IL-12 could induce monocytic tumor cells directional differentiation.

abstract：:To help resolve the controversy as to whether or not Na(+)-H+ exchange is functioning during reperfusion of the ischemic myocardium we assessed the effects of dimethylamiloride (DMA, an amiloride analogue possessing selectivity for inhibition of the Na(+)-H+ exchanger) on cardiac function and intracellular pH during i...

journal_title：Molecular and cellular biochemistry

authors： Docherty JC,Yang L,Pierce GN,Deslauriers R

更新日期：1997-11-01 00:00:00

abstract：:In the present study it was investigated if Vitamin A supplementation could protect rat kidney microsomes and mitochondria from in vitro lipoperoxidation. After incubation of rat kidney microsomes and mitochondria in an ascorbate-Fe+2 system, at 37 degrees C during 60 min, it was observed that the total cpm/mg protein...

journal_title：Molecular and cellular biochemistry

authors： Piergiacomi VA,Palacios A,Catalá A

更新日期：1996-12-20 00:00:00

abstract：:Recent studies suggest JAK2 signaling may be a therapeutic target for treatment of gastric cancer (GC). However, the exact roles of JAK2 in gastric carcinogenesis are not very clear. Here, we have targeted JAK2 to be silenced by shRNA and investigated the biological functions and related mechanisms of JAK2 in GC cell ...

journal_title：Molecular and cellular biochemistry

authors： Qian C,Yao J,Wang J,Wang L,Xue M,Zhou T,Liu W,Si J

更新日期：2014-02-01 00:00:00

abstract：:One of the most clinically relevant biological activities of curcumin is its anti-cancer property, implicating multiple intracellular pathways in the process. In the present report, we investigated the effect of curcumin on the activation of apoptotic and anti-angiogenic pathways in Ehrlich Ascites Tumor (EAT) cells. ...

journal_title：Molecular and cellular biochemistry

authors： Belakavadi M,Salimath BP

更新日期：2005-05-01 00:00:00

abstract：:Silkworm (Bombyx mori) is not only a model organism for scientific studies, but also a commercial insect for agricultural production. BmAtg8 (a B. mori homolog of yeast Atg8) plays crucial roles in macroautophagy (hereafter referred to autophagy), which is helpful for silkworm metamorphosis. Relevant mechanism about B...

journal_title：Molecular and cellular biochemistry

authors： Xue S,Mao F,Hu D,Yan H,Lei J,Obeng E,Zhou Y,Quan Y,Yu W

更新日期：2019-07-01 00:00:00

abstract：:Hepcidin is a cysteine-rich, dual-function peptide with antimicrobial activity that plays a crucial role in iron homeostasis. Here, we have identified two hepcidin-like cDNA sequences from pigeon, Columba livia. The two cDNAs consist of 295 and 380 nucleotides, respectively, and were named HP1 and HP2. Sequence alignm...

journal_title：Molecular and cellular biochemistry

authors： Fu YM,Li SP,Wu YF,Chang YZ

更新日期：2007-11-01 00:00:00

abstract：:The bioenergetics of Ca2+ transport in bacteria are discussed with special emphasis on the interrelationship between transport and other cellular functions such as substrate oxidation by the respiratory chain and oxidative phosphorylation. The unusual polarity of Ca2+ movement provides an exceptional tool to compare a...

journal_title：Molecular and cellular biochemistry

authors： Devés R,Brodie AF

更新日期：1981-04-27 00:00:00

abstract：:Cryptotanshinone (CPT) is a natural compound extracted from herbal medicine that has been previously shown to possess antitumor properties in various types of human cancer cells. In the present study, we examined the potential role of CPT in the treatment of colorectal cancer. Using SW480, HCT116, and LOVO colorectal ...

journal_title：Molecular and cellular biochemistry

authors： Li W,Saud SM,Young MR,Colburn NH,Hua B

更新日期：2015-08-01 00:00:00

abstract：:Members of the family of intracellular lipid binding proteins (iLBPs) have been implicated in cytoplasmic transport of lipophilic ligands, such as long-chain fatty acids and retinoids. iLBPs are low molecular mass proteins (14-16 kDa) sharing a common structural fold. The iLBP family likely arose through duplication a...

journal_title：Molecular and cellular biochemistry

authors： Schaap FG,van der Vusse GJ,Glatz JF

更新日期：2002-10-01 00:00:00

abstract：:Pulmonary atresia (PA) with ventricular septal defect (VSD) is an extreme form of tetralogy of Fallot with characteristic right ventricular hypertrophy. To reduce the right ventricular overload, these children have to undergo staged corrective surgery to restore physiological pulmonary perfusion. We studied the degree...

