Huntingtin interacting protein 1 as a histopathologic adjunct in the diagnosis of Merkel cell carcinoma.


BACKGROUND:Huntington interacting protein 1 (HIP1), an antiapoptotic protein normally expressed in the brain, is highly expressed in Merkel cell carcinomas (MCCs). Given this, the aim of the current study was to ascertain the value of HIP1 as a histopathologic adjunct in the diagnosis of MCC. METHODS:In this retrospective study, archival material from 26 cases with a diagnosis of MCC and/or neuroendocrine carcinoma were retrieved from the pathology files of the Skin Pathology Laboratory (Boston University School of Medicine, Boston, MA, USA). Histopathologic sections of all cases were re-reviewed and the diagnosis confirmed. All patient data were de-identified. Immunohistochemical studies were performed using antibodies to HIP1 and cytokeratins (CK) 20 and 7. RESULTS:A semiquantitative scoring system for immunohistochemical expression of HIP1 was utilized by deriving a cumulative score (based on percentage positivity of cells and intensity of expression). Using a cut-off total score of 3 or more as positive, the total number of positive cases was 22 for HIP1, 24 for CK20, and 11 for CK7. CONCLUSION:Comparing the results of HIP1 and CK20, there were four discordant pairs (three positive for CK20 but negative for HIP1 and one positive for HIP1 but negative for CK20). McNemar's test indicated that there was no statistical significance (P = 0.625), thereby implying a close agreement between the expression of HIP1 and CK20 in these neuroendocrine neoplasms.


Int J Dermatol


Marghalani S,Feller JK,Mahalingam M,Mirzabeigi M




Has Abstract


2015-06-01 00:00:00












  • Tinea capitis in Lahore, Pakistan.

    abstract:BACKGROUND:The causative fungi of tinea capitis vary with geography and time. This study was planned to identify the etiologic agents and determine clinicoetiologic correlations of tinea capitis in Lahore, Pakistan. METHODS:From clinically suspected cases of tinea capitis, skin scrapings and hair samples were taken an...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Hussain I,Aman S,Haroon TS,Jahangir M,Nagi AH

    更新日期:1994-04-01 00:00:00

  • Papulonecrotic tuberculid secondary to disseminated Mycobacterium avium complex.

    abstract:BACKGROUND:Papulonecrotic tuberculid is a rarely reported cutaneous reaction to the mycobacterium bacillus. It is most often encountered in association with tuberculosis. The clinical and histologic picture of the entity is a distinctive one, but the etiology of the disease process is uncertain. Therapy directed agains...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Williams JT,Pulitzer DR,DeVillez RL

    更新日期:1994-02-01 00:00:00

  • Would healing: a brief review.

    abstract::The biology of wound healing is indeed a complex process. From phase 1 to phase 3, an orderly progression of events take place in the repair process. Various factors influence the rapidity and cosmetic appearance of this phenomenon. Physical, microbial, nutritional and environmental factors all have some role in the e...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Cohen BH,Lewis LA,Resnik SS

    更新日期:1975-12-01 00:00:00

  • Evaluation of the correlation between serum levels of vitamin D and vitamin D receptor gene polymorphisms in an Egyptian population.

    abstract:BACKGROUND:Vitiligo is an autoimmune depigmentation disorder. Polymorphisms in the vitamin D receptor (VDR) have been found to be associated with vitiligo. OBJECTIVES:To evaluate the potential association between VDR gene polymorphisms (ApaI, TaqI, and FokI) and vitiligo susceptibility, and to detect if there is corre...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sobeih S,Mashaly HM,Gawdat H,Amr K,Hamid MF,Shaalan E

    更新日期:2016-12-01 00:00:00

  • Coincidence of cutaneous follicle center lymphoma and diffuse large B-cell lymphoma.

    abstract::Primary cutaneous follicle center lymphoma (PCFCL) is a neoplasm with differentiation of centrocytes and centroblasts presenting in the skin. At the time of initial manifestation, extracutaneous involvement is absent. PCFCL is considered as an indolent variant of primary cutaneous B-cell lymphomas since dissemination ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: van Tuyll van Serooskerken AM,Mosterd K,Veraart JC,Vermeer MH,Frank J,van Marion AM

