Distinct molecular sites of anaesthetic action: pentobarbital block of human brain sodium channels is alleviated by removal of fast inactivation.

abstract：:The speeds of onset of pancuronium, atracurium and vecuronium are increased by prior administration of magnesium sulphate. A prospective, randomized, double-blind, controlled, clinical study was performed to examine the effects of prior i.v. administration of magnesium sulphate 60 mg kg-1 on the neuromuscular blocking...

journal_title：British journal of anaesthesia

authors： Kussman B,Shorten G,Uppington J,Comunale ME

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Propofol and sevoflurane are suitable agents for maintenance of anaesthesia during neurosurgical procedures. We have prospectively compared these agents in combination with the short-acting opioid, remifentanil. METHODS:Fifty unpremedicated patients undergoing elective craniotomy received remifentanil 1 mic...

journal_title：British journal of anaesthesia

authors： Sneyd JR,Andrews CJ,Tsubokawa T

更新日期：2005-06-01 00:00:00

abstract：:A total of 1442 patients who had major gynaecological surgery were recruited into three multicentre studies using a standard general anaesthetic technique in order to assess the efficacy of various doses of orally administered ondansetron in the prevention of postoperative nausea and vomiting. A total of 1257 patients...

journal_title：British journal of anaesthesia

authors： Haigh CG,Kaplan LA,Durham JM,Dupeyron JP,Harmer M,Kenny GN

更新日期：1993-10-01 00:00:00

abstract：:The pupils in brainstem-dead patients are classically fixed and dilated. We present a case of a brainstem-dead patient whose pupils displayed persistent asynchronous pupillary constriction and dilatation independent of external physical stimuli. Central causes for the phenomenon were excluded leaving an unexplained pe...

journal_title：British journal of anaesthesia

authors： Shlugman D,Parulekar M,Elston JS,Farmery A

更新日期：2001-05-01 00:00:00

abstract：:We have studied the effects of amrinone on left and right ventricular haemodynamics in patients with impaired ventricular performance caused by coronary artery disease. Anaesthesia was achieved with fentanyl, flunitrazepam and pancuronium. After reaching steady state, a bolus dose of amrinone 0.5 mg kg-1 was administe...

journal_title：British journal of anaesthesia

authors： Petry A,Dütschke P

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Isoflurane has been reported to induce caspase-3 activation, which may induce neurotoxicity and contribute to the pathogenesis of Alzheimer's disease. However, the underlying mechanism is largely unknown, especially whether or not isoflurane can induce ryanodine receptors (RyRs)-associated endoplasmic reticu...

journal_title：British journal of anaesthesia

authors： Wang H,Dong Y,Zhang J,Xu Z,Wang G,Swain CA,Zhang Y,Xie Z

更新日期：2014-10-01 00:00:00

abstract：:The effects of different premedication (i.m. and i.v.) on the usefulness of midazolam or thiopentone as induction agents for minor surgery was studied in 194 women undergoing either dilatation and curettage or explorative fractionate curettage. Midazolam appeared to produce light sedation which required powerful preme...

journal_title：British journal of anaesthesia

authors： Kanto J,Sjövall S,Vuori A

更新日期：1982-05-01 00:00:00

abstract：:The time course of the plasma lignocaine concentration, following caudal anaesthesia, was studied in 11 healthy children (3.5-9 yr). Plasma lignocaine concentrations were measured for up to 6 h after administration (5 mg kg-1). Peak plasma concentration was 2.05 +/- 0.08 micrograms ml-1 and occurred at 28.2 +/- 2.9 mi...

journal_title：British journal of anaesthesia

authors： Ecoffey C,Desparmet J,Berdeaux A,Maury M,Giudicelli JF,Saint-Maurice C

更新日期：1984-12-01 00:00:00

abstract：:A 55-yr-old man received a left supraclavicular brachial plexus block with 0.42% bupivacaine; he had profound motor and sensory block 26 h after injection; complete recovery occurred at 40 h. ...

journal_title：British journal of anaesthesia

authors： Brockway MS,Winter AW,Wildsmith JA

更新日期：1989-11-01 00:00:00

abstract：:We evaluated the use of an inexpensive trans-illuminating light wand for tracheal intubation. Expertise in its use was acquired quickly, thereby providing successful per-oral intubation in all patients who were able to open the mouth, irrespective of the view obtained of the epiglottis and larynx. ...

