Dehydroepiandrosterone may be one of the regulators of cytokine production in atopic dermatitis.

abstract：:The incidence of epithelioid sarcoma among patients with malignant soft tissue tumors is small, but the rates of recurrence and metastasis of this type of sarcoma are high. To date, effective chemotherapy for advanced epithelioid sarcoma has not been established and, furthermore, epithelioid sarcoma is known to exhibi...

journal_title：Archives of dermatological research

authors： Kusakabe H,Iwasaki H,Sano K,Kiyokane K

更新日期：2000-06-01 00:00:00

abstract：:This study was designed in order to prove on a large-scale basis the efficacy of oral photochemotherapy (PUVA) in the prevention of polymorphous light eruption (PLE), to work out indication criteria for PUVA treatment of this disease, and to establish a simple method based on anamnestic data to differentiate UVA from ...

journal_title：Archives of dermatological research

authors： Gschnait F,Schwarz T,Ladich I

更新日期：1983-01-01 00:00:00

abstract：:Mice homozygous for three different recessive mutations known to cause pleiotropic defects in the immune system and in the skin were used to evaluate the relationship between the classical immune system and dendritic epidermal cell populations. Numbers of Langerhans cells (LCs) and Thy-1+ dendritic cells (Thy-1+DEC) w...

journal_title：Archives of dermatological research

authors： Sprecher E,Becker Y,Kraal G,Hall E,Shultz LD

更新日期：1990-01-01 00:00:00

abstract：:Human alpha 1(I) and alpha 1(III) procollagen mRNA expression in skin tissue from 15 systemic sclerosis (SSc) patients and from 7 normal control subjects was quantitatively analyzed using in situ hybridization. The grains accumulating in each area, representing procollagen mRNA expression per cell, were counted. To no...

journal_title：Archives of dermatological research

authors： Ohtsuka T,Koibuchi N,Sakai H,Yamakage A,Yamazaki S

更新日期：1999-11-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by...

journal_title：Archives of dermatological research

authors： Speeckaert R,Colebunders B,Boelaert JR,Brochez L,Van Acker J,Van Wanzeele F,Hemmer R,Speeckaert MM,Verhofstede C,De Buyzere M,Arendt V,Plum J,Delanghe JR

更新日期：2011-12-01 00:00:00

abstract：:We have observed that lipopolysaccharide (LPS) induces pigmentation in melanocytes and in this study have examined whether these responses are mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. LPS appears to stimulate the pigmentation of melanocytes and cultured skin. LPS was found to indu...

journal_title：Archives of dermatological research

authors： Ahn JH,Jin SH,Kang HY

更新日期：2008-07-01 00:00:00

abstract：:Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix (ECM) in the dermis. It is a late spreading skin overgrowth and may be considered a plastic surgeon's nightmare. In nature, curcuminoid is composed of curcumin, demethoxycurcumin (DMC) and bisdemethoxycurcumin (bDMC). Curcumino...

journal_title：Archives of dermatological research

authors： Hsu YC,Chen MJ,Yu YM,Ko SY,Chang CC

更新日期：2010-12-01 00:00:00

abstract：:We previously showed that the homeodomain protein HOXC13 is involved in the expression control of the early human hair keratin genes hHa5 and hHa2, which contain specific HOXC13 binding sites in their proximal promoters. Hox specificity is generally thought to be enhanced by the interaction with members of the TALE su...

journal_title：Archives of dermatological research

authors： Jave-Suárez LF,Schweizer J

更新日期：2006-02-01 00:00:00

abstract：:The function of microphages has been studied in two patients with chronic pyoderma vegetans by in vitro determination of phagocytosis as well as chemotaxis. The results showed a striking decrease in the chemotactic activity of the neutrophil granulocytes, a reduced phagocytosis of Candida albicans and Staphylococcus a...

journal_title：Archives of dermatological research

authors： Djawari D,Hornstein OP

更新日期：1978-01-01 00:00:00

abstract：:Tranilast is used clinically as a drug for hypertrophic scars or keloids. Recently, the roles of keratinocytes in the pathogenesis of those conditions have been noted. Therefore, we first examined the effect of tranilast on the cell growth of normal human keratinocytes. A cell growth assay demonstrated that the cell n...

