Huntingtin interacting protein 1 as a histopathologic adjunct in the diagnosis of Merkel cell carcinoma.

Abstract:

BACKGROUND:Huntington interacting protein 1 (HIP1), an antiapoptotic protein normally expressed in the brain, is highly expressed in Merkel cell carcinomas (MCCs). Given this, the aim of the current study was to ascertain the value of HIP1 as a histopathologic adjunct in the diagnosis of MCC. METHODS:In this retrospective study, archival material from 26 cases with a diagnosis of MCC and/or neuroendocrine carcinoma were retrieved from the pathology files of the Skin Pathology Laboratory (Boston University School of Medicine, Boston, MA, USA). Histopathologic sections of all cases were re-reviewed and the diagnosis confirmed. All patient data were de-identified. Immunohistochemical studies were performed using antibodies to HIP1 and cytokeratins (CK) 20 and 7. RESULTS:A semiquantitative scoring system for immunohistochemical expression of HIP1 was utilized by deriving a cumulative score (based on percentage positivity of cells and intensity of expression). Using a cut-off total score of 3 or more as positive, the total number of positive cases was 22 for HIP1, 24 for CK20, and 11 for CK7. CONCLUSION:Comparing the results of HIP1 and CK20, there were four discordant pairs (three positive for CK20 but negative for HIP1 and one positive for HIP1 but negative for CK20). McNemar's test indicated that there was no statistical significance (P = 0.625), thereby implying a close agreement between the expression of HIP1 and CK20 in these neuroendocrine neoplasms.

journal_name

Int J Dermatol

authors

Marghalani S,Feller JK,Mahalingam M,Mirzabeigi M

doi

10.1111/ijd.12454

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

640-7

issue

6

eissn

0011-9059

issn

1365-4632

journal_volume

54

pub_type

杂志文章
  • A retrospective review of the dermatologic manifestations of chronic arsenic poisoning in the Philippines.

    abstract:BACKGROUND:The Section of Dermatology of the University of the Philippines, Philippine General Hospital, reported a case of chronic arsenic poisoning from a community in Luzon island to the Department of Health resulting in the conduct of two health and environmental assessment missions in December 2014. OBJECTIVE:To ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.13615

    authors: Sy SMT,Salud-Gnilo CM,Yap-Silva C,Tababa EJL

    更新日期:2017-07-01 00:00:00

  • Clinical study of a new preparation of 8-methoxypsoralen in photochemotherapy.

    abstract:BACKGROUND:Oral 8-methoxypsoralen is the drug of choice in photochemotherapy of several dermatoses, e.g., vitiligo and psoriasis. The aim of this trial is to produce a new preparation of the drug, which is able to overcome the difficulties met with the oral use of the older preparations. METHODS:A new preparation cont...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-4362.1994.tb02904.x

    authors: el-Mofty AM,el-Sawalhy H,el-Mofty M

    更新日期:1994-08-01 00:00:00

  • Facial contact dermatitis. Pathogenetic factors in China.

    abstract::In 107 cases of facial contact dermatitis, routine Finn chamber epicutaneous tests with TROLAB European Standard Allergens (ESAs) were performed. Sixty-one (57%) had positive reaction. The most frequent contact allergens were paraphenylenediamine dihydrochloride (16%), followed by fragrance mix (15%), and nickel sulfa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1991.tb04867.x

    authors: Zhao B,Fan WX

    更新日期:1991-07-01 00:00:00

  • Autologous epidermal grafting with PUVA-irradiated donor skin for the treatment of vitiligo.

    abstract:BACKGROUND:Epidermal autografting has been used to treat vitiligo. The pigmentation achieved at the recipient site can be variegated and incomplete compared with that of the surrounding normal skin, and sometimes remains that way for a fairly long time. OBJECTIVE:We investigated whether the clinical results from epide...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.1998.00437.x

    authors: Lee AY,Jang JH

    更新日期:1998-07-01 00:00:00

  • Immunoperoxidase technique for detecting spirochetes in tissue sections: comparison with other methods.

    abstract:BACKGROUND:With the increasing incidence of human immunodeficiency virus (HIV) infection and immunosuppressive therapy, the incidence of syphilis has been increasing. Given the fact that the above conditions may mask or obscure the usual clinical signs and symptoms of syphilis, a means of enhanced detection is essentia...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-4362.2000.00029.x

    authors: Phelps RG,Knispel J,Tu ES,Cernainu G,Saruk M

    更新日期:2000-08-01 00:00:00

  • Beta defensin-1 gene (DEFB1) polymorphisms are not associated with atopic dermatitis in children and adolescents from northeast Brazil (Recife, Pernambuco).

