HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy.

abstract：:The TIS11 gene is an immediate early gene that is induced rapidly and transiently by phorbol 12-myristate 13-acetate and various growth factors. To study transcriptional regulation of the gene, a genomic clone of rat TIS11 was isolated, and the organization of exon-intron structure and transcriptional initiation site ...

journal_title：Molecular and cellular biochemistry

authors： Kaneda N,Murata T,Niimi Y,Minamiyama M

更新日期：2000-10-01 00:00:00

abstract：:Biochemical and structural changes occurring in the myocardium with aging are mainly resulting from the association of a general tissue atrophy with the hypertrophy of the remaining myocytes. Whilst hypertrophy seems to be a compensatory process to the loss of cardiomyocytes and to a mild systolic hypertensive conditi...

journal_title：Molecular and cellular biochemistry

authors： Muscari C,Giaccari A,Giordano E,Clô C,Guarnieri C,Caldarera CM

更新日期：1996-07-01 00:00:00

abstract：:To evaluate the role of lipid oxidation in atherogenesis the levels of lipid- and protein-bound products of peroxidation in normal and atherosclerotic areas of human aorta were investigated. The level of fluorescent (360/430 nm) lipid products was measured in chloroform-methanol extracts of aortic tissue. Normal intim...

journal_title：Molecular and cellular biochemistry

authors： Tertov VV,Kaplun VV,Mikhailova IA,Suprun IV,Orekhov AN

更新日期：2001-09-01 00:00:00

abstract：:Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase which participates in many important cellular processes such as cell adhesion and migration. However, the role of FAK in renal tubular epithelial-to-mesenchymal transition (EMT) is still unknown. FAK was knocked down by transfection of specific small interf...

journal_title：Molecular and cellular biochemistry

authors： Deng B,Yang X,Liu J,He F,Zhu Z,Zhang C

更新日期：2010-07-01 00:00:00

abstract：:Telocytes (TCs) are a novel cell type identified among interstitial cells in various organs. TCs are characterized by very long cell processes (tens to hundreds micrometres) named telopodes (Tps) with uneven calibre: dilations (podoms) and very thin segments (podomers). However, little is known about the factors which...

journal_title：Molecular and cellular biochemistry

authors： Enciu AM,Popescu LM

更新日期：2015-12-01 00:00:00

abstract：:This paper describes a purification procedure and some properties of a nonspecific nucleoside phosphotransferase of chick embryo, an activity which catalyzes the transfer of chick embryo, an activity which catalyzes the transfer of the phosphate ester from a deoxyribonucleotide or a pyrimidine ribonucleotide to a deox...

journal_title：Molecular and cellular biochemistry

authors： Tesoriere G,Vento R,Calvaruso G,Taibi G

更新日期：1979-06-15 00:00:00

abstract：:Subsequent to the first alpha 2-adrenergic receptor (alpha 2-AR) gene cloning of alpha 2-C10 from human platelet, cloning of the first rodent alpha 2-AR cDNA, cA2-47, was reported. Based on the structural and limited pharmacological comparison, it was concluded that the rodent receptor is a molecular and pharmacologic...

journal_title：Molecular and cellular biochemistry

authors： Wypijewski K,Duda T,Sharma RK

更新日期：1995-03-23 00:00:00

abstract：:The effect of three different carbon sources on the biosynthesis of polyunsaturated fatty acids of the alpha-linolenic acid series was investigated in hepatoma tissue culture (HTC) cells. Alpha linolenic acid was converted to higher homologs by a desaturating route that synthetized mainly 18:4 (delta6, 9, 12, 15), 20:...

journal_title：Molecular and cellular biochemistry

authors： de Alaniz MJ,Brenner RR

更新日期：1976-08-30 00:00:00

abstract：:Phospholipase C-beta (PLCbeta) isozymes (PLCbeta(1) and PLCbeta(3)) have been extensively characterized in cardiac tissue, but no data are available for the PLCbeta(4) isozyme. In this study, PLCbeta((1-4)) isozymes mRNA relative expression was studied by real-time PCR (RT-PCR) in human, rat, and murine left ventricle...

journal_title：Molecular and cellular biochemistry

authors： Otaegui D,Querejeta R,Arrieta A,Lazkano A,Bidaurrazaga A,Arriandiaga JR,Aldazabal P,Garro MA

更新日期：2010-04-01 00:00:00

abstract：:Antimycin A (AMA) inhibits succinate oxidase, NADH oxidase, and mitochondrial electron transport chain between cytochrome b and c. We recently demonstrated that AMA inhibited the growth of Calu-6 lung cancer cells through apoptosis. Here, we investigated the effects of AMA and/or MAPK inhibitors on Calu-6 lung cancer ...