journal_title：Archives of dermatological research

authors： Kubo M,Zhao Y,Moriguchi T

更新日期：2012-11-01 00:00:00

abstract：:Human epidermal keratinocytes were grown in culture and the uptake of hematoporphyrin derivatives (HPDs) used in photodynamic therapy was estimated. Keratinocytes loaded with HPDs were irradiated with laser light of 632 nm generated by a helium-neon laser and cell toxicity was determined by the trypan blue exclusion t...

journal_title：Archives of dermatological research

authors： Artuc M,Ramshad M,Kappus H

更新日期：1989-01-01 00:00:00

abstract：:Vitiligo is an acquired clinical conundrum, characterized by white areas on the skin due to loss of functional melanocytes. Various studies demonstrated that vitiligo is associated with fewer risk of skin cancer but no exact molecular explanation for this interesting observation has been described. This article review...

journal_title：Archives of dermatological research

authors： Feily A,Pazyar N

更新日期：2011-11-01 00:00:00

abstract：:Interleukin-17 (IL-17) has been implicated in the pathogenesis of a large number of inflammatory and autoimmune conditions, including skin disorders such as psoriasis. Recently, much data have accumulated on the possible role of IL-17 in the pathogenesis of alopecia areata (AA). In this review, the available informati...

journal_title：Archives of dermatological research

authors： Ramot Y,Marzani B,Pinto D,Sorbellini E,Rinaldi F

更新日期：2018-07-01 00:00:00

abstract：:CCN2 plays an important role in the pathogenesis of hypertrophic scars (HTSs). Although CCN2 is involved in many fibroproliferative events, the CCN2 induction signaling pathway in HTSs is yet to be elucidated. Here, we first investigated the effect of the mitogen-activated protein kinases (MAPKs) on CCN2-induced α-smo...

journal_title：Archives of dermatological research

authors： Hu X,Wang H,Liu J,Fang X,Tao K,Wang Y,Li N,Shi J,Wang Y,Ji P,Cai W,Bai X,Zhu X,Han J,Hu D

更新日期：2013-07-01 00:00:00

abstract：:Studies have identified increased prevalence of vitamin D deficiency in patients with alopecia areata (AA), an autoimmune disease characterized by hair loss, but none have prospectively examined vitamin D status and incident AA. In 55,929 women in the Nurses' Health Study (NHS), we prospectively evaluated the associat...

journal_title：Archives of dermatological research

authors： Thompson JM,Li T,Park MK,Qureshi AA,Cho E

更新日期：2016-11-01 00:00:00

abstract：:In preparations of papillary dermis taken from clinically normal skin of patients with dermatitis herpetiformis (DH), the disappearance of granular IgA deposits induced by peptic digestion was partial at pH 4.5 and total at pH 4.1, as visualized by immunofluorescence microscopy. In a model system in which human monome...

journal_title：Archives of dermatological research

authors： Egelrud T,Bäck O

更新日期：1985-01-01 00:00:00

abstract：:Angiosarcoma, a malignant tumor of vascular endothelial cell origin, is a lethal disease for which complete cure is rarely seen. The objective of this study was to determine the efficiency of photodynamic therapy (PDT) as a new treatment for angiosarcoma. PDT (630 nm, 25 J/cm2) using Photofrin for a mouse angiosarcoma...

journal_title：Archives of dermatological research

authors： Jin I,Yuji M,Yoshinori N,Makoto K,Mikio M

更新日期：2008-04-01 00:00:00

abstract：:Bromodeoxyuridine (BrdU) has commonly been used for detecting of label-retaining cells (LRCs). To determine if there are LRCs and the distributions of LRCs in eccrine sweat glands, 20 newborn SD rats within 24 h after birth were injected intraperitoneally with 50 mg/kg/time BrdU four consecutive times at 2-h intervals...

journal_title：Archives of dermatological research

authors： Chen L,Zhang M,Li H,Tang S,Fu X

更新日期：2014-03-01 00:00:00

abstract：:Recent studies have demonstrated that tumor necrosis factor-alpha (TNF-alpha) selectively decreases production of collagens I and III, the major types of collagen in the dermis, and increases production of collagenase in cultured dermal fibroblasts. The effects of TNF-alpha on collagens I, III and VI, fibronectin and ...

journal_title：Archives of dermatological research

authors： Takeda K,Hatamochi A,Arakawa M,Ueki H

更新日期：1993-01-01 00:00:00

abstract：:Typical confluent lesions of lichen planus were transplanted onto nude mice and cultured in organ culture. The characteristic histologic appearance of lichen planus disappeared after grafting and became similar to normal skin within 6 weeks on nude mice; the dense lymphocyte infiltrate in dermis disappeared, the basal...

