Abstract:
BACKGROUND:Despite their benign nature, keloids are usually associated with considerable cosmetic effects and may lead to functional problems. Recently, it has been reported that vascular endothelial growth factor (VEGF), a potent angiogenic factor, is overexpressed in keloid tissue and may have a potential role in its evolution. METHODS:Twenty patients with keloids were included in this study and classified into two groups according to the treatment received: intralesional triamcinolone acetonide 20 mg/mL (group 1) and cryotherapy spray technique (group 2). Treatment was continued until clearance or for a maximum of six sessions, and the follow-up period was 1 year. Skin biopsies were taken from patients before and after treatment to evaluate keloid pathology and from patients and 10 healthy controls to detect the immunohistochemical expression of VEGF. RESULTS:Histopathologic examination revealed a remarkable resolution of the nodular arrangement of collagen after therapy, particularly in group 1. A statistically significant difference in VEGF expression was found between patients before therapy and controls, and between patients before and after therapy in each group. There was no significant difference in the treatment outcome between intralesional steroids and cryotherapy. No significant correlation was observed between the clinical variables of keloids and both VEGF expression and clinical response to therapy. CONCLUSION:VEGF seems to play an important role in the pathogenesis of keloids and may be a useful guide in the evaluation of keloid therapeutics. Modulation of its production may provide a valuable treatment for keloids.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Salem A,Assaf M,Helmy A,Nofal A,Ibrahim S,Eldeeb F,Youssef Cdoi
10.1111/j.1365-4632.2009.04143.xsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
1071-7issue
10eissn
0011-9059issn
1365-4632pii
IJD4143journal_volume
48pub_type
杂志文章abstract:BACKGROUND:Needle biopsy is a rapid, reliable, and reproducible procedure for histological confirmation of metastatic melanoma localization. Nonetheless, this procedure presents a theoretical risk of a mechanical weakening of the lymph node capsule with perinodal tumor seeding. The objective of the study was to evaluat...
journal_title:International journal of dermatology
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abstract::Ten patients with chronic purpuric and pigmented angiodermatitis in the extremities and two patients with acute and disseminated eczematoid-like purpura angiodermatitis were studied with current hemostasis parameters: (1) platelet aggregation, (2) platelet circulating aggregates, (3) clotting factor measurements and h...
journal_title:International journal of dermatology
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doi:10.1111/j.1365-4362.1992.tb04244.x
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abstract::We report the case of drug-induced, acrolocalized Kaposi sarcoma (KS), arising multicentrically in both palms and soles of a male patient who has had widespread psoriasis since 12 years of age. This 59-year-old man, of Mediterranean origin, was HIV antibody-negative and had received oral prednisolone treatment over 5 ...
journal_title:International journal of dermatology
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abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. It can also cause community-acquired infections. Indian reports about MRSA in community-acquired infections are rare. AIM:To evaluate the rate of MRSA in community-acquired pyoderma and the nasal colonisation with S. aur...
journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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abstract:BACKGROUND:Atrophic acne scars are a frequent problem after acne. Hitherto, mainly invasive treatment measures were possible. In a recent paper, we demonstrated the positive effects of iontophoresis with 0.025% tretinoin gel vs. estriol 0.03%. OBJECTIVE:In this further study, the recording of the clinical effects of i...
journal_title:International journal of dermatology
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doi:10.1046/j.1365-4362.1999.00586.x
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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abstract:BACKGROUND:Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes. OBJECTIVES:The aims of this study were: (i) to present quantitative information on the linoleic acid fractio...
journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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abstract:BACKGROUND:The Israel Defense Forces (IDF) medical records offer a unique and valid 28-year view of the striking differences in cutaneous leishmaniasis (CL) seasonality patterns and incidence rates between the military and civilian sectors in Israel. AIM:To determine the annual epidemiology and seasonality trends of C...
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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