Effect of topical paromomycin on cell-mediated immunity during cutaneous leishmaniasis.

Abstract:

BACKGROUND:The aim of this study was to evaluate the effect of topical paromomycin treatment on the development of immunity during cutaneous leishmaniasis. METHODS:Three parameters of immunity were measured in the course of the disease: leishmanicidal effector activity, lymphocyte proliferation (cell-mediated immunity), and antibody levels (humoral immunity). Peripheral blood specimens of 55 treated and 36 untreated patients were tested. RESULTS:The main results of this study showed that there was a significant delay in the development of leishmanicidal effector activity and to a lesser extent also a delay in the development of antigen-specific proliferative response in the treated compared with the untreated group. No difference was observed between the groups regarding the values achieved in the various tests. CONCLUSIONS:These results suggest that topical paromomycin treatment delays the development of cell-mediated immunity but does not affect the levels of immunity that are eventually achieved.

journal_name

Int J Dermatol

authors

Frankenburg S,Gross A,Jonas F,Klaus S

doi

10.1111/j.1365-4362.1993.tb00975.x

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

68-70

issue

1

eissn

0011-9059

issn

1365-4632

journal_volume

32

pub_type

临床试验,杂志文章,随机对照试验
  • The genetics of vitiligo in Korean patients.

    abstract:BACKGROUND:Vitiligo is a common disorder whose exact cause is unknown, but genetic factors are thought to be involved. We analyzed 120 Korean proband families to clarify which genetic factors are involved in the pathogenesis of vitiligo in Korean patients. METHODS:The genetics of vitiligo were analyzed in 120 Korean p...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.1998.00549.x

    authors: Kim SM,Chung HS,Hann SK

    更新日期:1998-12-01 00:00:00

  • Premycotic poikiloderma, mycosis fungoides and cutaneous squamous cell carcinoma. Two cases and a discussion of their relevance.

    abstract::Two patients with premycotic poikiloderma developed one squamous cell carcinoma each. A review of the literature reveals 28 reported cases of this association, but in 26 of these the patient had been exposed to carcinogens. Our patients had no history of exposure to carcinogenic agents. In both our cases, the squamous...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1986.tb03424.x

    authors: Colver G,Mortimer P,Dawber R

    更新日期:1986-07-01 00:00:00

  • Tricho-rhino-phalangeal syndrome.

    abstract::The major characteristics of tricho-rhino-phalangeal syndrome (TRPS) include shortened and deviated digits, a typical facies with a pear-shaped nose, a long philtrum and slow-growing, fine, sparse hair. Cone-shaped digital epiphyses are seen on x-ray. A few patients with TRPS are mentally retarded. Associated endocrin...

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    doi:10.1111/j.1365-4362.1979.tb01972.x

    authors: Hansen DD,Shewmake SW

    更新日期:1979-09-01 00:00:00

  • Office-based radiation therapy for cutaneous carcinoma: evaluation of 710 treatments.

    abstract::Skin cancers are the most common malignancies and, historically, ionizing radiation has played an important role in their treatment. However, less experienced dermatologists generally consider radiation last in the line of therapeutic options. The authors sought to evaluate the effectiveness and safety of office-based...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2006.03108.x

    authors: Hernández-Machin B,Borrego L,Gil-García M,Hernández BH

    更新日期:2007-05-01 00:00:00

  • Mycosis fungoides with oral involvement.

    abstract::Oral mucous membrane involvement occurs uncommonly in mycosis fungoides and reports of it are scarce. We present two patients with severe involvement of the oral mucous membranes. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1991.tb04353.x

    authors: Vicente A,Martí RM,Martín E,Estrach T,Herrero C,Mascaró JM

    更新日期:1991-12-01 00:00:00

  • Use of vegetable oils in dermatology: an overview.

    abstract::Vegetable oils have been used for a wide variety of purposes since time immemorial; however, their principle use remains as skin moisturizers, especially in neonates and children. Because of their considerable efficacy and a low side effect profile and bearable cost, these oils are hugely popular as moisturizers among...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.13623

    authors: Sarkar R,Podder I,Gokhale N,Jagadeesan S,Garg VK

    更新日期:2017-11-01 00:00:00

  • Buschke-Ollendorff syndrome.

    abstract:BACKGROUND:Buschke-Ollendorff syndrome is a rare autosomal dominant disease featuring osteopoikilosis and skin lesions. It is caused by genetic mutations in a protein deeply involved in bone and connective tissue morphogenesis. METHODS:We describe a 39-year-old woman with Buschke-Ollendorff syndrome. RESULTS:After a ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03727.x

    authors: Schena D,Germi L,Zamperetti MR,Colato C,Girolomoni G

    更新日期:2008-11-01 00:00:00

  • Lingual traumatic ulceration (Riga-Fede disease).

    abstract::An 11-month-old male infant was referred to our clinic because of a painful ulcer of approximately 5 months' duration on the ventral surface of the tongue (Fig. 1). On physical examination, the lesion was circular (3 cm x 2 cm) with erythematous, raised, and indurated borders. No pathologic findings emerged from the l...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2004.02554.x

    authors: Baroni A,Capristo C,Rossiello L,Faccenda F,Satriano RA

    更新日期:2006-09-01 00:00:00

  • Coexisting subacute and systemic lupus erythematosus after terbinafine administration: successful treatment with mycophenolate mofetil.

    abstract::A 39-year-old female patient with systemic lupus erythematosus was treated with terbinafine for onychomycosis. After only 7 days of treatment with 250 mg terbinafine, a widespread severe erythematous eruption developed. The results of clinical, histological and immunofluorescent examinations confirmed the diagnosis of...

