Abstract：
BACKGROUND:Cellulite, which appears as orange peel-type or cottage cheese-like dimpling of the skin on the thighs and buttocks, is a complex, multifactorial, cosmetic disorder of the subcutaneous fat layer and the overlying superficial skin. Adiponectin is an adipocyte-derived hormone mainly produced by subcutaneous fat that shows important protective anti-inflammatory and vasodilatory effects. We hypothesized that adiponectin expressed in the subcutaneous adipose tissue (SAT) might play a role in the pathogenesis of cellulite. We reasoned that a reduction in the expression of adiponectin - a humoral vasodilator - in the SAT of cellulite areas might contribute to the altered microcirculation frequently found in these regions. METHODS:A total of 15 lean (body mass index [BMI] < 25 kg/m(2) ) women with cellulite and 15 age- and BMI-matched women without cellulite participated in this study. Real-time reverse transcription polymerase chain reaction (RT-PCR) was used to assess adiponectin gene expression. Plasma adiponectin levels were measured using a commercial enzyme immunoassay kit. RESULTS:Adiponectin mRNA expression in the SAT of the gluteal region was significantly lower in areas with cellulite compared with those without (12.6 ± 3.1 AU versus 16.6 ± 4.1 AU; P=0.006). However, plasma adiponectin levels did not differ between women with (20.3 ± 7.3 μg/ml) and without (19.3 ± 6.1 μg/ml) cellulite (P=0.69). CONCLUSIONS:Adiponectin expression is significantly reduced in the SAT in areas affected by cellulite. Our findings provide novel insights into the nature of cellulite and may give clues to the treatment of this cosmetic issue.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Emanuele E,Minoretti P,Altabas K,Gaeta E,Altabas Vdoi
10.1111/j.1365-4632.2010.04713.xsubject
Has Abstractpub_date
2011-04-01 00:00:00pages
412-6issue
4eissn
0011-9059issn
1365-4632journal_volume
50pub_type
杂志文章abstract：BACKGROUND:Dandruff is a common scalp condition characterized by flakes, pruritus and sometimes mild erythema. These symptoms reflect underlying histopathologic and biochemical events that must be reversed if treatment is to be effective. OBJECTIVES:This study aimed to better characterize the state of the epidermis in...
journal_title：International journal of dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-4632.2010.04629.x
更新日期：2011-01-01 00:00:00
abstract：BACKGROUND:Cutaneous melanoma is the most aggressive type of skin cancer, with high implications on the morbidity and mortality of patients. Matrix metalloproteinases (MMP) 2 and 9 have been involved in melanoma progression because they degrade important components of the basement membrane. We studied the relationship ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2012.05772.x
更新日期：2014-05-01 00:00:00
abstract：:Acanthosis nigricans (AN) and scleredema are two skin conditions that have been reported in association with diabetes mellitus. Few cases associating scleredema and AN have been reported. A literature search did not reveal any reports of diabetic patients developing AN on top of a scleredema plaque. Here we report a p...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02003.x
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Hypocomplementemic urticarial vasculitis (HUV) has been defined as a syndrome associated with urticarial lesions caused by leukocytoclastic vasculitis. It has been observed in patients with systemic lupus erythematosus and related conditions. Immunoglobulin G4 (IgG4)-related disease is a lymphoproliferative ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12868
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Surgery, in any setting, has several inherent risks not only to the patient, but the physician and his assistants as well. Safe handling and management of the sharps to prevent inoculation injuries is one of these risks, in particular: 1) instrument hand-off of the needle and needle driver between the physic...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2008.03651.x
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Anetoderma has been reported in patients with HIV-1 disease. In patients with autoimmune disease, anetoderma has been associated with increased levels of antiphospholipid antibodies (APL) that include anticardiolipin antibodies (ACA) and lupus anticoagulant (LA). This has led to speculation tha...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1995.tb04442.x
更新日期：1995-06-01 00:00:00
abstract：BACKGROUND:Dermatofibrosarcoma protuberans (DFSP) is an uncommon malignant tumor of the skin, the diagnosis of which can be difficult not only clinically but also histologically. The tumor has a low metastatic potential, but tends to recur locally if removal is incomplete. METHODS:We reviewed the clinical and histolog...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1995.tb01591.x
更新日期：1995-04-01 00:00:00
