Clinical use of conditioned media of adipose tissue-derived stem cells in female pattern hair loss: a retrospective case series study.


BACKGROUND:Female pattern hair loss (FPHL) is a common disorder but presents severe psychosocial problems in many female patients. Adipose tissue-derived stem cells (ADSCs) and conditioned media of ADSCs (ADSC-CM) are reported to promote hair growth in vitro. However, there are no clinical reports on the treatment of alopecia using ADSC-CM. OBJECTIVES:This study evaluates our clinical experience in the use of ADSC-CM for the treatment of FPHL. METHODS:A retrospective, observational study of outcomes in 27 patients with FPHL treated with ADSC-CM was performed. To evaluate the efficacy of the treatment, patients' medical records and phototrichographic images were analyzed. RESULTS:The application of ADSC-CM showed efficacy in treating FPHL after 12 weeks of therapy. Hair density increased from 105.4 to 122.7 hairs/cm(2) (P < 0.001). Hair thickness increased from 57.5 μm to 64.0 μm (P < 0.001). None of the patients reported severe adverse reactions. CONCLUSIONS:The application of ADSC-CM is a potential treatment option for FPHL.


Int J Dermatol


Shin H,Ryu HH,Kwon O,Park BS,Jo SJ




Has Abstract


2015-06-01 00:00:00












  • Pheohyphomycosis caused by Exophiala spinifera: a rare occurrence.

    abstract::A 10-year-old immunocompetent boy presented with multiple, verrucous, disseminated pheohyphomycotic lesions caused by Exophiala spinifera. The patient was not responsive to combination antifungal therapy (itraconazole, terbinafine, fluconazole) and cryotherapy. As antifungal susceptibility is known to be variable for ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Singal A,Pandhi D,Bhattacharya SN,Das S,Aggarwal S,Mishra K

    更新日期:2008-01-01 00:00:00

  • Dowling-Degos disease: a review.

    abstract::Dowling-Degos disease is a rare autosomal dominant genodermatosis. It is characterized by acquired reticulate hyperpigmentation over the flexures, comedone-like follicular papules, and pitted perioral scars that usually develop during adulthood. Mutations in genes affecting melanosome transfer, and melanocyte and kera...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Stephan C,Kurban M,Abbas O

    更新日期:2020-12-23 00:00:00

  • Dermatologic infestations.

    abstract::Head lice are transmitted by head to head contact. Optimal therapy includes malathion lotion 0.5% repeated in one week left on for 30 minutes to 8 hours. Spinosad topical suspension 0.9% repeated in one week left on for 10 minutes is another option. Scabies is transmitted mainly by direct contact but also via heavily ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Shmidt E,Levitt J

    更新日期:2012-02-01 00:00:00

  • Cutaneous manifestations of marantic endocarditis.

    abstract::A 70-year-old patient with a history of hypertension and hypercholesterolemia was referred for evaluation of necrotic toes. The patient had a history of several cerebrovascular accidents during the previous month. Initially, she developed sudden-onset left upper extremity weakness which, over the ensuing 4 days, progr...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Kimyai-Asadi A,Usman A,Milani F

    更新日期:2000-04-01 00:00:00

  • Hair loss in children in South-East Nigeria: common and uncommon cases.

    abstract:BACKGROUND:The cosmetic importance of hair as a unique structure of the scalp is immense, such that once the loss of hair becomes an issue for a child, parents, in most cases, project their own concerns, often expressed as guilt. The clinical presentation of hair loss and scalp disorders in children varies widely, ofte...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Nnoruka EN,Obiagboso I,Maduechesi C

    更新日期:2007-10-01 00:00:00

  • The CARE approach to reducing diagnostic errors.

    abstract:BACKGROUND:Diagnostic errors appear to be the most common, costly, and dangerous of all medical mistakes. There has been a notable increase on the focus of error prevention as part of a growing patient safety movement. However, diagnostic errors have received less attention than other types of error. Our goal is to pre...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Rush JL,Helms SE,Mostow EN

    更新日期:2017-06-01 00:00:00

  • Clear cell acanthoma: a rare clinical diagnosis prior to biopsy.

