression. METHODS:We describe a patient with variant-type xeroderma pigmentosum who developed actinic keratoses, a squamous cell carcinoma, and its metastasis into a lymph node. DNA ploidy was measured and analyzed in cells of these tumors and the patient's sun-exposed as well as sun-shielded skin. RESULTS:The sun-shielded skin showed a normal diploid DNA distribution pattern, while the sun-exposed skin had an increased number of hyperdiploid cells. The actinic keratosis showed further increased hyperdiploid cells. The squamous cell carcinoma showed a large number of hyperdiploid cells and formed an aneuploid cell fraction. Histographically, the aneuploid cell fraction became more apparent and was revealed to be a major fraction in the metastatic squamous cell carcinoma. CONCLUSIONS:The changes in the DNA ploidy pattern well reflect the clinical and histologic characteristics of the respective skin conditions and likely provide the cellular basis for the sequential or stepwise carcinogenic process in the patient's xeroderma pigmentosum skin. Further studies are necessary to determine whether the present results explain the similar carcinogenic process in sun-damaged skin of the nonpredisposed general population.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Chi H,Kawachi Y,Otsuka Fdoi
10.1111/j.1365-4362.1994.tb00990.xsubject
Has Abstractpub_date
1994-11-01 00:00:00pages
775-8issue
11eissn
0011-9059issn
1365-4632journal_volume
33pub_type
杂志文章abstract::Neuropathic ulcers or diabetic foot ulcers are preventable ulcers associated with diabetes mellitus. These ulcers occur in the setting of unrecognized trauma, peripheral neuropathy, and foot deformities; however, they are often complicated by peripheral arterial disease and infection. Approximately 15% of individuals ...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.15362
更新日期:2020-12-17 00:00:00
abstract::Trimethylpsoralen, psoralen and 8-methoxypsoralen were adminstered in 10 mg dosage orally to 37, 29 and 23 patients with vitiligo. Complete improvement was noted in 8.9% and partial improvement was recorded in 59.5%. The overall results produced by trimethylpsoralen and psoralen were superior to those of 8-methoxyps...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/ijd.1975.14.3.205
更新日期:1975-04-01 00:00:00
abstract::A 58-year-old woman with ulcerative colitis of 5 years' duration was first seen in March 2002 with a 5-month history of widespread erosions on the palate and gingiva, subtle scarring of the conjunctiva, and xerostomia accompanying a flare of ulcerative colitis. No skin lesions were observed. Direct immunofluorescence ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02961.x
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Community-associated methicillin-resistant Staphylococci aureus (CA-MRSA) pediatric skin infections have been reported worldwide. However, little is known about pathogens' implications in Egyptian children, and beta-lactams are still the empiric antimicrobials prescribed. This warrants Egyptian studies on an...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05515.x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Phenytoin (5,5 diphenylhydantoin), a widely-used anticonvulsant, has been employed both topically and systemically in the treatment of some dermatological disorders. Immunological and non-immunological defects suggests that phenytoin could be therapeutically effective for vitiligo repigmentation. AIM OF STU...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05551.x
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Primary Antiphospholipid Antibody Syndrome (PAAS) is characterized by detection of antiphospholipid antibodies associated with venous or arterial thrombosis and/or miscarriages by patients with no other associated disease such as systemic lupus erythematosus (SLE). Primary Antiphospholipid Antibody Syndrome ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.01939.x
更新日期:2004-09-01 00:00:00
abstract::Idiopathic palmar and plantar hyperhidrosis is a relatively common disorder of eccrine sweat gland function. Treatment with glutaraldehyde of formaldehyde, although successful, may cause undesirable side effects. Methenamine is a polycyclic organic compound which release ammonia and formaldehyde at acid pH. Five per c...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1976.tb00240.x
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Onychomycosis, a fungal infection of the nail, is caused by dermatophytes, yeasts, and nondermatophyte molds. The causative pathogen and incidence of onychomycosis depend on age, gender, geographic and climatic conditions, living habits, and immune status of the host. AIM:To determine the incidence and etio...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04126.x
更新日期:2009-09-01 00:00:00
abstract::The epidemiology of scabies for the last twelve years has been studied in Turkey. Information was obtained from three regions (Istanbul, Ankara and Erzurum) having different climates. There has been an increase in scabies in the years following 1969 in Ankara and Erzurum and from 1967 on in Istanbul. It reached its ma...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1980.tb01993.x
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Melanocytic nevi are well-known, important precursors of melanoma among children and adults. The adolescence period is an important period for nevi formation and evolution. This study provides data of a longitudinal study of nevi in a Hispanic adolescent population. MATERIALS AND METHODS:A cross-sectional s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.5784.x
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Lipodermatosclerosis (LDS) is a chronic fibrosing panniculitis associated with venous insufficiency. Although LDS is often a clinical diagnosis, it can be confused with other panniculitides. Microscopic examination is therefore essential to support the diagnosis in this condition. Histopathologic changes, ho...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12856
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Reed's nevi are distinguished from Sptiz tumors by their significant melanogenesis and growth pattern. They may be confused with melanoma on clinical and histologic grounds. CASE REPORT:An unusual case in which multiple agminated Reed's nevi mimicked acral lentiginous malignant melanoma in an African-Americ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1993.tb04268.x
更新日期:1993-04-01 00:00:00
abstract::Nevus lipomatosus cutaneus superficialis (Hoffman-Zurhelle) is a distinct clinical entity. A case is reported in which the lesions were large, appeared early in childhood and were linear in distribution along the natal cleft. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1975.tb00110.x
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:Skin disease is a common problem, accounting for significant morbidity in developing countries. Knowledge about the prevalence of different skin conditions allows appropriate planning for provision for these health needs. There are currently few data about the needs in rural areas; therefore, this study was ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1996.tb03688.x
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:The use of lasers is very common in dermatology; however, many patients fear it and have various misconceptions about it. A literature search failed to show any studies on this topic. OBJECTIVE:To explore the various misconceptions of patients about lasers in dermatology. METHODS:A self-administered questi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05028.x
更新日期:2011-11-01 00:00:00
abstract::Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy. The disease typically affects older individuals aged 60-80 years and is seen most frequently in postmenopausal Caucasian women and Asian men. EMPD exhibits a predilection for the genital and perianal regions and may be associated with an underlying ca...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.14328
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Though little known by medical personnel, an immediate nonallergic psychotic reaction to intramuscular procaine penicillin has been reported occasionally from many countries since 1951. MATERIALS AND METHODS:A case report describes a patient whose violent behavior, provoked by this reaction, resulted in leg...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb01089.x
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Several case reports and case series have recently explored the association between hidradenitis suppurativa (HS) and inflammatory bowel disease (IBD). OBJECTIVE:We performed a systematic review and meta-analysis of case-control studies to determine (i) the pooled prevalence of IBD in HS cohorts, and (ii) ...
