Abstract：
:A 36-year-old Asian man with von Hippel-Lindau syndrome was referred to the dermatology clinic in January 2005 with stiff fingers and ankles of 3 months' duration. He had undergone bilateral nephrectomy for renal squamous cell carcinoma in 2002 and had started hemodialysis. Multiple cerebellar hemangiomata were resected in 1991, 2001, and 2003, and consequently he underwent multiple magnetic resonance imaging (MRI) scans with gadolinium-based contrast agents whilst on hemodialysis. The serum creatinine level and calculated glomerular filtration rate (GFR) at the time of his first exposure to gadolinium were 584 micromol/L and 13.31 mL/min, respectively. The patient recalled his symptoms worsening dramatically immediately after he had undergone two MRI scans on a day on which he was not dialyzed. On examination, he had thickening and edema on the hands and feet with significant pain and loss of range of movement. Autoantibodies for connective tissue disorders and thrombophilia screen were negative. Histology showed a proliferation of fibroblasts and dendritic cells, thickened collagen bundles, increased elastic fibers, and mucin deposition, consistent with the diagnosis of nephrogenic fibrosing dermopathy (NFD) (Figs 1 and 2). A trial of thalidomide for several months was unhelpful. He received a live, unrelated renal transplant in August 2005 but, despite excellent renal function and early conversion to sirolimus, his symptoms continued to progress. He now has contractures of all the limbs (Figs 3 and 4) and great difficulty with the activities of daily living. He is receiving physiotherapy and being considered for extracorporeal photophoresis therapy.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Gulati A,Harwood CA,Raftery M,Cerio R,Ashman N,Proby CAdoi
10.1111/j.1365-4632.2008.03655.xsubject
Has Abstractpub_date
2008-09-01 00:00:00pages
947-9issue
9eissn
0011-9059issn
1365-4632pii
IJD3655journal_volume
47pub_type
杂志文章abstract：BACKGROUND:Linear focal elastosis is an uncommon disorder that clinically shows band-like stria and a histological focal increase in elastic fibers. The disorder preferentially affects men after the age of 60 years and occurs on the lower back. The pathogenesis of linear focal elastosis is still somewhat of an enigma. ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2003.01733.x
更新日期：2003-07-01 00:00:00
abstract：:Affecting approximately 9.4% of the population worldwide, acne vulgaris is a common chronic inflammatory skin disease. Medical students are exposed to higher levels of stress and have a higher prevalence of acne. However, the risk factors and the impact of acne on medical students' mental health remains poorly underst...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/ijd.15280
更新日期：2020-10-31 00:00:00
abstract：:Dermatosis papulosa nigra (DPN) is a disorder commonly encountered in the adult black population. We describe 20 cases of clinicopathologically confirmed DPN cases treated with light abrasive curettage without local anesthesia. We found this procedure to be an effective therapy, which did not cause postoperative scarr...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1983.tb02131.x
更新日期：1983-12-01 00:00:00
abstract：BACKGROUND:Melanoma is responsible for 75% of all skin cancer-related deaths. Lentigo maligna (LM), the most prevalent melanoma in situ (MIS), accounts for 79-83% of all MIS. Its location in the head and neck area requires that tissue be spared in the course of clearing the tumor. METHODS:We conducted a therapeutic st...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.12430
更新日期：2014-07-01 00:00:00
abstract：:Sera from 25 patients with type 1 (Lepra), upgrading and downgrading, and type 2 (erythema nodosum leprosum [ENL]) reactions were assayed, during the reaction and after its clinical remission, for changes in levels of alpha-1-antitrypsin (A1A) and C-reactive protein (CRP). The results were compared with those from nor...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1992.tb03981.x
更新日期：1992-09-01 00:00:00
abstract：BACKGROUND:Acne is a common skin disorder that affects both adolescents and adults. However, few epidemiological studies on this condition have been conducted in Asia. OBJECTIVES:The purpose of this study was to analyze the incidence of acne and to identify its demographic and clinical features and aggravating factors...
