Efficacy of topical calcineurin inhibitors in vitiligo.

Abstract:

:Topical tacrolimus and pimecrolimus are indicated for the treatment of atopic dermatitis, but they have been studied in many off-label uses. We reviewed the English language literature to define their roles in treatment of vitiligo. Double-blind studies show that tacrolimus 0.1% ointment combined with excimer laser is superior to placebo, especially for UV resistant areas, such as bony prominences of the extremities. When used alone, tacrolimus 0.1% ointment is almost as effective as clobetasol propionate 0.05% ointment. Other studies suggest it can also be effective for facial lesions. Double blind studies show that pimecrolimus 1% cream combined with narrow band UVB is superior to placebo, especially for facial lesions. Additional studies would further clarify the role of topical calcineurin inhibitors in vitiligo.

journal_name

Int J Dermatol

authors

Wong R,Lin AN

doi

10.1111/j.1365-4632.2012.05697.x

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

491-6

issue

4

eissn

0011-9059

issn

1365-4632

journal_volume

52

pub_type

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