Artificial reproduction of atypical hydRoa vacciniforme caused by latent EpStein-Barr virus infection.

Abstract:

BACKGROUND:Cases of hydroa vacciniforme-like eruptions caused by latent Epstein-Barr virus (EBV) infection have been reported in Asia and Mexico, some of which progressed to lymphoproliferative disorders. The precise clinical features of the disease are not, however, clear. METHODS:We performed an artificial provocation test with repeated exposures of ultraviolet A (UVA) and UVB in an 8-year-old Korean girl who had severe hydroa vacciniforme-like skin eruptions on exposed areas. RESULTS:The patient showed features of latent EBV infection serologically, and an in situ hybridization study indicated that most infiltrating mononuclear cells in the dermis were positive for EBV. After three exposures to UVA irradiation with a total dose of 90 J/cm2, erythema and vesicles appeared on the UVA-irradiated site but not on the UVB-irradiated site. CONCLUSIONS:Atypical hydroa vacciniforme caused by latent EBV infection could be reproduced by repeated UVA irradiation. Further study on the photo-protection would be necessary to prevent its progression to lymphoproliferative malignancies.

journal_name

Int J Dermatol

authors

Heo EP,Park SH,Kim TH

doi

10.1046/j.1365-4362.2003.01307_2.x

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

476-9

issue

6

eissn

0011-9059

issn

1365-4632

journal_volume

42

pub_type

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