Abstract:
BACKGROUND:Mucosa-associated epithelial chemokine (MEC; CCL28) is considered to be pivotal in mediating the migration of CC chemokine receptor 3- and 10- (CCR3- and CCR10)-expressing, skin-homing, memory, cutaneous lymphocyte-associated antigen-positive (CLA(+)) T cells. CCL28 is selectively and continuously expressed by epidermal keratinocytes, but highly upregulated in inflammatory skin diseases, such as atopic dermatitis (AD). AIM:This controlled longitudinal study was designed to evaluate the expression of CCL28 in serum in childhood AD and bronchial asthma (BA), and its possible relationship to disease severity and activity. METHODS:Serum CCL28 levels were measured in 36 children with AD, 23 with BA, 14 with both conditions, and 21 healthy age- and sex-matched controls. Sixteen patients in the AD group were followed up and resampled for serum CCL28 after clinical remission. Serum CCL28 levels were correlated with some AD disease activity and severity variables. RESULTS:Serum CCL28 levels in AD, whether during flare [median, 1530 pg/mL; mean +/- standard deviation (SD) = 1590.4 +/- 724.3 pg/mL] or quiescence (median, 1477 pg/mL; mean +/- SD = 1575.2 +/- 522.1 pg/mL), were significantly higher than those in healthy children (median, 301 pg/mL; mean +/- SD = 189.6 +/- 92.8 pg/mL); however, the levels during flare and quiescence were statistically comparable. The serum levels in BA (median, 340 pg/mL; mean +/- SD = 201.6 +/- 109.5 pg/mL) were significantly lower than those in the AD group, and comparable with those in healthy controls. Serum CCL28 levels in severe AD were significantly higher than those in mild and moderate cases, and correlated positively with the calculated severity scores [Leicester Sign Score (LSS) and Scoring Atopic Dermatitis (SCORAD)]. CCL28 levels during the exacerbation of AD were positively correlated with the corresponding values during remission, the peripheral absolute eosinophil counts, and serum lactate dehydrogenase levels. Serum CCL28 levels were not correlated with the serum total immunoglobulin E values in AD. CONCLUSIONS:Our data reinforce the concept that CCL28 might contribute to the pathogenesis of AD, probably through the selective migration and infiltration of effector/memory T-helper-2 cells in the skin. CCL28 may also represent an objective prognostic marker for disease severity. Further studies may pave the way for CCL28 antagonism among adjuvant therapeutic strategies.
journal_name
Int J Dermatoljournal_title
International journal of dermatologyauthors
Ezzat MH,Sallam MA,Shaheen KYdoi
10.1111/j.1365-4632.2009.04069.xsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
822-9issue
8eissn
0011-9059issn
1365-4632pii
IJD4069journal_volume
48pub_type
杂志文章abstract:BACKGROUND:Chronic arsenic exposure can lead to palmoplantar keratosis. In the stratum corneum of skin, linoleic acid is of the utmost importance to the inflammation, keratinization, and regeneration processes. OBJECTIVES:The aims of this study were: (i) to present quantitative information on the linoleic acid fractio...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12831
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Ant sting reactions are becoming an increasing problem in tropical countries. It is important for physicians to be aware of their possible cutaneous and systemic manifestations. METHODS:A child with a severe allergic reaction to an ant sting was examined and is discussed. This is the first case described in...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2002.01480.x
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Methotrexate (MTX) is a risky medication requiring careful attention to dosing and monitoring. Dosing and monitoring practices are not well characterized. AIMS:The aim of this study was to assess variation in the dosing and monitoring of methotrexate among Iranian dermatologists. METHODS:A questionnaire wa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.12201
更新日期:2014-03-01 00:00:00
abstract::An 11-month-old male infant was referred to our clinic because of a painful ulcer of approximately 5 months' duration on the ventral surface of the tongue (Fig. 1). On physical examination, the lesion was circular (3 cm x 2 cm) with erythematous, raised, and indurated borders. No pathologic findings emerged from the l...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2004.02554.x
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:The Section of Dermatology of the University of the Philippines, Philippine General Hospital, reported a case of chronic arsenic poisoning from a community in Luzon island to the Department of Health resulting in the conduct of two health and environmental assessment missions in December 2014. OBJECTIVE:To ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13615
更新日期:2017-07-01 00:00:00
abstract::Netherton syndrome is a rare disorder inherited in an autosomal recessive pattern consisting of ichthyosiform dermatosis, hair shaft abnormalities (trichorrhexis invaginata), and an atopic diathesis. Patients with Netherton syndrome have been found to have a mutation on chromosome 5q32 in a gene named SPINK5 (serine p...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4632.2005.02637.x
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Hepatitis C virus (HCV) infection induces variable dermatologic manifestations. Our purpose was to determine whether there is an association between HCV infection and oral lichen planus (OLP). METHODS:Antibodies to HCV were determined in patients with OLP (263 patients; 156 women and 107 men, with a mean ag...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.1998.00510.x
更新日期:1998-08-01 00:00:00
abstract:OBJECTIVE:To assess the safety and efficacy of a 0.005% mixture of solasodine glycosides (Zycure) in the treatment of basal cell carcinoma. Design Double-blind, randomized, and vehicle-controlled, parallel group study. SETTING:Ten centers in the United Kingdom. Participants Male, n = 50; female, n = 44; age range, 32-...