    更新日期:2008-11-01 00:00:00

  • Non-melanoma skin cancer and keratoacanthoma in Filipinos: an incidence report from Kauai, Hawaii.

    abstract:BACKGROUND:Non-melanoma skin cancer is the most common malignancy in the white population of the United States with an estimated 700,000 new cases each year. Regrettably, data on minority racial groups are either scarce or lacking entirely. METHODS:This study was designed as a 5-year prospective incidence study of non...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Chuang TY,Reizner GT,Elpern DJ,Stone JL,Farmer ER

    更新日期:1993-10-01 00:00:00

  • Treatment of impetigo and ecthyma. A comparison of sulconazole with miconazole.

    abstract::In a randomized, double-blind, parallel comparative study of 80 patients, impetigo and ecthyma were treated effectively by sulconazole nitrate 1% cream and miconazole nitrate 2% cream applied to lesions twice daily for 14 days. When treatment began, bacterial cultures from all pyodermal lesions yielded Group A beta-he...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nolting S,Strauss WB

    更新日期:1988-12-01 00:00:00

  • Ketoconazole 2% emulsion in the treatment of seborrheic dermatitis.

    abstract::Fifty patients (42 men, 8 women) with seborrheic dermatitis were included in the trial. Ketoconazole 2% emulsion or the same emulsion without active drug was applied b.i.d. for 4 weeks. Two patients dropped out in the ketoconazole group and nine in the placebo group. Pityrosporum ovale was cultured from all patients a...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Piérard GE,Piérard-Franchimont C,Van Cutsem J,Rurangirwa A,Hoppenbrouwers ML,Schrooten P

    更新日期:1991-11-01 00:00:00

  • Seasonal variations in the severity of acne vulgaris.

    abstract:BACKGROUND AND OBJECTIVE:The improvement of acne in summertime or the aggravation of acne in winter is a traditional dermatologic opinion. Ultraviolet rays are thought to be beneficial in the treatment of acne. In the existing literature there is no proof of this. The purpose of this study was to find out whether or no...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Gfesser M,Worret WI

    更新日期:1996-02-01 00:00:00

  • Bullous pemphigoid in childhood: report of three cases and a review of literature.

    abstract::Three proven cases of bullous pemphigoid in childhood which responded to dapsone are reported. The clinical and immunological criteria for diagnosis were similar to those in the aged. This report emphasizes that the condition is a distinctive clinical entity and entirely different from dermatitis herpetiformis and ben...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Piamphongsant T,Chaikittisilpa S,Kullavanijaya P

    更新日期:1977-03-01 00:00:00

  • Cutaneous stigmata associated with insulin resistance and increased cardiovascular risk.

    abstract::Certain cutaneous conditions have been reported to be associated with diabetes mellitus, insulin resistance, and metabolic syndrome. In this novel review paper, the evidence linking various cutaneous phenomena (e.g. skin tags, acanthosis nigricans, ear lobe creases, and xanthelasma) and metabolic syndrome and cardiova...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Schilling WH,Crook MA

    更新日期:2014-09-01 00:00:00

  • Dermatological and epidemiological profile of patients with albinism in Togo in 2019: results of two consultation campaigns.

    abstract:BACKGROUND:People with albinism (PWA) are targets of prejudice and social exclusion and have limited access to specialized medical care and resources. Our study aimed to describe the epidemiological and dermatological profile of PWA in Togo. METHOD:We carried out a cross-sectional study of 294 medical records of PWA s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Saka B,Mouhari-Toure A,Adam S,Mahamadou G,Kassang P,Teclessou JN,Akakpo SA,Gnossikè P,Elegbede Y,Darré T,Kombaté K,Pitché P

    更新日期:2020-09-01 00:00:00

  • Factors affecting patient presentation at a national dermatology referral clinic in Kampala, Uganda.

    abstract:BACKGROUND:This study sought to gain a better understanding of the patient population in Kampala and was further designed to elucidate barriers that may delay individuals from receiving proper dermatologic care. METHODS:The study took place at the dermatovenereology clinic of a tertiary care hospital in Kampala. New a...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Song ES,Musinguzi P,Dieckhaus KD

    更新日期:2017-03-01 00:00:00

  • Live bee acupuncture (Bong-Chim) dermatitis: dermatitis due to live bee acupuncture therapy in Korea.

