Abstract:
:The formylpeptide receptor (FPR), previously found only on polymorphonuclear leukocytes and monocytes/macrophages, responds to both synthetic N-formyl oligopeptides and those produced by bacteria. The cDNA for human FPR has been cloned and a rabbit polyclonal antiserum directed against a synthetic 11-amino-acid peptide corresponding to the deduced carboxy-terminus has been produced. We have now extensively characterized and used the antibody to detect FPR on normal human tissues and cell types. The receptor antigen is present on some epithelial cells, especially those with a secretory function, and on some endocrine cells, e.g., follicular cells of the thyroid and cortical cells of the adrenal. Liver hepatocytes and Kupffer cells are positive. Smooth muscle and endothelial cells are also generally positive. In the brain and spinal cord, the neurons of the motor, sensory, and cerebellar systems, and those of the parasympathetic and sympathetic systems stain positively. These data suggest that the putative endogenous agonist for FPR or an antigenically similar receptor reacts with cellular targets in the neuromuscular, vascular, endocrine, and immune systems.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Becker EL,Forouhar FA,Grunnet ML,Boulay F,Tardif M,Bormann BJ,Sodja D,Ye RD,Woska JR Jr,Murphy PMdoi
10.1007/s004410051042subject
Has Abstractpub_date
1998-04-01 00:00:00pages
129-35issue
1eissn
0302-766Xissn
1432-0878journal_volume
292pub_type
杂志文章abstract::The innervation of the anococcygeus muscle of the rat was investigated with regard to the histochemical features of nerve fibers within the muscle and to the location of the postganglionic autonomic neurons which are the source of these fibers. Acetylcholinesterase-positive fibers and catecholaminergic fibers are abun...
journal_title:Cell and tissue research
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journal_title:Cell and tissue research
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