journal_title：International journal of dermatology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-4632.2010.04726.x
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Primary Antiphospholipid Antibody Syndrome (PAAS) is characterized by detection of antiphospholipid antibodies associated with venous or arterial thrombosis and/or miscarriages by patients with no other associated disease such as systemic lupus erythematosus (SLE). Primary Antiphospholipid Antibody Syndrome ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.01939.x
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND:The treatment of melanoma in situ (MIS), particularly the lentigo maligna (LM) subtype, has been a controversial subject in the literature for over a decade. Surgical excision with 5 mm margins is the standard of care in the USA, while several variations of Mohs surgery are frequently used to treat clinicall...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4632.2010.04423.x
更新日期：2010-05-01 00:00:00
abstract：:A 23-year-old man with AIDS developed a lesion with the clinical characteristics of an ectopic geographic tongue in the lower lip, near the right commissure. ...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-4362.1990.tb04080.x
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:Melasma is an acquired hypermelanosis of the face. There is little information on its prevalence during pregnancy in Iran. Objective To determine the prevalence and awareness of melasma during pregnancy at the Shahed University Hospitals of Tehran, Iran. METHODS:A cross-sectional study was carried out by cl...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02470.x
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:A study was conducted to determine the chief agents of superficial mycoses in Malta. Data were collected over a 5-year period from mycologic investigations carried out on all dermatologic specimens sent to the Mycology Laboratory at St. Luke's Hospital in Malta. METHODS:In the period between January 1995 an...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.2003.01789.x
更新日期：2003-04-01 00:00:00
abstract：:We present two cases of Eosinophilic pustular folliclulitis (EPF) who were successfully treated with topical tacrolimus. Indomethacin is the most frequently used agent for the treatment of EPF, however, tacrolimus ointment may become the treatment of choice for patients with EPF. ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02109.x
更新日期：2004-08-01 00:00:00
abstract：BACKGROUND:Although genital ulceration with or without scar formation is an important manifestation of Behçet's syndrome, formal data on the rate of genital scarring are lacking. OBJECTIVE:To study prospectively the frequency of genital scar formation after genital ulcers in patients with Behçet's syndrome. Methods On...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2006.02859.x
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Hand dermatitis is an acute or chronic inflammation of the skin of the hands from a multifactorial cause which may be endogenous, exogenous, or a combination of both. With a wide range in severity and recurrent periods of flares, it has significant impact on the quality of life of its sufferers. A history of...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.13845
更新日期：2018-02-01 00:00:00
abstract：:Previous reports have shown that alterations in cutaneous and plasmatic fibrinolytic activity are found in cutaneous necrotizing vasculitis (CNV). In a combined investigation with direct immunofluorescence and autohistographic evaluation of tissue fibrinolytic activity in the lesional skin of 20 subjects affected by S...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1983.tb03323.x
更新日期：1983-03-01 00:00:00
abstract：:Hyperbaric oxygen therapy (HBOT) appears to enhance wound healing, increase bactericidal activity, and act synergistically with a number of antibiotics. The aim of this study was to evaluate the efficacy of HBOT as an adjunctive therapy in patients with hidradenitis suppurativa (HS) treated with a combination of syste...
journal_title：International journal of dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/ijd.12936
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Atrophic acne scars are a frequent problem after acne. Hitherto, mainly invasive treatment measures were possible. In a recent paper, we demonstrated the positive effects of iontophoresis with 0.025% tretinoin gel vs. estriol 0.03%. OBJECTIVE:In this further study, the recording of the clinical effects of i...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-4362.1999.00586.x
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:Dermatologic diseases vary widely as a result of geographic location and may be influenced by environmental factors. Aim To determine the epidemiology of dermatological diseases in the Peruvian Amazonia. METHODS:Transversal and multicentric study, which were carried out during February of 2006, 2007, and 20...