journal_title:International journal of dermatology
pub_type: 杂志文章,meta分析
doi:10.1111/ijd.14697
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Despite their benign nature, keloids are usually associated with considerable cosmetic effects and may lead to functional problems. Recently, it has been reported that vascular endothelial growth factor (VEGF), a potent angiogenic factor, is overexpressed in keloid tissue and may have a potential role in its...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04143.x
更新日期:2009-10-01 00:00:00
abstract::Scleromyxedema is a rare disease characterized by papular mucinous deposits, dermal fibroblast proliferation, and a monoclonal paraproteinemia. Its chronic course tends to be complicated by gastrointestinal, muscular, pulmonary, and neurologic disorders. We review the literature to identify the common systemic manifes...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-4362.2003.01565.x
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Pseudopelade is a rare idiopathic progressive alopecia that has no initial inflammatory phase. Even so, pseudopelade has been classified as scarring alopecia with postinflammatory alopecias. Atrophy rather than true scarring is the cardinal feature of pseudopelade. MATERIALS AND METHODS:A review of reported...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1996.tb00644.x
更新日期:1996-10-01 00:00:00
abstract::A clinical trial using tretinoin lotion 0.05%, benzoyl peroxide 5% and 10% as topical application was performed on 250 ambulatory patients suffering from various degrees of acne vulgaris. The results indicate that tretinoin applied in the morning and benzoyl peroxide applied at night is the most efficacious regimen to...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1979.tb01956.x
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:With the increasing incidence of human immunodeficiency virus (HIV) infection and immunosuppressive therapy, the incidence of syphilis has been increasing. Given the fact that the above conditions may mask or obscure the usual clinical signs and symptoms of syphilis, a means of enhanced detection is essentia...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2000.00029.x
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND:Antitumor necrosis factor (anti-TNF) agents are a well-established treatment for various medical conditions, including psoriasis and psoriatic arthritis. However, anti-TNF agents may themselves induce psoriasis in some patients. METHODS:The authors report two cases of patients with severe and refractory inf...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05601.x
更新日期:2013-02-01 00:00:00
abstract::Health authorities in the USA, Canada and Australia recommend a "no nit" policy, i.e. the immediate dismissal of all children who have head lice, eggs and/or nits on their hair from school, camp or child-care settings. These children would be readmitted to the institution only when all head lice, eggs and nits have be...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2006.02827.x
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:The relationship between infantile seborrheic dermatitis (ISD) and infantile atopic dermatitis (IAD) is controversial. METHODS:Ninety-six children aged 2-12 months diagnosed with atopic dermatitis and a comparable control group of healthy children were evaluated. Demographic data, personal history of ISD an...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2002.01497.x
更新日期:2002-06-01 00:00:00
abstract::A 64-year-old woman presented with erythematous, infiltrative plaques with a central atrophic area on both zygomatic regions. Several yellow-reddish papules were seen at the periphery of the plaques and showed an "apple-jelly" color on diascopy (Fig. 1). No visceral involvement was detected. The past medical history r...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03240.x
更新日期:2008-06-01 00:00:00
abstract::An 11-year-old girl who at 9 1/2 months was diagnosed as having keratoderma of the palms and soles, present since birth, developed typical granuloma annulare at the age of 11 years. To the authors' knowledge, this is the first report of epidermolytic palmo-plantar keratoderma associated with granuloma annulare. There ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1984.tb01225.x
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Postadolescent acne is defined as acne that is seen even after the age of 25 years, regardless of the age at onset. The causes of postadolescent acne have not been completely clarified up to now. Androgens are considered to be the major factor involved in pathogenesis. OBJECTIVE:We aimed to investigate the ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12547
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Anetoderma has been reported in patients with HIV-1 disease. In patients with autoimmune disease, anetoderma has been associated with increased levels of antiphospholipid antibodies (APL) that include anticardiolipin antibodies (ACA) and lupus anticoagulant (LA). This has led to speculation tha...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1995.tb04442.x
更新日期:1995-06-01 00:00:00