    abstract:BACKGROUND:Clear cell acanthoma is a rare, benign epidermal tumor with a clinical hybrid appearance and a distinct histological one. It is frequently mistaken for other clinical lesions. OBJECTIVE:To evaluate the frequency that clear cell acanthoma was listed in the clinical differential diagnosis of histologically co...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Morrison LK,Duffey M,Janik M,Shamma HN

    更新日期:2010-09-01 00:00:00

  • Erythroderma in adults: a report of 80 cases.

    abstract:BACKGROUND:Erythroderma is a generalized erythema of the skin accompanied by a variable degree of scaling. However, most of the published series originate from Western countries. There is only one report from Africa, conducted in Dakar in 1979. The aim of our study was to provide information about this condition in our...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Rym BM,Mourad M,Bechir Z,Dalenda E,Faika C,Iadh AM,Amel BO

    更新日期:2005-09-01 00:00:00

  • The insecticidal activity of four medicinal plants against the blowfly Lucilia sericata (Diptera: Calliphoridae).

    abstract:BACKGROUND:The larvae of Lucilia sericata induce myiasis and transmit mycobacterial infections to humans and animals. Consequently, the blowfly should be controlled for human welfare and economic reasons. METHODS:The insecticidal effect of fenugreek (Trigonella foenum-graecum), celery (Apium graveolens), radish (Rapha...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Khater HF,Khater DF

    更新日期:2009-05-01 00:00:00

  • Coexisting subacute and systemic lupus erythematosus after terbinafine administration: successful treatment with mycophenolate mofetil.

    abstract::A 39-year-old female patient with systemic lupus erythematosus was treated with terbinafine for onychomycosis. After only 7 days of treatment with 250 mg terbinafine, a widespread severe erythematous eruption developed. The results of clinical, histological and immunofluorescent examinations confirmed the diagnosis of...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Cetkovská P,Pizinger K

    更新日期:2006-03-01 00:00:00

  • The incidence of pemphigus in the southern region of Saudi Arabia.

    abstract:BACKGROUND:This is the first epidemiologic study of pemphigus in the southern region of Saudi Arabia. METHODS:Data were collected from patient records in the outpatient and inpatient departments of Asir Central Hospital during the period 1990-99. The diagnosis of pemphigus was based on the clinical, histopathologic, a...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Tallab T,Joharji H,Bahamdan K,Karkashan E,Mourad M,Ibrahim K

    更新日期:2001-09-01 00:00:00

  • Evaluation of the correlation between serum levels of vitamin D and vitamin D receptor gene polymorphisms in an Egyptian population.

    abstract:BACKGROUND:Vitiligo is an autoimmune depigmentation disorder. Polymorphisms in the vitamin D receptor (VDR) have been found to be associated with vitiligo. OBJECTIVES:To evaluate the potential association between VDR gene polymorphisms (ApaI, TaqI, and FokI) and vitiligo susceptibility, and to detect if there is corre...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Sobeih S,Mashaly HM,Gawdat H,Amr K,Hamid MF,Shaalan E

    更新日期:2016-12-01 00:00:00

  • Morphologic observations on the dermal nerves in vitiligo: an ultrastructural study.

    abstract:BACKGROUND:Vitiligo is a common idiopathic skin disorder. The etiology is unknown, although various hypotheses have been advanced. These include the neuronal hypothesis, where neuronal factors are thought to play a role in the pathogenesis of this disease. METHODS:Skin biopsies were taken from marginal and central par...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Al'Abadie MS,Warren MA,Bleehen SS,Gawkrodger DJ

    更新日期:1995-12-01 00:00:00

  • Familial anetoderma.

    abstract::A 31-year-old Caucasian male presented with a history of erythematous, saccular outpouchings of the skin on his back, shoulders, and upper extremities (Fig. 1). The patient reported that his mother and aunt had a similar skin disorder, which initially began with inflammation, but healed leaving lax skin in its wake. H...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Thomas JE,Mehregan DR,Holland J,Mehregan DA

    更新日期:2003-01-01 00:00:00

  • Prevention of post-herpetic neuralgia. Evaluation of treatment with oral prednisone, oral acyclovir, and radiotherapy.