abstract：BACKGROUND:There is little research available that describes the natural progression of split-thickness skin graft (STSG) donor site wounds after re-epithelialization. The purpose of this study was to evaluate the longitudinal clinical progress of transepidermal water loss (TEWL), color, and sensory elements in STSG do...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14389
更新日期：2019-05-01 00:00:00
abstract：:Primary cutaneous follicle center lymphoma (PCFCL) is a neoplasm with differentiation of centrocytes and centroblasts presenting in the skin. At the time of initial manifestation, extracutaneous involvement is absent. PCFCL is considered as an indolent variant of primary cutaneous B-cell lymphomas since dissemination ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2008.03953.x
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of a...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12650
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:The majority of lasers used for hair removal target melanin as the chromophore. In contrast with other cutaneous applications of lasers, lasers used for hair removal must generate a limited, controlled degree of thermal damage to permanently remove hairs. AIM:To remove excess back hair from two male patient...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2001.01251.x
更新日期：2001-08-01 00:00:00
abstract：BACKGROUND:Pediculosis, caused by head lice (Pediculidae: Pediculus humanus var. capitis), is experiencing a global resurgence, with the prevalence in primary schools averaging as high as 40% in some areas regardless of socioeconomic factors. Control efforts using chemical treatments are becoming increasingly ineffecti...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2007.03132.x
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Exposure to sunlight is an important etiologic factor in cutaneous melanoma (CM). In several countries, more cases of CM are diagnosed in summer than in winter. AIM:To analyze whether there is seasonal variation in the diagnosis of CM in southern Brazil. METHODS:Data were collected from a hospital-based re...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.04174.x
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:There are few published guidelines that describe the forethought and logistical considerations needed to create a dermatology-specific medical mission. OBJECTIVE:To report the experience of planning and executing a successful medical mission to an underserved community in Puerto Rico. METHODS:We identified...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2012.05750.x
更新日期：2013-03-01 00:00:00
abstract：:Although tamoxifen (TAM) is routinely used in advanced melanoma, it is still uncertain whether evidence exists to support this practice. This review assesses the benefits and harms of systemic therapy with TAM vs. without TAM on response and mortality in patients with advanced melanoma. MEDLINE, The Cochrane Database ...
journal_title：International journal of dermatology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1365-4632.2010.04529.x
更新日期：2010-10-01 00:00:00
abstract：:A 47-year-old male developed both longitudinal melanonychia and periungual hyperpigmentation 6 months after initiation of hydroxycarbamide (synonym: hydroxyurea) therapy for chronic myeloproliferative disease. Based on the clinical symptoms observed in this patient, the broad differential diagnostic spectrum of hyperp...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2007.03502.x
更新日期：2007-11-01 00:00:00
abstract：:Vitiligo is one of the most important skin disorders that does not cause much physical impairment, but due to its disfiguring appearance, patients have disturbances in mental health and quality of life (QoL). The dermatology life quality index (DLQI), as one of the most specific QoL instruments, is now used widely for...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/ijd.13198
更新日期：2016-06-01 00:00:00
abstract：:Cutaneous calcium deposition can occur in long-term inflammation. The deposition of calcium in long-standing acne may produce either small pigmented nodules or no visible lesions. The former type is or no visible lesions. The former type is much less common, with the nodules containing particulate spheres of mineral w...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1977.tb01897.x
更新日期：1977-11-01 00:00:00
abstract：:A male fetus which was the product of full-term pregnancy and normal delivery with no family history is presented. The skin was hard and thick, waxy, yellowish in color, and was crossed by horizontal and or perpendicular red fissures. The eyelids were semiclosed, hard, and stiff resulting in ectropion and the conjunct...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1982.tb03144.x
更新日期：1982-07-01 00:00:00
abstract：BACKGROUND:Phototherapy is already established as an effective mode of therapy in vitiligo. An evidence-based study was carried out of the effect of narrow-band (311 nm) ultraviolet-B (NB-UV-B) radiation in 66 surgically treated patients with recalcitrant vitiligo in whom autologous mini-punch grafting was deployed. M...
