Levocetirizine is an effective treatment in patients suffering from chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled, parallel, multicenter study.

Abstract:

BACKGROUND:Chronic idiopathic urticaria (CIU) is defined by the almost daily presence of urticaria for at least 6 weeks without an identifiable cause. Symptoms include short-lived wheals, itching, and erythema. CIU impedes significantly a patient's quality of life (QoL). Levocetirizine is an antihistamine from the latest generation approved for CIU. AIM:To investigate the efficacy of levocetirizine, 5 mg, and placebo for the symptoms and signs of CIU, as well as for the QoL and productivity. METHODS:The primary criteria of evaluation were the pruritus severity scores over 1 week of treatment and over 4 weeks. The QoL was assessed via the Dermatology Life Quality Index (DLQI). RESULTS:Baseline pruritus severity scores were comparable in the two treatment groups (2.06+/-0.58). After 1 week, levocetirizine was superior to placebo and demonstrated a considerable efficacy (difference=0.78, P<0.001). This efficacy was maintained over the entire study period (4 weeks, P<0.001). The number and size of wheals were considerably reduced compared with placebo over 1 week and over the total treatment period (P

journal_name

Int J Dermatol

authors

Kapp A,Pichler WJ

doi

10.1111/j.1365-4632.2005.02609.x

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

469-74

issue

4

eissn

0011-9059

issn

1365-4632

pii

IJD2609

journal_volume

45

pub_type

杂志文章,多中心研究,随机对照试验
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    abstract:BACKGROUND:The Israel Defense Forces (IDF) medical records offer a unique and valid 28-year view of the striking differences in cutaneous leishmaniasis (CL) seasonality patterns and incidence rates between the military and civilian sectors in Israel. AIM:To determine the annual epidemiology and seasonality trends of C...

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    doi:10.1111/j.1365-4632.2009.03979.x

    authors: Mimouni D,Balicer RD,Levine H,Klement E,Bar-Zeev Y,Davidovitch N,Zarka S

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  • The prevalence of pediculosis capitis in schoolchildren in Mersin, Turkey.

    abstract:BACKGROUND:Pediculosis capitis is an endemic parasitosis affecting many countries of the world. The aim of this study was to investigate the incidence of head lice infestation in Mersin, Turkey. METHODS:A total of 5318 elementary schoolchildren, aged 8-16 years, were examined for the presence of Pediculus capitis. If ...

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    doi:10.1046/j.1365-4362.2003.01836.x

    authors: Kokturk A,Baz K,Bugdayci R,Sasmaz T,Tursen U,Kaya TI,Ikizoglu G

    更新日期:2003-09-01 00:00:00

  • Role of vascular endothelial growth factor in keloids: a clinicopathologic study.

    abstract:BACKGROUND:Despite their benign nature, keloids are usually associated with considerable cosmetic effects and may lead to functional problems. Recently, it has been reported that vascular endothelial growth factor (VEGF), a potent angiogenic factor, is overexpressed in keloid tissue and may have a potential role in its...

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    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2009.04143.x

    authors: Salem A,Assaf M,Helmy A,Nofal A,Ibrahim S,Eldeeb F,Youssef C

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  • Vaccinations in the presence of skin diseases.

    abstract::The authors collected data from the literature and from experts on the subject of vaccination of patients with dermatologic disorders. They assembled these data into categories of specific skin conditions and vaccinations. These data may be used in deciding whether or not to vaccinate, and at which stage of the dermat...

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    authors: Weber G,Falk U

    更新日期:1975-03-01 00:00:00

  • Pityriasis in dermatology: an updated review.

    abstract::Dermatology has a very distinctive lexicon. The term pityriasis refers to several dermatologic conditions which all feature scaling of the skin. According to the Merriam-Webster dictionary, the term pityriasis was first used in print in 1684. Although the diseases beginning with the name pityriasis are of diverse caus...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ijd.15097

    authors: Chin LD,Parvinnejad N,Haber RM

    更新日期:2020-08-11 00:00:00

  • Treatment of axillary hyperhidrosis with botulinum-A toxin.

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    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-4362.2002.01448.x

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    更新日期:2002-07-01 00:00:00

  • Specific causes of death in patients with bullous pemphigoid as measured by death certificate data: a retrospective cohort study.

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    doi:10.1111/ijd.12243

    authors: Barrick BJ,Lohse CM,Lehman JS

    更新日期:2015-01-01 00:00:00

  • Dermatologists' level of compliance with the prescription guidelines of isotretinoin for females of childbearing potential.

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    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4632.2011.04875.x

    authors: AlGhamdi KM,Khurram H,Asiri YA,Mandil A

    更新日期:2011-09-01 00:00:00

  • Conservative thickness layers in Mohs micrographic surgery.

    abstract:BACKGROUND:Mohs micrographic surgery (MMS) is used to treat cutaneous malignancies in locations to maximize tissue sparing. The authors' aim is to demonstrate the utility of conservative thickness layers (CTL) in MMS and review patient and tumor characteristics and the potential anatomic locations where this technique ...