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    doi:10.1111/j.1365-4632.2004.02472.x

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    更新日期:2006-03-01 00:00:00

  • Huntingtin interacting protein 1 as a histopathologic adjunct in the diagnosis of Merkel cell carcinoma.

    abstract:BACKGROUND:Huntington interacting protein 1 (HIP1), an antiapoptotic protein normally expressed in the brain, is highly expressed in Merkel cell carcinomas (MCCs). Given this, the aim of the current study was to ascertain the value of HIP1 as a histopathologic adjunct in the diagnosis of MCC. METHODS:In this retrospec...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12454

    authors: Marghalani S,Feller JK,Mahalingam M,Mirzabeigi M

    更新日期:2015-06-01 00:00:00

  • Incidence of pemphigus vulgaris and pemphigus foliaceus in North-East Poland (Podlaskie Province) - a 15-year (2001-2015) bicentric retrospective study.

    abstract:BACKGROUND:The average incidence of pemphigus reported from European countries ranged between 0.5 and eight cases per one million inhabitants. Studies on epidemiology of pemphigus group in entire Province of Poland over a period of more than a decade are lacking. AIM:To analyze the incidence of pemphigus vulgaris (PV)...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14078

    authors: Serwin AB,Koper M,Flisiak I

    更新日期:2018-08-01 00:00:00

  • Organizing a dermatology service mission.

    abstract:BACKGROUND:There are few published guidelines that describe the forethought and logistical considerations needed to create a dermatology-specific medical mission. OBJECTIVE:To report the experience of planning and executing a successful medical mission to an underserved community in Puerto Rico. METHODS:We identified...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

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  • Assessment of thyroid function and lipid profile in patients with postadolescent acne in a Mediterranean population from Turkey.

    abstract:BACKGROUND:Postadolescent acne is defined as acne that is seen even after the age of 25 years, regardless of the age at onset. The causes of postadolescent acne have not been completely clarified up to now. Androgens are considered to be the major factor involved in pathogenesis. OBJECTIVE:We aimed to investigate the ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

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  • The incidence of pemphigus in the southern region of Saudi Arabia.

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    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.2001.01247.x

    authors: Tallab T,Joharji H,Bahamdan K,Karkashan E,Mourad M,Ibrahim K

    更新日期:2001-09-01 00:00:00

  • Topical cannabinoid receptor 1 agonist attenuates the cutaneous inflammatory responses in oxazolone-induced atopic dermatitis model.

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    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12841

    authors: Kim HJ,Kim B,Park BM,Jeon JE,Lee SH,Mann S,Ahn SK,Hong SP,Jeong SK

    更新日期:2015-10-01 00:00:00

  • A randomized, controlled and blinded study of papulopustular lesions in Turkish Behçet's patients.

    abstract:BACKGROUND:Papulopustular lesions (PPL), the commonest presentation of skin lesions in Behcet's disease (BD) are cutaneous, sterile folliculitis or acne-like lesions on erythematous base. Our purpose was to determine the true frequency and anatomic location of the PPL and compare this with controls. We also sought to d...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.1998.00401.x

    authors: Alpsoy E,Aktekin M,Er H,Durusoy C,Yilmaz E

    更新日期:1998-11-01 00:00:00

  • Sporotrichosis in Uttarakhand (India): a report of nine cases.

    abstract:BACKGROUND:Sporotrichosis is a chronic granulomatous infection caused by Sporothrichum schenckii. The disease has worldwide distribution. Majority of cases from India are reported from North-eastern states. METHODS:The demographic, clinico-investigative profile and therapeutic results of nine patients with cutaneous s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03538.x

    authors: Agarwal S,Gopal K,Umesh,Kumar B

    更新日期:2008-04-01 00:00:00

  • Dermatological and epidemiological profile of patients with albinism in Togo in 2019: results of two consultation campaigns.

    abstract:BACKGROUND:People with albinism (PWA) are targets of prejudice and social exclusion and have limited access to specialized medical care and resources. Our study aimed to describe the epidemiological and dermatological profile of PWA in Togo. METHOD:We carried out a cross-sectional study of 294 medical records of PWA s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.15069

    authors: Saka B,Mouhari-Toure A,Adam S,Mahamadou G,Kassang P,Teclessou JN,Akakpo SA,Gnossikè P,Elegbede Y,Darré T,Kombaté K,Pitché P