    abstract:BACKGROUND:Atopic dermatitis (AD) is a common inflammatory skin disease resulting from the interplay between environmental, immunological and genetic factors. In our study, we investigated the role of three single nucleotide polymorphisms (SNPs) at 5'-UTR of DEFB1 gene, encoding for the human beta defensin-1, on the su...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2009.04343.x

    authors: Segat L,Guimarães RL,Brandão LA,Rocha CR,Zanin V,Trevisiol C,de Lima Filho JL,Crovella S

    更新日期:2010-06-01 00:00:00

  • Prevention of post-herpetic neuralgia. Evaluation of treatment with oral prednisone, oral acyclovir, and radiotherapy.

    abstract::The effects of prednisone, oral acyclovir, and radiotherapy were compared with placebo in the prevention of post-herpetic neuralgia. No treatment used was able to prevent, with statistical significance, post-herpetic neuralgia, although prednisone and acyclovir showed some pain reduction in the acute phase. Radiothera...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-4362.1991.tb04642.x

    authors: Benoldi D,Mirizzi S,Zucchi A,Allegra F

    更新日期:1991-04-01 00:00:00

  • Cheyletiella dermatitis.

    abstract::A mild dermatitis probably due to Cheyletiella yasguri was observed in 2 persons whose pet dog was infested with this parasite. Cheyletiella mites differ morphologically from sarcoptic mites, which cause canine and human scabies. Treatment of man and dog with 1% gamma benzene hexachloride is usually successful in clea...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1977.tb01882.x

    authors: Powell RF,Palmer SM,Palmer CH,Smith EB

    更新日期:1977-10-01 00:00:00

  • International recommendations for an effective control of head louse infestations.

    abstract::Head louse infestations continue to be a concern of public health in most countries, including the most developed ones. The present recommendations are intended to inform and stress the role and impact of the different authorities, institutions, industry, and the public in the control of head lice in order to reduce t...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.15096

    authors: Mumcuoglu KY,Pollack RJ,Reed DL,Barker SC,Gordon S,Toloza AC,Picollo MI,Taylan-Ozkan A,Chosidow O,Habedank B,Ibarra J,Meinking TL,Vander Stichele RH

    更新日期:2020-08-07 00:00:00

  • Tinea versicolor of the scalp.

    abstract:BACKGROUND:Tinea versicolor (TV) is commonly described on the trunk without giving attention to involvement of the scalp. We examined cases with dandruff with and without TV on the body to see how frequent Malassezia furfur (M. furfur) is present in dandruff scales. METHODS:A total of 80 patients were examined mycolog...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1995.tb02946.x

    authors: el-Gothamy Z,Ghozzi M

    更新日期:1995-08-01 00:00:00

  • The cutaneous effects of long-term use of Dead Sea mud on healthy skin: a 4-week study.

    abstract:PURPOSE:To investigate the effects of various types of Dead Sea mud (DSM) on skin barrier properties over a period of four weeks. METHODS:The effects of a 4-week application of three types of DSM (as is mud, mud with extra Dead Sea salt, and over the shelf mud) on the barrier properties of normal skin were investigate...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.15304

    authors: Hamed S,Almalty AM,Alkhatib HS

    更新日期:2020-12-07 00:00:00

  • Increased cutaneous fibrinolytic activity in a case of aquagenic pruritus.

    abstract::Cutaneous fibrinolytic activity was found to be increased in a patient with aquagenic pruritus both before and after contact with water. This could explain the lack of wheal formation in this affection, which is characterized by increased histamine release. ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1984.tb05665.x

    authors: Lotti T,Cappugi P,Lattari P,Panconesi E

    更新日期:1984-01-01 00:00:00

  • Tinea capitis in Lahore, Pakistan.

    abstract:BACKGROUND:The causative fungi of tinea capitis vary with geography and time. This study was planned to identify the etiologic agents and determine clinicoetiologic correlations of tinea capitis in Lahore, Pakistan. METHODS:From clinically suspected cases of tinea capitis, skin scrapings and hair samples were taken an...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1994.tb01037.x

    authors: Hussain I,Aman S,Haroon TS,Jahangir M,Nagi AH

    更新日期:1994-04-01 00:00:00

  • Skin cancer prevention campaign aimed at beachgoers on the Costa del Sol (southern Spain).

