Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.

Abstract:

:Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine improved itching (P < 0.0058) and clinical scores (P < 0.032) significantly more than topical steroids. Disease activity did not correlate with CD4+ and CD8+ T cell counts and was independent of anti-retroviral medication. Therefore, oral antihistamines are an effective first-line treatment for PPE.

journal_name

Int J Dermatol

authors

Navarini AA,Stoeckle M,Navarini S,Mossdorf E,Jullu BS,Mchomvu R,Mbata M,Kibatala P,Tanner M,Hatz C,Schmid-Grendelmeier P

doi

10.1111/j.1365-4632.2009.04279.x

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

83-6

issue

1

eissn

0011-9059

issn

1365-4632

pii

IJD4279

journal_volume

49

pub_type

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