journal_title：Molecular and cellular biochemistry

authors： Peters TH,de Jong PL,Klompe L,Berger RM,Saxena PR,Sharma HS,Bogers AJ

更新日期：2003-09-01 00:00:00

abstract：:The continuous advancements in cancer research have contributed to the overwhelming evidence of the presence of telomerase in primary and secondary tumours together with hsp90 and c-Myc. This review will discuss the important role of telomerase together with hsp90 and c-Myc within the initiation and progression of gli...

journal_title：Molecular and cellular biochemistry

authors： Shervington A,Cruickshanks N,Wright H,Atkinson-Dell R,Lea R,Roberts G,Shervington L

更新日期：2006-02-01 00:00:00

abstract：:Radioprotection by an aqueous extract of Podophyllum hexandrum (RP-1) was investigated in HepG2 cells by evaluating colony forming efficacy (CFE), redox status of mitochondria, reactive oxygen species (ROS), generation of nitric oxide (NO), peroxidation of lipids and intracellular glutathione. Lower concentrations of ...

journal_title：Molecular and cellular biochemistry

authors： Gupta D,Arora R,Garg AP,Goel HC

更新日期：2003-08-01 00:00:00

abstract：:The collagen metabolism alterations triggered by reactive oxygen species are involved in the development of various connective tissue diseases and skin aging. This study was designed to examine whether (E)-anethole possesses a protective effect on H2O2-induced alterations in collagen metabolism as well as whether it c...

journal_title：Molecular and cellular biochemistry

authors： Galicka A,Krętowski R,Nazaruk J,Cechowska-Pasko M

更新日期：2014-09-01 00:00:00

abstract：:We investigated the expression of the nuclear-encoded genes controlling the mitochondrial properties in the mouse gastrocnemius muscle to gain insight into the mitochondrial biogenesis that occurs during the muscle degeneration/regeneration induced by freezing. In addition, we tested whether the muscle regeneration is...

journal_title：Molecular and cellular biochemistry

authors： Wagatsuma A,Kotake N,Yamada S

更新日期：2011-03-01 00:00:00

abstract：:AcMNPV is the first baculovirus to be sequenced and is considered a model of baculovirus. ac154 is a later expression gene in AcMNPV genome and its function is unknown. In this study, we explored the function of Ac154 in AcMNPV infection process in host Sf9 cells. The results showed that Ac154 was distributed in both ...

journal_title：Molecular and cellular biochemistry

authors： Bai H,Liang A,Fu Y

更新日期：2020-01-01 00:00:00

abstract：:The effects of Mg2+ concentration (Mg2+o, 0, 1.2, 2.4, and 4.8 mM) on the incidence of reperfusion arrhythmias and on the cellular electrical activity were studied in spontaneously beating rat hearts. The surface electrogram and the membrane potential were recorded in control conditions, during 10 min of regional isch...

journal_title：Molecular and cellular biochemistry

authors： Ponce Zumino A,Risler NR,Schanne OF,Ruiz Petrich E,Carrión A

更新日期：1997-06-01 00:00:00

abstract：:The contractile hyporesponsiveness of the streptozotocin diabetic rat heart in vitro to beta-adrenergic agonists is eliminated when the heart is perfused with N(G)-nitro-L-arginine methyl ester (L-NAME), a non-selective inhibitor of nitric oxide synthase (NOS). The following study evaluated the hypothesis that an incr...

journal_title：Molecular and cellular biochemistry

authors： Smith JM,Sondgeroth KB,Wahler GM

更新日期：2007-06-01 00:00:00

abstract：:Accumulating data support the idea that apoptosis in cardiac myocytes, in part, contributes to the development of heart failure. Since a number of neurohormonal factors are activated in this state, these factors may be involved in the positive and negative regulation of apoptosis in cardiac myocytes. Norepinephrine is...

journal_title：Molecular and cellular biochemistry

authors： Iwai-Kanai E,Hasegawa K

更新日期：2004-04-01 00:00:00

abstract：:We investigated whether chronic in vivo treatment with the peroxisome proliferator-activated receptor alpha agonist Wy-14,643 attenuates cardiac contractile function by impairing mitochondrial respiration. Wy-14,643 (25 mg kg(-1) day(-1)) was administered to Wistar rats by oral gavage for 14 consecutive days, after wh...

journal_title：Molecular and cellular biochemistry

authors： Zungu M,Young ME,Stanley WC,Essop MF

更新日期：2009-10-01 00:00:00

abstract：:The TP53 signal transduction pathway is an attractive target for cancer treatments. In this study, we conducted a comprehensive molecular evaluation of 907 patients with cancer in Japan to identify genomic alterations in the TP53 pathway. TP53 mutations were frequently detected in many cancers, except melanoma, thymic...

journal_title：Molecular and cellular biochemistry

authors： Ohnami S,Ohshima K,Nagashima T,Urakami K,Shimoda Y,Saito J,Naruoka A,Hatakeyama K,Mochizuki T,Serizawa M,Ohnami S,Kusuhara M,Yamaguchi K

