Effect of topical paromomycin on cell-mediated immunity during cutaneous leishmaniasis.


BACKGROUND:The aim of this study was to evaluate the effect of topical paromomycin treatment on the development of immunity during cutaneous leishmaniasis. METHODS:Three parameters of immunity were measured in the course of the disease: leishmanicidal effector activity, lymphocyte proliferation (cell-mediated immunity), and antibody levels (humoral immunity). Peripheral blood specimens of 55 treated and 36 untreated patients were tested. RESULTS:The main results of this study showed that there was a significant delay in the development of leishmanicidal effector activity and to a lesser extent also a delay in the development of antigen-specific proliferative response in the treated compared with the untreated group. No difference was observed between the groups regarding the values achieved in the various tests. CONCLUSIONS:These results suggest that topical paromomycin treatment delays the development of cell-mediated immunity but does not affect the levels of immunity that are eventually achieved.


Int J Dermatol


Frankenburg S,Gross A,Jonas F,Klaus S




Has Abstract


1993-01-01 00:00:00












  • Tinea capitis in Saudi Arabia.

    abstract:BACKGROUND:Tinea capitis is a dermatophyte infection of the scalp, eyebrows, and eyelashes caused by species of Microsporum and Trichophyton. The purpose of this study was to discover the incidence and causal agents of tinea capitis in Saudi Arabia. METHODS:Hair roots, skin scrapings, and pus swabs were collected from...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Venugopal PV,Venugopal TV

    更新日期:1993-01-01 00:00:00

  • Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients.

    abstract:BACKGROUND:Vitiligo is a hypopigmentation disease characterized by achromatic or hypochromatic macules in several sites of human skin. Although monochromatic excimer light (MEL) and narrowband-ultraviolet B (NB-UVB) have recently been used for efficacious treatment of vitiligo, the repigmentation process and role of me...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Hirobe T,Enami H

    更新日期:2019-02-01 00:00:00

  • Current therapies for actinic keratosis.

    abstract::Actinic keratosis (AK) is a very common skin disease caused by chronic sun damage, which in 75% of cases arises on chronically sun-exposed areas, such as face, scalp, neck, hands, and forearms. AKs must be considered an early squamous cell carcinoma (SCC) for their probable progression into invasive SCC. For this reas...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Dianzani C,Conforti C,Giuffrida R,Corneli P,di Meo N,Farinazzo E,Moret A,Magaton Rizzi G,Zalaudek I

    更新日期:2020-06-01 00:00:00

  • Pneumocystis jiroveci pneumonia in patients treated with systemic immunosuppressive agents for dermatologic conditions: a systematic review with recommendations for prophylaxis.

    abstract::Pneumocystis jiroveci pneumonia is an opportunistic infection associated with substantial rates of mortality in immunosuppressed patients. Prophylaxis recommendations are mostly targeted toward patients with non-dermatologic diagnoses. This study was conducted to determine when dermatology patients treated with immuno...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Gonzalez Santiago TM,Wetter DA,Kalaaji AN,Limper AH,Lehman JS

    更新日期:2016-08-01 00:00:00

  • Behçet's disease and surgical intervention.

    abstract::Behçet's Disease (BD) is a systemic disorder with an unknown etiopathogenesis. The need for clinical criteria in the establishment of diagnosis is of great importance. We present the case of a 27-year-old man with BD, who had a surgical operation during the active period of his disease and experienced subsequent compl...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Bozkurt M,Torin G,Aksakal B,Ataoglu O

    更新日期:1992-08-01 00:00:00

  • Treatment of psoriasis with topical nitrogen mustard.

    abstract::With the advent of various new methods of treating psoriasis, it is necessary to remind physicians to consider an agent that is easy to administer, locally effective, relatively inexpensive, not time-consuming and without systemic toxic effects. Nineteen patients were treated with topical nitrogen mustard between 1972...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Handler RM,Medansky RS