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    pub_type: 杂志文章

    doi:10.1111/ijd.14043

    authors: Tolkachjov SN,Cappel JA,Bryant EA,Harmon CB

    更新日期:2018-09-01 00:00:00

  • Testicular and epididymal involvement in leprosy patients, with special reference to gynecomastia.

    abstract::Sixty-six male patients with leprosy were studied. Only those with the lepromatous type developed testicular and epididymal changes. Nine of the 38 patients showed decreased sexual function, and 7 developed gynecomastia. These changes were believed to be due to the altered gonadal state. ...

    journal_title:International journal of dermatology

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    authors: El-Shiemy S,El-Hefnawi H,Abdel-Fattah A,El-Okbi M,Farid A

    更新日期:1976-01-01 00:00:00

  • Onchocerciasis: clinical presentation and host parasite interactions in patients of southern Sudan.

    abstract:BACKGROUND:Onchocerciasis, an infection by the filarial nematode Onchoverca volvulus, is widely distributed in tropical Africa and of great dermatologic interest. This study analyses the dermatologic presentation and tries to determine the correlations between clinical disease and host parasite interactions in onchocer...

    journal_title:International journal of dermatology

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    doi:10.1046/j.1365-4362.1997.00007.x

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  • Effects of vitamin C vs. multivitamin on melanogenesis: comparative study in vitro and in vivo.

    abstract:BACKGROUND:Vitamin C has been used for the treatment of hyperpigmented diseases. However, there is no study available on hypopigmenting effect of multivitamin. OBJECTIVES:To investigate the inhibitory effects of multivitamin and vitamin C on melanogenesis. METHODS:We assessed the effect of multivitamin and vitamin C ...

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    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-4632.2009.04336.x

    authors: Choi YK,Rho YK,Yoo KH,Lim YY,Li K,Kim BJ,Seo SJ,Kim MN,Hong CK,Kim DS

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  • Treatment of psoriasis with topical nitrogen mustard.

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    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1979.tb05017.x

    authors: Handler RM,Medansky RS

    更新日期:1979-11-01 00:00:00

  • Dermatologic sequelae of breast cancer: From disease, surgery, and radiation.

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    pub_type: 杂志文章,评审

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    更新日期:2020-11-23 00:00:00

  • Curative effect of dexamethasone-cyclophosphamide pulse therapy for the treatment of pemphigus vulgaris.

    abstract::In 1982, five patients having pemphigus vulgaris, four men and one woman, ranging in age between 16 and 48 years, were treated with an arbitrary regimen designed by us. The regimen consisted of giving 100 mg dexamethasone in 500 mL of 5% glucose by a slow intravenous infusion on three consecutive days, along with 500 ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1992.tb03549.x

    authors: Pasricha JS,Das SS

    更新日期:1992-12-01 00:00:00

  • Molluscum contagiosum in Greek children: a case series.

    abstract:BACKGROUND:Epidemiological studies of molluscum contagiosum (MC) in children are limited. PATIENTS AND METHOD:Between 1997 and 1999, 110 children with MC (60 boys, 50 girls, mean age: 4.8 years) were studied. Treatment consisted of removal of all MC lesions in a single session by sterilized tweezers. RESULTS:In child...

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    pub_type: 杂志文章

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    更新日期:2005-03-01 00:00:00

  • Adiponectin expression in subcutaneous adipose tissue is reduced in women with cellulite.

    abstract:BACKGROUND:Cellulite, which appears as orange peel-type or cottage cheese-like dimpling of the skin on the thighs and buttocks, is a complex, multifactorial, cosmetic disorder of the subcutaneous fat layer and the overlying superficial skin. Adiponectin is an adipocyte-derived hormone mainly produced by subcutaneous fa...

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    pub_type: 杂志文章

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    更新日期:2011-04-01 00:00:00

  • Hemostasis and platelet aggregation in purpuric pigmented angiodermatitis eruptions.

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  • Purpura annularis telangiectodes of Majocchi: case report and review of the literature.

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    更新日期:2009-10-01 00:00:00

  • Polymerase chain reaction in cutaneous tuberculosis: is it a reliable diagnostic method in paraffin-embedded tissues?

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    更新日期:2002-12-01 00:00:00

  • Exacerbations of oral lichen planus and elevated levels of aminotransferases.

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    更新日期:2017-08-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2019-03-01 00:00:00

  • Dermatofibrosarcoma protuberans.

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    pub_type: 杂志文章

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    更新日期:1995-04-01 00:00:00

  • IgA dermatosis in an adult Chinese population. A 10-year study of linear IgA and dermatitis herpetiformis in Singapore.

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  • Skin manifestations in patients hospitalized with confirmed COVID-19 disease: a cross-sectional study in a tertiary hospital.

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    pub_type: 杂志文章

    doi:10.1111/j.1365-4362.1990.tb04755.x

    authors: Dompmartin D,Dompmartin A,Deluol AM,Grosshans E,Coulaud JP

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    pub_type: 杂志文章

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    authors: Claro G,Meyer N,Meresse T,Gangloff D,Grolleau JL,Chaput B

    更新日期:2018-04-01 00:00:00

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    doi:10.1111/j.1365-4362.1991.tb03483.x

    authors: Jimbow K,Jewell LD

    更新日期:1991-09-01 00:00:00