    abstract::The effects of prednisone, oral acyclovir, and radiotherapy were compared with placebo in the prevention of post-herpetic neuralgia. No treatment used was able to prevent, with statistical significance, post-herpetic neuralgia, although prednisone and acyclovir showed some pain reduction in the acute phase. Radiothera...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Benoldi D,Mirizzi S,Zucchi A,Allegra F

    更新日期:1991-04-01 00:00:00

  • Prospective trial of curettage and cryosurgery in the management of non-facial, superficial, and minimally invasive basal and squamous cell carcinoma.

    abstract:BACKGROUND:As a variation of the curettage and destruction technique, cryosurgery can be used in place of electrodesiccation for the destructive component when managing superficial basal and squamous cell carcinomas. There are few studies, though, demonstrating the long-term cure rate associated with similar methods. T...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Peikert JM

    更新日期:2011-09-01 00:00:00

  • Iron, copper, and zinc concentrations in normal skin and in various nonmalignant and malignant lesions.

    abstract::The concentrations of zinc (Zn), copper (Cu), and iron (Fe) in the skin have been noninvasively determined in vivo by diagnostic x-ray spectrometry. The skin of healthy controls was divided into two major groups based upon the distribution of the concentrations of these elements. In the face and upper neck, the follow...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Gorodetsky R,Sheskin J,Weinreb A

    更新日期:1986-09-01 00:00:00

  • Leiomyosarcoma of the skin: review of the literature with an emphasis on prognosis and management.

    abstract::Leiomyosarcoma (LMS) of the skin is rare, and no management guideline currently exists. Although LMS is historically classified as either dermal (cutaneous) or subcutaneous, definition for its classfication is inconsistent in the literature. Studies on the managenent of LMS are scarce, and there is no consensus on the...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Kazlouskaya V,Lai YC,Khachemoune A

    更新日期:2020-02-01 00:00:00

  • Oral lichen planus and HCV infection: a clinical evaluation of 263 cases.

    abstract:BACKGROUND:Hepatitis C virus (HCV) infection induces variable dermatologic manifestations. Our purpose was to determine whether there is an association between HCV infection and oral lichen planus (OLP). METHODS:Antibodies to HCV were determined in patients with OLP (263 patients; 156 women and 107 men, with a mean ag...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Mignogna MD,Lo Muzio L,Favia G,Mignogna RE,Carbone R,Bucci E

    更新日期:1998-08-01 00:00:00

  • Tachyphylaxis to topical steroid measured by histamine-induced wheal suppression.

    abstract::Ten healthy volunteers were studied to find out whether tachyphylaxis occurs on repeated application of topical steroids. The Singh and Singh modification of the Reddy and Singh (1976) technique was used. Fluocinolone acetonide cream (0.1%) under occlusion was applied daily for 14 days on the flexor aspect of the fore...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Singh G,Singh PK

    更新日期:1986-06-01 00:00:00

  • Acupuncture in dermatology: an historical perspective.

    abstract::Classical acupuncture focuses primarily on treating the person, and secondarily treating the illness. The "symptoms" are regarded as "branch" expressions of a "root" (constitutional) imbalance. Different root imbalances can produce the same symptoms. Five patients with eczema, for example, may reveal five distinct roo...

    journal_title:International journal of dermatology

    pub_type: 历史文章,杂志文章


    authors: Tan EK,Millington GW,Levell NJ

    更新日期:2009-06-01 00:00:00

  • Malignant melanoma in World War II veterans.

    abstract::In a consecutive series of 1,067 patients entered into the data base of the Melanoma Cooperative Group at New York University School of Medicine between 1972 and 1980, 120 men were of draft age (18-31 years) during World War II (1941-1945). Questionnaires were sent to these 120 individuals; 89 responded. Simultaneousl...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Brown J,Kopf AW,Rigel DS,Friedman RJ

    更新日期:1984-12-01 00:00:00

  • Papulonecrotic tuberculid secondary to disseminated Mycobacterium avium complex.

    abstract:BACKGROUND:Papulonecrotic tuberculid is a rarely reported cutaneous reaction to the mycobacterium bacillus. It is most often encountered in association with tuberculosis. The clinical and histologic picture of the entity is a distinctive one, but the etiology of the disease process is uncertain. Therapy directed agains...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Williams JT,Pulitzer DR,DeVillez RL