    更新日期:1979-11-01 00:00:00

  • Immunohistochemical expression of Bcl-2 and Ki-67 in oral lichen planus and leukoplakia with different degrees of dysplasia.

    abstract:OBJECTIVES:Oral lichen planus (OLP) is a chronic inflammatory disease of unknown cause. Malignant transformation in OLP lesions may be favored by changes in the expression of proteins that regulate cell proliferation and apoptosis. This study aimed to investigate these issues by immunohistochemical staining for Bcl-2 a...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Pigatti FM,Taveira LA,Soares CT

    更新日期:2015-02-01 00:00:00

  • Lingual traumatic ulceration (Riga-Fede disease).

    abstract::An 11-month-old male infant was referred to our clinic because of a painful ulcer of approximately 5 months' duration on the ventral surface of the tongue (Fig. 1). On physical examination, the lesion was circular (3 cm x 2 cm) with erythematous, raised, and indurated borders. No pathologic findings emerged from the l...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Baroni A,Capristo C,Rossiello L,Faccenda F,Satriano RA

    更新日期:2006-09-01 00:00:00

  • Autologous epidermal grafting with PUVA-irradiated donor skin for the treatment of vitiligo.

    abstract:BACKGROUND:Epidermal autografting has been used to treat vitiligo. The pigmentation achieved at the recipient site can be variegated and incomplete compared with that of the surrounding normal skin, and sometimes remains that way for a fairly long time. OBJECTIVE:We investigated whether the clinical results from epide...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Lee AY,Jang JH

    更新日期:1998-07-01 00:00:00

  • Skin diseases in displaced populations: a review of contributing factors, challenges, and approaches to care.

    abstract::There are 70.8 million persons displaced worldwide due to war, persecution, and violence. Eighty percent of displaced persons reside in low- and middle-income countries with limited healthcare resources. Cutaneous diseases are commonly reported among displaced persons owing to numerous interrelated factors such as ina...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Knapp AP,Rehmus W,Chang AY

    更新日期:2020-07-19 00:00:00

  • Scanning electron microscopic examination of the egg of the pubic louse (Anoplura: Pthirus pubis).

    abstract:OBJECTIVE:The purpose of the study was to examine the eggs of pubic lice with consideration of their clinical relevance. STUDY DESIGN:Pubic lice eggs were examined by scanning electron microscopy (SEM). RESULTS:The egg is totally encased by a proteinaceous sheath, except for the operculum, by which oxygen exchange oc...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Burkhart CN,Gunning W,Burkhart CG

    更新日期:2000-03-01 00:00:00

  • Antihistamines are superior to topical steroids in managing human immunodeficiency virus (HIV)-associated papular pruritic eruption.

    abstract::Papular pruritic eruption (PPE) is a frequent HIV-comorbidity in tropical countries. Because of constant itching and social stigma, effective treatment is highly valued. In our HIV cohort in rural Tanzania with 12% prevalence of PPE, we have retrospectively analyzed responses to available treatments. Oral promethazine...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Navarini AA,Stoeckle M,Navarini S,Mossdorf E,Jullu BS,Mchomvu R,Mbata M,Kibatala P,Tanner M,Hatz C,Schmid-Grendelmeier P

    更新日期:2010-01-01 00:00:00

  • Prevalence of different skin conditions in an outpatients' setting in north-western Nigeria.

    abstract:BACKGROUND:Information on skin diseases in north-western Nigeria is scanty. We therefore conducted a prospective survey of 2611 new patients seen between August 1999 and July 2001 at the consultant medical/dermatology clinics of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. METHODS:The personal bio-d...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Onayemi O,Isezuo SA,Njoku CH

    更新日期:2005-01-01 00:00:00

  • Myiasis owing to Dermatobia hominis in a HIV-infected subject: Treatment by topical ivermectin.

    abstract::We report the occurrence of myiasis owing to Dermatobia hominis (Dh) in a HIV-infected subject. HIV infection did not modify the pathogenicity of myiasis. However, the clinical presentation seemed unusual with voluminous inflammatory nodules. Use of topical ivermectin killed the larvae and facilitated their extraction...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Clyti E,Nacher M,Merrien L,El Guedj M,Roussel M,Sainte-Marie D,Couppié P

