Abstract：
BACKGROUND:This is the first epidemiologic study of pemphigus in the southern region of Saudi Arabia. METHODS:Data were collected from patient records in the outpatient and inpatient departments of Asir Central Hospital during the period 1990-99. The diagnosis of pemphigus was based on the clinical, histopathologic, and direct immunofluorescence patterns which were consistent with pemphigus. RESULTS:The results showed that the mean incidence of the disease in the general population was 0.16/100 000; the mean incidence of the disease in the population above 20 years of age was 0.27/100 000. The prevalence of the disease at the end of the study period was 1.56/100 000 for the total population, and 2.7/100 000 for the population above 20 years of age. The male to female ratio was 2.2 : 1. The age of onset of the disease ranged from 23 to 67 years, except for one case at an age of 9 years, giving an average of 43.1 +/- 13.4 years and a median of 40 years. Pemphigus vulgaris was the most commonly encountered type, followed by pemphigus erythematosus (94.7% and 5.3%, respectively). Mucosal involvement occurred in 84.2% of cases. No association with neoplasia was found in the current study. CONCLUSIONS:Pemphigus in the southern region of Saudi Arabia is as common as in other parts of the world, but with higher mucosal involvement.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Tallab T,Joharji H,Bahamdan K,Karkashan E,Mourad M,Ibrahim Kdoi
10.1046/j.1365-4362.2001.01247.xsubject
Has Abstractpub_date
2001-09-01 00:00:00pages
570-2issue
9eissn
0011-9059issn
1365-4632pii
1247journal_volume
40pub_type
杂志文章abstract：:There is some debate regarding the risk of developing malignancy and progression of malignancy in patients with psoriasis treated with biologics. The lack of extensive, long-term, and large studies, including patients with psoriasis, to assess these aforementioned risks makes it difficult to ascertain the safety profi...
journal_title：International journal of dermatology
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