    更新日期:2020-09-01 00:00:00

  • A recombinant human hyaluronidase sustained release gel for the treatment of post-surgical edema.

    abstract:BACKGROUND:Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (r...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12304

    authors: Nekoroski T,Paladini RD,Sauder DN,Frost GI,Keller GA

    更新日期:2014-06-01 00:00:00

  • Dermatopathological characteristics of dermatofibromas from dermatoscopic clues.

    abstract:BACKGROUND:Several types of dermatofibroma (DF) have been identified dermatopathologically and with dermatoscopic correlation, the dermatopathology has been predictable in limited studies so far. We identify DFs with specific dermatoscopic structures and determine the respective dermatopathological correlates. METHODS...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14559

    authors: Genc Y,Akay BN,Okcu Heper A,Rosendahl C,Erdem C

    更新日期:2020-01-01 00:00:00

  • Adaptation of a Runyankore version of Skindex-16 for oral administration in Mbarara, Uganda.

    abstract:BACKGROUND:Health-related quality of life instruments are typically developed and validated for use in developed countries by patients who can read and write. Little is known about the feasibility of using adaptations of validated instruments in situations where literacy rates are low. OBJECTIVE:We aimed to translate,...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2011.04894.x

    authors: Chua SL,Maurer T,Chren MM

    更新日期:2011-10-01 00:00:00

  • Topical mechlorethamine for psoriasis. An attempt to avoid the development of sensitization by the use of a topical tolerogenic schedule.

    abstract::The topical application of mechlorethamine is associated with a high incidence of irritant contact dermatitis. An attempt was made to avoid this complication by the use of a topical tolerogenic schedule. Seven of ten patients developed contact dermatitis to the medication after they had completed the schedule, The use...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.1979.18.5.390

    authors: Price NM

    更新日期:1979-06-01 00:00:00

  • Diagnostic evaluation of the lupus band test in discoid and systemic lupus erythematosus.

    abstract:BACKGROUND:The usefulness of the lupus band test (LBT) in the diagnosis of cutaneous lupus erythematosus remains controversial. The study was done to determine the sensitivity, specificity, and predictive value of the LBT in discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE). METHODS:During the s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1995.tb01560.x

    authors: George R,Kurian S,Jacob M,Thomas K

    更新日期:1995-03-01 00:00:00

  • Favus.

    abstract::Favus has become a rarly found chronic fungal infection mainly caused by Trichophyton schoenleini and occasionally by Trichophyton violaceum or Microsporum gypseum. It can still be found in areas where the population suffers from poor hygiene and malnutrition. Cases are seen in the Mediterranean basin, the Middle East...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1980.tb00259.x

    authors: Dvoretzky I,Fisher BK,Movshovitz M,Schewach-Millet M

    更新日期:1980-03-01 00:00:00

  • Gardner-Diamond syndrome: a systematic review of treatment options for a rare psychodermatological disorder.

    abstract::Gardner-Diamond syndrome (GDS) is a rare psychodermatological condition characterized by the formation of spontaneous, painful skin lesions that develop into ecchymosis following episodes of severe physiological or psychological stress. The majority of GDS cases occur in young adult females, and although the etiology ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.14235

    authors: Block ME,Sitenga JL,Lehrer M,Silberstein PT

    更新日期:2019-07-01 00:00:00

  • Basal cell carcinoma in tropical Australia.

    abstract::A survey of people with skin cancer in tropical Australia detected a change in site of the prevalent cancer. In the post-war generation more basal cell carcinomas are occurring on the back and fewer on the head and neck. A reversal of the sex ratio was also detected, with more women being afflicted. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1992.tb02667.x

    authors: Czarnecki D,Collins N,Nash C

    更新日期:1992-06-01 00:00:00

  • Nargile (Hubble-Bubble) smoking-induced hand eczema.

    abstract::A 65-year-old retired man with hand eczema presented to the Dermatology clinic in October of 2001. He complained of scaly, fissured plaque-type lesions over the radial margin of his right index finger and thumb (Fig. 1). He first noticed these changes 2 years ago. There was no history of irritation from his occupation...

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    pub_type: 杂志文章

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  • Acral lentiginous melanoma: an immunohistochemical study of 20 cases.

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    pub_type: 杂志文章

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    更新日期:2003-02-01 00:00:00

  • Adult T-cell leukemia/lymphoma and cutaneous T-cell lymphoma. Are they related?

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    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1989.tb01329.x

    authors: Yamada M,Takigawa M,Iwatsuki K,Inoue F

    更新日期:1989-03-01 00:00:00

  • Linear basal cell epithelioma.

    abstract::A 73-year-old Celtic man presented with a linear pigmented 20-mm lesion on the left infraorbital cheek (Fig. 1). Clinical impression was pigmented basal cell epithelioma. Removal was accomplished by linear excision under local anesthesia. The wound was closed with a running 5-0 nylon subcuticular suture, which was rem...

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    更新日期:1985-03-01 00:00:00