    abstract:BACKGROUND:Sunbathing on the beach is one of the main risks for skin cancer. OBJECTIVE:In the summer of 2010, a skin cancer prevention campaign aimed at beachgoers was undertaken on the western Costa del Sol (southern Spain). METHODS:The campaign took place on beaches during July and August. A multicomponent interven...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.12389

    authors: de Troya-Martín M,Delgado-Sánchez N,Blázquez-Sánchez N,Ortega-Tudela G,Toribio-Montero JC,Jabalera-Mesa ML,Ríos-Almellones I,Rivas-Ruiz F

    更新日期:2014-11-01 00:00:00

  • Azelaic acid (15% gel) in the treatment of acne rosacea.

    abstract::In December of 2002, the FDA approved azelaic acid 15% gel for the topical treatment of inflammatory papules and pustules of mild to moderate rosacea. Azelaic acid is a saturated dicarboxylic acid, which is naturally occurring and has been used in the treatment of rosacea, acne, and melasma. The 15% gel has a high eff...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4632.2005.02769.x

    authors: Gupta AK,Gover MD

    更新日期:2007-05-01 00:00:00

  • Onychomycosis infections in the Middle Black Sea Region, Turkey.

    abstract:BACKGROUND:Onychomycosis, a fungal infection of the nail, is caused by dermatophytes, yeasts, and nondermatophyte molds. The causative pathogen and incidence of onychomycosis depend on age, gender, geographic and climatic conditions, living habits, and immune status of the host. AIM:To determine the incidence and etio...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2009.04126.x

    authors: Yenişehirli G,Bulut Y,Sezer E,Günday E

    更新日期:2009-09-01 00:00:00

  • Clinical and mycological status of the Trichophyton mentagrophytes (interdigitale) syndrome of chronic dermatophytosis of the skin and nails.

    abstract::The syndrome of tinea pedis caused by human-adapted Trichophyton mentagrophytes (interdigitale) can be recognized by two signs not characteristically seen in tinea pedis caused by T. rubrum and Epidermophyton floccosum:1 bullous > 2 mm vesicles in the thin skin of the plantar arch and along the sides of the feet and h...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-4362.2003.01783.x

    authors: Zaias N,Rebell G

    更新日期:2003-10-01 00:00:00

  • Helicobacter pylori and idiopathic chronic urticaria.

    abstract:BACKGROUND:Different studies have shown a high prevalence of Helicobacter pylori (HP) infection in patients with chronic urticaria (CU), and occasional remission of the skin lesions after eradication therapy. Recent investigations, however, have failed to find a significant relationship between the two conditions. We d...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-4362.2000.00995.x

    authors: Daudén E,Jiménez-Alonso I,García-Díez A

    更新日期:2000-06-01 00:00:00

  • The impact of stratifying initial dose of corticosteroids by severity of pemphigus vulgaris on long-term disease severity.

    abstract:BACKGROUND:Pemphigus vulgaris (PV) is a life-threatening disease affecting skin and mucous membranes. The "epitope spreading" theory posits that uncontrolled PV can gradually worsen because of exposure of cellular antigens to the immune system. To this end, high-dose systemic corticosteroids have been advocated as firs...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2010.04828.x

    authors: Lyakhovitsky A,Baum S,Scope A,Amichai B,Barzilai A,Rimer J,Trau H

    更新日期:2011-08-01 00:00:00

  • Photochemotherapy (PUVA) and psoriasis: comparison of 8-MOP and 8-MOP/5-MOP.

    abstract::Twenty-eight psoriatic patients received PUVA treatment (psoralen and long ultraviolet irradiations. Two preparations were used; 8-methoxypsoralen and a mixture of 5-methoxypsoralen and 8-methoxypsoralen. Both gave considerable improvement, but in 6 cases the lesions reappeared after 2 to 8 weeks, in spite of maintena...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1976.tb01829.x

    authors: Langner A,Wolska H,Kowalski J,Duralska H,Murawska E

    更新日期:1976-11-01 00:00:00

  • The nevus comedonicus syndrome: a case report with emphasis on associated internal manifestations.

    abstract::A 14-year-old boy with nevus comedonicus, multiple congenital abnormalities of the spine, and a central nervous system disorder is described. The associated abnormalities previously reported with nevus comedonicus are summarized. Thorough evaluation of patients with nevus comedonicus may disclose the occurrence of cer...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/ijd.1978.17.9.745

    authors: Engber PB

    更新日期:1978-11-01 00:00:00

  • Occlusive hydrocolloid dressings applied to chronic neuropathic ulcers. A study of efficacy in patients at a rural South Indian Hospital.