    更新日期:1994-02-01 00:00:00

  • Immunohistochemical analysis of FOXP3+ regulatory T cells in healthy human skin and autoimmune dermatoses.

    abstract:BACKGROUND:Regulatory T cells (Tregs) play an important role in autoimmune diseases. In skin, the presence of Tregs is thought to be mandatory for suppression of autoreactive T cells. Here, we assess the number of Tregs in skin of healthy subjects and patients with an autoimmune dermatosis. METHODS:Immunohistochemical...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Terras S,Gambichler T,Moritz RK,Altmeyer P,Lambert J

    更新日期:2014-03-01 00:00:00

  • Diagnostic evaluation of the lupus band test in discoid and systemic lupus erythematosus.

    abstract:BACKGROUND:The usefulness of the lupus band test (LBT) in the diagnosis of cutaneous lupus erythematosus remains controversial. The study was done to determine the sensitivity, specificity, and predictive value of the LBT in discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE). METHODS:During the s...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: George R,Kurian S,Jacob M,Thomas K

    更新日期:1995-03-01 00:00:00

  • Cephalic pyoderma gangrenosum (PG)-like lesions as a presenting sign of Wegener's granulomatosis.

    abstract:BACKGROUND:Pyoderma gangrenosum (PG)-like lesions can be associated with Wegener's granulomatosis (WG); in rare instances, they could be the presenting sign of WG. The purpose of this study was to elucidate the relationship between these two disorders. METHODS:The clinical and histologic data from a case of WG with pr...

    journal_title:International journal of dermatology

    pub_type: 杂志文章,评审


    authors: Micali G,Cook B,Ronan S,Yadgir J,Solomon LM

    更新日期:1994-07-01 00:00:00

  • A comparative clinical evaluation of trimethylpsoralen, psoralen and 8-methoxypsoralen in treating vitiligo.

    abstract::Trimethylpsoralen, psoralen and 8-methoxypsoralen were adminstered in 10 mg dosage orally to 37, 29 and 23 patients with vitiligo. Complete improvement was noted in 8.9% and partial improvement was recorded in 59.5%. The overall results produced by trimethylpsoralen and psoralen were superior to those of 8-methoxyps...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章


    authors: Sehgal VN

    更新日期:1975-04-01 00:00:00

  • Most common patterns of acne in male adolescents: a population-based study.

    abstract:BACKGROUND:Acne vulgaris is a common skin disease affecting more than 85% of adolescents and often continuing into adulthood. Population-based studies to assess the patterns and severity of acne have not been achieved. OBJECTIVES:The aim of this study was to assess the most common patterns of facial and trunk acne in ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Duquia RP,de Almeida HL Jr,Breunig JA,Souzat PR,Göellner CD

    更新日期:2013-05-01 00:00:00

  • Hepatitis C virus and lichen planus in Nigerians: any relationship?

    abstract:BACKGROUND:The association of lichen planus with Hepatitis C virus (HCV) has been widely reported in the literature. No such association, however, has been reported amongst black Africans in whom HCV is thought to be endemic. Lichen planus is a frequently encountered dermatosis in this racial group as well. The aim of ...

    journal_title:International journal of dermatology

    pub_type: 杂志文章


    authors: Daramola OO,George AO,Ogunbiyi AO

    更新日期:2002-04-01 00:00:00

  • Immunochemotherapy for cutaneous leishmaniasis: a controlled trial using killed Leishmania (Leishmania) amazonensis vaccine plus antimonial.

    abstract:BACKGROUND:Leishmaniasis is endemic in 88 countries in the world, and 350 million individuals are at risk of acquiring the disease. Treatment for American cutaneous leishmaniasis (ACL) is long, expensive, and associated with important side-effects. METHODS:In this double-blind, placebo-controlled study, we treated 102...

    journal_title:International journal of dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Machado-Pinto J,Pinto J,da Costa CA,Genaro O,Marques MJ,Modabber F,Mayrink W

    更新日期:2002-02-01 00:00:00