Etanercept therapy allows the tapering of methotrexate and sustained clinical responses in patients with moderate to severe psoriasis.

Abstract:

:Methotrexate, the most common systemic small molecule used in the treatment of moderate to severe psoriasis, is associated with significant toxicities and adverse events. Long-term continuous usage is not recommended due to potential liver toxicity, myelosuppression, and other side effects. Abrupt cessation of methotrexate without tapering can lead to flare-up and rebound of psoriasis. Here we describe sustained clinical responses in 6 patients with psoriasis following gradual cessation of methotrexate through the addition of etanercept therapy.

journal_name

Int J Dermatol

authors

Yamauchi PS,Lowe NJ

doi

10.1111/j.1365-4632.2008.03419.x

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

202-4

issue

2

eissn

0011-9059

issn

1365-4632

pii

IJD3419

journal_volume

47

pub_type

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