    abstract::The response of 47 chronic ulcers (41 neuropathic [leprosy], 3 stasis, 1 traumatic, and 2 of unknown etiology) to hydrocolloid occlusive dressings was evaluated at a rural south Indian hospital. The response to treatment was objectively evaluated by photographic estimation of the surface areas of the ulcers. Eight ulc...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1988.tb04931.x

    authors: Mumford JW,Mumford SP

    更新日期:1988-04-01 00:00:00

  • Tricho-rhino-phalangeal syndrome.

    abstract::The major characteristics of tricho-rhino-phalangeal syndrome (TRPS) include shortened and deviated digits, a typical facies with a pear-shaped nose, a long philtrum and slow-growing, fine, sparse hair. Cone-shaped digital epiphyses are seen on x-ray. A few patients with TRPS are mentally retarded. Associated endocrin...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1979.tb01972.x

    authors: Hansen DD,Shewmake SW

    更新日期:1979-09-01 00:00:00

  • Pheohyphomycosis caused by Exophiala spinifera: a rare occurrence.

    abstract::A 10-year-old immunocompetent boy presented with multiple, verrucous, disseminated pheohyphomycotic lesions caused by Exophiala spinifera. The patient was not responsive to combination antifungal therapy (itraconazole, terbinafine, fluconazole) and cryotherapy. As antifungal susceptibility is known to be variable for ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4632.2007.03430.x

    authors: Singal A,Pandhi D,Bhattacharya SN,Das S,Aggarwal S,Mishra K

    更新日期:2008-01-01 00:00:00

  • Epidemiological and clinical patterns of genital lesions.

    abstract::A 5-year study of 668 patients with genital lesions revealed that teenagers and those in the age group of 20 to 40 are most vunerable. The poor, the uneducated and unmarried persons are at high risk. Chancroid and syphilis are the majority of cases. Inguinal bubo, herpes pregenitalis, condylomata acuminata, erosive ba...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:

    authors: Sehgal VN,Rege VL,Sehgal N,Kharangate VN,Mascarenhas MF

    更新日期:1976-10-01 00:00:00

  • Psoriasis and pregnancy: hormone and immune system interaction.

    abstract:BACKGROUND:Various hormonal states are known to be associated with the waxing and waning of psoriasis. Patients with psoriasis commonly experience changes in their cutaneous disease during pregnancy or post partum. OBJECTIVE:We evaluated 100 women with psoriasis by questionnaire and interview. The women had been seen ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1996.tb01632.x

    authors: Boyd AS,Morris LF,Phillips CM,Menter MA

    更新日期:1996-03-01 00:00:00

  • Surgical pearl: a simple means of disarming the "locked and loaded" needle.

    abstract:BACKGROUND:Surgery, in any setting, has several inherent risks not only to the patient, but the physician and his assistants as well. Safe handling and management of the sharps to prevent inoculation injuries is one of these risks, in particular: 1) instrument hand-off of the needle and needle driver between the physic...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03651.x

    authors: Kunishige J,Wanitphakdeedecha R,Nguyen TH,Chen TM

    更新日期:2008-08-01 00:00:00

  • Infection versus disease in South American blastomycosis.

    abstract::The mechanism of infection in South American blastomycosis is discussed, and the probability of a mild or asymptomatic form of the disease, regressing spontaneously with subsequent immunity, in persons living in endemic areas. Primary lesions in the oral mucosa or in the skin have not been convincingly shown to occur ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-4362.1975.tb01428.x

    authors: Furtado T

    更新日期:1975-03-01 00:00:00

  • Epidermoid cysts: an exclusive palatal presentation and a case series.

    abstract:BACKGROUND:Epidermoid cysts (EC) can occur anywhere in the body. In the head and neck region, they more often present in the midline between the submental region and the supra sternal notch. EC in the oral cavity are extremely rare and present as benign, slow growing lesions. METHODS:Records from College of Dental Sur...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2009.03490.x

    authors: Ravindranath AP,Ramalingam K,Natesan A,Ramani P,Premkumar P,Thiruvengadam C

    更新日期:2009-04-01 00:00:00

  • Necrolytic acral erythema: successful treatment with topical tacrolimus ointment.

    abstract::Necrolytic acral erythema is a relatively recently described psoriasis-like skin eruption seen in people infected with hepatitis C virus. Hepatitis C virus infection is endemic in many parts of the world with a steady increase of incidence in Pakistan. Recognition of this disorder is crucial to an early treatment of t...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2008.03710.x

    authors: Manzur A,Siddiqui AH

    更新日期:2008-10-01 00:00:00