journal_title：Molecular and cellular biochemistry

authors： Han YH,Park WH

更新日期：2010-01-01 00:00:00

abstract：:The aim of our study is to explore the regulation of C1QTNF1-AS1 on its target miR-221-3p/SOCS3 in human hepatocellular carcinoma (HCC). To explore the underlying molecular regulation of non-coding RNA for HCC, differentially expressed patterns of lncRNAs and genes were examined by RNA-seq. GO and KEGG pathway analysi...

journal_title：Molecular and cellular biochemistry

authors： Han W,Yu G,Meng X,Hong H,Zheng L,Wu X,Zhang D,Yan B,Ma Y,Li X,Wang Q

更新日期：2019-10-01 00:00:00

abstract：:Under normal and ischemic conditions backdiffusion of radiolabeled non-esterified fatty acids (NEFA) has been demonstrated. In the fasted normal canine heart the extraction fraction (EF) during interventions with glucose or lactate loading, vasodilation, and metabolic level augmentation was determined, and compared wi...

journal_title：Molecular and cellular biochemistry

authors： Duwel CM,Visser FC,van Eenige MJ,Roos JP

更新日期：1989-06-27 00:00:00

abstract：:By qualitative and quantitative PCR, we evaluated the expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas). Qualitative PCR demonstrated, in human tissues but not in the cell lines examined, the presence of an mRNA ...

journal_title：Molecular and cellular biochemistry

authors： Gornati R,Chini V,Rimoldi S,Meregalli M,Schiaffino E,Bernardini G

更新日期：2007-04-01 00:00:00

abstract：:Liver glycogen synthase b phosphatase, chromatographically separable from phosphorylase a phosphatase, is decreased in 48-hour alloxan diabetic rats. The phosphatase activities are measured in an in vitro system using exogenous isolated phospho-enzyme as substrates with added phosphatases. Synthase and phosphorylase p...

journal_title：Molecular and cellular biochemistry

authors： Gold AH,Dickemper D,Haverstick DM

更新日期：1979-05-06 00:00:00

abstract：:In order to establish the distribution with time of proteins microinjected into mammalian cells, horseradish peroxidase (HRP) was microinjected into baby hamster kidney (BHK) cells using chicken erythrocyte ghosts. At time intervals following initiation of fusion between ghosts and target cells, samples were fixed wit...

journal_title：Molecular and cellular biochemistry

authors： McClung JK,Ulrich RG,Kletzien RF

更新日期：1987-01-01 00:00:00

abstract：:The involvement of a hypocalcemic hormone calcitonin (CT) in the expression of hepatic Ca(2+)-binding protein regucalcin mRNA was investigated. The change of regucalcin mRNA levels was analyzed by Northern blotting using liver regucalcin complementary DNA (0.9 kb). A single oral administration of calcium chloride (100...

journal_title：Molecular and cellular biochemistry

authors： Yamaguchi M,Kanayama Y,Shimokawa N

更新日期：1994-07-13 00:00:00

abstract：:Glioblastoma is the most common and deadly type of brain cancer. The poor prognosis may be largely attributed to inadequate disease response to current chemotherapeutic agents. Activation of p38 is associated with deleterious outcomes in glioblastoma patients, as its signaling mediates chemoresistance mechanisms. Anti...

journal_title：Molecular and cellular biochemistry

authors： Su BC,Chen JY

更新日期：2020-01-01 00:00:00

abstract：:Hybridization characteristics of purified chloroplast DNA, immobilized in 'dot blots' on nitrocellulose filters using radiolabeled chloroplast DNA restriction fragments or recombinant DNA probes were investigated. Conditions are described which proved a near linear relationship between amounts of hybridization and amo...

journal_title：Molecular and cellular biochemistry

authors： Smith MA

更新日期：1984-09-01 00:00:00

abstract：:In view of the accumulation of H2O2 in the myocardium due to ischemia-reperfusion and changes in beta-adrenoceptor mechanisms in the ischemic-reperfused heart, we investigated the effects of H2O2 on the beta-adrenoceptor, G-protein and adenylyl cyclase complex. Rat hearts were perfused with 1 mM H2O2 for 10 min before...

journal_title：Molecular and cellular biochemistry

authors： Persad S,Panagia V,Dhalla NS

更新日期：1998-09-01 00:00:00

abstract：:In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were s...

journal_title：Molecular and cellular biochemistry

authors： Kovacs V,Gasz B,Balatonyi B,Jaromi L,Kisfali P,Borsiczky B,Jancso G,Marczin N,Szabados S,Melegh B,Nasri A,Roth E