journal_title:International journal of dermatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1365-4632.2007.03363.x
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Diagnostic errors appear to be the most common, costly, and dangerous of all medical mistakes. There has been a notable increase on the focus of error prevention as part of a growing patient safety movement. However, diagnostic errors have received less attention than other types of error. Our goal is to pre...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13532
更新日期:2017-06-01 00:00:00
abstract::Topical anthralin application producing a brisk irritant contact dermatitis has been reported to have therapeutic benefit in alopecia areata. A pilot clinical study was undertaken to determine whether topical anthralin application in doses low enough to produce only minimal contact dermatitis would produce a similar t...
journal_title:International journal of dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-4362.1985.tb05863.x
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Mechanic's hand is a defined specific skin eruption associated with dermatomyositis; there are few reports concerning its histopathology. As mechanic's hand clinically resembles hand eczema, it is important to distinguish between these two conditions. AIM:To determine the characteristic clinical and histopa...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2009.04164.x
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Psoriasis is a chronic debilitating disease affecting approximately one million Canadians. The objective of this study is to estimate the economic burden in $CDN (2008) of moderate to severe plaque psoriasis among Canadian adults. METHODS:Using a cross-sectional design, direct resource use, costs, lost prod...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05359.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women. Topical 5% cysteamine is an antioxidant and tyrosinase inhibitor that has been shown to be effective in the treatment of melasma. However, to date, no study has compared the performan...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15146
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:The Psoriasis Area and Severity Index (PASI) is used to quantify the extent of the disease, and to evaluate its improvement with treatment. It is considered to be a slow, rough, nonsensitive, and complex tool, with high interobserver variability and low reproducibility. OBJECTIVES AND METHODS:To develop a s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2000.00017.x
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The improvement of acne in summertime or the aggravation of acne in winter is a traditional dermatologic opinion. Ultraviolet rays are thought to be beneficial in the treatment of acne. In the existing literature there is no proof of this. The purpose of this study was to find out whether or no...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1996.tb03274.x
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Sporotrichosis is a chronic granulomatous infection caused by Sporothrichum schenckii. The disease has worldwide distribution. Majority of cases from India are reported from North-eastern states. METHODS:The demographic, clinico-investigative profile and therapeutic results of nine patients with cutaneous s...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03538.x
更新日期:2008-04-01 00:00:00
abstract::In 1982, five patients having pemphigus vulgaris, four men and one woman, ranging in age between 16 and 48 years, were treated with an arbitrary regimen designed by us. The regimen consisted of giving 100 mg dexamethasone in 500 mL of 5% glucose by a slow intravenous infusion on three consecutive days, along with 500 ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1992.tb03549.x
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:The aim of this study is to reveal demographic and clinical features of Behçet's disease (BD) in a Turkish population. METHODS:We retrospectively evaluated the clinical findings of 521 patients with BD. RESULTS:A total of 521 patients (287 female and 234 male) were included in this study. Onset signs: oral...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2012.05756.x
更新日期:2014-05-01 00:00:00
abstract::A 31-year-old Caucasian male presented with a history of erythematous, saccular outpouchings of the skin on his back, shoulders, and upper extremities (Fig. 1). The patient reported that his mother and aunt had a similar skin disorder, which initially began with inflammation, but healed leaving lax skin in its wake. H...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-4362.2003.01742.x
更新日期:2003-01-01 00:00:00
