Abstract:
:We propose a simple mechanism which enables decrease of the free pool of channelled metabolite in static spatial channelling, when the concentration of the enzyme consuming the channelled metabolite is greater than the concentration of the enzyme producing this metabolite. Spatial channelling occurs between two enzymes when the common metabolite is released to a small space between these enzymes and does not from a ternary covalent complex with them, as is the case in covalent (dynamic or static) channelling. The mechanism proposed is qualitatively independent of rate constants, metabolite concentrations as well as other kinetic properties and is quantitatively significant for all physiologically relevant conditions. Calculations show that the free metabolite pool must decrease, when the concentration of the enzyme consuming the channelled metabolite is greater than the enzyme producing it. This mechanism is much more effective than increase in the concentration (or rate constant) of the enzyme consuming the metabolite in the absence of spatial channelling.
journal_name
Mol Cell Biochemjournal_title
Molecular and cellular biochemistryauthors
Korzeniewski B,Quant PAdoi
10.1023/a:1006882029611subject
Has Abstractpub_date
1997-04-01 00:00:00pages
135-42issue
1-2eissn
0300-8177issn
1573-4919journal_volume
169pub_type
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