Abstract:
UNLABELLED:BACKGROUND> An unchecked proliferation of fibrous tissue after an injury to the skin is the basic mechanism for keloid formation. Recent studies have shown the inhibitory effect of interferons on dermal fibroblast growth and/or collagen production. Various therapeutic modalities have been used for the treatment of keloids, although only with limited success. There are only a few reports on the use of interferons in the treatment of keloids. To our knowledge no controlled clinical trials have examined the efficacy of intralesional interferon-alpha 2b on mature keloid lesions. In this study, recombinant human interferon-alpha 2b was examined for its ability to modify keloids clinically. METHODS:Twenty-two patients with at least two mature keloids were studied twice weekly for 3 weeks. Patients were treated by injection of recombinant human interferon-alpha 2b, 0.5 million per cm2 of keloid, into one lesional site and diluent alone into another lesional site. Lesions were measured before and on days 8, 15, 22, and 29 after starting treatment. RESULTS:Only 13 of 22 patients could be evaluated at the end of the study; seven patients withdrew from the study because of severe local pain during injection. Three of the 13 patients showed insignificant reduction in the height of keloids after interferon treatment. No serious laboratory abnormalities were detected.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
al-Khawajah MMdoi
10.1111/j.1365-4362.1996.tb01671.xsubject
Has Abstractpub_date
1996-07-01 00:00:00pages
515-7issue
7eissn
0011-9059issn
1365-4632journal_volume
35pub_type
临床试验,杂志文章abstract::A variety of cutaneous manifestations has been described in multiple myeloma including extramedullary cutaneous plasmacytomas, cutaneous amyloidosis, pyoderma gangrenosum, leukocytoclastic vasculitis, necrobiotic xanthogranuloma, scleromyxedema, Sweet's syndrome, subcorneal pustular dermatosis, scleredema, and plane x...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02414.x
更新日期:2006-05-01 00:00:00
abstract::Scars are problematic for thousands of patients. Scarring is a natural part of the healing process after an injury. However, the appearance of a scar and its treatment depend on multiple factors and on the experience of the therapist and the options available. Despite a plethora of rapidly evolving treatment options a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13253
更新日期:2016-08-01 00:00:00
abstract::Two patients with premycotic poikiloderma developed one squamous cell carcinoma each. A review of the literature reveals 28 reported cases of this association, but in 26 of these the patient had been exposed to carcinogens. Our patients had no history of exposure to carcinogenic agents. In both our cases, the squamous...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1986.tb03424.x
更新日期:1986-07-01 00:00:00
abstract::Eccrine poroma (EP) is a benign tumor of the eccrine duct. Multiple EPs are defined as eccrine poromatosis (EPS), an uncommon phenomenon. To date there are only eight reported cases of EPS. This review exemplifies the epidemiology, pathogenesis, differential diagnosis, and histology of EP, while reviewing the eight ca...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2012.05831.x
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:The cosmetic importance of hair as a unique structure of the scalp is immense, such that once the loss of hair becomes an issue for a child, parents, in most cases, project their own concerns, often expressed as guilt. The clinical presentation of hair loss and scalp disorders in children varies widely, ofte...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03457.x
更新日期:2007-10-01 00:00:00
abstract::Old World cutaneous leishmaniasis (OWCL) is an endemic and major health problem in Iran. The optimal treatment of OWCL is unknown, and current treatments are not ideally effective and have many adverse effects. To compare the efficacy and tolerability of combined oral azithromycin and allopurinol with intramuscular Gl...
journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-4632.2012.05610.x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Liver enzymes appear to be involved in oral lichen planus (OLP), but it is not known whether the elevation develops concomitantly with exacerbations of disease. We compared the levels of serum hepatic aspartate (AST) and alanine (ALT) aminotransferases as markers of OLP exacerbation in patients with chronic ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13626
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Pemphigus herpetiformis (PH) is a rare subtype of pemphigus that presents challenges in diagnosis. OBJECTIVE:To review the presentation, diagnosis, and management of PH. METHODS:We reviewed the charts of all patients diagnosed and treated for PH in an immunobullous referral center between September 2007 an...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.12582
更新日期:2015-09-01 00:00:00
abstract::Skin lesions are frequent in human T-cell lymphotropic virus type 1 (HTLV-1) infection and may constitute an alert for the diagnosis of this condition. The most severe skin diseases related to this virus are adult T-cell leukemia/lymphoma (ATLL), an aggressive form of leukemia/lymphoma that fails to respond to chemoth...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2010.04568.x
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Assessment of severity is essential in the clinical care of rosacea patients and in the research on rosacea. OBJECTIVE:To determine the range of methods used to assess rosacea severity in clinical trials. METHODS:The medical literature from 1965 through 2001 was searched for rosacea clinical trials using M...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-4362.2003.01780.x
更新日期:2003-06-01 00:00:00
abstract:INTRODUCTION:Diffuse dermal angiomatosis is an entity in the spectrum of reactive angiomatoses characterized by erythematous plaques that mainly affect the lower extremities of patients with a personal history of peripheral vascular disease. Involvement of the breast is a rare event that has only been described as sing...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05812.x
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:Onychomycosis in temperate countries has been studied extensively, but few data are available on its epidemiology in tropical countries. We performed a survey of patients seen in Hong Kong for the 8-year period from January 1987 to December 1994. METHODS:A retrospective study of the mycology laboratory reco...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1997.00048.x
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVES:Oral lichen planus (OLP) is a chronic inflammatory disease of unknown cause. Malignant transformation in OLP lesions may be favored by changes in the expression of proteins that regulate cell proliferation and apoptosis. This study aimed to investigate these issues by immunohistochemical staining for Bcl-2 a...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12279