abstract::A 58-year-old woman with progressive systemic sclerosis developed a butterfly erythematous eruption, hemorrhagic maculae, crusting, and erosions on the face 15 days following administration of D-penicillamine. This appeared to be a lupus erythematosus-like eruption due to an adverse drug reaction to D-penicillamine be...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1990.tb03471.x
更新日期:1990-10-01 00:00:00
abstract:BACKGROUND:Altered levels of sex hormones have been observed in many autoimmune disorders, but there is no considerable data about pemphigus. The aim of this study is to compare serum total and free prolactin and dehydroepiandrosterone sulfate (DHEAS) levels between patients with pemphigus and healthy controls and to d...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.13199
更新日期:2016-06-01 00:00:00
abstract::Sézary cells were present in a number of less than 1000/mm3 in 52 of 78 cases of various benign diffuse dermatoses and mycosis fungoides. The count was higher than 1000/mm3 in two cases of Sézary syndrome in which the histopathology was that of mycosis fungoides and in six cases of exfoliative erythroderma of undeterm...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1988.tb03219.x
更新日期:1988-05-01 00:00:00
abstract::Primary cutaneous follicle center lymphoma (PCFCL) is a neoplasm with differentiation of centrocytes and centroblasts presenting in the skin. At the time of initial manifestation, extracutaneous involvement is absent. PCFCL is considered as an indolent variant of primary cutaneous B-cell lymphomas since dissemination ...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2008.03953.x
更新日期:2008-11-01 00:00:00
abstract::The present work compared the clinical efficacy of topically applied 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25-(OH)2D3) in 16 cases with psoriasis vulgaris, 5 with ichthyosis vulgaris and 8 with X-linked ichthyosis. Sixty-nine percent of the psoriatic cases responded to 1 alpha,25-(OH)2D3 therapy, whereas no ichthyot...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4362.1991.tb05885.x
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Acne is a common skin disorder that affects both adolescents and adults. However, few epidemiological studies on this condition have been conducted in Asia. OBJECTIVES:The purpose of this study was to analyze the incidence of acne and to identify its demographic and clinical features and aggravating factors...
journal_title:International journal of dermatology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-4632.2010.04726.x
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Targeted therapies and immunotherapies are increasingly prescribed, but classic chemotherapy agents are still highly used in cancer treatment. Both therapies, the old and the new, are associated with cutaneous adverse events (CAEs) that can cause treatment interruptions or reduce the quality of life of patie...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/ijd.15081
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Primary cutaneous cryptococcosis is an uncommon infectious disease caused by Cryptococcus neoformans or Cryptococcus gattii affecting immunosuppressed as well as immunocompetent patients. It is often misdiagnosed as it may mimic other cutaneous diseases. MATERIALS AND METHODS:We report a series of cases dia...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2011.05298.x
更新日期:2012-07-01 00:00:00
abstract::Necrolytic migratory erythema (NME) is a rare skin disorder that is a cutaneous manifestation of the glucagonoma syndrome. It presents with annular eruptions of migrating erythematous papules and plaques with superficial epidermal necrosis, central flaccid bullae, and crusted erosions located primarily in the intertri...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/ijd.13947
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Prurigo pigmentosa (PP), a rare inflammatory disease of the skin, is mostly reported in the ethnic Japanese population. Its pathogenesis remains unclear. The chronic and recurrent nature of PP implies a possible role of viral infection in the pathogenesis. The anti-inflammatory mechanism of doxycycline, whic...
journal_title:International journal of dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-4632.2010.04625.x
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Contact allergy to corticosteroids has recently gained increased attention. METHODS:Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described. The Japanese literature was reviewed for reports on this allergy, and the occurrence due to budesonide was compared with that of ot...
journal_title:International journal of dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-4362.1994.tb01516.x
更新日期:1994-10-01 00:00:00