Abstract：
:In rats the "fast" fibular nerve was transposed to the "slow" soleus muscle outside the original innervation band. Formation of new neuromuscular junctions was induced by cutting the soleus nerve after different periods of time. The morphological maturation of these junctions was studied by electron microscopy. New neuromuscular junctions do not form when the original innervation is left intact. Three to five days after denervation, vesicle-laden terminal boutons contact muscle fibers with only the basal lamina of the latter intervening. Three weeks after denervation, most boutons are larger and postsynaptic folds are present, although younger stages are also seen. Sixteen weeks after denervation, the neuromuscular junctions appear mature. This corresponds well with electrophysiological findings in the same material. The fully developed neuromuscular junctions sixteen weeks after denervation possess postsynaptic folds similar to those of normal "fast" muscle fibers. This suggests that the "fast" fibular nerve rather than the "slow" soleus muscle fibers determines the morphology of the postsynaptic folds. Possible trophic neuromuscular interactions are discussed.
journal_name
Cell Tissue Resjournal_title
Cell and tissue researchauthors
Korneliussen H,Sommerschild Hdoi
10.1007/BF00215176keywords:
subject
Has Abstractpub_date
1976-04-09 00:00:00pages
439-52issue
4eissn
0302-766Xissn
1432-0878journal_volume
167pub_type
杂志文章abstract：:Horseradish peroxidase (HRP) was injected into the left dorsal column nuclei of adult cats. Large dorsal funiculi axons of the C3, C5, C8 and L7 segments were searched for HRP-activity after 12, 24, 36 and 48h using light and electron microscopy. Accumulations of intra-axonal HRP-positive bodies occurred at nodes of R...
journal_title：Cell and tissue research
pub_type： 杂志文章
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
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doi：10.1007/BF00228443
更新日期：1984-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
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journal_title：Cell and tissue research
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
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journal_title：Cell and tissue research
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更新日期：1992-03-01 00:00:00
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journal_title：Cell and tissue research
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更新日期：2005-08-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219145
更新日期：1976-04-02 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00219415
更新日期：1976-07-30 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0347-5
更新日期：2007-05-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00234855
更新日期：1979-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00327750
更新日期：1990-10-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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更新日期：1994-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00218365
更新日期：1982-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-006-0181-9
更新日期：2006-09-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00305731
更新日期：1991-04-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00214807
更新日期：1982-01-01 00:00:00
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journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/BF00354799
更新日期：1994-04-01 00:00:00
abstract：:Growth/differentiation factor-15 (Gdf-15) is a member of the transforming growth factor-β (Tgf-β) superfamily and has been shown to be a potent neurotrophic factor for midbrain dopaminergic (DAergic) neurons both in vitro and in vivo. Gdf-15 has also been shown to be involved in inflammatory processes. The aim of this...
journal_title：Cell and tissue research
pub_type： 杂志文章
doi：10.1007/s00441-016-2406-x
更新日期：2016-08-01 00:00:00