    abstract::Live bee acupuncture (Bong-Chim) dermatitis is an iatrogenic disease induced by so-called live bee acupuncture therapy, which applies the honeybee (Apis cerana) stinger directly into the lesion to treat various diseases in Korea. We present two cases of live bee acupuncture dermatitis and review previously published a...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Park JS,Lee MJ,Chung KH,Ko DK,Chung H

    更新日期:2013-12-01 00:00:00

  • Adiponectin expression in subcutaneous adipose tissue is reduced in women with cellulite.

    abstract:BACKGROUND:Cellulite, which appears as orange peel-type or cottage cheese-like dimpling of the skin on the thighs and buttocks, is a complex, multifactorial, cosmetic disorder of the subcutaneous fat layer and the overlying superficial skin. Adiponectin is an adipocyte-derived hormone mainly produced by subcutaneous fa...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Emanuele E,Minoretti P,Altabas K,Gaeta E,Altabas V

    更新日期:2011-04-01 00:00:00

  • Pellagra probably due to pyrazinamide: development during combined chemotherapy of tuberculosis.

    abstract::Pellagra secondary to antituberculous chemotherapy can result from isoniazide therapy, as well as from pyrazinamide treatment. Because of the similarity in structural formulas between pyrazinamide, isoniazide, and nicotinamide, the substrate competition is the mechanism most likely involved. The patient was cured by a...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Jørgensen J

    更新日期:1983-01-01 00:00:00

  • Nargile (Hubble-Bubble) smoking-induced hand eczema.

    abstract::A 65-year-old retired man with hand eczema presented to the Dermatology clinic in October of 2001. He complained of scaly, fissured plaque-type lesions over the radial margin of his right index finger and thumb (Fig. 1). He first noticed these changes 2 years ago. There was no history of irritation from his occupation...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Onder M,Oztas M,Arnavut O

    更新日期:2002-11-01 00:00:00

  • Deep mycoses in Amazon region.

    abstract::Patients with deep mycoses diagnosed in dermatologic clinics of Manaus (state of Amazonas, Brazil) were studied from November 1973 to December 1983. They came from the Brazilian states of Amazonas, Pará, Acre, and Rondônia and the Federal Territory of Roraima. All of these regions, with the exception of Pará, are situ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Talhari S,Cunha MG,Schettini AP,Talhari AC

    更新日期:1988-09-01 00:00:00

  • Pseudopelade: an inherited alopecia.

    abstract:BACKGROUND:Pseudopelade is a rare idiopathic progressive alopecia that has no initial inflammatory phase. Even so, pseudopelade has been classified as scarring alopecia with postinflammatory alopecias. Atrophy rather than true scarring is the cardinal feature of pseudopelade. MATERIALS AND METHODS:A review of reported...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sahl WJ

    更新日期:1996-10-01 00:00:00

  • Acitretin-induced subungual hemorrhage.

    abstract::A 20-year-old woman with a 2-year history of histologically confirmed palmoplantar keratoderma due to psoriasis, resistant to several topical agents, was admitted to the Department of Dermatology, Uludag University, Bursa, Turkey. Therapy with oral acitretin (0.5 mg/kg/day, 35 mg/day) was initiated. A month after star...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Aydogan K,Karadogan SK,Tunali S

    更新日期:2007-05-01 00:00:00

  • The diagnostic value of ultrasonography with 5-15-MHz probes in benign subcutaneous lesions.

    abstract:BACKGROUND:Ultrasonography (US) has recently proved to be useful in diagnostic dermatology. It is convenient to use, completely safe, and provides valuable information. OBJECTIVE:This study was performed to compare the diagnostic accuracy of US with that of clinical diagnosis in patients with benign subcutaneous lesio...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Hwang EJ,Yoon HS,Cho S,Park HS

    更新日期:2015-11-01 00:00:00

  • Mycosis fungoides presenting as reticular erythematous mucinosis.

    abstract:BACKGROUND:Mycosis fungoides has numerous clinical presentations. METHODS:We present two cases in which mycosis fungoides clinically mimicked reticular erythematous mucinosis. RESULTS:Both patients had extracutaneous involvement. One had a fatal outcome. CONCLUSIONS:We suggest that full systemic evaluation be perfor...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Twersky JM,Mutasim DF