journal_title：British journal of anaesthesia

authors： Ainsworth QP,Howells TH

更新日期：1989-05-01 00:00:00

abstract：:We have assessed the role of the cell-cell adhesion molecule, E-cadherin, in the pathogenesis of multiorgan failure in 24 intensive care patients with sepsis and varying degrees of organ dysfunction, compared with 21 healthy subjects. Plasma soluble E-cadherin (sE-cadherin) was measured by enzyme immunoassay. The medi...

journal_title：British journal of anaesthesia

authors： Pittard AJ,Banks RE,Galley HF,Webster NR

更新日期：1996-05-01 00:00:00

abstract：:Eighteen patients were studied, during operations under subarachnoid or extradural anaesthesia combined with general anaesthesia, to assess the influence of occlusion of inspiration on the duration of inspiration, and the likelihood of a relationship between lung volume and duration of inspiration. Ten patients breath...

journal_title：British journal of anaesthesia

authors： Drummond GB

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:The memory effect of dexmedetomidine has not been prospectively evaluated in children. We evaluated the feasibility of measuring memory and sedation responses in children during dexmedetomidine sedation for non-painful radiological imaging studies. Secondarily, we quantified changes in memory in relation to ...

journal_title：British journal of anaesthesia

authors： Mason KP,Kelhoffer ER,Prescilla R,Mehta M,Root JC,Young VJ,Robinson F,Veselis RA

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The second gas effect (SGE) is considered to be significant only during periods of large volume N(2)O uptake (VN(2)O); however, the SGE of small VN(2)O has not been studied. We hypothesized that the SGE of N(2)O on sevoflurane would become less pronounced when sevoflurane administration is started 60 min aft...

journal_title：British journal of anaesthesia

authors： Hendrickx JF,Carette R,Lemmens HJ,De Wolf AM

更新日期：2006-03-01 00:00:00

abstract：:The gliding characteristics were evaluated of 10-ml plastic syringes used to identify the extradural space by "loss of resistance" techniques. This was undertaken quantitatively, by measuring the force necessary to depress syringe plungers, and qualitatively, by examining travel characteristics in terms of the force a...

journal_title：British journal of anaesthesia

authors： Bricker SR,Coleman P

更新日期：1988-12-01 00:00:00

abstract：:A study of core temperature monitoring during general anesthesia indicates that this can be introduced as a routine procedure in order to reduce mortality from malignant hyperpyrexia. The temperature profiles of 2410 patients are presented. Both mean rectal and mean oesophageal temperatures decreased during general an...

journal_title：British journal of anaesthesia

authors： Crocker BD,Okumura F,McCuaig DI,Denborough MA

更新日期：1980-12-01 00:00:00

abstract：:One hundred and one patients with osteoarthritis were randomly allocated to undergo total hip arthroplasty under either spinal (subarachnoid) or general anaesthesia. Venous blood was sampled before, during and after surgery and on the 5th day after operation to study the haemostatic mechanism. There were no preoperati...

journal_title：British journal of anaesthesia

authors： Davis FM,McDermott E,Hickton C,Wells E,Heaton DC,Laurenson VG,Gillespie WJ,Foate J

更新日期：1987-05-01 00:00:00

abstract：:In this study, we simultaneously evaluated the spasmolytic effects of prostaglandin E1 (PGE1) on serotonin-induced bronchoconstriction and pulmonary hypertension. Eleven mongrel dogs (8-12 kg) anaesthetized with pentobarbital were assigned to two groups: saline (n = 4) and PGE1 (n = 7). Bronchoconstriction and pulmona...

journal_title：British journal of anaesthesia

authors： Hashimoto Y,Hirota K,Yoshioka H,Hashiba E,Kudo T,Ishihara H,Matsuki A

更新日期：2000-09-01 00:00:00

abstract：:Experiments were performed on rats using two analgesimetric tests (tail-flick; hot-plate) before and after injection i.v. of graded doses of aprotinin (12.5, 25.0 and 50 KIU g-1). A dose-related analgesic effect was noted with both tests. Prior administration of naloxone 0.001 mg g-1 i.p. inhibited the analgesic actio...

journal_title：British journal of anaesthesia

authors： Novelli GP,Pieraccioli E,Peduto VA,Festimanni F

更新日期：1980-11-01 00:00:00

abstract：:We studied psychomotor performance in 10 healthy volunteers during recovery after a target-controlled infusion of propofol. Choice reaction time, dual task tracking with secondary reaction time and a within-list recognition task were assessed at target blood propofol concentrations of 0.8, 0.4 and 0.2 microgram ml-1. ...