journal_title：Archives of dermatological research

authors： Tammi R,Hyyryläinen A,Fräki JE

更新日期：1988-01-01 00:00:00

abstract：:Female hairless mice (strain mutant hr/hr) have been irradiated with increasing doses of UV-B over a period of 4 weeks. They were compared with untreated controls Additional groups of 30 mice were treated with milk base or cream base or milk SPF6 or cream SPF6 or cream SPF8 daily before irradiation. No changes of body...

journal_title：Archives of dermatological research

authors： Vogel HG,Alpermann HG,Futterer E

更新日期：1981-01-01 00:00:00

abstract：:We investigated the effects of glucocorticoids on IL-3-dependent proliferation and c-kit expression of cells of the mouse mast cell line, MC/9. Glucocorticoids (dexamethasone, prednisolone, and hydrocortisone) inhibited IL-3-dependent MC/9 cell proliferation, whereas sex steroids (progesterone, beta-estradiol, and tes...

journal_title：Archives of dermatological research

authors： Sakai H,Toyota N,Ito F,Takahashi H,Hashimoto Y,Iizuka H

更新日期：1999-04-01 00:00:00

abstract：:Epstein-Barr virus (EBV) can infect epithelial cells as well as B lymphocytes. Infection of the male and female genital tracts has recently been demonstrated, and it has been suggested that the virus may be sexually transmissible. In our study we investigated whether EBV can be found in the anal region of sexually act...

journal_title：Archives of dermatological research

authors： Näher H,Lenhard B,Wilms J,Nickel P

更新日期：1995-01-01 00:00:00

abstract：:The penetration through the epidermis in vitro of various topically used corticosteroids was compared. The amount penetrating through the epidermis from an ethanolic solution showed good correlation with the polarity of the corticosteroids under study. Hydrocortisone, the most polar corticosteroid, penetrates the epid...

journal_title：Archives of dermatological research

authors： Ponec M,Polano MK

更新日期：1979-05-29 00:00:00

abstract：:The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of patients. We assessed the effects of IVIg and CsA on TEN lesional and apparently uninvolved skin using standard histo...

journal_title：Archives of dermatological research

authors： Paquet P,Jacob E,Damas P,Pirson J,Piérard G

更新日期：2005-12-01 00:00:00

abstract：:Plectin, a widespread cytoskeletal linker protein, is prominently expressed in basal keratinocytes of the epidermis. HD1, originally identified as a hemidesmosomal protein, has been suggested to be an isoform of or closely related to plectin, but the exact relationship between these proteins is unknown. Plectin has re...

journal_title：Archives of dermatological research

authors： Shimizu H,Masunaga T,Kurihara Y,Owaribe K,Wiche G,Pulkkinen L,Uitto J,Nishikawa T

更新日期：1999-10-01 00:00:00

abstract：:Six patients with delayed pressure urticaria (DPU) applied clobetasol propionate (0.05%) ointment or its base to predetermined test sites on the right and left thigh as part of a randomized, double-blind study. A pressure challenge was administered to each test site at the initial visit and repeated after 3 days and 6...

journal_title：Archives of dermatological research

authors： Barlow RJ,Macdonald DM,Black AK,Greaves MW

更新日期：1995-01-01 00:00:00

abstract：:The effect of 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) on type-IV-procollagen (basement-membrane collagen) and laminin synthesis, turnover, and secretion was studied in human A431 squamous epidermoid carcinoma cells. Type-IV procollagen and laminin were biochemically and immunologic...

journal_title：Archives of dermatological research

authors： Panneerselvam M,Sahai A,Salomon DS

更新日期：1985-01-01 00:00:00

abstract：:Stratum corneum forms the UV barrier. The effect of ultraviolet B (UVB) on normal skin was extensively studied; however, its effect on barrier perturbed skin remains undefined. Both barrier perturbation and UVB irradiation induce endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in keratinocytes. M...

journal_title：Archives of dermatological research

authors： Lee SE,Takagi Y,Nishizaka T,Baek JH,Kim HJ,Lee SH

更新日期：2017-09-01 00:00:00

abstract：:Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. The condition is more frequent in females and begins often in young adults and in mid-adult life. The mechanism of PLE is under active research as shown ...

journal_title：Archives of dermatological research

authors： Aubin F

更新日期：2004-10-01 00:00:00