    更新日期:2006-03-01 00:00:00

  • The combined use of topical benzoyl peroxide and tretinoin in the treatment of acne vulgaris.

    abstract::A clinical trial using tretinoin lotion 0.05%, benzoyl peroxide 5% and 10% as topical application was performed on 250 ambulatory patients suffering from various degrees of acne vulgaris. The results indicate that tretinoin applied in the morning and benzoyl peroxide applied at night is the most efficacious regimen to...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Handojo I

    更新日期:1979-07-01 00:00:00

  • Satellite repigmentation after punch grafting.

    abstract::Punch grafting is an established treatment modality for management of localized, nonprogressive vitiligo resistant to conventional therapies.(1) In our set up, punch grafting is routinely carried out in focal vitiligo, segmental vitiligo and even in few cases of generalized vitiligo, especially when it is a serious co...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Agarwal US,Gulati R,Shukla SR,Mathur N

    更新日期:2004-04-01 00:00:00

  • Etanercept therapy allows the tapering of methotrexate and sustained clinical responses in patients with moderate to severe psoriasis.

    abstract::Methotrexate, the most common systemic small molecule used in the treatment of moderate to severe psoriasis, is associated with significant toxicities and adverse events. Long-term continuous usage is not recommended due to potential liver toxicity, myelosuppression, and other side effects. Abrupt cessation of methotr...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Yamauchi PS,Lowe NJ

    更新日期:2008-02-01 00:00:00

  • Epidemiological and clinical patterns of genital lesions.

    abstract::A 5-year study of 668 patients with genital lesions revealed that teenagers and those in the age group of 20 to 40 are most vunerable. The poor, the uneducated and unmarried persons are at high risk. Chancroid and syphilis are the majority of cases. Inguinal bubo, herpes pregenitalis, condylomata acuminata, erosive ba...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sehgal VN,Rege VL,Sehgal N,Kharangate VN,Mascarenhas MF

    更新日期:1976-10-01 00:00:00

  • Successful treatment of a patient with recurrent furunculosis by vitamin C: improvement of clinical course and of impaired neutrophil functions.

    abstract:BACKGROUND:Neutrophils play a critical role in host defense against a variety of microbial pathogens. There is much information to suggest a role for vitamin C in the physiology of neutrophils. Thus, the effects of vitamin C treatment were studied in a patient with a history of recurrent furunculosis who showed altered...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Levy R,Schlaeffer F

    更新日期:1993-11-01 00:00:00

  • Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients.

    abstract:BACKGROUND:Vitiligo is a hypopigmentation disease characterized by achromatic or hypochromatic macules in several sites of human skin. Although monochromatic excimer light (MEL) and narrowband-ultraviolet B (NB-UVB) have recently been used for efficacious treatment of vitiligo, the repigmentation process and role of me...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Hirobe T,Enami H

    更新日期:2019-02-01 00:00:00

  • Sequence variants in nine different genes underlying rare skin disorders in 10 consanguineous families.

    abstract:BACKGROUND:Genodermatoses represent genetic anomalies of skin tissues including hair follicles, sebaceous glands, eccrine glands, nails, and teeth. Ten consanguineous families segregating various genodermatosis phenotypes were investigated in the present study. METHODS:Homozygosity mapping, exome, and Sanger sequencin...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Shah K,Mehmood S,Jan A,Abbe I,Hussain Ali R,Khan A,Chishti MS,Lee K,Ahmad F,Ansar M,University of Washington Center for Mendelian Genomics.,Shahzad S,Nickerson DA,Bamshad MJ,Coucke PJ,Santos-Cortez RLP,Spritz RA,Leal SM

    更新日期:2017-12-01 00:00:00

  • Serum angiopoietin-2 level as a novel biomarker in atopic dermatitis.

    abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease. Angiopoietin is an intrinsic mediator induced by T helper 2 cytokines and has been reported it to play a critical role in the pathogenesis of AD. OBJECTIVES:To determine the relationship between circulating angiopoietin-2 (Ang-2) in AD...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Khattab FM,Said NM

    更新日期:2019-11-04 00:00:00