journal_title：British journal of anaesthesia

authors： Grant SA,Murdoch J,Millar K,Kenny GN

更新日期：2000-09-01 00:00:00

abstract：:We have studied the relationship between gas exchange and mechanical frequency response during high frequency jet ventilation (HFJV) at 0.5-5.0 Hz in anaesthetized pigs. The mechanical gain curve showed a minimal "anti-resonant" response at 0.8 Hz (f1) and a maximal "resonant" response at 5.0 Hz (f2). This finding may...

journal_title：British journal of anaesthesia

authors： Lin ES,Jones MJ,Mottram SD,Smith BE,Smith G

更新日期：1990-04-01 00:00:00

abstract：:We have examined the effects of the highly selective alpha 2-adrenoceptor agonist, dexmedetomidine, on noradrenaline release and cell firing in isolated, superfused slices of rat locus coeruleus. Dexmedetomidine decreased both noradrenaline release and cell firing rate in a concentration-dependent fashion, with an EC5...

journal_title：British journal of anaesthesia

authors： Jorm CM,Stamford JA

更新日期：1993-09-01 00:00:00

abstract：:In 105 patients undergoing day-case surgery recovery of consciousness was significantly faster after enfluane compared with halothane anaesthesia. There was no difference in postoperative morbidity between the two anaesthetic groups. ...

journal_title：British journal of anaesthesia

authors： Stanford BJ,Plantevin OM,Gilbert JR

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:The aim of this retrospective study was to compare the failure rates and the frequency of anaesthesia-related complications of two different methods of regional anaesthesia used for carotid endarterectomy--cervical epidural (CE) anaesthesia and cervical plexus block (CPB). METHODS:The study included 1828 ca...

journal_title：British journal of anaesthesia

authors： Hakl M,Michalek P,Sevcík P,Pavlíková J,Stern M

更新日期：2007-09-01 00:00:00

abstract：:Using human nasal cytological brushings, we have investigated the effects of morphine on ciliary function by measurement of cilia beat frequency in vitro, and we have also determined opioid receptor binding in these specimens. We obtained ciliated samples from seven volunteers, and measured cilia beat frequency using ...

journal_title：British journal of anaesthesia

authors： Selwyn DA,Raphael JH,Lambert DG,Langton JA

更新日期：1996-02-01 00:00:00

abstract：:Seventy-six Chinese patients aged between 15 and 30 yr, undergoing 3rd molar extraction, were randomly allocated to two groups. One group received halothane and the other isoflurane. The incidence of arrhythmia during surgery under anaesthesia with isoflurane was significantly less than with halothane. Sinus tachycard...

journal_title：British journal of anaesthesia

authors： Rodrigo MR,Moles TM,Lee PK

更新日期：1986-04-01 00:00:00

abstract：:We have undertaken a prospective, randomized study to determine the incidence of postoperative nausea and vomiting during intensive care stay after cardiac surgery, and to study the effect of addition of droperidol to an infusion of morphine used for postoperative analgesia. Data from 398 patients were examined. The u...

journal_title：British journal of anaesthesia

authors： Grebenik CR,Allman C

更新日期：1996-09-01 00:00:00

abstract：:Intraoperative awareness, with or without recall, continues to be a topic of clinical significance and neurobiological interest. In this article, we review evidence pertaining to the incidence, sequelae, and prevention of intraoperative awareness. We also assess which aspects of the complication are well understood (i...

journal_title：British journal of anaesthesia

authors： Mashour GA,Avidan MS

更新日期：2015-07-01 00:00:00

abstract：:The kinetics of morphine were studied during balanced anaesthesia in 10 patients undergoing lower abdominal or body surface surgery, and compared with those obtained in nine awake patients receiving morphine i.v. for the relief of chronic non-cancer pain. All patients received morphine sulfphate pentahydrate 10 mg i.v...

journal_title：British journal of anaesthesia

authors： Sear JW,Hand CW,Moore RA,McQuay HJ

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Lower thoracic epidural anaesthesia and analgesia (EDA) has gained increasing importance in perioperative pain therapy. The loss-of-resistance technique used to identify the epidural space is thought to rely on the penetration of the ligamentum flavum. Investigations at the cervical and lumbar regions have d...

journal_title：British journal of anaesthesia

authors： Lirk P,Colvin J,Steger B,Colvin HP,Keller C,Rieder J,Kolbitsch C,Moriggl B

更新日期：2005-06-01 00:00:00