journal_title：International journal of dermatology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-4632.2005.02697.x
更新日期：2006-06-01 00:00:00
abstract：:Topical tacrolimus and pimecrolimus are indicated for the treatment of atopic dermatitis, but they have been studied in many off-label uses. We reviewed the English language literature to define their roles in treatment of vitiligo. Double-blind studies show that tacrolimus 0.1% ointment combined with excimer laser is...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4632.2012.05697.x
更新日期：2013-04-01 00:00:00
abstract：:Fifty-seven patients with primary localized cutaneous amyloidosis (PLCA) were clinically and histopathologically reviewed. Two-thirds of patients had macular amyloidosis (MA). Intermediate cases having macular lesions with micropapules and/or lichens were identified. A spectrum for the disease is proposed, in which th...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb03245.x
更新日期：1992-02-01 00:00:00
abstract：:We report the occurrence of myiasis owing to Dermatobia hominis (Dh) in a HIV-infected subject. HIV infection did not modify the pathogenicity of myiasis. However, the clinical presentation seemed unusual with voluminous inflammatory nodules. Use of topical ivermectin killed the larvae and facilitated their extraction...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2006.03028.x
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:Epidemiological studies of molluscum contagiosum (MC) in children are limited. PATIENTS AND METHOD:Between 1997 and 1999, 110 children with MC (60 boys, 50 girls, mean age: 4.8 years) were studied. Treatment consisted of removal of all MC lesions in a single session by sterilized tweezers. RESULTS:In child...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02074.x
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:To assess the efficacy and safety of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women. Topical 5% cysteamine is an antioxidant and tyrosinase inhibitor that has been shown to be effective in the treatment of melasma. However, to date, no study has compared the performan...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.15146
更新日期：2020-12-01 00:00:00
abstract：:Scars are problematic for thousands of patients. Scarring is a natural part of the healing process after an injury. However, the appearance of a scar and its treatment depend on multiple factors and on the experience of the therapist and the options available. Despite a plethora of rapidly evolving treatment options a...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.13253
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Leishmaniasis is endemic in 88 countries in the world, and 350 million individuals are at risk of acquiring the disease. Treatment for American cutaneous leishmaniasis (ACL) is long, expensive, and associated with important side-effects. METHODS:In this double-blind, placebo-controlled study, we treated 102...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.1365-4362.2002.01336.x
更新日期：2002-02-01 00:00:00
abstract：:A 30-year-old woman presented with an orange-yellow discoloration of the skin, most noticeable on the palms and soles and nasolabial folds; sclera appeared normal. The patient had observed the abnormal pigmentation of her skin 3 months earlier and noticed that it had become more evident after a sauna she had taken 2 d...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb03521.x
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND:Millions of people are infested by head lice every year. However, louse transfer between hosts is not well-understood. Our goals were to determine: (1) which stages were most likely to disperse and why, (2) the likelihood of fomites transmission, and (3) if host blood gender affects louse development. METHO...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2005.02418.x
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Lichen planus (LP) is a chronic inflammatory disease that has been shown to be positively associated with dyslipidemia. However, the magnitude and types of the underlying lipid abnormalities have not been investigated. This study aims to conduct a systematic review and meta-analysis to investigate the qualit...
journal_title：International journal of dermatology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/ijd.13234
更新日期：2016-05-01 00:00:00
