Abstract:
BACKGROUND:Edema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (rHuPH20) is a human hyaluronidase that acts transiently and locally to depolymerize HA. A non-liposomal gel formulation that provides a sustained release of rHuPH20 was tested in vivo in a preclinical murine model of acquired lymphedema. METHODS:Lymphedemic mice were injected 24 hours before surgery, and at 2 and 12 days following surgery with rHuPH20 sustained release gel (PH20 SR gel). Quantitative assessment of treatment response indicated that a single dose of PH20 SR gel resulted in accelerated resolution and reduced severity of post-surgical edema as compared to the gel vehicle (control). RESULTS:Statistically significant enzymatic degradation of HA was demonstrated up to 5 mm from the injection site, and histological analysis confirmed removal of HA up to 72 hours following PH20 SR gel administration. CONCLUSIONS:These results demonstrate sustained hyaluronidase enzymatic activity that promotes diffusion of accumulated post-surgical edematous fluid, suggesting that PH20 SR gel may be a useful adjuvant in promoting postoperative edema resolution.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Nekoroski T,Paladini RD,Sauder DN,Frost GI,Keller GAdoi
10.1111/ijd.12304subject
Has Abstractpub_date
2014-06-01 00:00:00pages
777-85issue
6eissn
0011-9059issn
1365-4632journal_volume
53pub_type
杂志文章abstract::The calcipotriene/betamethasone dipropionate two-compound scalp formulation has been shown to be safe and effective in the treatment of scalp psoriasis over 8 weeks, but the patients studied were mainly White and non-Hispanic. The aim of this study was to evaluate the efficacy and safety of the two-compound scalp form...
journal_title:International journal of dermatology
pub_type: 杂志文章,随机对照试验
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abstract::Cutaneous fibrinolytic activity was found to be increased in a patient with aquagenic pruritus both before and after contact with water. This could explain the lack of wheal formation in this affection, which is characterized by increased histamine release. ...
journal_title:International journal of dermatology
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journal_title:International journal of dermatology
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doi:10.1111/j.1365-4362.1993.tb04268.x
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journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
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journal_title:International journal of dermatology
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doi:10.1111/j.1365-4362.1995.tb01591.x
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journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4362.1990.tb04080.x
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