Effect of topical paromomycin on cell-mediated immunity during cutaneous leishmaniasis.

Abstract:

BACKGROUND:The aim of this study was to evaluate the effect of topical paromomycin treatment on the development of immunity during cutaneous leishmaniasis. METHODS:Three parameters of immunity were measured in the course of the disease: leishmanicidal effector activity, lymphocyte proliferation (cell-mediated immunity), and antibody levels (humoral immunity). Peripheral blood specimens of 55 treated and 36 untreated patients were tested. RESULTS:The main results of this study showed that there was a significant delay in the development of leishmanicidal effector activity and to a lesser extent also a delay in the development of antigen-specific proliferative response in the treated compared with the untreated group. No difference was observed between the groups regarding the values achieved in the various tests. CONCLUSIONS:These results suggest that topical paromomycin treatment delays the development of cell-mediated immunity but does not affect the levels of immunity that are eventually achieved.

journal_name

Int J Dermatol

authors

Frankenburg S,Gross A,Jonas F,Klaus S

doi

10.1111/j.1365-4362.1993.tb00975.x

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

68-70

issue

1

eissn

0011-9059

issn

1365-4632

journal_volume

32

pub_type

临床试验,杂志文章,随机对照试验
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