    更新日期:2007-01-01 00:00:00

  • Trends in the epidemiology of cutaneous leishmaniasis in a young adult population in Israel: a long-term survey.

    abstract:BACKGROUND:The Israel Defense Forces (IDF) medical records offer a unique and valid 28-year view of the striking differences in cutaneous leishmaniasis (CL) seasonality patterns and incidence rates between the military and civilian sectors in Israel. AIM:To determine the annual epidemiology and seasonality trends of C...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Mimouni D,Balicer RD,Levine H,Klement E,Bar-Zeev Y,Davidovitch N,Zarka S

    更新日期:2009-06-01 00:00:00

  • Artificial reproduction of atypical hydRoa vacciniforme caused by latent EpStein-Barr virus infection.

    abstract:BACKGROUND:Cases of hydroa vacciniforme-like eruptions caused by latent Epstein-Barr virus (EBV) infection have been reported in Asia and Mexico, some of which progressed to lymphoproliferative disorders. The precise clinical features of the disease are not, however, clear. METHODS:We performed an artificial provocati...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Heo EP,Park SH,Kim TH

    更新日期:2003-06-01 00:00:00

  • Use of vegetable oils in dermatology: an overview.

    abstract::Vegetable oils have been used for a wide variety of purposes since time immemorial; however, their principle use remains as skin moisturizers, especially in neonates and children. Because of their considerable efficacy and a low side effect profile and bearable cost, these oils are hugely popular as moisturizers among...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Sarkar R,Podder I,Gokhale N,Jagadeesan S,Garg VK

    更新日期:2017-11-01 00:00:00

  • Sweaty skin, background and assessments.

    abstract::Overproduction of sweat, sweaty skin, and body malodors are felt unpleasant by many people in diverse social groups. This review summarizes the functional aspects of the eccrine, apocrine, and apoeccrine sweat glands as encountered in health and disease. A series of measuring methods are conveniently used to explore a...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Noël F,Piérard-Franchimont C,Piérard GE,Quatresooz P

    更新日期:2012-06-01 00:00:00

  • Prevalence of skin diseases in Iraq: a community based study.

    abstract::We sought to determine the prevalence of skin diseases in Iraq. Most such studies performed in Iraq have been hospital based. One community based study was performed in the southern area of Iraq but involved only an urban population. Our study was carried out in two Iraqi governorates, Tikrit and Kirkuk, and involved ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Al Samarai AG

    更新日期:2009-07-01 00:00:00

  • Chronic benign familial pemphigus.

    abstract::Ten patients with benign familial chronic pemphigus (BFCP) (Hailey-Hailey disease) were evaluated; semiologic and localization differences were described, and special attention was given to solitary or atypical forms. In all the cases, the diagnosis was confirmed by histopathology; some histopathologic differences and...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Galimberti RL,Kowalczuk AM,Bianchi O,Bonino MV,Garcia Garcia A

    更新日期:1988-09-01 00:00:00

  • Primary Merkel cell tumor: a clinical analysis of eight cases.

    abstract:BACKGROUND:In recent years, an unusual biologic behavior of Merkel cell tumor (MCT) has been noted. In some patients, the tumor was indolent and well controlled by therapy, while in others it was lethal in a few months. Even though the majority of the reported cases are between these two biologic extremes, it seems evi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Micali G,Ferraú F,Innocenzi D

    更新日期:1993-05-01 00:00:00

  • Clinical study of twenty-nail dystrophy in Korea.

    abstract:BACKGROUND:Twenty-nail dystrophy (TND) is an idiopathic and non-congenital nail dystrophy that is characterized by excess longitudinal ridges and loss of luster in multiple nail plates. There are a few studies on TND. MATERIALS AND METHODS:In order to investigate the demographic and clinical characteristics of patient...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Lee YB,Cheon MS,Park HJ,Cho BK

