Abstract:
:Gardner-Diamond syndrome (GDS) is a rare psychodermatological condition characterized by the formation of spontaneous, painful skin lesions that develop into ecchymosis following episodes of severe physiological or psychological stress. The majority of GDS cases occur in young adult females, and although the etiology of this rare disorder is unknown, there appears to be a psychological component correlated with the coexistence of previous psychiatric diagnoses. Due to the rare nature of this disorder, there exist few guidelines for prompt clinical diagnosis and optimal treatment. Here, a systematic review was conducted to include 45 cases of patients with GDS to better understand clinical presentation as well as current treatment options. Ultimately, GDS is a diagnosis of exclusion after other coagulopathies and causes of purpura are ruled out. High clinical suspicion following laboratory and clinical exclusion of known physiological causes is necessary for diagnosis. Selective serotonin reuptake inhibitors (SSRIs) and corticosteroids are cost effective first line treatments for GDS with proven efficacy in symptomatic relief. GDS refractory to initial treatment may require regular psychotherapy and titrated SSRI dosages to achieve long-term success. This review of available case studies serves to comprehensively describe the clinical presentation and available treatment approaches to this rare psychodermatological disorder.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Block ME,Sitenga JL,Lehrer M,Silberstein PTdoi
10.1111/ijd.14235subject
Has Abstractpub_date
2019-07-01 00:00:00pages
782-787issue
7eissn
0011-9059issn
1365-4632journal_volume
58pub_type
杂志文章abstract:BACKGROUND:There is some evidence that basal cell carcinomas (BCCs) arising on different anatomic sites and developing to different histological subtypes differ in their pathophysiology. The expression of a number of proteins, including PTCH1, COX-2, p53, and Ki-67, is frequently altered in BCC development. OBJECTIVES...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13276
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Psoriasis is a common Th1-mediated skin disease whose etiology remains obscure. Loss of sweating caused by retention hyperkeratosis is seen in psoriasis plaques, which is likely to have resulted from autonomic dysfunction. OBJECTIVE:In the present study, we aimed to evaluate autonomic nervous system (ANS) f...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05111.x
更新日期:2012-05-01 00:00:00
abstract::Despite an array of topical and systemic antifungal agents, cases of resistant dermatophytosis still exist. Use of naftifine, the first commercially available allylamine derivative, proved successful in the management of four such cases. ...
journal_title:International journal of dermatology
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doi:10.1111/j.1365-4362.1991.tb02649.x
更新日期:1991-08-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
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更新日期:1994-08-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:International journal of dermatology
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doi:10.1111/j.1365-4632.2007.03272.x
更新日期:2007-07-01 00:00:00
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journal_title:International journal of dermatology
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doi:10.1111/j.1365-4632.2005.02086.x
更新日期:2005-04-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13493
更新日期:2017-06-01 00:00:00
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journal_title:International journal of dermatology
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journal_title:International journal of dermatology
pub_type: 杂志文章,评审
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更新日期:2010-10-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2006.02775.x
更新日期:2006-07-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1978.tb05977.x
更新日期:1978-12-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01789.x
更新日期:2003-04-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4362.1975.tb01428.x
更新日期:1975-03-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1998.00401.x
更新日期:1998-11-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.15303
更新日期:2020-11-23 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13050
更新日期:2016-02-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1991.tb04793.x
更新日期:1991-11-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2007.03201.x
更新日期:2007-10-01 00:00:00
abstract::Vitiligo is one of the most important skin disorders that does not cause much physical impairment, but due to its disfiguring appearance, patients have disturbances in mental health and quality of life (QoL). The dermatology life quality index (DLQI), as one of the most specific QoL instruments, is now used widely for...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.13198
更新日期:2016-06-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02109.x
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Psoriasis is a chronic debilitating disease affecting approximately one million Canadians. The objective of this study is to estimate the economic burden in $CDN (2008) of moderate to severe plaque psoriasis among Canadian adults. METHODS:Using a cross-sectional design, direct resource use, costs, lost prod...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05359.x
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:The use of lasers is very common in dermatology; however, many patients fear it and have various misconceptions about it. A literature search failed to show any studies on this topic. OBJECTIVE:To explore the various misconceptions of patients about lasers in dermatology. METHODS:A self-administered questi...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05028.x
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pub_type: 杂志文章
doi:10.1111/j.1365-4362.1996.tb00644.x
更新日期:1996-10-01 00:00:00
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journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.04875.x
更新日期:2011-09-01 00:00:00
abstract::Twenty-nine patients who had decubitus ulcers and a variety of underlying diseases had good responses to the use of the Clinitron Bed, an air-fluidized system. More research is needed to determine its place in dermatologic care. ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1980.tb00379.x
更新日期:1980-11-01 00:00:00
abstract::Many dermatological disorders have a psychosomatic or behavioral aspect. Skin and brain continually interact through psychoneuroimmunoendocrine mechanisms and through behaviors that can strongly affect the initiation or flaring of skin disorders. It is important to consider these mind-body interactions when planning t...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2011.05096.x
更新日期:2011-11-01 00:00:00