更新日期：2017-07-01 00:00:00

abstract：:Treatment with alpha-difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC), depletes the putrescine and spermidine content, and reduces the growth rate of Ehrlich ascites tumor cells. The addition of putrescine, which is the immediate precursor of spermidine, promp...

journal_title：Molecular and cellular biochemistry

authors： Oredsson SM,Anehus S,Heby O

更新日期：1984-09-01 00:00:00

abstract：:Endothelial cell nitric oxide synthase (NOS) is known to have a N-myristoylation consensus sequence. Such a consensus sequence is not evident in the macrophage, smooth muscle and neuronal NOS. A functional role for this N-terminal myristoylation is not clear yet. In the present study, we examined the effect of N-termi...

journal_title：Molecular and cellular biochemistry

authors： Sakoda T,Hirata K,Kuroda R,Miki N,Suematsu M,Kawashima S,Yokoyama M

更新日期：1995-11-22 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) has been thought to play a major role during cardiac fibrosis in the development of diabetic cardiomyopathy, and cardiac fibrosis mainly as a result of an increase of collagen type III occurs in the human hearts with diabetes. Thrombospondin-1 (TSP-1) has been reported to activat...

journal_title：Molecular and cellular biochemistry

authors： Tang M,Zhou F,Zhang W,Guo Z,Shang Y,Lu H,Lu R,Zhang Y,Chen Y,Zhong M

更新日期：2011-01-01 00:00:00

abstract：:Tryptophan as a circulating precursor of serotonin (5-HT) may suppress food intake and body weight. Tryptophan administration can enhance the generation of reactive oxygen species (ROS) by inducing oxidative pathway in vivo and in vitro. We have examined the effect of repeated tryptophan administration on food consump...

journal_title：Molecular and cellular biochemistry

authors： Coşkun S,Ozer C,Gönül B,Take G,Erdoğan D

更新日期：2006-06-01 00:00:00

abstract：:Under normal and ischemic conditions backdiffusion of radiolabeled non-esterified fatty acids (NEFA) has been demonstrated. In the fasted normal canine heart the extraction fraction (EF) during interventions with glucose or lactate loading, vasodilation, and metabolic level augmentation was determined, and compared wi...

journal_title：Molecular and cellular biochemistry

authors： Duwel CM,Visser FC,van Eenige MJ,Roos JP

更新日期：1989-06-27 00:00:00

abstract：:L-asparaginase EC 3.5.1.1 was purified to homogeneity from Thermus thermophilus. The apparent molecular mass of L-asparaginase by SDS-PAGE was found to be 33 kDa, whereas by its mobility on Sephacryl S-300 superfine column was around 200 kDa, indicating that the enzyme at the native stage acts as hexamer. The purified...

journal_title：Molecular and cellular biochemistry

authors： Pritsa AA,Kyriakidis DA

更新日期：2001-01-01 00:00:00

abstract：:Peroxisome proliferator activated receptor gamma coactivator 1α (PGC-1α) induced by hypoxia regulates mitochondrial biogenesis and oxidative stress. However, the potential role of PGC-1α in hypoxia-promoted proliferation of pulmonary arterial vascular smooth muscle cells (PASMCs) is completely unknown. In this study, ...

journal_title：Molecular and cellular biochemistry

authors： Rao J,Li J,Liu Y,Lu P,Sun X,Sugumaran PK,Zhu D

更新日期：2012-08-01 00:00:00

abstract：:Osteosarcoma (OS) is a type of malignant tumor arising from soft-tissues of bone and displays poor prognosis in most cases. However, the molecular mechanism by which OS initiates and progresses is still not completely elucidated. miR-155 has been shown to be overexpressed in OS specimen and cell lines. Our study is in...

journal_title：Molecular and cellular biochemistry

authors： Sun X,Geng X,Zhang J,Zhao H,Liu Y

更新日期：2015-05-01 00:00:00

abstract：:Myofibroblasts are metabolically and morphologically distinctive fibroblasts expressing alpha-smooth muscle actin (alpha-SMA), and their activation plays a key role in development of the fibrotic response. In an activated state, myofibroblasts cease to proliferate and start to synthesize large amounts of extracellular...

journal_title：Molecular and cellular biochemistry

authors： Nakatani T,Honda E,Hayakawa S,Sato M,Satoh K,Kudo M,Munakata H

更新日期：2008-01-01 00:00:00

abstract：:To investigate insulin action in muscle and adipose tissue in hepatic cirrhosis, a recently described animal model was used. Dimethylnitrosamine administration induced histologically proven cirrhosis. Contrary to expectation, muscle strips from cirrhotic rats displayed increased insulin sensitivity both with respect t...

journal_title：Molecular and cellular biochemistry

authors： Chowdhury SA,Taylor R

更新日期：1989-08-15 00:00:00