    更新日期:2012-06-01 00:00:00

  • Diffuse dermal angiomatosis of the breast: clinical and histopathological features.

    abstract:INTRODUCTION:Diffuse dermal angiomatosis is an entity in the spectrum of reactive angiomatoses characterized by erythematous plaques that mainly affect the lower extremities of patients with a personal history of peripheral vascular disease. Involvement of the breast is a rare event that has only been described as sing...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sanz-Motilva V,Martorell-Calatayud A,Rongioletti F,Escutia-Muñoz B,López-Gómez S,Rodríguez-Peralto JL,Vanaclocha F

    更新日期:2014-04-01 00:00:00

  • A sociodemographic, clinical study of patients with venous ulcer.

    abstract:BACKGROUND:Venous ulcer is the most serious consequence of chronic venous insufficiency and is responsible for almost 70% of chronic leg ulcers. The main purpose of this research was to describe social, demographic and clinical characteristics of patients with venous ulcers and to identify some professional repercussio...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Abbade LP,Lastória S,de Almeida Rollo H,Stolf HO

    更新日期:2005-12-01 00:00:00

  • What lichen planus patients die of. A retrospective study.

    abstract::The causes of death of 50 patients who had had lichen planus have been investigated and compared with those of 50 patients with psoriasis and with those of the general population. Patients with lichen planus were as old as those with psoriasis and in the general population at the time of death, but the diseases causin...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Anonide A,Rebora A

    更新日期:1989-10-01 00:00:00

  • Facial linear focal elastosis: a case report.

    abstract:BACKGROUND:Linear focal elastosis is an uncommon disorder that clinically shows band-like stria and a histological focal increase in elastic fibers. The disorder preferentially affects men after the age of 60 years and occurs on the lower back. The pathogenesis of linear focal elastosis is still somewhat of an enigma. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Inaloz HS,Kirtak N,Karakok M,Ozgoztasi O

    更新日期:2003-07-01 00:00:00

  • Treatment of hyperhidrosis with topical methenamine.

    abstract::Idiopathic palmar and plantar hyperhidrosis is a relatively common disorder of eccrine sweat gland function. Treatment with glutaraldehyde of formaldehyde, although successful, may cause undesirable side effects. Methenamine is a polycyclic organic compound which release ammonia and formaldehyde at acid pH. Five per c...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Bergstresser PR,Quero R

    更新日期:1976-07-01 00:00:00

  • Treatment of impetigo and ecthyma. A comparison of sulconazole with miconazole.

    abstract::In a randomized, double-blind, parallel comparative study of 80 patients, impetigo and ecthyma were treated effectively by sulconazole nitrate 1% cream and miconazole nitrate 2% cream applied to lesions twice daily for 14 days. When treatment began, bacterial cultures from all pyodermal lesions yielded Group A beta-he...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nolting S,Strauss WB

    更新日期:1988-12-01 00:00:00

  • Cardiovascular risk factors in subjects with psoriasis: a cross-sectional general population study.

    abstract:BACKGROUND:Epidemiological data have established an association between cardiovascular disease and psoriasis. Only one general population study has so far compared prevalences of cardiovascular risk factors among subjects with psoriasis and control subjects. We aimed to determine the prevalence of cardiovascular risk f...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Jensen P,Thyssen JP,Zachariae C,Hansen PR,Linneberg A,Skov L

    更新日期:2013-06-01 00:00:00

  • Comèl-Netherton syndrome and peeling skin syndrome type B: overlapping syndromes or one entity?

    abstract:BACKGROUND:A 42-year-old male patient suffering from the rare Comèl-Netherton syndrome is reported, and the symptoms are discussed together with the results of light and electron microscopic examinations. CASE REPORT:Our case presented peeling skin syndrome type B with spontaneous, lifelong skin shedding with underlyi...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sárdy M,Fáy A,Kárpáti S,Horváth A

    更新日期:2002-05-01 00:00:00