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND: Leprosy is a chronic infection of the skin and peripheral nerves caused by the bacterium Mycobacterium leprae, which causes peripheral insensitivity and disfigurements of the skin, limbs, and digits. Social stigma is a common consequence of leprosy and may differ according to level of physical disfiguremen...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05226.x
更新日期:2013-04-01 00:00:00
abstract::The biology of wound healing is indeed a complex process. From phase 1 to phase 3, an orderly progression of events take place in the repair process. Various factors influence the rapidity and cosmetic appearance of this phenomenon. Physical, microbial, nutritional and environmental factors all have some role in the e...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4362.1975.tb00088.x
更新日期:1975-12-01 00:00:00
abstract:BACKGROUND:Chronic plaque psoriasis has a profound impact on a patient's daily life. To understand the effects of psoriasis treatments, it is essential to assess the patient's experience of symptoms and how they impact their daily life. The goal of this study was to develop and establish the content validity of a new p...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05798.x
更新日期:2014-06-01 00:00:00
abstract::Young white men (1176 men, mean age 20 years, age range from 18 to 26 years) were examined for dysplastic nevi. In 78 patients (6.63%), 107 clinically dysplastic nevi were observed, demonstrating all three NIH criteria (diameter greater than 5mm, irregularities of border, irregularities of color) suggestive for clinic...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03947.x
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is an important nosocomial pathogen. It can also cause community-acquired infections. Indian reports about MRSA in community-acquired infections are rare. AIM:To evaluate the rate of MRSA in community-acquired pyoderma and the nasal colonisation with S. aur...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02138.x
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Common treatment of atrophic acne scars consists of invasive methods such as dermabrasion, chemopeeling, or implantation of bovine collagen. In our study a new noninvasive treatment method consisting of local iontophoresis is demonstrated. Local iontophoresis was performed with either estriol--a mainly topic...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1995.tb04381.x
更新日期:1995-01-01 00:00:00
abstract::A 4-year-old boy presented with mildly itchy, linear, skin lesions over the trunk, arms, and face of 3 months' duration. He had previously been admitted to a private hospital for generalized exfoliation of the skin following drug intake for fever and throat pain. The nature of the drugs was not known. The exfoliative ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03618.x
更新日期:2008-09-01 00:00:00
abstract::Dermatology has a very distinctive lexicon. The term pityriasis refers to several dermatologic conditions which all feature scaling of the skin. According to the Merriam-Webster dictionary, the term pityriasis was first used in print in 1684. Although the diseases beginning with the name pityriasis are of diverse caus...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.15097
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:In Sri Lanka, cutaneous leishmaniasis is a well-established disease caused by Leishmania donovani. Only a few cases of visceral disease and mucosal localization have been reported to date. CASE REPORT:A 52-year-old man presented with severe local destruction of his upper and lower lip and total destruction ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2010.04376.x
更新日期:2010-05-01 00:00:00
abstract::Acquired facial hyperpigmentation is a common problem among African patients, particularly women, where the causes of the dermatoses are identified largely from circumstantial evidence of exposure to known agents. These include hydroquinone-induced exogenous ochronosis from skin-bleaching creams, mercury deposits from...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4362.1991.tb03848.x
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Pruritus is a common subjective symptom of psoriasis whose levels may be affected by a range of variables. The objective of this study was to evaluate the frequency of pruritus and its associations with clinical and psychological characteristics of psoriasis patients. MATERIALS AND METHODS:One-hundred and s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12074
更新日期:2014-07-01 00:00:00
abstract::The authors collected data from the literature and from experts on the subject of vaccination of patients with dermatologic disorders. They assembled these data into categories of specific skin conditions and vaccinations. These data may be used in deciding whether or not to vaccinate, and at which stage of the dermat...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1975.tb01431.x
更新日期:1975-03-01 00:00:00
abstract::A male patient with underlying lepromatous leprosy mimicked Sweet's syndrome clinically. He was believed to be in an atypical reactional state recognized as a variant form of erythema nodosum leprosum. In addition to the antileprosy treatment, steroid hormone was required to control the systemic symptoms. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1987.tb02293.x
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Epidemiological data have established an association between cardiovascular disease and psoriasis. Only one general population study has so far compared prevalences of cardiovascular risk factors among subjects with psoriasis and control subjects. We aimed to determine the prevalence of cardiovascular risk f...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05408.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:The purpose of this study is to review the published articles regarding different surgical modalities including laser therapy in the treatment of congenital melanocytic nevi (CMN). METHODS:A systematic review was done using several databases including PubMed, Ovid Medline, Google Scholar, and Medline to sea...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.14727
更新日期:2020-05-01 00:00:00
abstract::Despite an array of topical and systemic antifungal agents, cases of resistant dermatophytosis still exist. Use of naftifine, the first commercially available allylamine derivative, proved successful in the management of four such cases. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1991.tb02649.x
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND:Postadolescent acne is defined as acne that is seen even after the age of 25 years, regardless of the age at onset. The causes of postadolescent acne have not been completely clarified up to now. Androgens are considered to be the major factor involved in pathogenesis. OBJECTIVE:We aimed to investigate the ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12547
更新日期:2015-12-01 00:00:00