journal_title：International journal of dermatology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-4632.2010.04473.x
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Mucosa-associated epithelial chemokine (MEC; CCL28) is considered to be pivotal in mediating the migration of CC chemokine receptor 3- and 10- (CCR3- and CCR10)-expressing, skin-homing, memory, cutaneous lymphocyte-associated antigen-positive (CLA(+)) T cells. CCL28 is selectively and continuously expressed ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.04069.x
更新日期：2009-08-01 00:00:00
abstract：:Asiaticoside, isolated from Centella asiatica, promotes fibroblast proliferation and extracullar matrix synthesis in wound healing. The precise mechanism, however, in molecular and gene expression levels still remains partially understood. Using cDNA microarray technology, the alternation of genes expression profiles ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2004.02047.x
更新日期：2004-11-01 00:00:00
abstract：:Fifty patients (42 men, 8 women) with seborrheic dermatitis were included in the trial. Ketoconazole 2% emulsion or the same emulsion without active drug was applied b.i.d. for 4 weeks. Two patients dropped out in the ketoconazole group and nine in the placebo group. Pityrosporum ovale was cultured from all patients a...
journal_title：International journal of dermatology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1365-4362.1991.tb04793.x
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:Dysfunction of adhesion molecules is believed to play an early and important role in developing cancer. Accordingly, this study aims to compare beta-catenin (β-catenin) and CD44 expression in oral lichen planus (OLP) as a condition with malignant potential and oral squamous cell carcinoma (OSCC). METHODS:β-...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/ijd.14007
更新日期：2018-07-01 00:00:00
abstract：:A survey on communicable dermatoses in economically weak villages in India showed wide variations in prevalence rates in similar ecologic setup. A skin diseases, on-spot-treatment, 1-day-camp was organized to treat 1787 subjects in five villages. Two applications of 1% lindane 1 week apart was the only treatment used ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4362.1985.tb05790.x
更新日期：1985-06-01 00:00:00
abstract：:Data on the potential influence of the angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) genotype on psoriasis are contradictory. Our aim was to investigate the relationship between the ACE gene I/D polymorphism and psoriasis/psoriatic arthritis. To investigate this, a genetic association study was conduct...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2009.04245.x
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Psoriasis presents many management complexities. A cornerstone of therapy has been topical corticosteroids, although over the past 10 years there have been many additions to the medication armamentarium. Furthermore, various combination regimens and approaches have been advocated. OBJECTIVE:We sought to cha...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2006.02532.x
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:Cellulite, which appears as orange peel-type or cottage cheese-like dimpling of the skin on the thighs and buttocks, is a complex, multifactorial, cosmetic disorder of the subcutaneous fat layer and the overlying superficial skin. Adiponectin is an adipocyte-derived hormone mainly produced by subcutaneous fa...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2010.04713.x
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:In Sri Lanka, cutaneous leishmaniasis is a well-established disease caused by Leishmania donovani. Only a few cases of visceral disease and mucosal localization have been reported to date. CASE REPORT:A 52-year-old man presented with severe local destruction of his upper and lower lip and total destruction ...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2010.04376.x
更新日期：2010-05-01 00:00:00
abstract：:There are 70.8 million persons displaced worldwide due to war, persecution, and violence. Eighty percent of displaced persons reside in low- and middle-income countries with limited healthcare resources. Cutaneous diseases are commonly reported among displaced persons owing to numerous interrelated factors such as ina...
journal_title：International journal of dermatology
pub_type： 杂志文章,评审
doi：10.1111/ijd.15063
更新日期：2020-07-19 00:00:00
abstract：BACKGROUND:Community-associated methicillin-resistant Staphylococci aureus (CA-MRSA) pediatric skin infections have been reported worldwide. However, little is known about pathogens' implications in Egyptian children, and beta-lactams are still the empiric antimicrobials prescribed. This warrants Egyptian studies on an...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2012.05515.x
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Twenty-nail dystrophy (TND) is an idiopathic and non-congenital nail dystrophy that is characterized by excess longitudinal ridges and loss of luster in multiple nail plates. There are a few studies on TND. MATERIALS AND METHODS:In order to investigate the demographic and clinical characteristics of patient...
journal_title：International journal of dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-4632.2011.05118.x
更新日期：2012-06-01 00:00:00