更新日期：2014-04-01 00:00:00

abstract：:Vaccinia virus (VV) and other pathogenic poxviruses encode for a complement control protein. The VV complement control protein or VCP, was one of the first soluble microbial proteins postulated to have an active role in the immunomodulation of the host defense. Since then, 2 other poxviruses, including variola virus a...

journal_title：Molecular and cellular biochemistry

authors： Kotwal GJ,Miller CG,Justus DE

更新日期：1998-08-01 00:00:00

abstract：:Experiments were designed to determine if cotton bract tannin, a component of cotton mill dust, would promote the phosphorylation of alveolar macrophage proteins in doses potentially achievable in vivo. Rabbit alveolar macrophages were loaded with 32PO4 and challenged with various doses of tannin for time periods rang...

journal_title：Molecular and cellular biochemistry

authors： Hempel SL,Rohrbach MS

更新日期：1989-04-11 00:00:00

abstract：:Endothelial progenitor cell (EPC) transplantation has shown advantages in the treatment of myocardial infarction (MI) in animal models and clinical trials through mechanisms of direct intercellular contacts, autocrine, and paracrine. However, the effects of EPC transplantation for MI treatment remain controversial and...

journal_title：Molecular and cellular biochemistry

authors： Zhou W,Zheng X,Cheng C,Guo G,Zhong Y,Liu W,Liu K,Chen Y,Liu S,Liu S

更新日期：2020-10-23 00:00:00

abstract：UNLABELLED:Since recent findings indicate the involvement of G-proteins in the mechanism of ischaemic preconditioning (PC), the present study was aimed to investigate the role of adrenergic mechanisms, such as G-proteins and stimulation of adrenergic receptors, in this phenomenon. For this purpose, isolated Langendorff...

journal_title：Molecular and cellular biochemistry

authors： Ravingerová T,Pyne NJ,Parratt JR

更新日期：1995-06-07 00:00:00

abstract：:Susceptibility of four major rat tissues to oxidative damage in terms of lipid peroxidation induced by in vitro by ascorbate-Fe2+ in homogenates and mitochondria has been examined. Lipid peroxidation, as assessed by thiobarbituric acid reactive substances (TBARS) and conjugated dienes was maximum in brain followed by ...

journal_title：Molecular and cellular biochemistry

authors： Pushpendran CK,Subramanian M,Devasagayam TP,Singh BB

更新日期：1998-01-01 00:00:00

abstract：:1. Glucokinase is one of four glucose phosphorylating enzymes present in rat liver. Its distinctive features are a high K-m for glucose (high-K-m isozyme) and a rather narrow substrate specificity. In contrast, the other three enzymes, collectively called hexokinases or low-K-m isozymes, exhibit low K-m values for glu...

journal_title：Molecular and cellular biochemistry

authors： Niemeyer H,Ureta T,Clark-Turri L

更新日期：1975-02-28 00:00:00

abstract：:Modulation of Ca(2+) homoeostasis in cardiac myocytes plays a major role in beat-to-beat regulation of heart function. Previous studies suggest that sphingosine-1-phosphate (S1P), a biologically active sphingomyelin metabolite, regulates Ca(2+) handling in cardiac myocytes, but the underlying mechanism is unclear. In ...

journal_title：Molecular and cellular biochemistry

authors： Egom EE,Bae JS,Capel R,Richards M,Ke Y,Pharithi RB,Maher V,Kruzliak P,Lei M

更新日期：2016-08-01 00:00:00

abstract：:Pediatric cataract of the congenital type is the most common form of childhood blindness and it is clinically and genetically heterogeneous. Mutations in 22 different genes have been identified to be associated with congenital cataracts, and among them, eight mutants belong to αA-crystallin. To explain how mutations i...

journal_title：Molecular and cellular biochemistry

authors： Kore R,Hedges RA,Oonthonpan L,Santhoshkumar P,Sharma KK,Abraham EC

更新日期：2012-03-01 00:00:00

abstract：:Chemical and enzymatic properties of four collagenases newly isolated from anaerobic Clostridium histolyticum, aerobic Achromobacter iophagus, and from two lower eucaryotes, the fungus Entomophthora coronata and the insect Hypoderma lineatum are reviewed. The problems of their biosynthesis and precursors, namely the e...

journal_title：Molecular and cellular biochemistry

authors： Keil B

更新日期：1979-01-26 00:00:00

abstract：:Unidirectional promoters dominate among mammalian genomes. However, the mechanism through which the transcriptional directionality of promoters is accomplished remains to be clarified. Insulin-degrading enzyme (IDE) is a ubiquitously expressed zinc metalloprotease, whose promoter contains a CpG island. We previously s...

journal_title：Molecular and cellular biochemistry

authors： Zhang L,Wang P,Ding Q,Wang Z

更新日期：2013-10-01 00:00:00